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Dragomir B. Krastev
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Journal Articles

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

Marta J. Llorca-Cardenosa, Lauren I. Aronson, Dragomir B. Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T. Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros Roumeliotis, Jyoti Choudhary, Stephen J. Pettitt, Johann de Bono, Andres Cervantes, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Irene Y. Chong
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3962–3973.
https://doi.org/10.1158/0008-5472.CAN-21-4339
Published: 02 November 2022
View article titled, SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Open the PDF for SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract 804: Trapped PARP1 cytotoxicity is modulated by the ubiquitin-dependentsegregase p97

Dragomir B. Krastev, Chris Lord
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 804.
https://doi.org/10.1158/1538-7445.AM2022-804
Published: 15 June 2022
View article titled, Abstract 804: Trapped PARP1 cytotoxicity is modulated by the ubiquitin-dependentsegregase p97
Journal Articles

PARP Inhibitors – Trapped in a Toxic Love Affair

Dragomir B. Krastev, Andrew J. Wicks, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5605–5607.
https://doi.org/10.1158/0008-5472.CAN-21-3201
Published: 15 November 2021
View article titled, PARP Inhibitors – Trapped in a Toxic Love Affair
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Journal Articles

Abstract 410: Genome-wide and focused CRISPR screens to study PARP inhibitor resistance mediated by mutations in PARP1

Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Maria I. Harrell, Rachel Brough, Jessica Frankum, Jung-Min Lee, Elizabeth M. Swisher, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 410.
https://doi.org/10.1158/1538-7445.AM2018-410
Published: 01 July 2018
View article titled, Abstract 410: Genome-wide and focused CRISPR screens to study PARP inhibitor resistance mediated by mutations in <em>PARP1</em>
Journal Articles

Abstract 1360: A PARylation biosensor genetic screen to identify novel PARylation targets

Dragomir B. Krastev, Stephen J. Pettitt, James Campbell, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1360.
https://doi.org/10.1158/1538-7445.AM2018-1360
Published: 01 July 2018
View article titled, Abstract 1360: A PARylation biosensor genetic screen to identify novel PARylation targets
Journal Articles

ATR Is a Therapeutic Target in Synovial Sarcoma

Samuel E. Jones, Emmy D.G. Fleuren, Jessica Frankum, Asha Konde, Chris T. Williamson, Dragomir B. Krastev, Helen N. Pemberton, James Campbell, Aditi Gulati, Richard Elliott, Malini Menon, Joanna L. Selfe, Rachel Brough, Stephen J. Pettitt, Wojciech Niedzwiedz, Winette T.A. van der Graaf, Janet Shipley, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (24): 7014–7026.
https://doi.org/10.1158/0008-5472.CAN-17-2056
Published: 14 December 2017
View article titled, ATR Is a Therapeutic Target in Synovial Sarcoma
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Includes: Supplementary data
Journal Articles

Abstract 2743: Finding determinants of PARP inhibitor sensitivity using genome-wide and focused CRISPR screens

Stephen Pettitt, Dragomir B. Krastev, Feifei Song, Alan Ashworth, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2743.
https://doi.org/10.1158/1538-7445.AM2016-2743
Published: 15 July 2016
View article titled, Abstract 2743: Finding determinants of PARP inhibitor sensitivity using genome-wide and focused CRISPR screens