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Donald P. McDonnell
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Journal Articles

Abstract ND02: Discovery of BMS-986365, a ligand-directed androgen receptor degrader (AR LDD) with a dual mechanism-of-action and best-in-class potential, for the treatment of advanced prostate cancer

Shuichan Xu, Surendra Nayak, John D. Norris, Massimo Ammirante, Emyly Rychak, Suzanne E. Wardell, Toshiya Tsuji, Ken Liu, Joseph Meiring, Joseph R. Piccotti, Deepak Dalvie, Debbie Liao, Raju Kandimalla, Nadia Guerrero, Lisa Sapinoso, Jennifer G. Baker, Yeeun Bae, Joshua Baughman, Brandon Toyama, Celia Fontanillo Fontanillo, Stephen Norris, Evan J. Horn, Veronique Plantevin-Krenitsky, Deborah Mortensen, Brian Cathers, Marie Hong Nguyen, Joshua D. Hensen, Lawrence G. Hamann, Donald P. McDonnell, Rama Krishna Narla, Mark Rolfe
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): ND02.
https://doi.org/10.1158/1538-7445.AM2024-ND02
Published: 05 April 2024
View article titled, Abstract ND02: Discovery of BMS-986365, a ligand-directed androgen receptor degrader (AR LDD) with a dual mechanism-of-action and best-in-class potential, for the treatment of advanced prostate cancer
Journal Articles

Abstract B033: Targeting CaMKK2 inhibits actin cytoskeletal assembly to suppress cancer metastasis

Debarati Mukherjee, Rebecca A Previs, Corinne N Haines, Muthana Al Abo, Patrick K Juras, Kyle C Strickland, Binita Chakraborty, Regina Whitaker, Steven R Patierno, Jennifer A Freedman, Ching-Yi Chang, Donald P McDonnell
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): B033.
https://doi.org/10.1158/1538-7445.ADVBC23-B033
Published: 01 February 2024
View article titled, Abstract B033: Targeting CaMKK2 inhibits actin cytoskeletal assembly to suppress cancer metastasis
Journal Articles

Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis

Debarati Mukherjee, Rebecca A. Previs, Corinne Haines, Muthana Al Abo, Patrick K. Juras, Kyle C. Strickland, Binita Chakraborty, Sandeep Artham, Regina S. Whitaker, Katherine Hebert, Jake Fontenot, Steven R. Patierno, Jennifer A. Freedman, Frank H. Lau, Matthew E. Burow, Ching-Yi Chang, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2023) 83 (17): 2889–2907.
https://doi.org/10.1158/0008-5472.CAN-22-1622
Published: 01 September 2023
View article titled, Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product

Maria V. Liberti, Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, Mahya Mehrmohamadi, Marc O. Johnson, Neel S. Madhukar, Alexander Shestov, Iok I. C. Chio, Olivier Elemento, Jeffrey C. Rathmell, Frank C. Schroeder, Donald P. McDonnell, Jason W. Locasale
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5496.
https://doi.org/10.1158/1538-7445.AM2018-5496
Published: 01 July 2018
View article titled, Abstract 5496: A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product
Journal Articles

Abstract 1588: Effects of the selective CYP17-lyase and androgen receptor (AR) inhibitor, seviteronel, and the cyclin-dependent kinase (CDK) 4/6 inhibitor, G1T38, on tumor growth in an AR-V7+ castration-resistant prostate cancer (CRPC) xenograft model

Suzanne E. Wardell, Alexander P. Yllanes, John D. Norris, James P. Stice, Hannah White, Ronald A. Fleming, Jay C. Strum, William R. Moore, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1588.
https://doi.org/10.1158/1538-7445.AM2017-1588
Published: 01 July 2017
View article titled, Abstract 1588: Effects of the selective CYP17-lyase and androgen receptor (AR) inhibitor, seviteronel, and the cyclin-dependent kinase (CDK) 4/6 inhibitor, G1T38, on tumor growth in an AR-V7+ castration-resistant prostate cancer (CRPC) xenograft model
Journal Articles

CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer

Mahmoud A. Alfaqih, Erik R. Nelson, Wen Liu, Rachid Safi, Jeffery S. Jasper, Everardo Macias, Joseph Geradts, J. Will Thompson, Laura G. Dubois, Michael R. Freeman, Ching-yi Chang, Jen-Tsan Chi, Donald P. McDonnell, Stephen J. Freedland
Journal: Cancer Research
Cancer Res (2017) 77 (7): 1662–1673.
https://doi.org/10.1158/0008-5472.CAN-16-2738
Published: 02 April 2017
View article titled, CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract 2820: Effects of a CDK 4/6 inhibitor, G1T38, in androgen receptor sensitive and resistant models of castrate resistant prostate cancer

James P. Stice, Hannah S. White, Suzanne E. Wardell, Alex Y. Yllanes, Scott A. Lawrence, Holly Alley, Donald P. McDonnell, Jay C. Strum
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2820.
https://doi.org/10.1158/1538-7445.AM2016-2820
Published: 15 July 2016
View article titled, Abstract 2820: Effects of a CDK 4/6 inhibitor, G1T38, in androgen receptor sensitive and resistant models of castrate resistant prostate cancer
Journal Articles

Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106

Yazan Alwarawrah, Philip Hughes, Rachid Safi, Donald P. McDonnell, Neil L. Spector, Timothy A. Haystead
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2703.
https://doi.org/10.1158/1538-7445.AM2015-2703
Published: 01 August 2015
View article titled, Abstract 2703: Overcoming Lapatinib resistance by the fatty acid synthase inhibitor HS-106
Journal Articles

Copper Signaling Axis as a Target for Prostate Cancer Therapeutics

Rachid Safi, Erik R. Nelson, Satish K. Chitneni, Katherine J. Franz, Daniel J. George, Michael R. Zalutsky, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2014) 74 (20): 5819–5831.
https://doi.org/10.1158/0008-5472.CAN-13-3527
Published: 14 October 2014
View article titled, Copper Signaling Axis as a Target for Prostate Cancer Therapeutics
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Journal Articles

Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer

Mahmoud A. Alfaqih, Erik R. Nelson, Rachid Safi, Jeff Jasper, Ching-yi Chang, Stephen J. Freedland, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3311.
https://doi.org/10.1158/1538-7445.AM2014-3311
Published: 01 October 2014
View article titled, Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer
Journal Articles

Abstract 4570: Role of ERRalpha in ovarian cancer

Ellen V. Stevens, Regina Whitaker, Audrey Guinet, Ching-Yi Chang, Carole Grenier, Jeffrey Marks, Donald P. McDonnell, Susan K. Murphy, Andrew Berchuck, Stephanie Gaillard
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4570.
https://doi.org/10.1158/1538-7445.AM2014-4570
Published: 01 October 2014
View article titled, Abstract 4570: Role of ERRalpha in ovarian cancer
Journal Articles

Obesity, Cholesterol Metabolism, and Breast Cancer Pathogenesis

Donald P. McDonnell, Sunghee Park, Matthew T. Goulet, Jeff Jasper, Suzanne E. Wardell, Ching-yi Chang, John D. Norris, John R. Guyton, Erik R. Nelson
Journal: Cancer Research
Cancer Res (2014) 74 (18): 4976–4982.
https://doi.org/10.1158/0008-5472.CAN-14-1756
Published: 14 September 2014
View article titled, Obesity, Cholesterol Metabolism, and Breast Cancer Pathogenesis
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Journal Articles

Abstract PR3: The cholesterol metabolite 27-hydroxycholesterol increases breast cancer tumor growth and metastasis

