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Eiki Kikuchi
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Journal Articles

Abstract 1991: Notch pathway regulates proliferation of osimertinib drug-tolerant cells in epidermal growth factor receptor mutated non-small cell lung cancer

Hirofumi Takahashi, Jun Sakakibara-Konishi, Shotaro Ito, Kosuke Tsuji, Eiki Kikuchi, Junko Kikuchi, Naofumi Shinagawa, Satoshi Konno
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1991.
https://doi.org/10.1158/1538-7445.AM2021-1991
Published: 01 July 2021
View article titled, Abstract 1991: Notch pathway regulates proliferation of osimertinib drug-tolerant cells in epidermal growth factor receptor mutated non-small cell lung cancer
Journal Articles

CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC

Jeffrey H. Becker, Yandi Gao, Margaret Soucheray, Ines Pulido, Eiki Kikuchi, María L. Rodríguez, Rutu Gandhi, Aranzazu Lafuente-Sanchis, Miguel Aupí, Javier Alcácer Fernández-Coronado, Paloma Martín-Martorell, Antonio Cremades, José M. Galbis-Caravajal, Javier Alcácer, Camilla L. Christensen, Patricia Simms, Ashley Hess, Hajime Asahina, Michael P. Kahle, Fatima Al-Shahrour, Jeffrey A. Borgia, Agustín Lahoz, Amelia Insa, Oscar Juan, Pasi A. Jänne, Kwok-Kin Wong, Julian Carretero, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4439–4452.
https://doi.org/10.1158/0008-5472.CAN-19-0024
Published: 03 September 2019
View article titled, CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Open the PDF for CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC in another window
Includes: Supplementary data
Journal Articles

Abstract 3158: DLL3 regulates migration and invasion of small cell lung cancer

Megumi Furuta, Jun Konishi Sakakibara, Tetsuaki Shoji, Yuta Takashima, Hajime Kikuchi, Eiki Kikuchi, Junko Kikuchi, Ichiro Kinoshita, Hirotoshi Dosaka Akita, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3158.
https://doi.org/10.1158/1538-7445.AM2018-3158
Published: 01 July 2018
View article titled, Abstract 3158: DLL3 regulates migration and invasion of small cell lung cancer
Journal Articles

Abstract 332: The BET bromodomain inhibitor JQ1 synergizes with WEE1 inhibitor AZD1775 by impairing non-homologous end joining and enhancing DNA damages in non-small cell lung cancer

Yuta Takashima, Eiki Kikuchi, Junko Kikuchi, Tetsuaki Shoji, Megumi Furuta, Hajime Kikuchi, Jun Sakakibara-Konishi, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 332.
https://doi.org/10.1158/1538-7445.AM2018-332
Published: 01 July 2018
View article titled, Abstract 332: The BET bromodomain inhibitor JQ1 synergizes with WEE1 inhibitor AZD1775 by impairing non-homologous end joining and enhancing DNA damages in non-small cell lung cancer
Journal Articles

Abstract 1172: Expression of notch1, numb, and musashi1 in non-small cell lung cancer

Hajime Kikuchi, Jun Sakakibara-Konishi, Yasuyuki Ikezawa, Taichi Takashina, Hidenori Mizugaki, Eiki Kikuchi, Junko Kikuchi, Naofumi Shinagawa, Satoshi Oizumi, Yasuhiro Hida, Kichizo Kaga, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1172.
https://doi.org/10.1158/1538-7445.AM2016-1172
Published: 15 July 2016
View article titled, Abstract 1172: Expression of notch1, numb, and musashi1 in non-small cell lung cancer
Journal Articles

Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition

Margaret Soucheray, Marzia Capelletti, Inés Pulido, Yanan Kuang, Cloud P. Paweletz, Jeffrey H. Becker, Eiki Kikuchi, Chunxiao Xu, Tarun B. Patel, Fatima Al-shahrour, Julián Carretero, Kwok-Kin Wong, Pasi A. Jänne, Geoffrey I. Shapiro, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2015) 75 (20): 4372–4383.
https://doi.org/10.1158/0008-5472.CAN-15-0377
Published: 14 October 2015
View article titled, Intratumoral Heterogeneity in <em>EGFR</em>-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Open the PDF for Intratumoral Heterogeneity in <em>EGFR</em>-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 766: Suppression of gefitinib-induced EMT in EGFR mutant NSCLC preferentially selects for acquired T790M

Margaret Soucheray, Marzia Capelletti, Ines Pulido, Yunan Kuang, Cloud P. Paweletz, Jeffrey H. Becker, Eiki Kikuchi, Chunxiao Xu, Tarun B. Patel, Fatima Al-shahrour, Julian Carretero, Kwok-Kin Wong, Pasi A. Janne, Geoffrey I. Shapiro, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 766.
https://doi.org/10.1158/1538-7445.AM2015-766
Published: 01 August 2015
View article titled, Abstract 766: Suppression of gefitinib-induced EMT in EGFR mutant NSCLC preferentially selects for acquired T790M
Journal Articles

Abstract 4851: Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC

Esra A. Akbay, Jeremy H. Tchaicha, Abigail Altabef, Oliver R. Mikse, Eiki Kikuchi, Kevin Rhee, Rachel Liao, Roderick T. Bronson, Lynette M. Sholl, Matthew Meyerson, Peter S. Hammerman, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4851.
https://doi.org/10.1158/1538-7445.AM2014-4851
Published: 01 October 2014
View article titled, Abstract 4851: Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC
Journal Articles

Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC

Jeremy H. Tchaicha, Esra A. Akbay, Abigail Altabef, Oliver R. Mikse, Eiki Kikuchi, Kevin Rhee, Rachel G. Liao, Roderick T. Bronson, Lynette M. Sholl, Matthew Meyerson, Peter S. Hammerman, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4676–4684.
https://doi.org/10.1158/0008-5472.CAN-13-3218
Published: 01 September 2014
View article titled, Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC
Open the PDF for Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC in another window
Includes: Supplementary data
Journal Articles

Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.

Takeshi Shimamura, Zhao Chen, Margaret Soucheray, Julian Carretero, Eiki Kikuchi, Jeremy H. Tchaicha, Yandhi Gao, Katherine A. Cheng, Travis J. Cohoon, Jun Qi, Esra A. Akbay, Alec C. Kimmelman, Andrew L. Kung, James E. Bradner, Kwok Kin Wong
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1126.
https://doi.org/10.1158/1538-7445.AM2013-1126
Published: 15 April 2013
View article titled, Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.
Journal Articles

Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET

Lu Xu, Eiki Kikuchi, Chunxiao Xu, Hiromichi Ebi, Dalia Ercan, Katherine A. Cheng, Robert Padera, Jeffrey A. Engelman, Pasi A. Jänne, Geoffrey I. Shapiro, Takeshi Shimamura, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3302–3311.
https://doi.org/10.1158/0008-5472.CAN-11-3720
Published: 01 July 2012
View article titled, Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET
Open the PDF for Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET in another window
Includes: Supplementary data
Journal Articles

Abstract 3263: Expression of Bim, Noxa, and Puma in non-small cell lung cancer

Jun Sakakibara-Konishi, Satoshi Oizumi, Junko Kikuchi, Eiki Kikuchi, Hidenori Mizugaki, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3263.
https://doi.org/10.1158/1538-7445.AM2012-3263
Published: 15 April 2012
View article titled, Abstract 3263: Expression of Bim, Noxa, and Puma in non-small cell lung cancer
Journal Articles

Abstract 2011: Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A against non-small cell lung cancer cells

Junko Kikuchi, Ichiro Kinoshita, Eiki Kikuchi, Yasushi Shimizu, Jun Sakakibara-Konishi, Satoshi Oizumi, Masaharu Nishimura, Hirotoshi Dosaka-Akita
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2011.
https://doi.org/10.1158/1538-7445.AM2011-2011
Published: 15 April 2011
View article titled, Abstract 2011: Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A against non-small cell lung cancer cells
Journal Articles

