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Edward L. Schwartz
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Journal Articles

Abstract 2928: Evaluating Cks1-Skp2 interface as an effective therapeutic target for RB1-deficient metastatic castration-resistant prostate cancer (mCRPC)

Yingjiao Xue, Liang Zhu, Hongling Zhao, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2928.
https://doi.org/10.1158/1538-7445.AM2021-2928
Published: 01 July 2021
View article titled, Abstract 2928: Evaluating Cks1-Skp2 interface as an effective therapeutic target for <em>RB1</em>-deficient metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 2008: Targeting SKP2 by p27 Inhibits stemness and prolong the survival in osteosarcoma

Jichuan Wang, Osama Aldahamsheh, Alexander Ferrena, Swapnil Singh, Amit Singla, Hasibagan Borjihan, Simon Yaguare, Valentina Viscarret, Janet Tingling, Xiaolin Zi, Yungtai Lo, Richard Gorlick, Deyou Zheng, Edward L. Schwartz, Hongling Zhao, Rui Yang, David S. Geller, Bang H. Hoang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2008.
https://doi.org/10.1158/1538-7445.AM2021-2008
Published: 01 July 2021
View article titled, Abstract 2008: Targeting SKP2 by p27 Inhibits stemness and prolong the survival in osteosarcoma
Journal Articles

Abstract 5930: Targeting Skp2 in synovial sarcoma reduces tumor-initiating properties and promotes apoptosis

Jichuan Wang, Kenji Sato, Ed O'Donnell, Amit Singla, Simon Yaguare, Osama Aldahamsheh, Brian Batko, Hasibagan Borjihan, Janet Tingling, Daniel A Weiser, David M Loeb, Richard Gorlick, Edward L Schwartz, Rui Yang, Xiaolin Zi, Hongling Zhao, David S Geller, Bang H Hoang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5930.
https://doi.org/10.1158/1538-7445.AM2020-5930
Published: 15 August 2020
View article titled, Abstract 5930: Targeting Skp2 in synovial sarcoma reduces tumor-initiating properties and promotes apoptosis
Journal Articles

Abstract 1060: Genetic and pharmacologic inhibition of Skp2, an E3 ubiquitin ligase and RB1-target, has antitumor activity in RB1-deficient human and mouse small cell lung cancer (SCLC)

Hongling Zhao, Vineeth Sukrithan, Niloy Iqbal, Cari Nicholas, Yingjiao Xue, Joseph Locker, Juntao Zou, Liang Zhu, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1060.
https://doi.org/10.1158/1538-7445.AM2020-1060
Published: 15 August 2020
View article titled, Abstract 1060: Genetic and pharmacologic inhibition of Skp2, an E3 ubiquitin ligase and RB1-target, has antitumor activity in RB1-deficient human and mouse small cell lung cancer (SCLC)
Journal Articles

Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer

Hongling Zhao, Niloy J. Iqbal, Vineeth Sukrithan, Cari Nicholas, Yingjiao Xue, Cindy Yu, Joseph Locker, Juntao Zou, Edward L. Schwartz, Liang Zhu
Journal: Cancer Research
Cancer Res (2020) 80 (11): 2355–2367.
https://doi.org/10.1158/0008-5472.CAN-19-2400
Published: 02 June 2020
View article titled, Targeted Inhibition of the E3 Ligase SCF<sup>Skp2/Cks1</sup> Has Antitumor Activity in <em>RB1</em>-Deficient Human and Mouse Small-Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract 1822: Antitumor activity of agents targeting the angiogenic factors angiopoietin-2 and thymidine phosphorylase in mouse models of lung and pancreatic neuroendocrine cancer

Evelyn Aranda, Ziqiang Yuan, Steven K. Libutti, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1822.
https://doi.org/10.1158/1538-7445.AM2017-1822
Published: 01 July 2017
View article titled, Abstract 1822: Antitumor activity of agents targeting the angiogenic factors angiopoietin-2 and thymidine phosphorylase in mouse models of lung and pancreatic neuroendocrine cancer
Journal Articles

