Search Results | Cancer Research | American Association for Cancer Research

1-20 of 57

2 3

Sort by

Sort Order Select

Journal Articles

Abstract 704: Development of a patient-derived xenograft (PDX) modeling program to enable pediatric precision medicine

Filemon S. Dela Cruz, Joseph G. McCarter, Daoqi You, Nancy Bouvier, Xinyi Wang, Kristina C. Guillan, Armaan H. Siddiquee, Katie B. Souto, Hongyan Li, Teng Gao, Dominik Glodzik, Daniel Diolaiti, Neerav N. Shukla, Joachim Silber, Umeshkumar K. Bhanot, Faruk Erdem Kombak, Diego F. Coutinho, Shanita Li, Juan E. Arango Ossa, Juan S. Medina-Martinez, Michael V. Ortiz, Emily K. Slotkin, Michael D. Kinnaman, Sameer F. Sait, Tara J. O'Donohue, Marissa Mattar, Maximiliano Meneses, Michael P. LaQuaglia, Todd E. Heaton, Justin T. Gerstle, Nicola Fabbri, Chelsey M. Burke, Irene M. Rodriquez-Sanchez, Christine A. Iacobuzio-Donahue, Julia L. Glade Bender, Ryan D. Roberts, Jason T. Yustein, Nino C. Rainusso, Brian D. Crompton, Elizabeth Stewart, Alejandro Sweet-Cordero, Leanne C. Sayles, Andrika D. Thomas, Michael H. Roehrl, Elisa de Stanchina, Elli Papaemmanuil, Andrew L. Kung

Cancer Res (2022) 82 (12_Supplement): 704.

DOI: https://doi.org/10.1158/1538-7445.AM2022-704

Published: 15 June 2022

View article

Journal Articles

Abstract 411: Reversibility of tumor adaptations to PI3K inhibition decreases as a function of time

Radha Mukherjee, Elisa de Stanchina, Sarat Chandarlapaty, Neal Rosen

Cancer Res (2022) 82 (12_Supplement): 411.

DOI: https://doi.org/10.1158/1538-7445.AM2022-411

Published: 15 June 2022

View article

Journal Articles

Abstract LB089: Effective in vivo treatment of endometrial tumor models with coexistent mutant PI3K and PTEN inactivation with a selective bi-steric mTORC1 kinase inhibitor

Hilla Solomon, Radha Mukherjee, Xiaoping Chen, HuiYong Zhao, Elisa de Stanchina, Britta Weigelt, Alison M. Schram, Carol Aghajanian, Mallika Singh, Jan Smith, Neal Rosen

Cancer Res (2022) 82 (12_Supplement): LB089.

DOI: https://doi.org/10.1158/1538-7445.AM2022-LB089

Published: 15 June 2022

View article

Journal Articles

Abstract 658: AKT pathway as a therapeutic target to constrain lineage plasticity leading to histological transdifferentiation

Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian A. Zhan, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Umesh K. Bhanot, Jacklynn Egger, Juan Qiu, Elisa de Stanchina, Natasha Rekhtman, Brian Houck-Loomis, Richard P. Koche, Helena A. Yu, Triparna Sen, Charles M. Rudin

Cancer Res (2022) 82 (12_Supplement): 658.

DOI: https://doi.org/10.1158/1538-7445.AM2022-658

Published: 15 June 2022

View article

Journal Articles

Abstract 3594: Exportin 1 inhibition as a therapeutic strategy for small cell lung cancer

Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yuan Hao, Andrew Chow, Yingqian A. Zhan, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Umesh K. Bhanot, Juan Qiu, Elisa de Stanchina, Richard P. Koche, Triparna Sen, John T. Poirier, Charles M. Rudin

Cancer Res (2022) 82 (12_Supplement): 3594.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3594

Published: 15 June 2022

View article

Journal Articles

Abstract 359: Pharmacologically induced polyploidy triggers BCL2 dependence in lymphomas

Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Zahra Asgari, Elisa de Stanchina, Anas Younes, Hans-Guido Wendel

Cancer Res (2022) 82 (12_Supplement): 359.

