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Elena Garralda
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Journal Articles

Abstract CT188: ICT01, an anti-butyrophilin 3A targeted mAb activating g9d2 T cells, induces immune remodeling of the tumor microenvironment and clinical responses in combination with pembrolizumab in patients with advanced solid tumors who failed prior checkpoint inhibitor therapy: EVICTION Trial

Stephane Champiat, Martin Wermke, Johann de Bono, Aurelien Marabelle, Christiane Jungels, Cécile Vicier, Norbert Vey, Catrin List, Katrin Wetzko, Leo Ruhnke, Elena Garralda, Vladimir Galvão de Aguiar, Patricia LoRusso, Nuria Kotecki, Aude De Gassart, Emmanuel Valentin, Patrick Brune, Marina Iché, Céline Leparquier, Daniel Olive, Paul Frohna
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT188.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT188
Published: 15 June 2022
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Journal Articles

Abstract CT131: RVU120 SOL-021: An open-label, single agent, phase I/II trial of RVU120 (SEL120) in patients with relapsed/refractory metastatic or advanced solid tumors

Rafal Dziadziuszko, Elena Garralda, Noemi Angelosanto, Tomasz Rzymski, Renata Dudziak, Krzysztof Brzózka, Peter Littlewood, Hendrik Nogai, Axel Glasmacher, Iwona Lugowska
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT131.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT131
Published: 15 June 2022
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Journal Articles

Abstract CT140: ANV419, an IL-2R-beta-gamma targeted antibody-IL-2 fusion protein, induces selective effector cell proliferation in patients with progressed cancer

Elena Garralda, Alonso Guzman, Juanita Lopez, Vicky Sanchez-Perez, Heinz Läubli, Emiliano Calvo, Christoph Huber, Nicole Egli, Aswathy Nair, Julie Mouton, Kirsten Richter, Carlo Lanza, Sangeeta Jethwa, Silvio Costanzo, Christoph Bucher
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT140.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT140
Published: 15 June 2022
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Journal Articles

Abstract CT241: ENVOY-001: A phase 1, multicenter, open-label study of SQZ-AAC-HPV as monotherapy and in combination with immune checkpoint inhibitors in HLA-A*02+ patients with HPV16+ recurrent, locally advanced, or metastatic solid tumors

Victoria Villaflor, Rajwanth Veluswamy, Elena Garralda, Richard Maziarz, Emese Zsiros, Anthony Shields, Mariano Ponz-Sarvise, Martijn Lolkema, Mehdi Brahmi, Julia Jennings, Nathan Miselis, Lindsay Moore, Katarina Blagovic, Rui-Ru Ji, Scott Loughhead, Ricardo Zwirtes, Sandip Patel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT241.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT241
Published: 15 June 2022
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Journal Articles

Abstract CT255: Study of PRS-344/S095012 a PD-L1/4-1BB bispecific antibody-Anticalin®-fusion in patients with solid tumors

Christiane Jungels, Nuria Kotecki, Emiliano Calvo, Elena Garralda, Timothy Price, Xiaojiang Zahn, Atif Abbas, Lisa Mahnke, Winrich Rauschning, Aizea Morales-Kastresana, Lucia Pattarini, Birgit Bossenmaier, Alix Scholer-Dahirel, Tim Demuth, Julie Legrande
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT255.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT255
Published: 15 June 2022
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Journal Articles

Abstract CT040: SOT101, an IL-2/IL-15 Rβγ superagonist, in combination with pembrolizumab in patients with advanced solid tumors: Interim safety and efficacy results from the AURELIO-03 dose escalation trial

Stephane Champiat, Aurelien Marabelle, Vladimir Galvao, Patricia LoRusso, Peter Grell, Philippe Cassier, Carlos Gomez-Roca, Iphigenie Korakis, Aung Naing, Lenka Palova Jelinkova, Irena Adkins, Ulrich Moebius, Richard Sachse, Sascha Tillmanns, David Bechard, Joachim Kiemle-Kallee, Elena Garralda
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT040.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT040
Published: 15 June 2022
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Journal Articles

Abstract CT149: A phase 1/2a first-in-human study of AFM24, a CD16A/epidermal growth factor (EGFR) bispecific Innate Cell Engager (ICE®), in patients with locally advanced or metastatic EGFR-expressing solid tumors: Preliminary findings from the dose-escalation phase

