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Edward Seto
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Journal Articles

Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB-Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer

Shuyan Zhou, Yi Zhang, Julie Belmar, Chunyan Hou, Yaqin Zhang, Changmin Peng, Yunxiao Meng, Zhuqing Li, Muhammad Jameel. Mughal, Yanjun Gao, Edward Seto, Min Shen, Matthew D. Hall, Junfeng Ma, Cynthia X. Ma, Shunqiang Li, Wenge Zhu
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2492
Published: 12 February 2025
View article titled, Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB-Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer
Open the PDF for Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB-Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3606: HDAC8-mediated inhibition of EP300 drives a neural crest-like transcriptional state that increases melanoma brain metastasis

Michael Emmons, Richard Bennett, Alberto Riva, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, John Koomen, Jiannong Li, Ann Chen, Edward Seto, Jonathan Licht, Keiran Smalley
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3606.
https://doi.org/10.1158/1538-7445.AM2023-3606
Published: 04 April 2023
View article titled, Abstract 3606: HDAC8-mediated inhibition of EP300 drives a neural crest-like transcriptional state that increases melanoma brain metastasis
Journal Articles

Abstract 1116: HDAC8 activity regulates stress induced phenotype switching in melanoma

Michael Emmons, Richard Bennett, Alberto Riva, Bin Fang, Edward Seto, john koomen, Jonathan Licht, Keiran Smalley
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1116.
https://doi.org/10.1158/1538-7445.AM2021-1116
Published: 01 July 2021
View article titled, Abstract 1116: HDAC8 activity regulates stress induced phenotype switching in melanoma
Journal Articles

HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma

Yixuan Li, Xiangyang Zhang, Shaoqi Zhu, Eden A. Dejene, Weiqun Peng, Antonia Sepulveda, Edward Seto
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3265–3278.
https://doi.org/10.1158/0008-5472.CAN-19-3613
Published: 14 August 2020
View article titled, HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma
Open the PDF for HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3800: HDAC8 regulates plasticity and escape from therapy in BRAF mutant melanoma

Michael Emmons, Fernanda Flores, John Koomen, Edward Seto, Jane Messina, Eric Lau, Jonathan Licht, Keiran Smalley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3800.
https://doi.org/10.1158/1538-7445.AM2019-3800
Published: 01 July 2019
View article titled, Abstract 3800: HDAC8 regulates plasticity and escape from therapy in BRAF mutant melanoma
Journal Articles

HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy

Michael F. Emmons, Fernanda Faião-Flores, Ritin Sharma, Ram Thapa, Jane L. Messina, Jurgen C. Becker, Dirk Schadendorf, Edward Seto, Vernon K. Sondak, John M. Koomen, Yian A. Chen, Eric K. Lau, Lixin Wan, Jonathan D. Licht, Keiran S.M. Smalley
Journal: Cancer Research
Cancer Res (2019) 79 (11): 2947–2961.
https://doi.org/10.1158/0008-5472.CAN-19-0040
Published: 03 June 2019
View article titled, HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy
Open the PDF for HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 1742: Potential roles of histone deacetylase 11 in cell cycle regulation and cancer.

Thejal Srikumar, Elphine Telles, Edward Seto
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1742.
https://doi.org/10.1158/1538-7445.AM2013-1742
Published: 15 April 2013
View article titled, Abstract 1742: Potential roles of histone deacetylase 11 in cell cycle regulation and cancer.
Journal Articles

Abstract 4260: Histone deacetylase 11 (HDAC11) as a novel therapeutic target in the regulation of myeloid-derived suppressor cell (MDSC)

Eva Sahakian, John Powers, Jennifer Rock-Klotz, Adriani Marsilio, Karune Woan, Oscar Merino, Ajaypal Gill, Susan Deng, Fengdong Cheng, Alejandro Villagra, Noreen Luekette, Edward Seto, Ivan Borrello, Eduardo Sotomayor, Javier I. Pinilla
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4260.
https://doi.org/10.1158/1538-7445.AM2012-4260
Published: 15 April 2012
View article titled, Abstract 4260: Histone deacetylase 11 (HDAC11) as a novel therapeutic target in the regulation of myeloid-derived suppressor cell (MDSC)
Journal Articles

Abstract 4517: HDAC inhibitors suppress p53 expression through transcriptional repression: Implication for therapy against metastatic breast cancer

Lisa Y. Zhao, Qiang Li, Edward Seto, Daiqing Liao
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4517.
https://doi.org/10.1158/1538-7445.AM10-4517
Published: 15 April 2010
View article titled, Abstract 4517: HDAC inhibitors suppress p53 expression through transcriptional repression: Implication for therapy against metastatic breast cancer
Journal Articles

The ARHI tumor suppressor gene is repressed by multiple histone deacetylases (HDACs) in breast cancer cells

Weiwei Feng, Zhen Lu, Robert Z. Luo, Xiaohong Zhang, Edward Seto, Robert C. Bast, Jr, Yinhua Yu
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 643.
Published: 01 May 2005
View article titled, The ARHI tumor suppressor gene is repressed by multiple histone deacetylases (HDACs) in breast cancer cells