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Journal Articles

Abstract CT010: Phase I dose-escalation and expansion study of JS107, a claudin 18.2 (CLDN18.2)-targeting antibody-drug conjugate (ADC), as monotherapy or in combination for patients (pts) with advanced solid tumors

Free
Rui-Hua Xu, Dan-Yun Ruan, Rong-Bo Lin, Jian-Zhen Shan, Peng Nie, Ying-Hua Ji, Jing Wang, Yu Cao, Fu-Nan Liu, Jie-Er Ying, Li Liu, Tao Zhang, Hui-Ting Xu, Yan-Qiao Zhang, Wen-Can Song, Jin Xia, Wen-Feng Li, Zhi-Ye Zhang, Jian Shi, Ming-Xia Wang, Long Wu, Yan-Yan Lu, Xiao Zhang, Yan-Yan Hu, Yong-Dong Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT010.
https://doi.org/10.1158/1538-7445.AM2025-CT010
Published: 25 April 2025
View articletitled, Abstract CT010: Phase I dose-escalation and expansion study of JS107, a claudin 18.2 (CLDN18.2)-targeting antibody-drug conjugate (ADC), as monotherapy or in combination for patients (pts) with advanced solid tumors
Journal Articles

Abstract 2799: SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses

Free
Liang Xu, Xiao hong Zhao, Yuan yuan Zhang, Lei Jin, Xu Dong Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2799.
https://doi.org/10.1158/1538-7445.AM2025-2799
Published: 21 April 2025
View articletitled, Abstract 2799: SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses
Journal Articles

MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer

Open Access
Si Min Zheng, Yu Chen Feng, Qin Zhu, Ruo Qi Li, Qian Qian Yan, Liu Teng, Yi Meng Yue, Man Man Han, Kaihong Ye, Sheng Nan Zhang, Teng Fei Qi, Cai Xia Tang, Xiao Hong Zhao, Yuan Yuan Zhang, Liang Xu, Ran Xu, Jun Xing, Mark Baker, Tao Liu, Rick F. Thorne, Lei Jin, Thomas Preiss, Xu Dong Zhang, Shundong Cang, Jin Nan Gao
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1460–1474.
https://doi.org/10.1158/0008-5472.CAN-23-3046
Published: 02 May 2024
View articletitled, MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Open the PDF for MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1363: Blocking inhibitory receptor ILT3 by an antibody with enhanced Fc function promoted adaptive immunity against hematopoietic malignancy independent of ADCC

Free
Shiming Ye, Dong Zhang, Min-Zu Wu, Harini Raghu, Diane Cohen, Mally Romero, Siu-Sze Tan, Donghee Choi, Jonathan Hickson, John Engelhardt, Alex Shoemaker
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1363.
https://doi.org/10.1158/1538-7445.AM2024-1363
Published: 22 March 2024
View articletitled, Abstract 1363: Blocking inhibitory receptor ILT3 by an antibody with enhanced Fc function promoted adaptive immunity against hematopoietic malignancy independent of ADCC
Journal Articles

Abstract 7052: p53 underpins a dependence on oxidative phosphorylation in glycolysis-competent colorectal cancer

Free
Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kai Hong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Tao Liu, Mark Baker, Rick F. Thorne, Xu Dong Zhang, Song Chen, Lei Jin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7052.
https://doi.org/10.1158/1538-7445.AM2024-7052
Published: 22 March 2024
View articletitled, Abstract 7052: p53 underpins a dependence on oxidative phosphorylation in glycolysis-competent colorectal cancer
Journal Articles

Abstract 5697: MILIP drives triple-negative breast cancer through complexing with transfer RNAs to promote protein production

Free
Yuchen Feng, Simin Zheng, Xiaohong Zhao, Yuanyuan Zhang, Ran Xu, Liang Xu, Thomas Preiss, Lei Jin, Jinnan Gao, Xu Dong Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5697.
https://doi.org/10.1158/1538-7445.AM2024-5697
Published: 22 March 2024
View articletitled, Abstract 5697: MILIP drives triple-negative breast cancer through complexing with transfer RNAs to promote protein production
Journal Articles

Abstract 741: Distinct functional effects of ILT family members in mediating the activity of an ILT2/ILT4/ILT5 cross-reactive monoclonal antibody in releasing the suppression on innate and adaptive anti-tumor immunity

