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Edwin M. Posadas
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Journal Articles

Abstract 4759: Targeting slow-cycling persisters in EGFR mutant non-small cell lung cancer

Manish Thiruvalluvan, Sandrine Billet, Zhenqiu Liu, Joseph Lownik, Gabrielle Gonzales, Hyoyoung Kim, Anton L. Villamejor, Larry Milshteyn, Kamya Sankar, Edwin M. Posadas, Jean Lopategui, Sungyong You, Karen Reckamp, Neil A. Bhowmick
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4759.
https://doi.org/10.1158/1538-7445.AM2024-4759
Published: 22 March 2024
View article titled, Abstract 4759: Targeting slow-cycling persisters in EGFR mutant non-small cell lung cancer
Journal Articles

Abstract 4302: ONECUT2 activates diverse resistance drivers of androgen receptor-independent heterogeneity in prostate cancer

Chen Qian, Qian Yang, Mirja Rotinen, Rongrong Huang, Hyoyoung Kim, Brad Gallent, Yiwu Yan, Radu M. Cadaneanu, Baohui Zhang, Salma Kaochar, Stephen J. Freedland, Edwin M. Posadas, Leigh Ellis, Dolores Di Vizio, Colm Morrissey, Peter S. Nelson, Lauren Brady, Ramachandran Murali, Moray J. Campbell, Wei Yang, Beatrice S. Knudsen, Elahe A. Mostaghel, Huihui Ye, Isla P. Garraway, Sungyong You, Michael R. Freeman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4302.
https://doi.org/10.1158/1538-7445.AM2024-4302
Published: 22 March 2024
View article titled, Abstract 4302: ONECUT2 activates diverse resistance drivers of androgen receptor-independent heterogeneity in prostate cancer
Journal Articles

Abstract B022: Dopamine receptor antagonists sensitize prostate cancer cells to androgen targeted therapy

Le Zhang, Sandrine Billet, Gabrielle Gonzales, Krizia Rohena-Rivera, Hayato Muranaka, Yeonjoo Lee, Sungyong You, Edwin M. Posadas, Neil A. Bhowmick
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B022.
https://doi.org/10.1158/1538-7445.PRCA2023-B022
Published: 02 June 2023
View article titled, Abstract B022: Dopamine receptor antagonists sensitize prostate cancer cells to androgen targeted therapy
Journal Articles

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Martin Sjöström, Shuang G. Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, Cameron Herberts, Adam Foye, Rahul Aggarwal, Junjie T. Hua, Haolong Li, Anna Bergamaschi, Corinne Maurice-Dror, Ashutosh Maheshwari, Sujun Chen, Sarah W.S. Ng, Wenbin Ye, Jessica Petricca, Michael Fraser, Lisa Chesner, Marc D. Perry, Thaidy Moreno-Rodriguez, William S. Chen, Joshi J. Alumkal, Jonathan Chou, Alicia K. Morgans, Tomasz M. Beer, George V. Thomas, Martin Gleave, Paul Lloyd, Tierney Phillips, Erin McCarthy, Michael C. Haffner, Amina Zoubeidi, Matti Annala, Robert E. Reiter, Matthew B. Rettig, Owen N. Witte, Lawrence Fong, Rohit Bose, Franklin W. Huang, Jianhua Luo, Anders Bjartell, Joshua M. Lang, Nupam P. Mahajan, Primo N. Lara, Christopher P. Evans, Phuoc T. Tran, Edwin M. Posadas, Chuan He, Xiao-Long Cui, Jiaoti Huang, Wilbert Zwart, Luke A. Gilbert, Christopher A. Maher, Paul C. Boutros, Kim N. Chi, Alan Ashworth, Eric J. Small, Housheng H. He, Alexander W. Wyatt, David A. Quigley, Felix Y. Feng
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3888–3902.
https://doi.org/10.1158/0008-5472.CAN-22-1123
Published: 02 November 2022
View article titled, The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
Open the PDF for The 5-Hydroxymethylcytosine Landscape of Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5447: Gene expression of circulating tumor cells is predictive of treatment response in patients with advanced prostate cancer

PAI-CHI TENG, Minhyung Kim, Yu Jen Jan, Jie-Fu Chen, Nu Yao, Gina C. Chu, Pin-Jung Chen, Jasmine J. Wang, Yi-Te Lee, Yazhen Zhu, Leland W. Chung, Felix Y. Feng, Michael R. Freeman, Sungyong You, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5447.
https://doi.org/10.1158/1538-7445.AM2020-5447
Published: 15 August 2020
View article titled, Abstract 5447: Gene expression of circulating tumor cells is predictive of treatment response in patients with advanced prostate cancer
Journal Articles

Abstract 5436: Purification and mRNA profiling of extracellular vesicles for early detection of hepatocellular carcinoma

