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Douglas A. Lauffenburger
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Journal Articles

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance

Simona Dalin, Mark R. Sullivan, Allison N. Lau, Beatrice Grauman-Boss, Helen S. Mueller, Emanuel Kreidl, Silvia Fenoglio, Alba Luengo, Jacqueline A. Lees, Matthew G. Vander Heiden, Douglas A. Lauffenburger, Michael T. Hemann
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5723–5733.
https://doi.org/10.1158/0008-5472.CAN-19-0960
Published: 15 November 2019
View article titled, Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance
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Includes: Supplementary data
Journal Articles

Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes

Nazanin Rohani, Liangliang Hao, Maria S. Alexis, Brian A. Joughin, Konstantin Krismer, Mira N. Moufarrej, Anthony R. Soltis, Douglas A. Lauffenburger, Michael B. Yaffe, Christopher B. Burge, Sangeeta N. Bhatia, Frank B. Gertler
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (8): 1952–1966.
https://doi.org/10.1158/0008-5472.CAN-18-1604
Published: 15 April 2019
View article titled, Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes
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Includes: Supplementary data
Journal Articles

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

Ran Li, Jess D. Hebert, Tara A. Lee, Hao Xing, Alexandra Boussommier-Calleja, Richard O. Hynes, Douglas A. Lauffenburger, Roger D. Kamm
Journal: Cancer Research
Cancer Res (2017) 77 (2): 279–290.
https://doi.org/10.1158/0008-5472.CAN-16-0442
Published: 16 January 2017
View article titled, Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
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Includes: Supplementary data
Journal Articles

Abstract A01: Mechanical properties of matrices strongly influence spontaneous tumor dormancy and responses to chemotherapy in a 3D model of metastasis

Amanda M. Clark, Sarah E. Wheeler, Carissa L. Young, Jaclyn Shepard Neiman, Venkateswaran Pillai, Linda Stockdale, Donna Stolz, Douglas A. Lauffenburger, Raman Venkataramanan, Linda G. Griffith, Alan Wells
Journal: Cancer Research
Cancer Res (2017) 77 (2_Supplement): A01.
https://doi.org/10.1158/1538-7445.EPSO16-A01
Published: 16 January 2017
View article titled, Abstract A01: Mechanical properties of matrices strongly influence spontaneous tumor dormancy and responses to chemotherapy in a 3D model of metastasis
Journal Articles

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme

Zachary D. Nagel, Gaspar J. Kitange, Shiv K. Gupta, Brian A. Joughin, Isaac A. Chaim, Patrizia Mazzucato, Douglas A. Lauffenburger, Jann N. Sarkaria, Leona D. Samson
Journal: Cancer Research
Cancer Res (2017) 77 (1): 198–206.
https://doi.org/10.1158/0008-5472.CAN-16-1151
Published: 02 January 2017
View article titled, DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme
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Includes: Supplementary data
Journal Articles

Abstract A41: Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis

Amanda M. Clark, Sarah E. Wheeler, Carissa L. Young, Venkateswaran C. Pillai, Donna B. Stolz, Douglas A. Lauffenburger, Raman Venkataramanan, Linda G. Griffith, Alan Wells
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): A41.
https://doi.org/10.1158/1538-7445.TUMMET15-A41
Published: 26 May 2016
View article titled, Abstract A41: Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis
Journal Articles

Abstract PR11: Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis

Amanda M. Clark, Sarah E. Wheeler, Carissa L. Young, Venkateswaran C. Pillai, Donna B. Stolz, Douglas A. Lauffenburger, Raman Venkataramanan, Linda G. Griffith, Alan Wells
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): PR11.
https://doi.org/10.1158/1538-7445.TUMMET15-PR11
Published: 26 May 2016
View article titled, Abstract PR11: Elucidating candidate biomarkers of breast cancer progression and dormancy using a 3D model of metastasis
Journal Articles

Abstract B1-33: Network analyses identify hidden regulators of TGFa shedding

Jennifer L. Wilson, Ernest Fraenkel, Douglas A. Lauffenburger, Andreas Herrlich
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): B1-33.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-B1-33
Published: 15 November 2015
View article titled, Abstract B1-33: Network analyses identify hidden regulators of TGFa shedding
Journal Articles

Abstract P1-07-01: Modeling breast cancer dormancy and re-emergence

Amanda M Clark, Sarah E Wheeler, Donald P Taylor, Carissa L Young, Venkateswaran C Pillai, Donna B Stolz, Raman Venkataramanan, Douglas A Lauffenburger, Linda G Griffith, Alan Wells
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P1-07-01.
https://doi.org/10.1158/1538-7445.SABCS14-P1-07-01
Published: 01 May 2015
View article titled, Abstract P1-07-01: Modeling breast cancer dormancy and re-emergence
Journal Articles

