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Douglas E. Linn
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Journal Articles

Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma

Handan Xiang, Yidan Pan, Marc A. Sze, Marta Wlodarska, Ling Li, Karyn Ann van de Mark, Haleema Qamar, Casey J. Moure, Douglas E. Linn, Josephine Hai, Ying Huo, James Clarke, Tze Guan Tan, Samantha Ho, Karen W. Teng, Muhammad N. Ramli, Michael Nebozhyn, Chunsheng Zhang, Julianne Barlow, Corinne E. Gustafson, Savanna Gornisiewicz, Thomas P. Albertson, Stephanie L. Korle, Raphael Bueno, Lily Y. Moy, Elisabeth H. Vollmann, Derek Y. Chiang, Philip E. Brandish, Andrey Loboda
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1410–1425.
https://doi.org/10.1158/0008-5472.CAN-23-1183
Published: 02 May 2024
View article titled, Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma
Open the PDF for Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1657: Evaluating anti-tumor activity of the human anti-PD-1 antibody pembrolizumab using humanized mouse models

Douglas E. Linn, Razvan Cristescu, Kallol Ray, Shuli Zhang, Sripriya Dhandapani, Sarav Kaliyaperumal, Jennifer H. Yearley, Brian J. Long
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1657.
https://doi.org/10.1158/1538-7445.AM2017-1657
Published: 01 July 2017
View article titled, Abstract 1657: Evaluating anti-tumor activity of the human anti-PD-1 antibody pembrolizumab using humanized mouse models
Journal Articles

Abstract LB-275: Single cell analysis identified LY6D as a novel marker of castration-resistant multipotent luminal progenitors

Douglas E. Linn, João Barros-Silva, Guoji Guo, Michael Brown, Garry Ashton, Noel W. Clarke, Guo-Cheng Yuan, Stuart H. Orkin, Esther Baena, Zhe Li
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-275.
https://doi.org/10.1158/1538-7445.AM2016-LB-275
Published: 15 July 2016
View article titled, Abstract LB-275: Single cell analysis identified LY6D as a novel marker of castration-resistant multipotent luminal progenitors
Journal Articles

Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression

Douglas E. Linn, Kathryn L. Penney, Roderick T. Bronson, Lorelei A. Mucci, Zhe Li
Journal: Cancer Research
Cancer Res (2016) 76 (7): 1869–1881.
https://doi.org/10.1158/0008-5472.CAN-15-1911
Published: 31 March 2016
View article titled, Deletion of Interstitial Genes between <em>TMPRSS2</em> and <em>ERG</em> Promotes Prostate Cancer Progression
Open the PDF for Deletion of Interstitial Genes between <em>TMPRSS2</em> and <em>ERG</em> Promotes Prostate Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells

Bojie Dai, Hege Chen, Shengjie Guo, Xi Yang, Douglas E. Linn, Feng Sun, Wei Li, Zhiyong Guo, Kexin Xu, Oekyung Kim, Xiangtian Kong, Jonathan Melamed, Shaopeng Qiu, Hegang Chen, Yun Qiu
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5587–5596.
https://doi.org/10.1158/0008-5472.CAN-09-4610
Published: 30 June 2010
View article titled, Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells
Open the PDF for Compensatory Upregulation of Tyrosine Kinase Etk/BMX in Response to Androgen Deprivation Promotes Castration-Resistant Growth of Prostate Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 4228: A functional role of OCT4 for prostate tumor initiation

Douglas E. Linn, Xi Yang, Feng Sun, Yingqiu Xie, Saranya Chumsri, Angelika Burger, Yun Qiu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4228.
https://doi.org/10.1158/1538-7445.AM10-4228
Published: 15 April 2010
View article titled, Abstract 4228: A functional role of OCT4 for prostate tumor initiation
Journal Articles

Abstract 1712: Androgen receptor splicing variants promote therapeutic resistance in prostate cancer

Zhiyong Guo, Xi Yang, Feng Sun, Douglas E. Linn, Richeng Jiang, Hege Chen, Hegang Chen, Xiangtian Kong, Jonathan Melamed, Clifford G. Tepper, Hsing-Jien Kung, Angela M. H. Brodie, Joanne Edwards, Yun Qiu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1712.
https://doi.org/10.1158/1538-7445.AM10-1712
Published: 15 April 2010
View article titled, Abstract 1712: Androgen receptor splicing variants promote therapeutic resistance in prostate cancer
Journal Articles

Abstract #2394: A novel androgen receptor splice variant promotes androgen-depletion_independent growth by regulating a unique set of target genes in human prostate cancer cells

Zhiyong Guo, Xi Yang, Feng Sun, Richeng Jiang, Douglas E. Linn, Hege Chen, Hegang Chen, Xiangtian Kong, Jonathan Melamed, Clifford G. Tepper, Hsing-Jien Kung, Angela M. H. Brodie, Joanne Edwards, Yun Qiu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2394.
Published: 01 May 2009
View article titled, Abstract #2394: A novel androgen receptor splice variant promotes androgen-depletion<sup>_</sup>independent growth by regulating a unique set of target genes in human prostate cancer cells
Journal Articles

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion–Resistant Growth

Zhiyong Guo, Xi Yang, Feng Sun, Richeng Jiang, Douglas E. Linn, Hege Chen, Hegang Chen, Xiangtian Kong, Jonathan Melamed, Clifford G. Tepper, Hsing-Jien Kung, Angela M.H. Brodie, Joanne Edwards, Yun Qiu
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2305–2313.
https://doi.org/10.1158/0008-5472.CAN-08-3795
Published: 17 March 2009
View article titled, A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion–Resistant Growth
Open the PDF for A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion–Resistant Growth in another window
Includes: Supplementary data