Abstract 3306: Inhibition of ribosomal protein S6 (rpS6) phosphorylation and cell proliferation by a novel chloroquine analog in lung cancer cells

Juan Sironi, Evelyn Aranda, Lars Nordstroem, Roman Perez Soler, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3306.
https://doi.org/10.1158/1538-7445.AM2017-3306
Published: 01 July 2017
View article titled, Abstract 3306: Inhibition of ribosomal protein S6 (rpS6) phosphorylation and cell proliferation by a novel chloroquine analog in lung cancer cells
Journal Articles

Abstract 1012: Discovery and synthesis of novel autophagy inhibitors with anti-proliferative activity in lung and pancreatic cancer cells

Juan Sironi, Lars Ulrik Nordstroem, Evelyn Aranda, Marina Shcherba, Roman Perez-Soler, Peng Wu, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1012.
https://doi.org/10.1158/1538-7445.AM2015-1012
Published: 01 August 2015
View article titled, Abstract 1012: Discovery and synthesis of novel autophagy inhibitors with anti-proliferative activity in lung and pancreatic cancer cells
Journal Articles

Abstract 2033: Identification of a novel genetic abnormality, the amplification of rictor (rapamycin-insensitive companion of mTOR), in a patient with non-small cell lung cancer.

Haiying Cheng, Bilal Piperdi, Edward L. Schwartz, Changcheng Zhu, Zhenfeng Zhang, Balazs Halmos, Vincent Miller, Roman Perez-Soler
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2033.
https://doi.org/10.1158/1538-7445.AM2013-2033
Published: 15 April 2013
View article titled, Abstract 2033: Identification of a novel genetic abnormality, the amplification of rictor (rapamycin-insensitive companion of mTOR), in a patient with non-small cell lung cancer.
Journal Articles

Abstract 850: Activation of autophagy by erlotinib protects NSCLC cells with wild-type EGFR from erlotinib cytotoxicity

Edward L. Schwartz, Yi-He Ling, Yiyu Zou, Bilal Piperdi, Roman Perez-Soler
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 850.
https://doi.org/10.1158/1538-7445.AM2012-850
Published: 15 April 2012
View article titled, Abstract 850: Activation of autophagy by erlotinib protects NSCLC cells with wild-type EGFR from erlotinib cytotoxicity
Journal Articles

Taxotere-Induced Inhibition of Human Endothelial Cell Migration Is a Result of Heat Shock Protein 90 Degradation

Janice Murtagh, Haiyan Lu, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2006) 66 (16): 8192–8199.
https://doi.org/10.1158/0008-5472.CAN-06-0748
Published: 15 August 2006
View article titled, Taxotere-Induced Inhibition of Human Endothelial Cell Migration Is a Result of Heat Shock Protein 90 Degradation
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Journal Articles

The microtubule binding drug laulimalide has synergistic inhibitory effects on human endothelial cell migration when combined with taxotere

Haiyan Lu, Janice Murtagh, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 702.
Published: 01 May 2005
View article titled, The microtubule binding drug laulimalide has synergistic inhibitory effects on human endothelial cell migration when combined with taxotere
Journal Articles

Taxotere inhibition of VEGF- and bFGF-induced endothelial cell migration is a result of Hsp90 degradation

Janice Murtagh, Haiyan Lu, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 713–714.
Published: 01 May 2005
View article titled, Taxotere inhibition of VEGF- and bFGF-induced endothelial cell migration is a result of Hsp90 degradation
Journal Articles

Laulimalide and taxotere inhibit human endothelial cell migration by different patterns of inhibition of phosphorylation of focal adhesion kinase (FAK) and paxillin

Haiyan Lu, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 597.
Published: 01 April 2004
View article titled, Laulimalide and taxotere inhibit human endothelial cell migration by different patterns of inhibition of phosphorylation of focal adhesion kinase (FAK) and paxillin
Journal Articles

Gene Expression Profiling-Based Prediction of Response of Colon Carcinoma Cells to 5-Fluorouracil and Camptothecin

