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Elana J. Fertig
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Journal Articles

Abstract 5296: Hepatocellular carcinoma resistance and recurrence to anti-PD-1 therapy is associated with tumor heterogeneity and plasticity driven by MYC

Free
Shuming Zhang, Ludmila Danilova, Jacob T. Mitchell, Iris Kwon, Aleksander S. Popel, Mark Yarchoan, Elizabeth M. Jaffee, Elana J. Fertig, Luciane T. Kagohara
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5296.
https://doi.org/10.1158/1538-7445.AM2025-5296
Published: 21 April 2025
View articletitled, Abstract 5296: Hepatocellular carcinoma resistance and recurrence to anti-PD-1 therapy is associated with tumor heterogeneity and plasticity driven by MYC
Journal Articles

Abstract 7493: Spatially resolved insights into epithelial-stromal co-evolution in pancreatic ductal adenocarcinoma

Free
Ahmed M. Elhossiny, Padma Kadiyala, Alexander Bray, Jamie Mills, Hannah Watkoske, Arvind Rao, Jude Okoye, Atul Deshpande, Jiaqi Shi, Elana J. Fertig, Filip Bednar, Yaqing Zhang, Eileen S. Carpenter, Timothy Frankel, Marina Pasca di Magliano
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7493.
https://doi.org/10.1158/1538-7445.AM2025-7493
Published: 21 April 2025
View articletitled, Abstract 7493: Spatially resolved insights into epithelial-stromal co-evolution in pancreatic ductal adenocarcinoma
Journal Articles

Abstract A032: Cancer associated fibroblasts drive classical to basal change associated with increased T cell presence in pancreatic ductal adenocarcinoma

Free
Jacquelyn W Zimmerman, Samantha Guinn, Mili Ramani, Brayan Perez, Joseph A Tandurella, Daniel J Zabransky, Jae W Lee, Emma Kartalia, Jignasha Patel, Sarah Shin, Alexei Hernandez, Courtney Cannon, Nicole Gross, Soren Charmsaz, Elana J Fertig, Richard A Burkhart, Won J Ho, Elizabeth M Jaffee
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A032.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A032
Published: 15 September 2024
View articletitled, Abstract A032: Cancer associated fibroblasts drive classical to basal change associated with increased T cell presence in pancreatic ductal adenocarcinoma
Journal Articles

Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery

Free
Shuming Zhang, Atul Deshpande, Babita K. Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth M. Jaffee, Qingfeng Zhu, Robert A. Anders, Mark Yarchoan, Luciane T. Kagohara, Elana J. Fertig, Aleksander S. Popel
Journal: Cancer Research
Cancer Res (2024) 84 (16): 2734–2748.
https://doi.org/10.1158/0008-5472.CAN-24-0943
Published: 15 August 2024
View articletitled, Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery
Open the PDF for Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery in another window
Includes: Multimedia, Supplementary data
Journal Articles

Is There a Mathematician on Board?

Available to Purchase
Elana J. Fertig
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2229–2230.
https://doi.org/10.1158/0008-5472.CAN-24-1396
Published: 15 July 2024
View articletitled, Is There a Mathematician on Board?
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Journal Articles

Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma

Available to Purchase
Samantha Guinn, Benedict Kinny-Köster, Joseph A. Tandurella, Jacob T. Mitchell, Dimitrios N. Sidiropoulos, Melanie Loth, Melissa R. Lyman, Alexandra B. Pucsek, Daniel J. Zabransky, Jae W. Lee, Emma Kartalia, Mili Ramani, Toni T. Seppälä, Christopher Cherry, Reecha Suri, Haley Zlomke, Jignasha Patel, Jin He, Christopher L. Wolfgang, Jun Yu, Lei Zheng, David P. Ryan, David T. Ting, Alec Kimmelman, Anuj Gupta, Ludmila Danilova, Jennifer H. Elisseeff, Laura D. Wood, Genevieve Stein-O'Brien, Luciane T. Kagohara, Elizabeth M. Jaffee, Richard A. Burkhart, Elana J. Fertig, Jacquelyn W. Zimmerman
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1517–1533.
https://doi.org/10.1158/0008-5472.CAN-23-1660
Published: 02 May 2024
View articletitled, Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
Open the PDF for Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract CT016: Immunomodulation of the tumor microenvironment of pancreatic ductal adenocarcinoma with histone deacetylase inhibition: Results of a phase 2 clinical trial of entinostat in combination with nivolumab

