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Elahe A. Mostaghel
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Journal Articles

Abstract 4302: ONECUT2 activates diverse resistance drivers of androgen receptor-independent heterogeneity in prostate cancer

Chen Qian, Qian Yang, Mirja Rotinen, Rongrong Huang, Hyoyoung Kim, Brad Gallent, Yiwu Yan, Radu M. Cadaneanu, Baohui Zhang, Salma Kaochar, Stephen J. Freedland, Edwin M. Posadas, Leigh Ellis, Dolores Di Vizio, Colm Morrissey, Peter S. Nelson, Lauren Brady, Ramachandran Murali, Moray J. Campbell, Wei Yang, Beatrice S. Knudsen, Elahe A. Mostaghel, Huihui Ye, Isla P. Garraway, Sungyong You, Michael R. Freeman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4302.
https://doi.org/10.1158/1538-7445.AM2024-4302
Published: 22 March 2024
View article titled, Abstract 4302: ONECUT2 activates diverse resistance drivers of androgen receptor-independent heterogeneity in prostate cancer
Journal Articles

Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM Complex

Michael D. Nyquist, Ilsa M. Coleman, Jared M. Lucas, Dapei Li, Brian Hanratty, Hannah Meade, Elahe A. Mostaghel, Stephen R. Plymate, Eva Corey, Michael C. Haffner, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2023) 83 (17): 2938–2951.
https://doi.org/10.1158/0008-5472.CAN-22-2613
Published: 01 September 2023
View article titled, Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM Complex
Open the PDF for Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM Complex in another window
Includes: Supplementary data
Journal Articles

Abstract 1209: Comprehensive in vitro characterization of the mechanism of action of EPI-7386, an androgen receptor N-terminal domain inhibitor

Nan Hyung Hong, Shihua Sun, Peter Virsik, Alessandra Cesano, Elahe A. Mostaghel, Stephen R. Plymate, Han-Jie Zhou, Ronan Le Moigne
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1209.
https://doi.org/10.1158/1538-7445.AM2021-1209
Published: 01 July 2021
View article titled, Abstract 1209: Comprehensive <em>in vitro</em> characterization of the mechanism of action of EPI-7386, an androgen receptor N-terminal domain inhibitor
Journal Articles

Abstract 379: Supraphysiological testosterone inhibits tumor growth and is associated with inhibition of ARV7 signaling and DNA damage response in preclinical models of enzalutamide-resistant prostate cancer

Hung-Ming Lam, Mark P. Labrecque, Holly M. Nguyen, Lisha G. Brown, Ilsa M. Coleman, Roman Gulati, Bryce Lakely, Daniel Sondheim, Brett Marck, Alvin M. Matsumoto, Elahe A. Mostaghel, Michael T. Schweizer, Peter S. Nelson, Eva Corey
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 379.
https://doi.org/10.1158/1538-7445.AM2019-379
Published: 01 July 2019
View article titled, Abstract 379: Supraphysiological testosterone inhibits tumor growth and is associated with inhibition of ARV7 signaling and DNA damage response in preclinical models of enzalutamide-resistant prostate cancer
Journal Articles

Downregulation of Dipeptidyl Peptidase 4 Accelerates Progression to Castration-Resistant Prostate Cancer

Joshua W. Russo, Ce Gao, Swati S. Bhasin, Olga S. Voznesensky, Carla Calagua, Seiji Arai, Peter S. Nelson, Bruce Montgomery, Elahe A. Mostaghel, Eva Corey, Mary-Ellen Taplin, Huihui Ye, Manoj Bhasin, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (22): 6354–6362.
https://doi.org/10.1158/0008-5472.CAN-18-0687
Published: 15 November 2018
View article titled, Downregulation of <em>Dipeptidyl Peptidase 4</em> Accelerates Progression to Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract A024: Prostate cancer neoadjuvant intensive androgen deprivation therapy selects for tumor foci with diverse oncogenic alterations

Adam G. Sowalsky, Huihui Ye, Manoj Bhasin, Eliezer M. Van Allen, Massimo Loda, Rosina T. Lis, Laleh Montaser, Carla Calagua, Fen Ma, Joshua W. Russo, Rachel J. Schaefer, Olga S. Voznesensky, Zhenwei Zhang, Glenn J. Bubley, Robert B. Montgomery, Elahe A. Mostaghel, Peter S. Nelson, Mary-Ellen Taplin, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A024.
https://doi.org/10.1158/1538-7445.PRCA2017-A024
Published: 14 August 2018
View article titled, Abstract A024: Prostate cancer neoadjuvant intensive androgen deprivation therapy selects for tumor foci with diverse oncogenic alterations
Journal Articles

Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations

Adam G. Sowalsky, Huihui Ye, Manoj Bhasin, Eliezer M. Van Allen, Massimo Loda, Rosina T. Lis, Laleh Montaser-Kouhsari, Carla Calagua, Fen Ma, Joshua W. Russo, Rachel J. Schaefer, Olga S. Voznesensky, Zhenwei Zhang, Glenn J. Bubley, Bruce Montgomery, Elahe A. Mostaghel, Peter S. Nelson, Mary-Ellen Taplin, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4716–4730.
https://doi.org/10.1158/0008-5472.CAN-18-0610
Published: 14 August 2018
View article titled, Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations
Open the PDF for Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations in another window
Includes: Supplementary data
Journal Articles

