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Journal Articles

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations that Overcome it’s Feedback Inhibition of RAC1 and Migration

Sunyana Gadal, Jacob A. Boyer, Simon F. Roy, Noah A. Outmezguine, Malvika Sharma, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Afsar Barlas, Qing Chang, Priya Pancholi, Neilawattie Merna. Timaul, Michael Overholtzer, Rona Yaeger, Katia Manova-Todorova, Elisa de Stanchina, Marcus W. Bosenberg, Neal Rosen
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2220
Published: 24 February 2025
View article titled, Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations that Overcome it’s Feedback Inhibition of RAC1 and Migration
Open the PDF for Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations that Overcome it’s Feedback Inhibition of RAC1 and Migration in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract C077: Functional Dissection of the Highly Plastic Basal Cell State in Pancreatic Cancer

Anupriya Singhal, Hannah C. Styers, Jonathan Rub, Zhuxuan Li, Zeynep Tarcan, Jill Hallin, Olca Basturk, Rona Yaeger, James G. Christensen, Doron Betel, Yan Yan, Elisa de Stanchina, Tuomas Tammela
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C077.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C077
Published: 15 September 2024
View article titled, Abstract C077: Functional Dissection of the Highly Plastic Basal Cell State in Pancreatic Cancer
Journal Articles

Abstract SY34-02: Age-related and organ-specific host mosaicism as a driver of dormant cancer cell awakening

Julio A. Aguirre-Ghiso, Michael Papanicolaou, Pablo Sánchez Vela, Julie Yang, Anton Safonov, Jacqueline Tao, Sebastia Franch Exposito, Vera Tiedje, Erica Dalla, Luis E. Valencia Salazar, Nicole Barth, Merve Sahin, Kevin Chen, Jinae Park, Matthew Wereski, Aishwarya Krishnan, Anthony Martinez Benitez, Ryan Ptashkin, Mark E. Robson, Elisa de Stanchina, Lior Z. Braunstein, Ahmet Zehir, Elizabeth Comen, Larry Norton, Michael Berger, Richard Koche, Pedram Razavi, Ross Levine
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): SY34-02.
https://doi.org/10.1158/1538-7445.AM2024-SY34-02
Published: 05 April 2024
View article titled, Abstract SY34-02: Age-related and organ-specific host mosaicism as a driver of dormant cancer cell awakening
Journal Articles

Abstract 6006: Modeling antibody drug conjugate sensitivity using urothelial carcinoma patient-derived models

Xinran Tang, Ziyu Chen, Jasmine Thomas, Karan Nagar, John Christin, Naryan Rustgi, Sizhi Gao, Elisa de Stanchina, Jonathan Coleman, Michael Shen, Hikmat Al-Ahmadie, Gopa Iyer, Kwanghee Kim, David Solit
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6006.
https://doi.org/10.1158/1538-7445.AM2024-6006
Published: 22 March 2024
View article titled, Abstract 6006: Modeling antibody drug conjugate sensitivity using urothelial carcinoma patient-derived models
Journal Articles

Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer

Zeda Zhang, Xin Fang, Yu-jui Ho, Sascha Haubner, Friederike Kogel, Clemens Hinterleitner, Stella Paffenholz, Kevin Chen, Wei Luan, Amanda Kulick, Gertrude Gunset, Andreina Garcia Angus, Jing Zhang, Zijian Xu, Adam Wang, Qingwen Jiang, Elisa de Stanchina, Britta Weigelt, Dmitriy Zamarin, Aveline Filliol, Judith Feucht, Jorge Mansilla-Soto, Corina Amor, Michel Sadelain, Scott Lowe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 115.
https://doi.org/10.1158/1538-7445.AM2024-115
Published: 22 March 2024
View article titled, Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer
Journal Articles

Abstract 5901: A targetable secreted protein drives pancreatic cancer metastatic colonization and HIF1a nuclear retention

Norihiro Yamaguchi, Gloria Wu, Ethan Ravetch, Mai Takahashi, Abdul G. Khan, Akimasa Hayashi, Wenbin Mei, Dennis Hsu, Elisa de Stanchina, Ivo C. Lorenz, Christine Iacobuzio-Donahue, Sohail F. Tavazoie
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5901.
https://doi.org/10.1158/1538-7445.AM2024-5901
Published: 22 March 2024
View article titled, Abstract 5901: A targetable secreted protein drives pancreatic cancer metastatic colonization and HIF1a nuclear retention
Journal Articles

