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Donald P. Bottaro
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Journal Articles

Clinical Evolution of Epithelial–Mesenchymal Transition in Human Carcinomas

Tony Navas, Robert J. Kinders, Scott M. Lawrence, Katherine V. Ferry-Galow, Suzanne Borgel, Melinda G. Hollingshead, Apurva K. Srivastava, Sergio Y. Alcoser, Hala R. Makhlouf, Rodrigo Chuaqui, Deborah F. Wilsker, Mariam M. Konaté, Sarah B. Miller, Andrea Regier Voth, Li Chen, Tomas Vilimas, Jyothi Subramanian, Lawrence Rubinstein, Shivaani Kummar, Alice P. Chen, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment
Journal: Cancer Research
Cancer Res (2020) 80 (2): 304–318.
https://doi.org/10.1158/0008-5472.CAN-18-3539
Published: 15 January 2020
View article titled, Clinical Evolution of Epithelial–Mesenchymal Transition in Human Carcinomas
Open the PDF for Clinical Evolution of Epithelial–Mesenchymal Transition in Human Carcinomas in another window
Includes: Supplementary data
Journal Articles

Abstract 4481: Tumor suppressive role of aquaglyceroporin-3 and PTPN13 in muscle invasive bladder cancer

Arpita A. Roy, Dinuka De Silva, Molly M. Lee, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4481.
https://doi.org/10.1158/1538-7445.AM2018-4481
Published: 01 July 2018
View article titled, Abstract 4481: Tumor suppressive role of aquaglyceroporin-3 and PTPN13 in muscle invasive bladder cancer
Journal Articles

Abstract 845: A clinically validated multiplex immunofluorescence assay for the quantitative assessment of changes in EMT phenotypes in FFPE tumor tissues in response to cancer therapeutics

Tony Navas, Melinda G. Hollingshead, Suzanne Borgel, John P. Carter, Angelena Millione, Brad A. Gouker, Donna Butcher, Susan Holbeck, Apurva K. Srivastava, Robert J. Kinders, Donald P. Bottaro, Shivaani Kumar, Alice Chen, James H. Doroshow, Ralph E. Parchment
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 845.
https://doi.org/10.1158/1538-7445.AM2017-845
Published: 01 July 2017
View article titled, Abstract 845: A clinically validated multiplex immunofluorescence assay for the quantitative assessment of changes in EMT phenotypes in FFPE tumor tissues in response to cancer therapeutics
Journal Articles

Abstract 5530: Evidence linking aquaporin-3 loss to increased invasiveness in bladder cancer

Arpita Roy, Dinuka M. DeSilva, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5530.
https://doi.org/10.1158/1538-7445.AM2017-5530
Published: 01 July 2017
View article titled, Abstract 5530: Evidence linking aquaporin-3 loss to increased invasiveness in bladder cancer
Journal Articles

Abstract 4575: Altered catalytic properties of a subset of Met cytoplasmic domain variants occurring in renal cell carcinoma

Dinuka De Silva, Young Lee, Arpita Roy, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4575.
https://doi.org/10.1158/1538-7445.AM2016-4575
Published: 15 July 2016
View article titled, Abstract 4575: Altered catalytic properties of a subset of Met cytoplasmic domain variants occurring in renal cell carcinoma
Journal Articles

Abstract 5082: Impact of HGF knockin microenvironment on epithelial-mesenchymal transition and cancer stem cells in a non-small cell lung cancer xenograft model

Tony Navas, Thomas D. Pfister, Scott M. Lawrence, Apurva K. Srivastava, Robert J. Kinders, Suzanne Borgel, Sergio Alcoser, Melinda G. Hollingshead, Lindsay M. Dutko, Brad A. Gouker, Donna Butcher, Elinor Ng-Eaton, Naoko Takebe, Young H. Lee, Donald P. Bottaro, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5082.
https://doi.org/10.1158/1538-7445.AM2015-5082
Published: 01 August 2015
View article titled, Abstract 5082: Impact of HGF knockin microenvironment on epithelial-mesenchymal transition and cancer stem cells in a non-small cell lung cancer xenograft model
Journal Articles

Abstract 140: Oncogenic signaling by MET and other cabozantinib targets in cells derived from urothelial carcinoma of the bladder

Young H. Lee, Tiffany K. Wong, Andrea B. Apolo, Piyush K. Agarwal, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 140.
https://doi.org/10.1158/1538-7445.AM2015-140
Published: 01 August 2015
View article titled, Abstract 140: Oncogenic signaling by MET and other cabozantinib targets in cells derived from urothelial carcinoma of the bladder
Journal Articles

Abstract 1049: Quantitative immunofluorescence assessment of MET and epithelial to mesenchymal transition (EMT) biomarker modulation by antiangiogenic inhibitors in xenograft tumor tissues

Tony Navas, Scott L. Lawrence, Donna Butcher, Lindsay M. Dutko, Melinda G. Hollingshead, Robert J. Kinders, Ralph E. Parchment, Donald P. Bottaro, W. Marston Linehan, Joseph E. Tomaszewski, Apurva K. Srivastava, James H. Doroshow
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1049.
https://doi.org/10.1158/1538-7445.AM2014-1049
Published: 01 October 2014
View article titled, Abstract 1049: Quantitative immunofluorescence assessment of MET and epithelial to mesenchymal transition (EMT) biomarker modulation by antiangiogenic inhibitors in xenograft tumor tissues
Journal Articles

Abstract 3691: Met target inhibition-guided efficacy in preclinical models

Apurva K. Srivastava, Melinda G. Hollingshead, Jeevan P. Govindharajulu, Joseph M. Covey, Dane Liston, James Peggins, Donald P. Bottaro, John J. Wright, Robert J. Kinders, Joseph E. Tomaszewski, James H. Doroshow, Ralph E. Parchment
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3691.
https://doi.org/10.1158/1538-7445.AM2014-3691
Published: 01 October 2014
View article titled, Abstract 3691: Met target inhibition-guided efficacy in preclinical models
Journal Articles

