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Journal Articles

Abstract PR007: ERG-driven luminal prostate cancers emerge from Ck5+/Nkx3.1+ basal cells

Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Ignas Masilionis, Katia Manova-Todorova, Ronan Chaligné, Elisa de Stanchina, Brett S. Carver, Yu Chen, Dong Gao, Christina S. Leslie, Charles L. Sawyers
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): PR007.
https://doi.org/10.1158/1538-7445.PRCA2023-PR007
Published: 02 June 2023
View article titled, Abstract PR007: ERG-driven luminal prostate cancers emerge from Ck5+/Nkx3.1+ basal cells
Journal Articles

Abstract 4007: Efficacy of vepafestinib in preclinical models of RET fusion-driven sarcoma models

Igor Odintsov, Ryan C. Cheng, Allan J. Lui, Tom Zhang, Yue C. Lu, Renate I. Kurth, Morana Vojnic, Inna Khodos, Qing Chang, Kevin Chen, Claudio Giuliano, Annalisa Bonifacio, Isao Miyazaki, Elisa de Stanchina, Emanuela Lovati, Marc Ladanyi, Romel Somwar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4007.
https://doi.org/10.1158/1538-7445.AM2023-4007
Published: 04 April 2023
View article titled, Abstract 4007: Efficacy of vepafestinib in preclinical models of <em>RET</em> fusion-driven sarcoma models
Journal Articles

Abstract 3999: Combination of T-DXd with the irreversible pan-HER TKI afatinib drives combination benefit in HER2-low gastric and lung tumors

Deepa Bhavsar, Laura Kazlauskas, Flavia Michelini, Matt Griffin, Matt Wilson, Fabiola Cecchi, Liz Croydon, Kim Maratea, Elisa de Stanchina, Yelena Y. Janjigian, Maurizio Scaltriti, Theresa Proia, Jerome Mettetal
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3999.
https://doi.org/10.1158/1538-7445.AM2023-3999
Published: 04 April 2023
View article titled, Abstract 3999: Combination of T-DXd with the irreversible pan-HER TKI afatinib drives combination benefit in HER2-low gastric and lung tumors
Journal Articles

Abstract 472: HER2 as a therapeutic target in bladder cancer

Xinran Tang, Ziyu Chen, Jasmine Thomas, Karan Nagar, John Christin, Naryan Rustgi, Sizhi Gao, Carissa Chu, Elisa De Stanchina, Michael F. Berger, Jonathan A. Coleman, Michael M. Shen, Hikmat A. Al-Ahmadie, Gopakumar V. Iyer, Kwanghee Kim, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 472.
https://doi.org/10.1158/1538-7445.AM2023-472
Published: 04 April 2023
View article titled, Abstract 472: HER2 as a therapeutic target in bladder cancer
Journal Articles

Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy J. Lee, Sandra Cohen, Jane Park, Corinne E. Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa de Stanchina, Michael F. Berger, Anuradha Gopalan, Lukas E. Dow, Juan Miguel Mosquera, Himisha Beltran, Cora N. Sternberg, Ping Chi, Howard I. Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): NG10.
https://doi.org/10.1158/1538-7445.AM2023-NG10
Published: 04 April 2023
View article titled, Abstract NG10: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models

Ziyu Chen, Xinran Tang, Eliyahu Havasov, Andrew Mcpherson, Carissa Chu, John R. Christin, Michael F. Berger, Nikolaus D. Schultz, Elisa de Stanchina, Michael M. Shen, Hikmat Al-Ahmadie, Kwanghee Kim, Gopa Iyer, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5931.
https://doi.org/10.1158/1538-7445.AM2023-5931
Published: 04 April 2023
View article titled, Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models
Journal Articles

Abstract 2: Vertical MAPK pathway targeting in novel genetically engineered mouse and cell line models of NF1-altered melanoma: the mSK-Mel murine cohort

Alexis M. Jones, Aphrothiti J. Hanrahan, Moriah H. Nissan, Sebastien Monette, Ziyu Chen, Wenhuo Hu, Sandra Misale, Isabell Schulze, Naresh Vasani, Cailian Liu, Xia Yang, Mohsen Abu-Akeel, Elisa de Stanchina, Nikolaus Schultz, Michael F. Berger, Neal Rosen, Taha Merghoub, David B. Solit
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2.
https://doi.org/10.1158/1538-7445.AM2023-2
Published: 04 April 2023
View article titled, Abstract 2: Vertical MAPK pathway targeting in novel genetically engineered mouse and cell line models of NF1-altered melanoma: the mSK-Mel murine cohort
Journal Articles

Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with MDM2 amplification

Arielle Elkrief, Vladimir Markov, Álvaro Quintanal-Villalonga, Rebecca Caeser, Pawel Sobczuk, Emily Cheng, Alexander Drilon, Gregory J. Riely, William W. Lockwood, Elisa de Stanchina, Charles M. Rudin, Igor Odintsov, Romel Somwar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6127.
https://doi.org/10.1158/1538-7445.AM2023-6127
Published: 04 April 2023
View article titled, Abstract 6127: MDM2 inhibition in combination with MEK inhibition in pre-clinical models of lung adenocarcinomas with <em>MDM2</em> amplification
Journal Articles

Abstract 3858: Exploring Exportin-1 as a therapeutic vulnerability in squamous cell carcinoma

Vidushi Durani, Rebecca Caeser, Charles M. Rudin, Alvaro Quintanal-Villalonga, Harsha Sridhar, Parvathy Manoj, Sam E. Tischfield, Marina Asher, Umeshkumar Bhanot, Jacklynn V. Egger, Nicholas D. Socci D. Socci, Nisargbhai S S. Shah, Elisa de Stanchina, Natasha Rekhtman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3858.
https://doi.org/10.1158/1538-7445.AM2023-3858
Published: 04 April 2023
View article titled, Abstract 3858: Exploring Exportin-1 as a therapeutic vulnerability in squamous cell carcinoma
Journal Articles

Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy Lee, Sandra Cohen, Jane Park, Corinne Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa De Stanchina, Michael Berger, Anuradha Gopalan, Lukas Dow, Juan Miguel Mosquera, Himisha Beltran, Cora Sternberg, Ping Chi, Howard Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B026.
https://doi.org/10.1158/1538-7445.CancEpi22-B026
Published: 01 December 2022
View article titled, Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Journal Articles

Abstract C015: EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype and promotes immune surveillance in PDAC

Loretah Chibaya, Katherine C. Murphy, Yvette Lopez Diaz, Kelly D. DeMarco, Haibo Liu, Sneha Gopalan, Melissa Faulkner, Junhui Li, John P. Morris IV, Yu-jui Ho, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua J. Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C015.
https://doi.org/10.1158/1538-7445.PANCA22-C015
Published: 15 November 2022
View article titled, Abstract C015: EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype and promotes immune surveillance in PDAC
Journal Articles

Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State

Kenneth L. Pitter, Olivera Grbovic-Huezo, Simon Joost, Anupriya Singhal, Melissa Blum, Katherine Wu, Matilda Holm, Alexander Ferrena, Arjun Bhutkar, Anna Hudson, Nicolas Lecomte, Elisa de Stanchina, Ronan Chaligne, Christine A. Iacobuzio-Donahue, Dana Pe'er, Tuomas Tammela
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3549–3560.
https://doi.org/10.1158/0008-5472.CAN-22-1742
Published: 04 October 2022
View article titled, Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State
Open the PDF for Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State in another window
Includes: Supplementary data
Journal Articles

Abstract 411: Reversibility of tumor adaptations to PI3K inhibition decreases as a function of time

Radha Mukherjee, Elisa de Stanchina, Sarat Chandarlapaty, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 411.
https://doi.org/10.1158/1538-7445.AM2022-411
Published: 15 June 2022
View article titled, Abstract 411: Reversibility of tumor adaptations to PI3K inhibition decreases as a function of time
Journal Articles

Abstract 90: STAT3-driven MAPK activation represents a therapeutic vulnerability in ASCL1 high SCLC

Rebecca Caeser, Christopher Hulton, Emily Costa, Vidushi Durani, Megan Little, Xiaoping Chen, Sam E. Tischfield, Marina Asher, Faruk Erdem Kombak, Shweta S. Chavan, Nisargbhai S. Shah, Metamia Ciampricotti, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 90.
https://doi.org/10.1158/1538-7445.AM2022-90
Published: 15 June 2022
View article titled, Abstract 90: STAT3-driven MAPK activation represents a therapeutic vulnerability in ASCL1 high SCLC
Journal Articles

Abstract 878: Frequent 4EBP1 amplification induces synthetic dependence on FGFR signaling in cancer