DOI: https://doi.org/10.1158/1538-7445.AM2022-359

Published: 15 June 2022

View article

Journal Articles

Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations

Sunyana Gadal, Jacob A. Boyer, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Elisa De Stanchina, Rona Yeager, Marcus Bosenberg, Katia M. Todorova, Neal Rosen

Cancer Res (2022) 82 (12_Supplement): 2422.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2422

Published: 15 June 2022

View article

Journal Articles

Abstract 878: Frequent 4EBP1 amplification induces synthetic dependence on FGFR signaling in cancer

Kamini Singh, Prathibha Mohan, Viraj R. Sanghvi, Giovanni Ciriello, Nathalie Lailler, Elisa de Stanchina, Hans-Guido Wendel

Cancer Res (2022) 82 (12_Supplement): 878.

DOI: https://doi.org/10.1158/1538-7445.AM2022-878

Published: 15 June 2022

View article

Journal Articles

Abstract 90: STAT3-driven MAPK activation represents a therapeutic vulnerability in ASCL1 high SCLC

Rebecca Caeser, Christopher Hulton, Emily Costa, Vidushi Durani, Megan Little, Xiaoping Chen, Sam E. Tischfield, Marina Asher, Faruk Erdem Kombak, Shweta S. Chavan, Nisargbhai S. Shah, Metamia Ciampricotti, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen

Cancer Res (2022) 82 (12_Supplement): 90.

DOI: https://doi.org/10.1158/1538-7445.AM2022-90

Published: 15 June 2022

View article

Journal Articles

Abstract 835: Estrogen receptor expression and ER dependent breast tumor growth are dependent on translation initiation factor EIF4A

Jacob A. Boyer, Madeline A. Dorso, Corina Amor, Jason Reiter, Jianing Xu, Elisa de Stanchina, Hans-Guido Wendel, Sarat Chandarlapaty, Neal Rosen

Cancer Res (2022) 82 (12_Supplement): 835.

DOI: https://doi.org/10.1158/1538-7445.AM2022-835

Published: 15 June 2022

View article

Journal Articles

CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma

Igor Odintsov, Michael V. Ortiz, Inna Khodos, Marissa S. Mattar, Allan J.W. Lui, Shinji Kohsaka, Elisa de Stanchina, Julia L. Glade Bender, Marc Ladanyi, Romel Somwar

Cancer Res (2022) 82 (6): 1110–1127.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-1397

Published: 15 March 2022

View article

Includes: Supplementary data

Journal Articles

Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy

Cancer Res (2022) 82 (3): 472–483.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-2964

Published: 02 February 2022

View article

Includes: Supplementary data

Journal Articles

Abstract PO-124: EZH2 blockade overcomes suppression of the proinflammatory senescence-associated secretory phenotype in the pancreas and drives NK cell-mediated pancreatic tumor responses

Loretah Chibaya, Yvette Lopez-Diaz, Haibo Liu, Katherine C. Murphy, John P. Morris, IV, Yu-jui Ho, Janelle Simon, Wei Luan, Amanda Kulick, Lakhena Leang, Elisa de Stanchina, Lihua J. Zhu, Scott W. Lowe, Marcus Ruscetti

Cancer Res (2021) 81 (22_Supplement): PO-124.

DOI: https://doi.org/10.1158/1538-7445.PANCA21-PO-124

Published: 15 November 2021

View article

Journal Articles

Abstract 956: The HER2×HER3 bi-specific antibody Zenocutuzumab is effective at blocking growth of tumors driven by NRG1 gene fusions

Igor Odintsov, Inna Khodos, Madelyn Espinosa-Cotton, Allan J. Lui, Marissa Mattar, Alison M. Schram, Ron C. Schackmann, Jeroen Lammerts van Bueren, Cecile A. Geuijen, Elisa de Stanchina, Marc Ladanyi, Romel Somwar

Cancer Res (2021) 81 (13_Supplement): 956.

DOI: https://doi.org/10.1158/1538-7445.AM2021-956

Published: 01 July 2021

View article

Journal Articles

Abstract 979: Bcl-2 inhibitor enhances anti-androgen therapy induced regression of castration sensitive prostate cancer

Rahim Hirani, Subhiksha Nandakumar, Teja Kalidindi, Deborah Fidele, Harisha Rajanala, Ying Mazzu, Yuki Yoshikawa, Lina Jehane, Gwo-Shu Mary Lee, Elisa de Stanchina, Adam Sowalsky, Michael J. Morris, Heiko Schoder, Naga Vara Kishore Pillarsetty, Lorelei A. Mucci, Daniel Danila, Goutam Chakraborty, Philip W. Kantoff

Cancer Res (2021) 81 (13_Supplement): 979.

