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Eike Gallmeier
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Journal Articles

Abstract #1071: Tumor stem cell targeted therapy with mTOR inhibitor RAD001 and hedgehog signalling inhibitor Cyclopamine reverts chemoresistance towards 5-Fluorouracil in human pancreatic carcinoma cells

Ivan Ischenko, Andrea Renner, Peter Camaj, Hendrik Seeliger, Joachim Ellwart, Eike Gallmeier, Martin Eichhorn, Karl-Walter Jauch, Christiane Bruns
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1071.
Published: 01 May 2009
View article titled, Abstract #1071: Tumor stem cell targeted therapy with mTOR inhibitor RAD001 and hedgehog signalling inhibitor Cyclopamine reverts chemoresistance towards 5-Fluorouracil in human pancreatic carcinoma cells
Journal Articles

Limits to Thymidylate Synthase and TP53 Genes as Predictive Determinants for Fluoropyrimidine Sensitivity and Further Evidence for RNA-Based Toxicity as a Major Influence

Jonathan R. Brody, Tomas Hucl, Christina L. Costantino, James R. Eshleman, Eike Gallmeier, Heng Zhu, Michiel S. van der Heijden, Jordan M. Winter, Agnieszka K. Wikiewicz, Charles J. Yeo, Scott E. Kern
Journal: Cancer Research
Cancer Res (2009) 69 (3): 984–991.
https://doi.org/10.1158/0008-5472.CAN-08-3610
Published: 29 January 2009
View article titled, Limits to Thymidylate Synthase and <em>TP53</em> Genes as Predictive Determinants for Fluoropyrimidine Sensitivity and Further Evidence for RNA-Based Toxicity as a Major Influence
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Journal Articles

A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to BRCA2

Tomas Hucl, Carlo Rago, Eike Gallmeier, Jonathan R. Brody, Myriam Gorospe, Scott E. Kern
Journal: Cancer Research
Cancer Res (2008) 68 (13): 5023–5030.
https://doi.org/10.1158/0008-5472.CAN-07-6189
Published: 01 July 2008
View article titled, A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to <em>BRCA2</em>
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Journal Articles

High Cancer-Specific Expression of Mesothelin (MSLN) Is Attributable to an Upstream Enhancer Containing a Transcription Enhancer Factor–Dependent MCAT Motif

Tomas Hucl, Jonathan R. Brody, Eike Gallmeier, Christine A. Iacobuzio-Donahue, Iain K. Farrance, Scott E. Kern
Journal: Cancer Research
Cancer Res (2007) 67 (19): 9055–9065.
https://doi.org/10.1158/0008-5472.CAN-07-0474
Published: 01 October 2007
View article titled, High Cancer-Specific Expression of Mesothelin (<em>MSLN</em>) Is Attributable to an Upstream Enhancer Containing a Transcription Enhancer Factor–Dependent MCAT Motif
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Journal Articles

Knock-in of Mutant K-ras in Nontumorigenic Human Epithelial Cells as a New Model for Studying K-ras–Mediated Transformation

Hiroyuki Konishi, Bedri Karakas, Abde M. Abukhdeir, Josh Lauring, John P. Gustin, Joseph P. Garay, Yuko Konishi, Eike Gallmeier, Kurtis E. Bachman, Ben Ho Park
Journal: Cancer Research
Cancer Res (2007) 67 (18): 8460–8467.
https://doi.org/10.1158/0008-5472.CAN-07-0108
Published: 17 September 2007
View article titled, Knock-in of Mutant K-<em>ras</em> in Nontumorigenic Human Epithelial Cells as a New Model for Studying K-<em>ras</em>–Mediated Transformation
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Includes: Supplementary data
Journal Articles

Creation of new cell models for ras-induced oncogenesis by targeted knock-in of mutant K-ras gene in immortalized human breast epithelial cells

Hiroyuki Konishi, Bedri Karakas, Abde Abukhdeir, Yuko Konishi, Eike Gallmeier, Kurtis Bachman, Ben Park
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3877.
Published: 01 May 2007
View article titled, Creation of new cell models for <em>ras</em>-induced oncogenesis by targeted knock-in of mutant K-<em>ras</em> gene in immortalized human breast epithelial cells
Journal Articles