Abstract 2004: CDC7 inhibition prevents neuroendocrine transformation in the lung and prostate through MYC degradation

Alvaro Quintanal-Villalonga, Fathema Uddin, Kenta Kawasaki, Esther Redin, Vidushi Durani, Amin Sabet, Wouter Karthaus, Yingqian A. Zhan, Samir Zaidi, Moniquetta Shaffer, Harsha Sridhar, Juan Qiu, Parvathy Manoj, Elisa De Stanchina, Michael C. Haffner, Charles L. Sawyers, Charles M. Rudin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2004.
https://doi.org/10.1158/1538-7445.AM2024-2004
Published: 22 March 2024
View article titled, Abstract 2004: CDC7 inhibition prevents neuroendocrine transformation in the lung and prostate through MYC degradation
Journal Articles

Abstract B089: Oncogenic signaling and responses to treatment in RAS mutant cancers are mutation-specific

Michelangelo Marasco, Dinesh Kumar, Riccardo Mezzadra, Wei Luan, Ilinca Aricescu, Rona Yaeger, Vladimir Markov, Yu Zhu, Elisa de Stanchina, Scott Lowe, Sandra Misale, Neal Rosen
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B089.
https://doi.org/10.1158/1538-7445.PANCA2023-B089
Published: 16 January 2024
View article titled, Abstract B089: Oncogenic signaling and responses to treatment in RAS mutant cancers are mutation-specific
Journal Articles

Abstract PR007: ERG-driven luminal prostate cancers emerge from Ck5+/Nkx3.1+ basal cells

Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Ignas Masilionis, Katia Manova-Todorova, Ronan Chaligné, Elisa de Stanchina, Brett S. Carver, Yu Chen, Dong Gao, Christina S. Leslie, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): PR007.
https://doi.org/10.1158/1538-7445.PRCA2023-PR007
Published: 02 June 2023
View article titled, Abstract PR007: ERG-driven luminal prostate cancers emerge from Ck5+/Nkx3.1+ basal cells
Journal Articles

Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with MDM2 amplification

Arielle Elkrief, Vladimir Markov, Álvaro Quintanal-Villalonga, Rebecca Caeser, Pawel Sobczuk, Emily Cheng, Alexander Drilon, Gregory J. Riely, William W. Lockwood, Elisa de Stanchina, Charles M. Rudin, Igor Odintsov, Romel Somwar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6127.
https://doi.org/10.1158/1538-7445.AM2023-6127
Published: 04 April 2023
View article titled, Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with <em>MDM2</em> amplification
Journal Articles

Abstract 472: HER2 as a therapeutic target in bladder cancer

Xinran Tang, Ziyu Chen, Jasmine Thomas, Karan Nagar, John Christin, Naryan Rustgi, Sizhi Gao, Carissa Chu, Elisa De Stanchina, Michael F. Berger, Jonathan A. Coleman, Michael M. Shen, Hikmat A. Al-Ahmadie, Gopakumar V. Iyer, Kwanghee Kim, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 472.
https://doi.org/10.1158/1538-7445.AM2023-472
Published: 04 April 2023
View article titled, Abstract 472: HER2 as a therapeutic target in bladder cancer
Journal Articles

Abstract 2: Vertical MAPK pathway targeting in novel genetically engineered mouse and cell line models of NF1-altered melanoma: the mSK-Mel murine cohort

Alexis M. Jones, Aphrothiti J. Hanrahan, Moriah H. Nissan, Sebastien Monette, Ziyu Chen, Wenhuo Hu, Sandra Misale, Isabell Schulze, Naresh Vasani, Cailian Liu, Xia Yang, Mohsen Abu-Akeel, Elisa de Stanchina, Nikolaus Schultz, Michael F. Berger, Neal Rosen, Taha Merghoub, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2.
https://doi.org/10.1158/1538-7445.AM2023-2
Published: 04 April 2023
View article titled, Abstract 2: Vertical MAPK pathway targeting in novel genetically engineered mouse and cell line models of NF1-altered melanoma: the mSK-Mel murine cohort
Journal Articles

Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy J. Lee, Sandra Cohen, Jane Park, Corinne E. Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa de Stanchina, Michael F. Berger, Anuradha Gopalan, Lukas E. Dow, Juan Miguel Mosquera, Himisha Beltran, Cora N. Sternberg, Ping Chi, Howard I. Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): NG10.
https://doi.org/10.1158/1538-7445.AM2023-NG10
Published: 04 April 2023
View article titled, Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models