Anthony El-Khoueiry, Juanita Lopez, Omar Saavedra, Mark Awad, Jacob Thomas, Crescens Tiu, Elena Garralda, Bettina Rehbein, Gabriele Hintzen, Kerstin Pietzko, Christa Raab, Erich Rajkovic, Paulien Ravenstijn, Michael Emig
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT149.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT149
Published: 15 June 2022
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Journal Articles

Abstract CT103: Phase I study of LHC165 ± spartalizumab (PDR001) in patients (pts) with advanced solid tumors

Giuseppe Curigliano, Miguel Martin Jimenez, Toshio Shimizu, Bhumsuk Keam, Funda Meric-Bernstam, Annemie Rutten, John Glaspy, Nehal S. Parikh, Mary Ising, Nadia Hassounah, Jincheng Wu, Kun Xu, Somesh Choudhry, Elena Garralda
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT103.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT103
Published: 01 July 2021
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Journal Articles

Abstract CT034: Activation of the antitumor immune response of gamma9delta2 T cells in patients with solid or hematologic malignancies with ICT01, a first-in-class, monoclonal antibody targeting butyrophilin 3A: The EVICTION study

Aurelien Marabelle, Christiane Jungels, Johann De Bono, Norbert Vey, Martin Wermke, Elena Garralda, Steven Le Gouill, Patricia LoRusso, Aude De Gassart, Emmanuel Valentin, Patrick Brune, Marina Iche, Daniel Olive, Paul A. Frohna
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT034.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT034
Published: 01 July 2021
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Journal Articles

Abstract CT154: Isatuximab (Isa) plus atezolizumab (Atezo) in patients (pts) with advanced malignancies: Results from a Phase 1/2 open-label multicenter study

Maria Vieito Villar, Matteo Simonelli, Ferry A.L.M. Eskens, Marta Gil-Martin, Chia-Jui Yen, Radka Obermannova, Yee Chao, Vittorina Zagonel, Bohuslav Melichar, Victor Moreno, Ming-Lung Yu, Alberto Bongiovanni, Emiliano Calvo, Sylvie Rottey, Jean-Pascal Machiels, Antonio González-Martín, Luis Paz-Ares, Chih-Long Chang, Warren Mason, Chia-Chi Lin, David Reardon, Elena Garralda, Armando Santoro, Robin Meng, Giovanni Abbadessa, Fatima Menas, Helen Lee, Qianying Liu, Cécile Combeau, Nils Ternes, Christophe Massard
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT154.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT154
Published: 01 July 2021
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Journal Articles

Abstract CT217: Phase I, first-in-human trial evaluating BI 1387446 (STING agonist) alone and in combination with ezabenlimab (BI 754091; anti-PD-1) in solid tumors

Kevin Harrington, Eileen Parkes, Jared Weiss, Mathew Ingham, Andrés Cervantes, Emiliano Calvo, Ute Klinkhardt, Patricia Sikken, Michael Schmohl, Elena Garralda
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT217.
DOI: https://doi.org/10.1158/1538-7445.AM2021-CT217
Published: 01 July 2021
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Journal Articles

Abstract CT147: Phase 1 dose escalation of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors

Alison Schram, Erkut Borazanci, Irene Brana, Maria Vieito Villar, Elena Garralda, Anna Spreafico, Marc Oliva, Nehal Lakhani, Robert Wasserman, Kimberly Hoffmann, Robin Hallett, Judit Anido, Dorotea Maetzel, Patricia Giblin, Enda Moran, Adrianne Kelly, Joan Seoane, Daniel D. Von Hoff, Lillian Siu, Josep Tabernero
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT147.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT147
Published: 15 August 2020
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Journal Articles

Abstract 2953: Adapting a molecular prescreening program to detect notch pathway alterations in the context of early drug development

Analía Azaro, Susana Aguilar, Zighereda Ogbah, Omar Saavedra, María Vieito, Ignacio Matos, Irene Braña, Enriqueta Felip, Joan Carles, Lorena Fariñas, Elena Elez, Teresa Macarulla, Cristina Saura, Rodrigo Dienstmann, Elena Garralda, Ana Vivancos
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2953.
DOI: https://doi.org/10.1158/1538-7445.AM2020-2953
Published: 15 August 2020
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Journal Articles