High-Throughput Screening Identifies Novel Agents Eliciting Hypersensitivity in Fanconi Pathway–Deficient Cancer Cells

Eike Gallmeier, Tomas Hucl, Jonathan R. Brody, David A. Dezentje, Khola Tahir, Jana Kasparkova, Viktor Brabec, Kurtis E. Bachman, Scott E. Kern
Journal: Cancer Research
Cancer Res (2007) 67 (5): 2169–2177.
https://doi.org/10.1158/0008-5472.CAN-06-2711
Published: 01 March 2007
View article titled, High-Throughput Screening Identifies Novel Agents Eliciting Hypersensitivity in Fanconi Pathway–Deficient Cancer Cells
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Journal Articles

Genomic Copy Number Changes Affecting the Thymidylate Synthase (TYMS) Gene in Cancer: A Model for Patient Classification to Aid Fluoropyrimidine Therapy

Jonathan R. Brody, Tomas Hucl, Eike Gallmeier, Jordan M. Winter, Scott E. Kern, Kathleen M. Murphy
Journal: Cancer Research
Cancer Res (2006) 66 (19): 9369–9373.
https://doi.org/10.1158/0008-5472.CAN-06-2165
Published: 03 October 2006
View article titled, Genomic Copy Number Changes Affecting the Thymidylate Synthase (<em>TYMS</em>) Gene in Cancer: A Model for Patient Classification to Aid Fluoropyrimidine Therapy
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Journal Articles

Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays

Eric S. Calhoun, Tomas Hucl, Eike Gallmeier, Kristen M. West, Dan E. Arking, Anirban Maitra, Christine A. Iacobuzio-Donahue, Aravinda Chakravarti, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (16): 7920–7928.
https://doi.org/10.1158/0008-5472.CAN-06-0721
Published: 15 August 2006
View article titled, Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays
Open the PDF for Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer without Matched Normals Using High-Density Single-Nucleotide Polymorphism Arrays in another window
Includes: Supplementary data
Journal Articles

Targeted Deletion of MKK4 in Cancer Cells: A Detrimental Phenotype Manifests as Decreased Experimental Metastasis and Suggests a Counterweight to the Evolution of Tumor-Suppressor Loss

Steven C. Cunningham, Eike Gallmeier, Tomas Hucl, David A. Dezentje, Eric S. Calhoun, Geppino Falco, Kotb Abdelmohsen, Myriam Gorospe, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (11): 5560–5564.
https://doi.org/10.1158/0008-5472.CAN-06-0555
Published: 01 June 2006
View article titled, Targeted Deletion of <em>MKK4</em> in Cancer Cells: A Detrimental Phenotype Manifests as Decreased Experimental Metastasis and Suggests a Counterweight to the Evolution of Tumor-Suppressor Loss
Open the PDF for Targeted Deletion of <em>MKK4</em> in Cancer Cells: A Detrimental Phenotype Manifests as Decreased Experimental Metastasis and Suggests a Counterweight to the Evolution of Tumor-Suppressor Loss in another window
Includes: Supplementary data
Journal Articles

A clinical assay for 5-Fluorouracil targeting and metabolism

Jonathan R. Brody, Eike Gallmeier, Tomas Hucl, Kiyoshi Yoshimura, Richard D. Schulick, Ralph H. Hruban, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 123.
Published: 15 April 2006
View article titled, A clinical assay for 5-Fluorouracil targeting and metabolism
Journal Articles

Targeted disruption of FANCC and FANCG in human cancer cells provides a preclinical model of specific therapeutic options

Eike Gallmeier, Carlo Rago, Jonathan R. Brody, Tomas Hucl, Eric S. Calhoun, Steven C. Cunninghham, Kurtis E. Bachman, Christoph Lengauer, Scott E. Kern
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 554.
Published: 15 April 2006
View article titled, Targeted disruption of <em>FANCC</em> and <em>FANCG</em> in human cancer cells provides a preclinical model of specific therapeutic options