Abstract 5259: Gene expression array and pathway profiling analyses distinguish HGF/Met pathways driving cell proliferation from invasion and identify events correlated with prostate cancer progression

Fabiola Cecchi, Jason Lih, Young Lee, William Walsh, Mickey Williams, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5259.
https://doi.org/10.1158/1538-7445.AM2014-5259
Published: 01 October 2014
View article titled, Abstract 5259: Gene expression array and pathway profiling analyses distinguish HGF/Met pathways driving cell proliferation from invasion and identify events correlated with prostate cancer progression
Journal Articles

Abstract 4670: Characterization of Met signaling in urothelial cancer of the bladder

Young H. Lee, Andrea Apolo, Piyush K. Agarwal, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4670.
https://doi.org/10.1158/1538-7445.AM2014-4670
Published: 01 October 2014
View article titled, Abstract 4670: Characterization of Met signaling in urothelial cancer of the bladder
Journal Articles

Abstract 489: Hypoxia-mediated ROS enhances HGF-induced cancer cell invasion and suppresses cell cycle progression

Young H. Lee, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 489.
https://doi.org/10.1158/1538-7445.AM2014-489
Published: 01 October 2014
View article titled, Abstract 489: Hypoxia-mediated ROS enhances HGF-induced cancer cell invasion and suppresses cell cycle progression
Journal Articles

Abstract 4085: Experimental metastasis by the prostate adenocarcinoma-derived cell line PC3M is driven by partial activation of the human Met pathway.

Fabiola Cecchi, Chih-Jian Lih, Young H. Lee, William D. Walsh, Michael P. Williams, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4085.
https://doi.org/10.1158/1538-7445.AM2013-4085
Published: 15 April 2013
View article titled, Abstract 4085: Experimental metastasis by the prostate adenocarcinoma-derived cell line PC3M is driven by partial activation of the human Met pathway.
Journal Articles

Abstract 5637: A cellular model of acquired resistance to rilotumumab (AMG 102) in glioblastoma.

Fabiola Cecchi, Karen Rex, Joanna Schmidt, Daniel Baker, Michael A. Damore, Angela Coxon, Teresa L. Burgess, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5637.
https://doi.org/10.1158/1538-7445.AM2013-5637
Published: 15 April 2013
View article titled, Abstract 5637: A cellular model of acquired resistance to rilotumumab (AMG 102) in glioblastoma.
Journal Articles

Abstract 4285: Hypoxia-mediated autophagy enhances HGF-induced cancer cell invasion.

Young H. Lee, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4285.
https://doi.org/10.1158/1538-7445.AM2013-4285
Published: 15 April 2013
View article titled, Abstract 4285: Hypoxia-mediated autophagy enhances HGF-induced cancer cell invasion.
Journal Articles

Abstract 1225: Integration of HGF/Met signaling and hypoxia response in cancer cell invasion and proliferation

Young H. Lee, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1225.
https://doi.org/10.1158/1538-7445.AM2012-1225
Published: 15 April 2012
View article titled, Abstract 1225: Integration of HGF/Met signaling and hypoxia response in cancer cell invasion and proliferation
Journal Articles

Abstract 773: Identification and characterization of natural product-based inhibitors of hypoxia inducible factor-2 alpha

Daniel C. Rabe, Tawnya McKee, Girma M. Woldemichael, James R. Vasselli, James McMahon, W Marston Linehan, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 773.
https://doi.org/10.1158/1538-7445.AM10-773
Published: 15 April 2010
View article titled, Abstract 773: Identification and characterization of natural product-based inhibitors of hypoxia inducible factor-2 alpha
Journal Articles

Abstract SY23-03: Oncogenic signal transduction via the hepatocyte growth factor/Met receptor kinase pathway

Fabiola Cecchi, Deborah Pajalunga, Brian McNeil, Daniel Rabe, Andrew Fowler, Yuan Liu, C. Robert Gagnon, Howard Kallender, Manish A. Shah, Robert Getzenberg, Mark Schoenberg, Anne-Marie Martin, Ramaprasad Srinivasan, W. Marston Linehan, R Andrew Byrd, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): SY23-03.
https://doi.org/10.1158/1538-7445.AM10-SY23-03
Published: 15 April 2010
View article titled, Abstract SY23-03: Oncogenic signal transduction via the hepatocyte growth factor/Met receptor kinase pathway
Journal Articles

Abstract 342: A hepatocyte growth factor antagonist engineered by disruption of heparan sulfate binding

Fabiola Cecchi, Deborah Pajalunga, Daniel C. Rabe, Benedetta Peruzzi, Andrew C. Fowler, Davida K. Blackman, Nicholas MacDonald, Stephen J. Stahl, Andrew R. Byrd, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 342.
https://doi.org/10.1158/1538-7445.AM10-342
Published: 15 April 2010
View article titled, Abstract 342: A hepatocyte growth factor antagonist engineered by disruption of heparan sulfate binding
Journal Articles

Abstract 3401: Genetic down-regulation of MET alters the metastatic phenotype of osteosarcoma cells

Lisa M. Niswander, Lillian M. Guenther, Fabiola Cecchi, Alessio Giubellino, Donald P. Bottaro, James G. Christensen, Chand Khanna, Lee J. Helman, Su Young Kim
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3401.
https://doi.org/10.1158/1538-7445.AM10-3401
Published: 15 April 2010
View article titled, Abstract 3401: Genetic down-regulation of MET alters the metastatic phenotype of osteosarcoma cells