John M. Mariadason, Diego Arango, Qiuhu Shi, Andrew J. Wilson, Georgia A. Corner, Courtney Nicholas, Maria J. Aranes, Martin Lesser, Edward L. Schwartz, Leonard H. Augenlicht
Journal: Cancer Research
Cancer Res (2003) 63 (24): 8791–8812.
Published: 24 December 2003
View article titled, Gene Expression Profiling-Based Prediction of Response of Colon Carcinoma Cells to 5-Fluorouracil and Camptothecin
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Journal Articles

Mechanisms by Which Tumor Cells and Monocytes Expressing the Angiogenic Factor Thymidine Phosphorylase Mediate Human Endothelial Cell Migration

Kylie A. Hotchkiss, Anthony W. Ashton, Robert S. Klein, Michelle L. Lenzi, Geng Hui Zhu, Edward L. Schwartz
Journal: Cancer Research
Cancer Res (2003) 63 (2): 527–533.
Published: 15 January 2003
View article titled, Mechanisms by Which Tumor Cells and Monocytes Expressing the Angiogenic Factor Thymidine Phosphorylase Mediate Human Endothelial Cell Migration
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Journal Articles

Regulation of Expression of Thymidine Phosphorylase/Platelet-derived Endothelial Cell Growth Factor in Human Colon Carcinoma Cells

Edward L. Schwartz, Emily Wan, Fu-Shen Wang, Nicole Baptiste
Journal: Cancer Research
Cancer Res (1998) 58 (7): 1551–1557.
Published: 01 April 1998
View article titled, Regulation of Expression of Thymidine Phosphorylase/Platelet-derived Endothelial Cell Growth Factor in Human Colon Carcinoma Cells
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Journal Articles

5-Ethoxy-2′-deoxyuridine, a Novel Substrate for Thymidine Phosphorylase, Potentiates the Antitumor Activity of 5-Fluorouracil When Used in Combination with Interferon, an Inducer of Thymidine Phosphorylase Expression

Edward L. Schwartz, Nicole Baptiste, Sreenivasalu Megati, Scott Wadler, Brian A. Otter
Journal: Cancer Research
Cancer Res (1995) 55 (16): 3543–3550.
Published: 01 August 1995
View article titled, 5-Ethoxy-2′-deoxyuridine, a Novel Substrate for Thymidine Phosphorylase, Potentiates the Antitumor Activity of 5-Fluorouracil When Used in Combination with Interferon, an Inducer of Thymidine Phosphorylase Expression
Open the PDF for 5-Ethoxy-2′-deoxyuridine, a Novel Substrate for Thymidine Phosphorylase, Potentiates the Antitumor Activity of 5-Fluorouracil When Used in Combination with Interferon, an Inducer of Thymidine Phosphorylase Expression in another window
Journal Articles

Potentiation of the Antitumor Activity of 5-Fluorouracil in Colon Carcinoma Cells by the Combination of Interferon and Deoxyribonucleosides Results from Complementary Effects on Thymidine Phosphorylase

Edward L. Schwartz, Nicole Baptiste, Carolyn J. O'Connor, Scott Wadler, Brian A. Otter
Journal: Cancer Research
Cancer Res (1994) 54 (6): 1472–1478.
Published: 01 March 1994
View article titled, Potentiation of the Antitumor Activity of 5-Fluorouracil in Colon Carcinoma Cells by the Combination of Interferon and Deoxyribonucleosides Results from Complementary Effects on Thymidine Phosphorylase
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Journal Articles

Phase I Trial of Cyclophosphamide, Doxorubicin, and 5-Fluorouracil plus Interferon-α2b in Patients with Advanced Breast Cancer

Joseph A. Sparano, Scott Wadler, Leonard Liebes, Nicholas J. Robert, Edward L. Schwartz, Janice P. Dutcher
Journal: Cancer Research
Cancer Res (1993) 53 (15): 3509–3512.
Published: 01 August 1993
View article titled, Phase I Trial of Cyclophosphamide, Doxorubicin, and 5-Fluorouracil plus Interferon-α2b in Patients with Advanced Breast Cancer
Open the PDF for Phase I Trial of Cyclophosphamide, Doxorubicin, and 5-Fluorouracil plus Interferon-α2b in Patients with Advanced Breast Cancer in another window