Abstract B73: To sleep or die: Cell fate after chemotherapy

Gerard J. Ostheimer, Douglas A. Lauffenburger, Michael B. Yaffe
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): B73.
https://doi.org/10.1158/0008-5472.FBCR09-B73
Published: 28 October 2014
View article titled, Abstract B73: To sleep or die: Cell fate after chemotherapy
Journal Articles

Abstract 1988: MenaINV interaction with α5β1 promotes tumor cell invasion in response to gradients of growth factors and fibronectin

Madeleine J. Oudin, Liliane C. Broye, Alisha Lussiez, Sreeja B. Asokan, Miles A. Miller, Douglas A. Lauffenburger, James E. Bear, Frank B. Gertler
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1988.
https://doi.org/10.1158/1538-7445.AM2014-1988
Published: 01 October 2014
View article titled, Abstract 1988: MenaINV interaction with α5β1 promotes tumor cell invasion in response to gradients of growth factors and fibronectin
Journal Articles

Abstract SY22-02: Mammalian functional genetic signatures identify efficacy landscapes of combination chemotherapy

Douglas A. Lauffenburger, Justin R. Pritchard, Michael T. Hemann
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): SY22-02.
https://doi.org/10.1158/1538-7445.AM2012-SY22-02
Published: 15 April 2012
View article titled, Abstract SY22-02: Mammalian functional genetic signatures identify efficacy landscapes of combination chemotherapy
Journal Articles

Bcl-2 Family Genetic Profiling Reveals Microenvironment-Specific Determinants of Chemotherapeutic Response

Justin R. Pritchard, Luke A. Gilbert, Corbin E. Meacham, Jennifer L. Ricks, Hai Jiang, Douglas A. Lauffenburger, Michael T. Hemann
Journal: Cancer Research
Cancer Res (2011) 71 (17): 5850–5858.
https://doi.org/10.1158/0008-5472.CAN-11-1014
Published: 30 August 2011
View article titled, Bcl-2 Family Genetic Profiling Reveals Microenvironment-Specific Determinants of Chemotherapeutic Response
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Includes: Supplementary data
Journal Articles

Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models

Julio Saez-Rodriguez, Leonidas G. Alexopoulos, MingSheng Zhang, Melody K. Morris, Douglas A. Lauffenburger, Peter K. Sorger
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5400–5411.
https://doi.org/10.1158/0008-5472.CAN-10-4453
Published: 11 August 2011
View article titled, Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models
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Includes: Supplementary data
Journal Articles

Impaired SHP2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Growth Factor Receptor–Activating Mutations

Matthew J. Lazzara, Keara Lane, Richard Chan, Paul J. Jasper, Michael B. Yaffe, Peter K. Sorger, Tyler Jacks, Benjamin G. Neel, Douglas A. Lauffenburger
Journal: Cancer Research
Cancer Res (2010) 70 (9): 3843–3850.
https://doi.org/10.1158/0008-5472.CAN-09-3421
Published: 28 April 2010
View article titled, Impaired SHP2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Growth Factor Receptor–Activating Mutations
Open the PDF for Impaired SHP2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Growth Factor Receptor–Activating Mutations in another window
Includes: Supplementary data
Journal Articles

RAS Mutations Affect Tumor Necrosis Factor–Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects

Pamela K. Kreeger, Roli Mandhana, Shannon K. Alford, Kevin M. Haigis, Douglas A. Lauffenburger
Journal: Cancer Research
Cancer Res (2009) 69 (20): 8191–8199.
https://doi.org/10.1158/0008-5472.CAN-09-1921
Published: 14 October 2009
View article titled, RAS Mutations Affect Tumor Necrosis Factor–Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects
Open the PDF for RAS Mutations Affect Tumor Necrosis Factor–Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects in another window
Includes: Supplementary data
Journal Articles

Understanding tumor cell migration in 3D matrices through confocal microscopy and computer simulations

Muhammad H. Zaman, Alan Wells, Paul T. Matsudaira, Douglas A. Lauffenburger
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 815.
Published: 15 April 2006
View article titled, Understanding tumor cell migration in 3D matrices through confocal microscopy and computer simulations
Journal Articles

Calpain-2 as a Target for Limiting Prostate Cancer Invasion

Asmaa Mamoune, Jian-Hua Luo, Douglas A. Lauffenburger, Alan Wells
Journal: Cancer Research
Cancer Res (2003) 63 (15): 4632–4640.
Published: 07 August 2003
View article titled, Calpain-2 as a Target for Limiting Prostate Cancer Invasion
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