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Journal Articles

Correction: Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells

Dongpo Cai, Vaughan M. Latham, Jr, Xinxin Zhang, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2020) 80 (2): 361.
https://doi.org/10.1158/0008-5472.CAN-19-3524
Published: 15 January 2020
View article titled, Correction: Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells
Open the PDF for Correction: Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells in another window
Journal Articles

Abstract CT047: Phase 1 dose-escalation study of the CDK inhibitor dinaciclib in combination with the PARP inhibitor veliparib in patients with advanced solid tumors

Geoffrey I. Shapiro, Khanh T. Do, Sara M. Tolaney, John F. Hilton, James M. Cleary, Andrew Wolanski, Brian Beardslee, Faith Hassinger, Ketki Bhushan, Dongpo Cai, Elizabeth Downey, Solida Pruitt-Thompson, Suzanne M. Barry, Bose Kochupurakkal, Joseph Geradts, Christine Unitt, Alan D. D'Andrea, Alona Muzikansky, Richard Piekarz, L. Austin Doyle, Jeffrey Supko
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT047.
https://doi.org/10.1158/1538-7445.AM2017-CT047
Published: 01 July 2017
View article titled, Abstract CT047: Phase 1 dose-escalation study of the CDK inhibitor dinaciclib in combination with the PARP inhibitor veliparib in patients with advanced solid tumors
Journal Articles

Abstract CT325: Combination of the PARP inhibitor veliparib (ABT888) with irinotecan in patients with triple negative breast cancer: Preliminary activity and signature of response

Patricia M. LoRusso, Sara M. Tolaney, Shukmei Wong, Ralph E. Parchment, Robert J. Kinders, Lihua Wang, Jessica Aldrich, Alice Chen, Diane Durecki, Scott A. Boerner, Tina Guthrie, Adam Bowditch, Lance K. Heilbrun, Mary Jo Pilat, David Craig, Dongpo Cai, Tracy Bell, John Carpten, Geoffrey Shapiro
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT325.
https://doi.org/10.1158/1538-7445.AM2015-CT325
Published: 01 August 2015
View article titled, Abstract CT325: Combination of the PARP inhibitor veliparib (ABT888) with irinotecan in patients with triple negative breast cancer: Preliminary activity and signature of response
Journal Articles

Abstract #3316: Cdk1 depletion disrupts BRCA1 function and selectively sensitizes cancer cells to DNA damaging agents

Neil Johnson, Dongpo Cai, Richard Kennedy, Shailja Pathania, Jeffrey Parvin, Alan D'Andrea, Geoffrey Shapiro
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3316.
Published: 01 May 2009
View article titled, Abstract #3316: Cdk1 depletion disrupts BRCA1 function and selectively sensitizes cancer cells to DNA damaging agents
Journal Articles

Proapoptotic BH3-Only BCL-2 Family Protein BIM Connects Death Signaling from Epidermal Growth Factor Receptor Inhibition to the Mitochondrion

Jing Deng, Takeshi Shimamura, Samanthi Perera, Nicole E. Carlson, Dongpo Cai, Geoffrey I. Shapiro, Kwok-Kin Wong, Anthony Letai
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11867–11875.
https://doi.org/10.1158/0008-5472.CAN-07-1961
Published: 18 December 2007
View article titled, Proapoptotic BH3-Only BCL-2 Family Protein BIM Connects Death Signaling from Epidermal Growth Factor Receptor Inhibition to the Mitochondrion
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Journal Articles

Concomitant CDK1 and CDK2 depletion induces irreparable DNA damage, G2/M arrest and cell death

neil johnson, Dongpo Cai, Geoffrey Shapiro
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4346.
Published: 01 May 2007
View article titled, Concomitant CDK1 and CDK2 depletion induces irreparable DNA damage, G2/M arrest and cell death
Journal Articles

Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells

Dongpo Cai, Vaughan M. Latham, Jr., Xinxin Zhang, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2006) 66 (18): 9270–9280.
https://doi.org/10.1158/0008-5472.CAN-06-1758
Published: 18 September 2006
View article titled, Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells
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Includes: Supplementary data
Journal Articles

Combined depletion of cdk2, cdk1 and cdk9 activities induces apoptosis in cancer cells

Dongpo Cai, Vaughan M. Latham, Xinxin Zhang, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1151.
Published: 15 April 2006
View article titled, Combined depletion of cdk2, cdk1 and cdk9 activities induces apoptosis in cancer cells
Journal Articles

AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9

Dongpo Cai, Kate F. Byth, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2006) 66 (1): 435–444.
https://doi.org/10.1158/0008-5472.CAN-05-1769
Published: 05 January 2006
View article titled, AZ703, an Imidazo[1,2-<em>a</em>]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9
Open the PDF for AZ703, an Imidazo[1,2-<em>a</em>]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9 in another window
Journal Articles

A novel CDK inhibitor induces cell cycle blockade, E2F-1-dependent apoptosis, and cytotoxic synergy with DNA-damaging agents

Dongpo Cai, Kate Byth, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 190.
Published: 01 April 2004
View article titled, A novel CDK inhibitor induces cell cycle blockade, E2F-1-dependent apoptosis, and cytotoxic synergy with DNA-damaging agents
Journal Articles

Flavopiridol-Induced Apoptosis during S Phase Requires E2F-1 and Inhibition of Cyclin A-Dependent Kinase Activity

Jingrui Jiang, Christian B. Matranga, Dongpo Cai, Vaughan M. Latham, Jr., Xinxin Zhang, April M. Lowell, Fabio Martelli, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2003) 63 (21): 7410–7422.
Published: 11 November 2003
View article titled, Flavopiridol-Induced Apoptosis during S Phase Requires E2F-1 and Inhibition of Cyclin A-Dependent Kinase Activity
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Journal Articles

AND-34/BCAR3, a GDP Exchange Factor Whose Overexpression Confers Antiestrogen Resistance, Activates Rac, PAK1, and the Cyclin D1 Promoter

Dongpo Cai, Anita Iyer, Kyriacos N. Felekkis, Richard I. Near, Zhijun Luo, Jonathan Chernoff, Chris Albanese, Richard G. Pestell, Adam Lerner
Journal: Cancer Research
Cancer Res (2003) 63 (20): 6802–6808.
Published: 28 October 2003
View article titled, AND-34/BCAR3, a GDP Exchange Factor Whose Overexpression Confers Antiestrogen Resistance, Activates Rac, PAK1, and the Cyclin D1 Promoter
Open the PDF for AND-34/BCAR3, a GDP Exchange Factor Whose Overexpression Confers Antiestrogen Resistance, Activates Rac, PAK1, and the Cyclin D1 Promoter in another window