Free
Marina Baretti, Ludmila Danilova, Jennifer N. Durham, Courtney B. Betts, Leslie Cope, Dimitrios N. Sidiropoulos, Joseph A. Tandurella, Soren Charmsaz, Nicole Gross, Alexei Hernandez, Won J. HO, Chris Thoburn, Rosalind Walker, James Leatherman Leatherman, Sarah Mitchell, Brian Christmas, Daria A. Gaykalova, Srinivasan Yegnasubramanian, Elana J. Fertig, Lisa M. Coussens, Mark Yarchoan, Elizabeth Jaffee, Nilofer S. Azad
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT016.
https://doi.org/10.1158/1538-7445.AM2024-CT016
Published: 05 April 2024
View articletitled, Abstract CT016: Immunomodulation of the tumor microenvironment of pancreatic ductal adenocarcinoma with histone deacetylase inhibition: Results of a phase 2 clinical trial of entinostat in combination with nivolumab
Journal Articles

Abstract 2312: Integrating spatial multi-omics data with spatial quantitative pharmacology (spQSP) model to simulate human neoadjuvant immunotherapy clinical trial of hepatocellular carcinoma

Free
Shuming Zhang, Atul Deshpande, Babita K. Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth M. Jaffee, Qingfeng Zhu, Robert A. Anders, Mark Yarchoan, Luciane T. Kagohara, Elana J. Fertig, Aleksander S. Popel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2312.
https://doi.org/10.1158/1538-7445.AM2024-2312
Published: 22 March 2024
View articletitled, Abstract 2312: Integrating spatial multi-omics data with spatial quantitative pharmacology (spQSP) model to simulate human neoadjuvant immunotherapy clinical trial of hepatocellular carcinoma
Journal Articles

Abstract 6212: A differential ligand-receptor network inference method to identify alterations in communication between myeloid cells and CD8 T cells in response to PancVAX neo-epitope peptide vaccine, anti-CTLA-4 and anti-PD-1 antibodies in a murine model of pancreatic ductal adenocarcinoma

Free
Jacob T. Mitchell, Atul Deshpande, Amanda L. Huff, Chris Cherry, Sushma Nagaraj, Kavita Krishnan, Dmitrijs Lvovs, Jennifer H. Elisseeff, Elizabeth M. Jaffee, Neeha Zaidi, Elana J. Fertig
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6212.
https://doi.org/10.1158/1538-7445.AM2024-6212
Published: 22 March 2024
View articletitled, Abstract 6212: A differential ligand-receptor network inference method to identify alterations in communication between myeloid cells and CD8 T cells in response to PancVAX neo-epitope peptide vaccine, anti-CTLA-4 and anti-PD-1 antibodies in a murine model of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1159: Machine learning integrating spatial omics uncovers humoral immunity patterns in intratumoral tertiary lymphoid structures in pancreatic cancer pathologic responders

Free
Dimitrios N. Sidiropoulos, Sarah M. Shin, Alexander Girgis, Daniel H. Shu, Janelle Montagne, Atul Deshpande, Jeanette A. Johnson, Lucie Dequiedt, Victoria Jacobs, Aleksandra Ogurtsova, Guanglan Mo, Xuan Yuan, Genevieve Stein-O’Brien, Mark Yarchoan, Qingfeng Zhu, Ashley Kiemen, Elizabeth M. Jaffee, Lei Zheng, Won Jin Ho, Robert Anders, Elana J. Fertig, Luciane T. Kagohara
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1159.
https://doi.org/10.1158/1538-7445.AM2024-1159
Published: 22 March 2024
View articletitled, Abstract 1159: Machine learning integrating spatial omics uncovers humoral immunity patterns in intratumoral tertiary lymphoid structures in pancreatic cancer pathologic responders
Journal Articles