Abstract 4313: Abiraterone acetate (AA) treatment of prostate cancer patient-derived xenografts (PDX) demonstrates heterogeneity of responses and identifies potential biomarkers of adaptive resistance

Hung-Ming Lam, Ryan McMullin, Holly M. Nguyen, Michael Gormley, Roman Gulati, Weimin Li, Deborah Ricci, Karin Verstraeten, Shibu Thomas, Elahe A. Mostaghel, Peter S. Nelson, Robert L. Vessella, Eva Corey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4313.
https://doi.org/10.1158/1538-7445.AM2015-4313
Published: 01 August 2015
View article titled, Abstract 4313: Abiraterone acetate (AA) treatment of prostate cancer patient-derived xenografts (PDX) demonstrates heterogeneity of responses and identifies potential biomarkers of adaptive resistance
Journal Articles

Abstract IA21: Transcriptional programs directed by the androgen receptor splice variants

Rong Hu, Changxue Lu, Elahe A. Mostaghel, Srinivasan Yegnasubramanian, Meltem Gurel, Clare Tannahill, Joanne Edwards, William Isaacs, Peter S. Nelson, Eric Bluemn, Stephen R. Plymate, Jun Luo
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): IA21.
https://doi.org/10.1158/1538-7445.PRCA2012-IA21
Published: 09 May 2013
View article titled, Abstract IA21: Transcriptional programs directed by the androgen receptor splice variants
Journal Articles

Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

Rong Hu, Changxue Lu, Elahe A. Mostaghel, Srinivasan Yegnasubramanian, Meltem Gurel, Clare Tannahill, Joanne Edwards, William B. Isaacs, Peter S. Nelson, Eric Bluemn, Stephen R. Plymate, Jun Luo
Journal: Cancer Research
Cancer Res (2012) 72 (14): 3457–3462.
https://doi.org/10.1158/0008-5472.CAN-11-3892
Published: 15 July 2012
View article titled, Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
Open the PDF for Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

Changmeng Cai, Sen Chen, Patrick Ng, Glenn J. Bubley, Peter S. Nelson, Elahe A. Mostaghel, Brett Marck, Alvin M. Matsumoto, Nicholas I. Simon, Hongyun Wang, Shaoyong Chen, Steven P. Balk
Journal: Cancer Research
Cancer Res (2011) 71 (20): 6503–6513.
https://doi.org/10.1158/0008-5472.CAN-11-0532
Published: 12 October 2011
View article titled, Intratumoral <em>De Novo</em> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors
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Includes: Supplementary data
Journal Articles

Variability in the Androgen Response of Prostate Epithelium to 5α-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention

Elahe A. Mostaghel, Linda Geng, Ilona Holcomb, Ilsa M. Coleman, Jared Lucas, Lawrence D. True, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2010) 70 (4): 1286–1295.
https://doi.org/10.1158/0008-5472.CAN-09-2509
Published: 14 February 2010
View article titled, Variability in the Androgen Response of Prostate Epithelium to 5α-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention
Open the PDF for Variability in the Androgen Response of Prostate Epithelium to 5α-Reductase Inhibition: Implications for Prostate Cancer Chemoprevention in another window
Includes: Supplementary data
Journal Articles

Reduced Tumor Necrosis Factor Receptor–Associated Death Domain Expression Is Associated with Prostate Cancer Progression

Diping Wang, R. Bruce Montgomery, Lucy J. Schmidt, Elahe A. Mostaghel, Haojie Huang, Peter S. Nelson, Donald J. Tindall
Journal: Cancer Research
Cancer Res (2009) 69 (24): 9448–9456.
https://doi.org/10.1158/0008-5472.CAN-09-1903
Published: 14 December 2009
View article titled, Reduced Tumor Necrosis Factor Receptor–Associated Death Domain Expression Is Associated with Prostate Cancer Progression
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Includes: Supplementary data
Journal Articles

Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth

R. Bruce Montgomery, Elahe A. Mostaghel, Robert Vessella, David L. Hess, Thomas F. Kalhorn, Celestia S. Higano, Lawrence D. True, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2008) 68 (11): 4447–4454.
https://doi.org/10.1158/0008-5472.CAN-08-0249
Published: 02 June 2008
View article titled, Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth
Open the PDF for Maintenance of Intratumoral Androgens in Metastatic Prostate Cancer: A Mechanism for Castration-Resistant Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer

Elahe A. Mostaghel, Stephanie T. Page, Daniel W. Lin, Ladan Fazli, Ilsa M. Coleman, Lawrence D. True, Beatrice Knudsen, David L. Hess, Colleen C. Nelson, Alvin M. Matsumoto, William J. Bremner, Martin E. Gleave, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2007) 67 (10): 5033–5041.
https://doi.org/10.1158/0008-5472.CAN-06-3332
Published: 17 May 2007
View article titled, Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer
Open the PDF for Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Analysis of gene expression pathways associated with prostate carcinogenesis after short term testosterone replacement in hypogonadal men

Elahe A. Mostaghel, Leonard S. Marks, Ilsa M. Coleman, David Hess, Ruth F. Dumpit, Peter S. Nelson
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 99.
Published: 15 April 2006
View article titled, Analysis of gene expression pathways associated with prostate carcinogenesis after short term testosterone replacement in hypogonadal men