DOI: https://doi.org/10.1158/1538-7445.AM2021-979

Published: 01 July 2021

View article

Journal Articles

Abstract LB186: MAPK pathway activation represents a therapeutic vulnerability in ASCL1-driven SCLC

Rebecca Caeser, Christopher Hulton, Vidushi Durani, Emily Costa, Megan Little, Nisargbhai S. Shah, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen

Cancer Res (2021) 81 (13_Supplement): LB186.

DOI: https://doi.org/10.1158/1538-7445.AM2021-LB186

Published: 01 July 2021

View article

Journal Articles

Abstract 1102: Integrated approach towards defining mechanism based combinations to guide clinical development of glutaminase inhibitors

Jeffrey J. Kovacs, Nakia D. Spencer, Christopher A. Bristow, Alessandro Carugo, Virginia Giluiani, Meredith A. Miller, Angela Harris, Ningping Feng, Michael L. Soth, Kang Le, Elisa de Stanchina, Charles M. Rudin, Giulio Draetta, Timothy A. Yap, Philip Jones, Timothy Heffernan

Cancer Res (2021) 81 (13_Supplement): 1102.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1102

Published: 01 July 2021

View article

Journal Articles

Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules

Cancer Res (2021) 81 (8): 2002–2014.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-2929

Published: 15 April 2021

View article

Includes: Supplementary data

Journal Articles

Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

Radha Mukherjee, Kiran Gireesan Vanaja, Jacob A. Boyer, Juan Qiu, Xiaoping Chen, Elisa de Stanchina, Sarat Chandarlapaty, Andre Levchenko, Neal Rosen

Cancer Res (2020) 80 (16_Supplement): 1090.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1090

Published: 15 August 2020

View article

Journal Articles

Abstract 1800A: STK11 and KEAP1 co-mutation cooperatively promotes rapid tumor growth in lung adenocarcinoma

Corrin A. Wohlhieter, Allison L. Richards, John T. Poirier, Fathema Uddin, Christopher Hulton, Elisa De Stanchina, Thales Papagiannakopoulos, Triparna Sen, Charles M. Rudin

Cancer Res (2020) 80 (16_Supplement): 1800A.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1800A

Published: 15 August 2020

View article

2 3

NARROW

Abstract 704: Development of a patient-derived xenograft (PDX) modeling program to enable pediatric precision medicine

Abstract 411: Reversibility of tumor adaptations to PI3K inhibition decreases as a function of time

Abstract LB089: Effective in vivo treatment of endometrial tumor models with coexistent mutant PI3K and PTEN inactivation with a selective bi-steric mTORC1 kinase inhibitor

Abstract 658: AKT pathway as a therapeutic target to constrain lineage plasticity leading to histological transdifferentiation

Abstract 3594: Exportin 1 inhibition as a therapeutic strategy for small cell lung cancer

Abstract 359: Pharmacologically induced polyploidy triggers BCL2 dependence in lymphomas

Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations

Abstract 878: Frequent 4EBP1 amplification induces synthetic dependence on FGFR signaling in cancer

Abstract 90: STAT3-driven MAPK activation represents a therapeutic vulnerability in ASCL1 high SCLC

Abstract 835: Estrogen receptor expression and ER dependent breast tumor growth are dependent on translation initiation factor EIF4A

CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma

Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy

Abstract PO-124: EZH2 blockade overcomes suppression of the proinflammatory senescence-associated secretory phenotype in the pancreas and drives NK cell-mediated pancreatic tumor responses

Abstract 956: The HER2×HER3 bi-specific antibody Zenocutuzumab is effective at blocking growth of tumors driven by NRG1 gene fusions

Abstract 979: Bcl-2 inhibitor enhances anti-androgen therapy induced regression of castration sensitive prostate cancer

Abstract LB186: MAPK pathway activation represents a therapeutic vulnerability in ASCL1-driven SCLC

Abstract 1102: Integrated approach towards defining mechanism based combinations to guide clinical development of glutaminase inhibitors

Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules

Abstract 1090: Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

Abstract 1800A: STK11 and KEAP1 co-mutation cooperatively promotes rapid tumor growth in lung adenocarcinoma

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only