Free
Shiming Ye, Dong Zhang, Brenal Singh, Jaishree Bankoti, Diane Cohen, Siusze Tan, Donghee Choi, Jonathan Hickson, Min-Zu Wu, Urvi Kolhatkar, Mikhail Binnewies, Wei Jin, Jason Hall, John Engelhardt, Alexander Shoemaker
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 741.
https://doi.org/10.1158/1538-7445.AM2024-741
Published: 22 March 2024
View articletitled, Abstract 741: Distinct functional effects of ILT family members in mediating the activity of an ILT2/ILT4/ILT5 cross-reactive monoclonal antibody in releasing the suppression on innate and adaptive anti-tumor immunity
Journal Articles

Abstract 3798: lncRNA LIMp27 promotes p53-defective cancer pathogenesis

Free
Ting La, Song Chen, Xiao Hong Zhao, Yuan Yuan Zhang, Yu Chen Feng, Xu Dong Zhang, Lei Jin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3798.
https://doi.org/10.1158/1538-7445.AM2023-3798
Published: 04 April 2023
View articletitled, Abstract 3798: lncRNA LIMp27 promotes p53-defective cancer pathogenesis
Journal Articles

Abstract 2153: Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1

Free
Jianhui Ma, Wen Liu, Heekyung Chung, Hooman Izadi, Petrus DeJong, Olivier Harismendy, Jia li, Fernando Doñate, Ahmed Samatar, Mark Lackner, Laure Escoubet, Kevin Bunker, Daehwan Kim, Nathan Jameson, Tugba Yildiran Ozmen, Kangjin Jeong, Dong Zhang, Wen-An Pan, Gordon Mills
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2153.
https://doi.org/10.1158/1538-7445.AM2023-2153
Published: 04 April 2023
View articletitled, Abstract 2153: Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1
Journal Articles

Abstract 3687: Disruption of nucleotide homeostasis confers cancer cell susceptibility to oxidative phosphorylation inhibition independently of energy depletion

Free
Xiaohong Zhao, Yuan Yuan Zhang, Liang Xu, Ting La, Yu Chen Feng, Hai Jie Tang, Ran Xu, Vinod K. Narayana, David P. De Souza, Lake-Ee Quek, Jeff Holst, Rick F. Thorne, Mark Baker, Tao Liu, Lei Jin, Xu Dong Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3687.
https://doi.org/10.1158/1538-7445.AM2023-3687
Published: 04 April 2023
View articletitled, Abstract 3687: Disruption of nucleotide homeostasis confers cancer cell susceptibility to oxidative phosphorylation inhibition independently of energy depletion
Journal Articles

Abstract 5627: Spatial protein profiling by cyclic immunofluorescence to interpret and improve bulk tumor-based predictor of response to chemotherapy with bevacizumab in neoadjuvant breast cancer treatment

Free
Mads Haugland Haugen, David Kilburn, Hongli Ma, Cameron Watson, Allison Creason, Dong Zhang, Maria Aa Dahle, Ole Christian Lingjaerde, Marianne L. Smebye, Oeystein Garred, Mette S. Foersund, Mai T. Nguyen, Gunhild M. Maelandsmo, Gordon Mills, Olav Engebraaten
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5627.
https://doi.org/10.1158/1538-7445.AM2023-5627
Published: 04 April 2023
View articletitled, Abstract 5627: Spatial protein profiling by cyclic immunofluorescence to interpret and improve bulk tumor-based predictor of response to chemotherapy with bevacizumab in neoadjuvant breast cancer treatment
Journal Articles

Abstract 3433: Novel dual antagonist anti-LILRB1/LILRB2 antibodies reprogram myeloid cells and potentiate T cells

Free
Guangan Hu, Quanju Zhao, Lai Shi, Nan Bing, Dong Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3433.
https://doi.org/10.1158/1538-7445.AM2022-3433
Published: 15 June 2022
View articletitled, Abstract 3433: Novel dual antagonist anti-LILRB1/LILRB2 antibodies reprogram myeloid cells and potentiate T cells
Journal Articles

The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance

Available to Purchase
Qing Lan, Pei Y. Liu, Jessica L. Bell, Jenny Y. Wang, Stefan Hüttelmaier, Xu Dong Zhang, Lirong Zhang, Tao Liu
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3431–3440.
https://doi.org/10.1158/0008-5472.CAN-20-4107
Published: 01 July 2021
View articletitled, The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance
Open the PDF for The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance in another window
Journal Articles