Abstract 4118: Expression of CD133 as a prognostic marker of non-small cell lung cancers

Hidenori Mizugaki, Jun Sakakibara Konishi, Junko Kikuchi, Eiki Kikuchi, Jun Moriya, Kanako Kubota, Ichiro Kinoshita, Satoshi Oizumi, Hirotoshi Dosaka Akita, Yoshihiro Matsuno, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4118.
https://doi.org/10.1158/1538-7445.AM2011-4118
Published: 15 April 2011
View article titled, Abstract 4118: Expression of CD133 as a prognostic marker of non-small cell lung cancers
Journal Articles

Abstract 4641: Distinctive expression of polycomb group proteins Bmi1 and EZH2 in non-small cell lung cancers and their clinical and clinicopathological significance

Junko Kikuchi, Ichiro Kinoshita, Eiki Kikuchi, Jun Konishi, Yasushi Shimizu, Satoshi Oizumi, Masaharu Nishimura, Hirotoshi Dosaka-Akita
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4641.
https://doi.org/10.1158/1538-7445.AM10-4641
Published: 15 April 2010
View article titled, Abstract 4641: Distinctive expression of polycomb group proteins Bmi1 and EZH2 in non-small cell lung cancers and their clinical and clinicopathological significance
Journal Articles

Abstract 4784: CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma

Noriyuki Yamada, Satoshi Oizumi, Eiki Kikuchi, Naofumi Shinagawa, Jun Konishi, Atsushi Ishimine, Keisuke Aoe, Kenichi Gemba, Takumi Kishimoto, Toshihiko Torigoe, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4784.
https://doi.org/10.1158/1538-7445.AM10-4784
Published: 15 April 2010
View article titled, Abstract 4784: CD8<sup>+</sup> tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma
Journal Articles

Abstract 4137: Verification of antitumor effect of γ-secretase-inhibitor and radiotherapy

Hidenori Mizugaki, Jun Konishi, Junko Kikuchi, Eiki Kikuchi, Naofumi Shinagawa, Satoshi Oizumi, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4137.
https://doi.org/10.1158/1538-7445.AM10-4137
Published: 15 April 2010
View article titled, Abstract 4137: Verification of antitumor effect of γ-secretase-inhibitor and radiotherapy
Journal Articles

Abstract #3323: The role of minichromosome maintenance (MCM) protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancer .

Junko Kikuchi, Ichiro Kinoshita, Yasushi Shimizu, Eiki Kikuchi, Jun Konishi, Kayoko Takeda, Hiroyuki Aburatani, Satoshi Oizumi, Masaharu Nishimura, Hirotoshi Dosaka-Akita.
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3323.
Published: 01 May 2009
View article titled, Abstract #3323: The role of minichromosome maintenance (MCM) protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancer .
Journal Articles

Expression and clinical significance of HLA class I antigen and tumor-infiltrating immune cells in human non-small cell lung cancer

Eiki Kikuchi, Koichi Yamazaki, Toshihiko Torigoe, Naofumi Shinagawa, Hiroshi Yokouchi, Satoshi Oizumi, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2750.
Published: 01 May 2007
View article titled, Expression and clinical significance of HLA class I antigen and tumor-infiltrating immune cells in human non-small cell lung cancer
Journal Articles

Anti-CD134 (OX-40) monoclonal antibody therapy in combination with irradiation results in a CD8+ T cell-dependent therapeutic immunity to lung cancer

Hiroshi Yokouchi, Koichi Yamazaki, Eiki Kikuchi, Naofumi Shinagawa, Fumihiro Honmura, Satoshi Oizumi, Hirotoshi Dosaka-Akita, Masaharu Nishimura
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 153–154.
Published: 15 April 2006
View article titled, Anti-CD134 (OX-40) monoclonal antibody therapy in combination with irradiation results in a CD8<sup>+</sup> T cell-dependent therapeutic immunity to lung cancer