Kamini Singh, Prathibha Mohan, Viraj R. Sanghvi, Giovanni Ciriello, Nathalie Lailler, Elisa de Stanchina, Hans-Guido Wendel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 878.
https://doi.org/10.1158/1538-7445.AM2022-878
Published: 15 June 2022
View article titled, Abstract 878: Frequent 4EBP1 amplification induces synthetic dependence on FGFR signaling in cancer
Journal Articles

Abstract 835: Estrogen receptor expression and ER dependent breast tumor growth are dependent on translation initiation factor EIF4A

Jacob A. Boyer, Madeline A. Dorso, Corina Amor, Jason Reiter, Jianing Xu, Elisa de Stanchina, Hans-Guido Wendel, Sarat Chandarlapaty, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 835.
https://doi.org/10.1158/1538-7445.AM2022-835
Published: 15 June 2022
View article titled, Abstract 835: Estrogen receptor expression and ER dependent breast tumor growth are dependent on translation initiation factor EIF4A
Journal Articles

Abstract 704: Development of a patient-derived xenograft (PDX) modeling program to enable pediatric precision medicine

Filemon S. Dela Cruz, Joseph G. McCarter, Daoqi You, Nancy Bouvier, Xinyi Wang, Kristina C. Guillan, Armaan H. Siddiquee, Katie B. Souto, Hongyan Li, Teng Gao, Dominik Glodzik, Daniel Diolaiti, Neerav N. Shukla, Joachim Silber, Umeshkumar K. Bhanot, Faruk Erdem Kombak, Diego F. Coutinho, Shanita Li, Juan E. Arango Ossa, Juan S. Medina-Martinez, Michael V. Ortiz, Emily K. Slotkin, Michael D. Kinnaman, Sameer F. Sait, Tara J. O'Donohue, Marissa Mattar, Maximiliano Meneses, Michael P. LaQuaglia, Todd E. Heaton, Justin T. Gerstle, Nicola Fabbri, Chelsey M. Burke, Irene M. Rodriquez-Sanchez, Christine A. Iacobuzio-Donahue, Julia L. Glade Bender, Ryan D. Roberts, Jason T. Yustein, Nino C. Rainusso, Brian D. Crompton, Elizabeth Stewart, Alejandro Sweet-Cordero, Leanne C. Sayles, Andrika D. Thomas, Michael H. Roehrl, Elisa de Stanchina, Elli Papaemmanuil, Andrew L. Kung
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 704.
https://doi.org/10.1158/1538-7445.AM2022-704
Published: 15 June 2022
View article titled, Abstract 704: Development of a patient-derived xenograft (PDX) modeling program to enable pediatric precision medicine
Journal Articles

Abstract 3594: Exportin 1 inhibition as a therapeutic strategy for small cell lung cancer

Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yuan Hao, Andrew Chow, Yingqian A. Zhan, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Umesh K. Bhanot, Juan Qiu, Elisa de Stanchina, Richard P. Koche, Triparna Sen, John T. Poirier, Charles M. Rudin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3594.
https://doi.org/10.1158/1538-7445.AM2022-3594
Published: 15 June 2022
View article titled, Abstract 3594: Exportin 1 inhibition as a therapeutic strategy for small cell lung cancer
Journal Articles

Abstract 359: Pharmacologically induced polyploidy triggers BCL2 dependence in lymphomas

Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Zahra Asgari, Elisa de Stanchina, Anas Younes, Hans-Guido Wendel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 359.
https://doi.org/10.1158/1538-7445.AM2022-359
Published: 15 June 2022
View article titled, Abstract 359: Pharmacologically induced polyploidy triggers BCL2 dependence in lymphomas
Journal Articles

Abstract LB089: Effective in vivo treatment of endometrial tumor models with coexistent mutant PI3K and PTEN inactivation with a selective bi-steric mTORC1 kinase inhibitor

Hilla Solomon, Radha Mukherjee, Xiaoping Chen, HuiYong Zhao, Elisa de Stanchina, Britta Weigelt, Alison M. Schram, Carol Aghajanian, Mallika Singh, Jan Smith, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB089.
https://doi.org/10.1158/1538-7445.AM2022-LB089
Published: 15 June 2022
View article titled, Abstract LB089: Effective <em>in vivo</em> treatment of endometrial tumor models with coexistent mutant PI3K and PTEN inactivation with a selective bi-steric mTORC1 kinase inhibitor