Abstract 3052: Targeting AXL in PIK3R2-amplified ovarian cancer

Free
Ling Rao, Victor C. Mak, Yuan Zhou, Dong Zhang, Xinran Li, Yiling Lu, Gordon B. Mills, Lydia W. Cheung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3052.
https://doi.org/10.1158/1538-7445.AM2020-3052
Published: 15 August 2020
View articletitled, Abstract 3052: Targeting AXL in PIK3R2-amplified ovarian cancer
Journal Articles

Abstract 4035: Cannabidiol inhibits the long-term survival of a variety of cancers

Free
Emily Seltzer, Andrea Watters, Dong Zhang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4035.
https://doi.org/10.1158/1538-7445.AM2020-4035
Published: 15 August 2020
View articletitled, Abstract 4035: Cannabidiol inhibits the long-term survival of a variety of cancers
Journal Articles

Editor's Note: PrLZ Protects Prostate Cancer Cells from Apoptosis Induced by Androgen Deprivation via the Activation of Stat3/Bcl-2 Pathway

Free
Dong Zhang, Dalin He, Yan Xue, Ruoxiang Wang, Kaijie Wu, Hongjun Xie, Jin Zeng, Xinyang Wang, Haiyen E. Zhau, Leland W.K. Chung, Luke S. Chang, Lei Li
Journal: Cancer Research
Cancer Res (2019) 79 (23): 6054.
https://doi.org/10.1158/0008-5472.CAN-19-3162
Published: 02 December 2019
View articletitled, Editor's Note: PrLZ Protects Prostate Cancer Cells from Apoptosis Induced by Androgen Deprivation via the Activation of Stat3/Bcl-2 Pathway
Open the PDF for Editor's Note: PrLZ Protects Prostate Cancer Cells from Apoptosis Induced by Androgen Deprivation via the Activation of Stat3/Bcl-2 Pathway in another window
Journal Articles

Abstract 3577: A p53-responsive long noncoding RNA GUARDIN is essential for genome integrity

Free
Lei Jin, Wang Lai Hu, An Xu, Yu Fang Wang, Rick F. Thorne, Xu Dong Zhang, Mian Wu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3577.
https://doi.org/10.1158/1538-7445.AM2019-3577
Published: 01 July 2019
View articletitled, Abstract 3577: A p53-responsive long noncoding RNA GUARDIN is essential for genome integrity
Journal Articles

Abstract 4504: MILIP is a pan cancer-associated long noncoding RNA that links MYC to inactivation of p53

Free
Yuchen Feng, Liu Teng, Simonne K. Sherwin, Xiaoying Liu, Jinming Li, Margaret Farrelly, Yongyan Wu, Wei Gao, Zhuanyun Du, Yanfeng Xi, Jin Liang, Ting La, Yuanyuan Zhang, Hessam Tabatabaee, Xu Guang Yan, Hamed Yari, Tao Liu, Rick F. Thorne, Su Tang Guo, Binquan Wang, Xu Dong Zhang, Lei Jin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4504.
https://doi.org/10.1158/1538-7445.AM2019-4504
Published: 01 July 2019
View articletitled, Abstract 4504: MILIP is a pan cancer-associated long noncoding RNA that links MYC to inactivation of p53
Journal Articles

Abstract 1309: Targeting GluN2C ion channels as a promising approach in the treatment of melanoma

Free
Hessam Tabatabaee, Yuchen Feng, Hamed Yari, Ting La, Simonne Sherwin, Lei Jin, Rebecca Lim, Alan Brichta, Xu Dong Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1309.
https://doi.org/10.1158/1538-7445.AM2019-1309
Published: 01 July 2019
View articletitled, Abstract 1309: Targeting GluN2C ion channels as a promising approach in the treatment of melanoma
Journal Articles

A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence

Free
Ting La, Guang Zhi Liu, Margaret Farrelly, Nicole Cole, Yu Chen Feng, Yuan Yuan Zhang, Simonne K. Sherwin, Hamed Yari, Hessam Tabatabaee, Xu Guang Yan, Su Tang Guo, Tao Liu, Rick F. Thorne, Lei Jin, Xu Dong Zhang
Journal: Cancer Research
Cancer Res (2018) 78 (23): 6666–6679.
https://doi.org/10.1158/0008-5472.CAN-18-1886
Published: 03 December 2018
View articletitled, A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence
Open the PDF for A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence in another window
Includes: Supplementary data