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Eleni Maniati
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Journal Articles

Human 3D Ovarian Cancer Models Reveal Malignant Cell–Intrinsic and –Extrinsic Factors That Influence CAR T-cell Activity

Joash D. Joy, Beatrice Malacrida, Florian Laforêts, Panoraia Kotantaki, Eleni Maniati, Ranjit Manchanda, Alessandro Annibaldi, Sarah Hopkins, Ianire Garrobo-Calleja, Julien Gautrot, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2432–2449.
https://doi.org/10.1158/0008-5472.CAN-23-3007
Published: 01 August 2024
View article titled, Human 3D Ovarian Cancer Models Reveal Malignant Cell–Intrinsic and –Extrinsic Factors That Influence CAR T-cell Activity
Open the PDF for Human 3D Ovarian Cancer Models Reveal Malignant Cell–Intrinsic and –Extrinsic Factors That Influence CAR T-cell Activity in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 6553: Targeting macrophages and regulatory T cells improves response to chemotherapy in high-grade serous ovarian cancer

Samar Elorbany, Chiara Berlato, Larissa Carnevalli, Simon Barry, Eleni Maniati, Jun Wang, Ranjit Manchanda, Julia Kzhyshkowska, Frances Balkwill
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6553.
https://doi.org/10.1158/1538-7445.AM2024-6553
Published: 22 March 2024
View article titled, Abstract 6553: Targeting macrophages and regulatory T cells improves response to chemotherapy in high-grade serous ovarian cancer
Journal Articles

Abstract PR-009: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer using human multicellular in vitro models

Beatrice Malacrida, Samar Elorbany, Eleni Maniati, Rachel Bryan-Ravenscroft, Sophie L.P. Skingsley, Florian Laforets, Ranjit Manchanda, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): PR-009.
https://doi.org/10.1158/1538-7445.OVARIAN23-PR-009
Published: 04 March 2024
View article titled, Abstract PR-009: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer using human multicellular in vitro models
Journal Articles

Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity

Joash D. Joy, Beatrice Malacrida, Florian Laforets, Panoraia Kotantaki, Eleni Maniati, Ranjit Manchanda, Sarah Hopkins, Ianire Garrobo-Calleja, Alessandro Annibaldi, Julien Gautrot, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B079.
https://doi.org/10.1158/1538-7445.OVARIAN23-B079
Published: 04 March 2024
View article titled, Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity
Journal Articles

Abstract LB195: Immunotherapies that repolarize macrophages and CD4 T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer

Samar Elorbany, Chiara Berlato, Larissa Carnevalli, Eleni Maniati, Jun Wang, Simon Barry, Ranjit Manchanda, Julia Kzhyshkowska, Frances Balkwill
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB195.
https://doi.org/10.1158/1538-7445.AM2023-LB195
Published: 14 April 2023
View article titled, Abstract LB195: Immunotherapies that repolarize macrophages and CD4 T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer
Journal Articles

Abstract 5957: Chemotherapy-induced extracellular matrix remodeling in HGSOC

Panoraia Kotantaki, Florian Laforêts, Eleni Maniati, Chiara Berlato, Anna Malliouri, Michael John Devlin, Beatrice Malacrida, Samar Elorbany, Ranjit Manchanda, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5957.
https://doi.org/10.1158/1538-7445.AM2023-5957
Published: 04 April 2023
View article titled, Abstract 5957: Chemotherapy-induced extracellular matrix remodeling in HGSOC
Journal Articles

Abstract 4551: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer: understanding the contribution of malignant cells

Beatrice Malacrida, Samar Elorbany, Eleni Maniati, Florian Laforets, Ranjit Manchanda, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4551.
https://doi.org/10.1158/1538-7445.AM2023-4551
Published: 04 April 2023
View article titled, Abstract 4551: Reconstructing the metastatic tumor microenvironment of high grade serous ovarian cancer: understanding the contribution of malignant cells
Journal Articles

Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer

Joash Dominic Joy, Beatrice Malacrida, Florian Laforêts, Panoraia Kotantaki, Eleni Maniati, Sarah Hopkins, Ianire Garrobo-Calleja, Julien Gautrot, Frances Balkwill
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4576.
https://doi.org/10.1158/1538-7445.AM2023-4576
Published: 04 April 2023
View article titled, Abstract 4576: 3D <em>in vitro</em> models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer
Journal Articles

Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer

Joash Dominic Joy, Beatrice Malacrida, Florian Laforêts, Panoraia Kotantaki, Eleni Maniati, Sarah Hopkins, Ianire Calleja, Sara Brett, Takis Athanasopoulos, Sadfer Ali, Peter Emery-Billcliff, Ida Ricciardelli, Charlotte Kay, Jayne Colebrook, Magda Ali, Katherine Strong, Frances Balkwill
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 693.
https://doi.org/10.1158/1538-7445.AM2022-693
Published: 15 June 2022
View article titled, Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer
Journal Articles

TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer

Laura S.M. Lecker, Chiara Berlato, Eleni Maniati, Robin Delaine-Smith, Oliver M.T. Pearce, Owen Heath, Samuel J. Nichols, Caterina Trevisan, Marian Novak, Jacqueline McDermott, James D. Brenton, Pedro R. Cutillas, Vinothini Rajeeve, Ana Hennino, Ronny Drapkin, Daniela Loessner, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5706–5719.
https://doi.org/10.1158/0008-5472.CAN-21-0536
Published: 15 November 2021
View article titled, TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
Open the PDF for TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2745: Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy

Chiara Berlato, Owen Heath, Eleni Maniati, Ganga Gopinathan, Panoraia Kotantaki, Samar Elorbany, Jacqueline McDermott, Colin Pegrum, Ludmila Szabova, Ruth Perets, Ronny Drapkin, Peter Bailey, Alessandro Annibaldi, Desmond P. Barton, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2745.
https://doi.org/10.1158/1538-7445.AM2021-2745
Published: 01 July 2021
View article titled, Abstract 2745: Murine high grade serous ovarian cancer (HGSOC) models replicate the human tumor microenvironment and suggest anti-tumor activities of macrophages after chemotherapy
Journal Articles

Abstract 2642: Using 3-Dimensional in vitro models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer

Beatrice Malacrida, Robin Delaine-Smith, Sam Nichols, Eleni Maniati, Roanne L. Jones, Martin M. Knight, Oliver M. Pearce, Frances R. Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2642.
https://doi.org/10.1158/1538-7445.AM2021-2642
Published: 01 July 2021
View article titled, Abstract 2642: Using 3-Dimensional <em>in vitro</em> models to unravel the complexity of the metastatic microenvironment in high-grade serous ovarian cancer
Journal Articles

Abstract 2748: Impact of ARID1A mutation on the tumor microenvironment of advanced clear cell ovarian cancer

Michael-John Devlin, Rebecca S. Kristeleit, Jacqueline McDermott, Eleni Maniati, Florian Laforêts, Panoraia Kotantaki, Rowan Miller, Frances Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2748.
https://doi.org/10.1158/1538-7445.AM2021-2748
Published: 01 July 2021
View article titled, Abstract 2748: Impact of ARID1A mutation on the tumor microenvironment of advanced clear cell ovarian cancer
Journal Articles

Abstract 1094: Differential responses and mechanisms of resistance to cediranib in high grade serous ovarian cancer mouse models

Ganga Gopinathan, Eleni Maniati, Chiara Berlato, Anissa Lakhani, Colin Pergum, Florian Laforets, Ludmila Szabova, Frances Balkwill
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1094.
https://doi.org/10.1158/1538-7445.AM2021-1094
Published: 01 July 2021
View article titled, Abstract 1094: Differential responses and mechanisms of resistance to cediranib in high grade serous ovarian cancer mouse models
Journal Articles

Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma

Naoka Tamura, Nadeem Shaikh, Daniel Muliaditan, Tanya N. Soliman, Jennifer R. McGuinness, Eleni Maniati, Daniela Moralli, Mary-Anne Durin, Catherine M. Green, Frances R. Balkwill, Jun Wang, Kit Curtius, Sarah E. McClelland
Journal: Cancer Research
Cancer Res (2020) 80 (22): 4946–4959.
https://doi.org/10.1158/0008-5472.CAN-19-0852
Published: 13 November 2020
View article titled, Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Open the PDF for Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance

Jesus Gomez-Escudero, Eleni Maniati, Freddie Whiting, Jun Wang, Trevor Graham, Kairbaan Hodivala-Dilke
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): A31.
https://doi.org/10.1158/1538-7445.CAMODELS2020-A31
Published: 02 June 2020
View article titled, Abstract A31: Tumor stroma in the development of acquired cancer therapy resistance
Journal Articles

Abstract 1103: The effects of neo-adjuvant chemotherapy on myeloid cells in high-grade serous ovarian cancer metastases

Owen M. Heath, Eleni Maniati, Chiara Belato, Ganga Gopinathan, Laura Lecker, Anissa Lakhani, Colin Pegrum, Jacqueline McDermott, Michelle Lockley, Desmond P. Barton, Frances Balkwill
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1103.
https://doi.org/10.1158/1538-7445.AM2019-1103
Published: 01 July 2019
View article titled, Abstract 1103: The effects of neo-adjuvant chemotherapy on myeloid cells in high-grade serous ovarian cancer metastases
Journal Articles

Abstract 5558: Deconstruction of a human tumor microenvironment

Frances R. Balkwill, Oliver M. Pearce, Robin Delaine-Smith, Eleni Maniati, Sam Nichols, Jun Wang, Conrad Bessant, Martin Knight
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5558.
https://doi.org/10.1158/1538-7445.AM2017-5558
Published: 01 July 2017
View article titled, Abstract 5558: Deconstruction of a human tumor microenvironment
Journal Articles

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma

Joshua B.N. Dawkins, Jun Wang, Eleni Maniati, James A. Heward, Lola Koniali, Hemant M. Kocher, Sarah A. Martin, Claude Chelala, Frances R. Balkwill, Jude Fitzgibbon, Richard P. Grose
Journal: Cancer Research
Cancer Res (2016) 76 (16): 4861–4871.
https://doi.org/10.1158/0008-5472.CAN-16-0481
Published: 14 August 2016
View article titled, Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma
Open the PDF for Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1076: Antagonists of the chemokine receptor CCR4 reverse the tumor-promoting microenvironment of renal cancer

Chiara Berlato, Moddasar N. Kahn, Tiziana Schioppa, Richard Thompson, Eleni Maniati, Monica Canosa, Hagen Kulbe, Chris Sheldon, Keith Wreggett, Urs Hagemann, Alexander Duncan, Laura Fletcher, Robert W. Wilkinson, Thomas Powles, Sergio Quezada, Frances Balkwill
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1076.
https://doi.org/10.1158/1538-7445.AM2014-1076
Published: 01 October 2014
View article titled, Abstract 1076: Antagonists of the chemokine receptor CCR4 reverse the tumor-promoting microenvironment of renal cancer