Abstract 1191: Personalized neoantigen DNA vaccine GNOS-PV02 and pembrolizumab as second-line treatment for advanced hepatocellular carcinoma

Free
Mark Yarchoan, Edward J. Gane, Thomas U. Marron, Renzo Perales-Linares, Jian Yan, Neil Cooch, Daniel Shu, Elana J. Fertig, Luciane T. Kagohara, Gabor Bartha, Josette Northcott, John Lyle, Sarah Rochestie, Joann Peters, Jason Connor, Elizabeth Jaffee, Alfredo Perales-Puchalt, David B. Weiner, Ildiko Csiki, Niranjan Y. Sardesai
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1191.
https://doi.org/10.1158/1538-7445.AM2024-1191
Published: 22 March 2024
View articletitled, Abstract 1191: Personalized neoantigen DNA vaccine GNOS-PV02 and pembrolizumab as second-line treatment for advanced hepatocellular carcinoma
Journal Articles

Abstract 1577: Cancer associated fibroblast - tumor cell crosstalk enhances epithelial to mesenchymal transition and promotes a classical to basal switch in human pancreatic ductal adenocarcinoma

Free
Samantha Guinn, Brayan Perez, Jignasha Patel, Jae Lee, Daniel Zabransky, Won Ho, Elana J. Fertig, Emma Kartalia, Joseph Tandurella, Richard Burkhart, Jacquelyn W. Zimmerman, Elizabeth Jaffee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1577.
https://doi.org/10.1158/1538-7445.AM2024-1577
Published: 22 March 2024
View articletitled, Abstract 1577: Cancer associated fibroblast - tumor cell crosstalk enhances epithelial to mesenchymal transition and promotes a classical to basal switch in human pancreatic ductal adenocarcinoma
Journal Articles

Abstract 2661: Identification of a novel morphology of tertiary lymphoid structure in patients with hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade

Free
Daniel H. Shu, Won Jin Ho, Luciane T. Kagohara, Alexander Girgis, Sarah M. Shin, Ludmila Danilova, Jae W. Lee, Dimitrios N. N. Sidiropoulos, Sarah Mitchell, Kabeer Munjal, Kathryn Howe, Kayla J. Bendinelli, Hanfei Qi, Guanglan Mo, Janelle Montagne, Tamara Y. Lopez-Vidal, Qingfeng Zhu, Amanda L. Huff, Xuan Yuan, Alexei Hernandez, Erin M. Coyne, Neeha Zaidi, Daniel J. Zabransky, Logan L. Engle, Aleksandra Ogurtsova, Marina Baretti, Daniel Laheru, Jennifer N. Durham, Hao Wang, Robert Anders, Elizabeth M. Jaffee, Elana J. Fertig, Mark Yarchoan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2661.
https://doi.org/10.1158/1538-7445.AM2024-2661
Published: 22 March 2024
View articletitled, Abstract 2661: Identification of a novel morphology of tertiary lymphoid structure in patients with hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade
Journal Articles

Abstract 6522: Epigenetic modulation decreases myeloid suppression to improve response to immune checkpoint inhibition in breast cancer

Free
Aaron G. Baugh, Edgar Gonzalez, Jesse Kreger, Yingtong Liu, Batul Al-Zubeidy, Ludmila Danilova, Sarah M. Shin, Valerie H. Narumi, Sofi Castanon, Julie Jang, Elana J. Fertig, Ashley Cimino-Mathews, Elizabeth M. Jaffee, Vered Stearns, Roisin M. Connolly, Won Jin Ho, Adam MacLean, Evanthia T. Roussos Torres
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6522.
https://doi.org/10.1158/1538-7445.AM2024-6522
Published: 22 March 2024
View articletitled, Abstract 6522: Epigenetic modulation decreases myeloid suppression to improve response to immune checkpoint inhibition in breast cancer
Journal Articles

Abstract 4027: From tumor progression to therapeutic control: Combinatorial targeting of immune vulnerabilities in TNBC