Yi-Te Lee, Na Sun, Ryan Y. Zhang, Rueihung Kao, Pin-Jung Chen, Pai-Chi Teng, Jasmine J. Wang, Yingying Yang, Minhyung Kim, Edwin M. Posadas, Sungyong You, Ju Dong Yang, Vatche G. Agopian, Hsian-Rong Tseng, Yazhen Zhu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5436.
https://doi.org/10.1158/1538-7445.AM2020-5436
Published: 15 August 2020
View article titled, Abstract 5436: Purification and mRNA profiling of extracellular vesicles for early detection of hepatocellular carcinoma
Journal Articles

Abstract 4331: Nuclear size of circulating tumor cells is associated with prognosis in metastatic, castration-resistant prostate cancer

JASMINE J. WANG, Pai-Chi Teng, Yu Jen Jan, Jie-Fu Chen, Galen Cook-Wiens, Nu Yao, Gina C. Chu, Pin-Jung Chen, Yingying Yang, Yee Hui Yeo, Yi-Te Lee, Leland W. Chung, Sungyong You, Yazhen Zhu, Michael R. Freeman, Andre Rogatko, Ju Dong Yang, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4331.
https://doi.org/10.1158/1538-7445.AM2020-4331
Published: 15 August 2020
View article titled, Abstract 4331: Nuclear size of circulating tumor cells is associated with prognosis in metastatic, castration-resistant prostate cancer
Journal Articles

Abstract 453: A circulating tumor cell assay for dynamic assessment of drug sensitivity in metastatic castration-resistant prostate cancer

Pai-Chi Teng, Yu Jen Jan, Junhee Yoon, Jie-Fu Chen, Pin-Jung Chen, Nu Yao, Shirley Cheng, Amber Lozano, Michael R. Freeman, Sungyong You, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 453.
https://doi.org/10.1158/1538-7445.AM2019-453
Published: 01 July 2019
View article titled, Abstract 453: A circulating tumor cell assay for dynamic assessment of drug sensitivity in metastatic castration-resistant prostate cancer
Journal Articles

Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential

Mariana Reis-Sobreiro, Jie-Fu Chen, Tatiana Novitskaya, Sungyong You, Samantha Morley, Kenneth Steadman, Navjot Kaur Gill, Adel Eskaros, Mirja Rotinen, Chia-Yi Chu, Leland W.K. Chung, Hisashi Tanaka, Wei Yang, Beatrice S. Knudsen, Hsian-Rong Tseng, Amy C. Rowat, Edwin M. Posadas, Andries Zijlstra, Dolores Di Vizio, Michael R. Freeman
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6086–6097.
https://doi.org/10.1158/0008-5472.CAN-18-0608
Published: 01 November 2018
View article titled, Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential
Open the PDF for Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1578: NanoVelcro CTC Purification Systems for expressional analysis of circulating tumor cells from prostate cancer patients

Yu Jen Jan, Jie-Fu Chen, Sungyong You, Junhee Yoon, Nu Yao, Shirley Cheng, Michael R. Freeman, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1578.
https://doi.org/10.1158/1538-7445.AM2018-1578
Published: 01 July 2018
View article titled, Abstract 1578: NanoVelcro CTC Purification Systems for expressional analysis of circulating tumor cells from prostate cancer patients
Journal Articles

Abstract 5208: Monocyte-produced Chitinase-3-like 1 is a driver of metastatic behavior in prostate cancer patients

Karen A. Cavassani, Rebecca J. Meza, David M. Habiel, Jie-Fu Chen, Alexander Montes, Manisha Tripathi, Gislaine A. Martins, Timothy R. Crother, Sungyong You, Cory M. Hogaboam, Neil Bhowmick, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5208.
https://doi.org/10.1158/1538-7445.AM2018-5208
Published: 01 July 2018
View article titled, Abstract 5208: Monocyte-produced Chitinase-3-like 1 is a driver of metastatic behavior in prostate cancer patients
Journal Articles

Abstract 3913: Selective targeting of circulating tumor cells with agonistic EphA2 ligand

Ahmed F. Salem, Si Wang, Sandrine Billet, Jie-Fu Chen, Parima Udompholkul, Luca Gambini, Carlo Baggio, Edwin M. Posadas, Neil A. Bhowmick, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3913.
https://doi.org/10.1158/1538-7445.AM2018-3913
Published: 01 July 2018
View article titled, Abstract 3913: Selective targeting of circulating tumor cells with agonistic EphA2 ligand
Journal Articles

Abstract 3780: Bio-competition-based smart NanoVelcro Chip for isolation and gene expression analysis of circulating tumor cells from prostate cancer patients

Jie-Fu Chen, Mo-Yuan Shen, Chun-Hao Luo, Shirley Cheng, Sangjun Lee, Shuang Hou, Edwin M. Posadas, Hsian-Rong Tseng, Hsiao-Hua Yu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3780.
https://doi.org/10.1158/1538-7445.AM2017-3780
Published: 01 July 2017
View article titled, Abstract 3780: Bio-competition-based smart NanoVelcro Chip for isolation and gene expression analysis of circulating tumor cells from prostate cancer patients
Journal Articles

MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer

Valentina R. Minciacchi, Cristiana Spinelli, Mariana Reis-Sobreiro, Lorenzo Cavallini, Sungyong You, Mandana Zandian, Xiaohong Li, Rajeev Mishra, Paola Chiarugi, Rosalyn M. Adam, Edwin M. Posadas, Giuseppe Viglietto, Michael R. Freeman, Emanuele Cocucci, Neil A. Bhowmick, Dolores Di Vizio
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (9): 2306–2317.
https://doi.org/10.1158/0008-5472.CAN-16-2942
Published: 30 April 2017
View article titled, MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer
Open the PDF for MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-266: Large oncosomes reprogram prostate fibroblasts toward a pro-angiogenic phenotype

Valentina Minciacchi, Cristiana Spinelli, Mariana Reis-Sobreiro, Mandana Zandian, Rosalyn M. Adam, Edwin M. Posadas, Freeman R. Michael, Emanuele Cocucci, Neil Bhowmick, Dolores Di Vizio
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-266.
https://doi.org/10.1158/1538-7445.AM2016-LB-266
Published: 15 July 2016
View article titled, Abstract LB-266: Large oncosomes reprogram prostate fibroblasts toward a pro-angiogenic phenotype
Journal Articles

Abstract LB-274: Microenvironment mediates the efficacy of Cabozantinib in prostate cancer

Manisha Tripathi, Srinivas Nandana, Sandrine Billet, Edwin M. Posadas, Leland W.K. Chung, Neil A. Bhowmick
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-274.
https://doi.org/10.1158/1538-7445.AM2016-LB-274
Published: 15 July 2016
View article titled, Abstract LB-274: Microenvironment mediates the efficacy of Cabozantinib in prostate cancer
Journal Articles

Abstract 4962: Very-small-nuclear circulating tumor cell (vsnCTC) as a putative biomarker for visceral metastasis in metastatic castration-resistant prostate cancer (mCRPC)

Jie-Fu Chen, Hao Ho, Elisabeth Hodara, Alexander Ureno, Ann Go, Elizabeth Kaufman, Margarit Sievert, Daniel J. Luthringer, Jiaoti Huang, Leland Chung, Zunfu Ke, Ker-Chau Li, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4962.
https://doi.org/10.1158/1538-7445.AM2016-4962
Published: 15 July 2016
View article titled, Abstract 4962: Very-small-nuclear circulating tumor cell (vsnCTC) as a putative biomarker for visceral metastasis in metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 3473: Sub-classification of prostate cancer circulating tumor cells (CTCs) by nuclear size reveals very-small nuclear CTCs in patients with visceral metastases

Jie-Fu Chen, Hao Ho, Jake Lichterman, Yi-Tsung Lu, Yang Zhang, Mitch A. Garcia, Shang-Fu Chen, An-Jou Liang, Haiyen E. Zhau, Shuang Hou, Rafi S. Ahmed, Daniel J. Luthringer, Jiaoti Huang, Ker-Chau Li, Leland WK Chung, Zunfu Ke, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3473.
https://doi.org/10.1158/1538-7445.AM2015-3473
Published: 01 August 2015
View article titled, Abstract 3473: Sub-classification of prostate cancer circulating tumor cells (CTCs) by nuclear size reveals very-small nuclear CTCs in patients with visceral metastases
Journal Articles

Abstract CT302: Pharmacokinetics (PK) and safety of ARN-509 with abiraterone acetate (AA) and prednisone (P) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)

Edwin M. Posadas, Kim N. Chi, Ronald de Wit, Maja JA de Jonge, Gerhardt Attard, Terence Friedlander, Margaret Yu, Peter Hellemans, Caly Chien, Charlene Abrams, Martha Gonzalez, Géralyn C. Trudel, Vijay Chauhan, Fred Saad
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT302.
https://doi.org/10.1158/1538-7445.AM2015-CT302
Published: 01 August 2015
View article titled, Abstract CT302: Pharmacokinetics (PK) and safety of ARN-509 with abiraterone acetate (AA) and prednisone (P) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 3459: SRC family kinase FYN promotes MET tyrosine kinase activation, epithelial to mesenchymal transition and metastasis in human prostate cancer

Murali Gururajan, Margarit Sievert, Sheldon Mink, Chia-Yi (Gina) Chu, Matteo Morello, Jake Lichterman, Michael R. Freeman, Edwin M. Posadas
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3459.
https://doi.org/10.1158/1538-7445.AM2014-3459
Published: 01 October 2014
View article titled, Abstract 3459: SRC family kinase FYN promotes MET tyrosine kinase activation, epithelial to mesenchymal transition and metastasis in human prostate cancer