Ziyu Chen, Xinran Tang, Eliyahu Havasov, Andrew Mcpherson, Carissa Chu, John R. Christin, Michael F. Berger, Nikolaus D. Schultz, Elisa de Stanchina, Michael M. Shen, Hikmat Al-Ahmadie, Kwanghee Kim, Gopa Iyer, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5931.
https://doi.org/10.1158/1538-7445.AM2023-5931
Published: 04 April 2023
View article titled, Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models
Journal Articles

Abstract 3858: Exploring Exportin-1 as a therapeutic vulnerability in squamous cell carcinoma

Vidushi Durani, Rebecca Caeser, Charles M. Rudin, Alvaro Quintanal-Villalonga, Harsha Sridhar, Parvathy Manoj, Sam E. Tischfield, Marina Asher, Umeshkumar Bhanot, Jacklynn V. Egger, Nicholas D. Socci D. Socci, Nisargbhai S S. Shah, Elisa de Stanchina, Natasha Rekhtman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3858.
https://doi.org/10.1158/1538-7445.AM2023-3858
Published: 04 April 2023
View article titled, Abstract 3858: Exploring Exportin-1 as a therapeutic vulnerability in squamous cell carcinoma
Journal Articles

Abstract 4007: Efficacy of vepafestinib in preclinical models of RET fusion-driven sarcoma models

Igor Odintsov, Ryan C. Cheng, Allan J. Lui, Tom Zhang, Yue C. Lu, Renate I. Kurth, Morana Vojnic, Inna Khodos, Qing Chang, Kevin Chen, Claudio Giuliano, Annalisa Bonifacio, Isao Miyazaki, Elisa de Stanchina, Emanuela Lovati, Marc Ladanyi, Romel Somwar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4007.
https://doi.org/10.1158/1538-7445.AM2023-4007
Published: 04 April 2023
View article titled, Abstract 4007: Efficacy of vepafestinib in preclinical models of <em>RET</em> fusion-driven sarcoma models
Journal Articles

Abstract 3999: Combination of T-DXd with the irreversible pan-HER TKI afatinib drives combination benefit in HER2-low gastric and lung tumors

Deepa Bhavsar, Laura Kazlauskas, Flavia Michelini, Matt Griffin, Matt Wilson, Fabiola Cecchi, Liz Croydon, Kim Maratea, Elisa de Stanchina, Yelena Y. Janjigian, Maurizio Scaltriti, Theresa Proia, Jerome Mettetal
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3999.
https://doi.org/10.1158/1538-7445.AM2023-3999
Published: 04 April 2023
View article titled, Abstract 3999: Combination of T-DXd with the irreversible pan-HER TKI afatinib drives combination benefit in HER2-low gastric and lung tumors
Journal Articles

Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy Lee, Sandra Cohen, Jane Park, Corinne Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa De Stanchina, Michael Berger, Anuradha Gopalan, Lukas Dow, Juan Miguel Mosquera, Himisha Beltran, Cora Sternberg, Ping Chi, Howard Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B026.
https://doi.org/10.1158/1538-7445.CancEpi22-B026
Published: 01 December 2022
View article titled, Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract C015: EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype and promotes immune surveillance in PDAC

Loretah Chibaya, Katherine C. Murphy, Yvette Lopez Diaz, Kelly D. DeMarco, Haibo Liu, Sneha Gopalan, Melissa Faulkner, Junhui Li, John P. Morris IV, Yu-jui Ho, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua J. Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C015.
https://doi.org/10.1158/1538-7445.PANCA22-C015
Published: 15 November 2022
View article titled, Abstract C015: EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype and promotes immune surveillance in PDAC
Journal Articles

Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State

Kenneth L. Pitter, Olivera Grbovic-Huezo, Simon Joost, Anupriya Singhal, Melissa Blum, Katherine Wu, Matilda Holm, Alexander Ferrena, Arjun Bhutkar, Anna Hudson, Nicolas Lecomte, Elisa de Stanchina, Ronan Chaligne, Christine A. Iacobuzio-Donahue, Dana Pe'er, Tuomas Tammela
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3549–3560.
https://doi.org/10.1158/0008-5472.CAN-22-1742
Published: 04 October 2022
View article titled, Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State
Open the PDF for Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State in another window
Includes: Supplementary data