Erik Russell Nelson, Suzanne E. Wardell, Matthew K. Howe, Nicole J. Carver, Michihisa Umetani, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): PR3.
https://doi.org/10.1158/1538-7445.TIM2013-PR3
Published: 01 May 2014
View article titled, Abstract PR3: The cholesterol metabolite 27-hydroxycholesterol increases breast cancer tumor growth and metastasis
Journal Articles

CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

Daniel E. Frigo, Matthew K. Howe, Bryan M. Wittmann, Abigail M. Brunner, Ian Cushman, Qianben Wang, Myles Brown, Anthony R. Means, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2011) 71 (2): 528–537.
https://doi.org/10.1158/0008-5472.CAN-10-2581
Published: 13 January 2011
View article titled, CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells
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Includes: Supplementary data
Journal Articles

WNT11 Expression Is Induced by Estrogen-Related Receptor α and β-Catenin and Acts in an Autocrine Manner to Increase Cancer Cell Migration

Mary A. Dwyer, James D. Joseph, Hilary E. Wade, Matthew L. Eaton, Rebecca S. Kunder, Dmitri Kazmin, Ching-yi Chang, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9298–9308.
https://doi.org/10.1158/0008-5472.CAN-10-0226
Published: 14 November 2010
View article titled, WNT11 Expression Is Induced by Estrogen-Related Receptor α and β-Catenin and Acts in an Autocrine Manner to Increase Cancer Cell Migration
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Includes: Supplementary data
Journal Articles

Estrogen-Related Receptor α Is Critical for the Growth of Estrogen Receptor–Negative Breast Cancer

Rebecca A. Stein, Ching-yi Chang, Dmitri A. Kazmin, James Way, Thies Schroeder, Melanie Wergin, Mark W. Dewhirst, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2008) 68 (21): 8805–8812.
https://doi.org/10.1158/0008-5472.CAN-08-1594
Published: 30 October 2008
View article titled, Estrogen-Related Receptor α Is Critical for the Growth of Estrogen Receptor–Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic

Andrea B. Sherk, Daniel E. Frigo, Christine G. Schnackenberg, Jeffrey D. Bray, Nicholas J. Laping, Walter Trizna, Marlys Hammond, Jaclyn R. Patterson, Scott K. Thompson, Dmitri Kazmin, John D. Norris, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2008) 68 (18): 7475–7483.
https://doi.org/10.1158/0008-5472.CAN-08-1047
Published: 14 September 2008
View article titled, Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic
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Includes: Supplementary data
Journal Articles

Definition of Functionally Important Mechanistic Differences among Selective Estrogen Receptor Down-regulators

Bryan M. Wittmann, Andrea Sherk, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2007) 67 (19): 9549–9560.
https://doi.org/10.1158/0008-5472.CAN-07-1590
Published: 01 October 2007
View article titled, Definition of Functionally Important Mechanistic Differences among Selective Estrogen Receptor Down-regulators
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Journal Articles

Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy

Rachid Safi, Agnes Kovacic, Stéphanie Gaillard, Yoko Murata, Evan R. Simpson, Donald P. McDonnell, Colin D. Clyne
Journal: Cancer Research
Cancer Res (2005) 65 (24): 11762–11770.
https://doi.org/10.1158/0008-5472.CAN-05-2792
Published: 15 December 2005
View article titled, Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy
Open the PDF for Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy in another window
Journal Articles

Pharmacological Uncoupling of Androgen Receptor-mediated Prostate Cancer Cell Proliferation and Prostate-specific Antigen Secretion

Ganesan Sathya, Ching-yi Chang, Dmitri Kazmin, C. Edgar Cook, Donald P. McDonnell
Journal: Cancer Research
Cancer Res (2003) 63 (22): 8029–8036.
Published: 21 November 2003
View article titled, Pharmacological Uncoupling of Androgen Receptor-mediated Prostate Cancer Cell Proliferation and Prostate-specific Antigen Secretion
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