Free
Amanda Poissonnier, Eivind Valen Egeland, Wesley Horton, Shamilene Sivagnanam, Orian Stapleton, Rossin Erbe, Nell Kirchberger, Konjit Betre, Alyza Skaist, Ludmila Danilova, Andrew Fields, Peter Ordentlich, Andrew C. Adey, Elana J. Fertig, Lisa M. Coussens
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4027.
https://doi.org/10.1158/1538-7445.AM2024-4027
Published: 22 March 2024
View articletitled, Abstract 4027: From tumor progression to therapeutic control: Combinatorial targeting of immune vulnerabilities in TNBC
Journal Articles

Abstract 1170: An off-the-shelf vaccine activates mutant KRAS-specific T cells in patients with resected pancreatic cancer

Free
Amanda L. Huff, Alex Girgis, Saurav D. Haldar, Emily Davis-Marcisak, Thatcher Heumann, Gabriella Longway, Lalitya Andaloori, Alexei Hernandez, Maximilian F. Konig, Brian Mog, Ludmila Danilova, Luciane T. Kagohara, Julie M. Nauroth, Amy M. Thomas, Elana J. Fertig, Won Jin Ho, Elizabeth M. Jaffee, Nilofer Azad, Neeha Zaidi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1170.
https://doi.org/10.1158/1538-7445.AM2024-1170
Published: 22 March 2024
View articletitled, Abstract 1170: An off-the-shelf vaccine activates mutant KRAS-specific T cells in patients with resected pancreatic cancer
Journal Articles

Abstract A042: Cancer associated fibroblasts drive transcriptional changes in tumor cells from classical to basal phenotype and promote epithelial-to-mesenchymal transition in human pancreatic ductal adenocarcinoma

Free
Samantha Guinn, Joseph Tandurella, Jae W. Lee, Daniel J. Zabransky, Mili Ramani, Jignasha Patel, Elana J. Fertig, Elizabeth M. Jaffee, Richard A. Burkhart, Jacquelyn W. Zimmerman
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A042.
https://doi.org/10.1158/1538-7445.PANCA2023-A042
Published: 16 January 2024
View articletitled, Abstract A042: Cancer associated fibroblasts drive transcriptional changes in tumor cells from classical to basal phenotype and promote epithelial-to-mesenchymal transition in human pancreatic ductal adenocarcinoma
Journal Articles

Abstract IA14: Forecasting pancreatic carcinogenesis through spatial multi-omics

Free
Elana J. Fertig
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): IA14.
https://doi.org/10.1158/1538-7445.PANCA2023-IA14
Published: 16 January 2024
View articletitled, Abstract IA14: Forecasting pancreatic carcinogenesis through spatial multi-omics
Journal Articles

Abstract A108: Spatial transcriptomic analysis of venous invasion in human pancreatic adenocarcinoma reveals widespread attenuation in features associated with aggression and mortality

Free
Alexander T.F. Bell, Peter Chianchiano, Katsuya Hirose, Doreen Gisder, Alexander I. Damanakis, Luciane T. Kagohara, Elana J. Fertig, Laura D. Wood
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A108.
https://doi.org/10.1158/1538-7445.PANCA2023-A108
Published: 16 January 2024
View articletitled, Abstract A108: Spatial transcriptomic analysis of venous invasion in human pancreatic adenocarcinoma reveals widespread attenuation in features associated with aggression and mortality
Journal Articles

Abstract B107: Spatial transcriptomics analysis of PanIN reveals loss of pro-inflammatory signaling and the presence of cancer-associated fibroblasts

Free
Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Melissa Lyman, Kohei Fujikura, Jae W. Lee, Erin Coyne, Sarah M. Shin, Pei-Hsun Wu, Jacquelyn W. Zimmerman, Denis Wirtz, Won J. Ho, Neeha Zaidi, Elizabeth Thompson, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig, Luciane T. Kagohara
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B107.
https://doi.org/10.1158/1538-7445.PANCA2023-B107
Published: 16 January 2024
View articletitled, Abstract B107: Spatial transcriptomics analysis of PanIN reveals loss of pro-inflammatory signaling and the presence of cancer-associated fibroblasts