Abstract CT302: Phase Ia/Ib dose-escalation study of the anti-TIGIT antibody tiragolumab as a single agent and in combination with atezolizumab in patients with advanced solid tumors

Johanna C. Bendell, Philippe Bedard, Yung-Jue Bang, Patricia LoRusso, Stephen Hodi, Michael Gordon, Sandra D'Angelo, Sandra D'Angelo, Jayesh Desai, Elena Garralda, Antoine Italiano, Myung-Ju Ahn, Andres Cervantes, Zev Wainberg, Emiliano Calvo, Marta Gil-Martin, Maria Martinez-Garcia, Rastilav Bahleda, Philippe Cassier, Jean-Pierre Delord, Amy Prawira, Ignacio Melero, Leisha Emens, Emanuela Romano, Karen Miller, Robert W. Hsieh, Cloris Xue, Kari Morrissey, Patrick Twomey, Kelly Gash, Namrata S. Patil, Jane Grogan, Raymond Meng, Byoung Cho, Tae Won Kim
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT302.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT302
Published: 15 August 2020
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Journal Articles

Abstract CT014: Initial results from the Phase I study of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors

Alison Schram, Anna Spreafico, Marc Oliva, Irene Brana, Elena Garralda, Nehal Lakhani, Daniel Von Hoff, Erkut Borazanci, Naimish Pandya, Kimberly Hoffman, Robin Hallett, Patricia Giblin, Judit Anido, Adrianne Kelly, Robert Wasserman, Joan Seoane, Lillian Siu, David M. Hyman, Josep Tabernero
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT014.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT014
Published: 01 July 2019
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Journal Articles

Abstract CT127: Phase I and expanded access experience of LOXO-195 (BAY 2731954), a selective next-generation TRK inhibitor (TRKi)

David Hyman, Shivaani Kummar, Anna Farago, Birgit Geoerger, Morten Mau-Sorensen, Matthew Taylor, Elena Garralda, Ramamoorthy Nagasubramanian, Michael Natheson, Lucy Song, Michael Capra, Mette Jorgensen, Alan Ho, Neerav Shukla, Steve Smith, Xin Huang, Brian Tuch, Nora Ku, Theodore W. Laetsch, Alexander Drilon, David Hong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT127.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT127
Published: 01 July 2019
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Journal Articles

Abstract CT043: Highly potent and selective RET inhibitor, BLU-667, achieves proof of concept in a phase I study of advanced, RET-altered solid tumors

Vivek Subbiah, Matthew Taylor, Jessica Lin, Mimi Hu, Sai-Hong Ignatius Ou, Marcia S. Brose, Elena Garralda, Corinne Clifford, Michael Palmer, Erica Evans, Hongliang Shi, Beni Wolf, Justin F. Gainor
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT043.
DOI: https://doi.org/10.1158/1538-7445.AM2018-CT043
Published: 01 July 2018
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Journal Articles

Abstract CT175: Biomarker analyses from a phase I study of WNT974, a first-in-class Porcupine inhibitor, in patients (pts) with advanced solid tumors

Jordi Rodon, Guillem Argilés, Roisin M. Connolly, Ulka Vaishampayan, Maja de Jonge, Elena Garralda, Marios Giannakis, David C. Smith, Jason R. Dobson, Margaret McLaughlin, Abdelkader Seroutou, Yan Ji, Sinead Dolan, Jennifer Morawiak, Susan Moody, Filip Janku
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT175.
DOI: https://doi.org/10.1158/1538-7445.AM2018-CT175
Published: 01 July 2018
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Journal Articles

Abstract 2205: Integrated next generation sequencing and patient-derived xenografts to personalized cancer treatment.

Elena Garralda, Keren Paz, Pedro P. López-Casas, Siân Jones, Amanda Katz, Lisa M. Kann, Fernando López-Rios, Francesca Sarno, Fátima Al-Shahrour, David Vasquez, Elizabeth Bruckheimer, Samuel V. Angiuoli, Luis A. Diaz, Alfonso Valencia, Victor E. Velculescu, David Sidransky, Manuel Hidalgo
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2205.
DOI: https://doi.org/10.1158/1538-7445.AM2013-2205
Published: 15 April 2013
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