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Donald L. Durden
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Journal Articles

Abstract 369: A novel class of multitarget small molecule PI3K-CDK4/6-CDK9-AURAKA/B inhibitor harnesses Warburg effect against non-small cell lung cancer

Free
Anna V. Ivanina Foureau, Cody C. McHale, Hailey L. Dryden, Krishnaiah Maddeboina, David M. Foureau, Fei Guo, Donald L. Durden, Kathryn F. Mileham
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 369.
https://doi.org/10.1158/1538-7445.AM2025-369
Published: 21 April 2025
View articletitled, Abstract 369: A novel class of multitarget small molecule PI3K-CDK4/6-CDK9-AURAKA/B inhibitor harnesses Warburg effect against non-small cell lung cancer
Journal Articles

Abstract 3006: Efficacy of novel CDK9/CDK4/6/PI3K triple inhibitors, LCI133 and LCI139, in Ewing sarcoma

Free
Kaitlyn H. Smith, Cody C. McHale, Kenzie Wells, Krishnaiah Maddeboina, Kimberly Q. McKinney, Poornima Gourabathini, Jeffrey S. Huo, Donald L. Durden, Javier Oesterheld
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3006.
https://doi.org/10.1158/1538-7445.AM2025-3006
Published: 21 April 2025
View articletitled, Abstract 3006: Efficacy of novel CDK9/CDK4/6/PI3K triple inhibitors, LCI133 and LCI139, in Ewing sarcoma
Journal Articles

Abstract 1976: Targeting metabolism in non-small cell lung cancer (NSCLC) with the novel multitarget small molecule PI3K-CDK4/6-CDK9 inhibitor LCI139

Free
Cody C. McHale, Anna V. Ivanina Foureau, Hailey L. Dryden, Krishnaiah Maddeboina, Dhananjaya Pal, Bharath Yada, Page Mangum Arditti, Fei Guo, Kathryn F. Mileham, David M. Foureau, Donald L. Durden
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1976.
https://doi.org/10.1158/1538-7445.AM2024-1976
Published: 22 March 2024
View articletitled, Abstract 1976: Targeting metabolism in non-small cell lung cancer (NSCLC) with the novel multitarget small molecule PI3K-CDK4/6-CDK9 inhibitor LCI139
Journal Articles

Abstract LB-298: The novel triple PI3K-CDK4/6-BRD4 inhibitor SRX3177 harnesses synthetic lethality relationships to orthogonally disrupt cancer cell signaling

Free
Adam M. Burgoyne, Francisco M. Vega, Alok Singh, Shweta Joshi, Joseph R. Garlich, Guillermo A. Morales, Tatiana G. Kutateladze, Donald L. Durden
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-298.
https://doi.org/10.1158/1538-7445.AM2017-LB-298
Published: 01 July 2017
View articletitled, Abstract LB-298: The novel triple PI3K-CDK4/6-BRD4 inhibitor SRX3177 harnesses synthetic lethality relationships to orthogonally disrupt cancer cell signaling
Journal Articles

Abstract C61: A macrophage autonomous α4β1integrin-Syk-Rac2 signaling axis controls macrophage differentiation, tumor growth, and metastasis

Free
Shweta Joshi, Alok Ranjan Singh, Muamera Zulcic, Bao Lei, Karen Messer, Donald L. Durden
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): C61.
https://doi.org/10.1158/1538-7445.TIM2013-C61
Published: 01 May 2014
View articletitled, Abstract C61: A macrophage autonomous α4β1integrin-Syk-Rac2 signaling axis controls macrophage differentiation, tumor growth, and metastasis
Journal Articles

Abstract 2489: A phase II trial of poly-ICLC in the management of recurrent or progressive pediatric low grade gliomas

Free
Lisa R. Hartman, Donald L. Durden
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2489.
https://doi.org/10.1158/1538-7445.AM2012-2489
Published: 15 April 2012
View articletitled, Abstract 2489: A phase II trial of poly-ICLC in the management of recurrent or progressive pediatric low grade gliomas
Journal Articles

Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptional Activity

Free
Yuan Rong, Vladimir E. Belozerov, Carol Tucker-Burden, Gang Chen, Donald L. Durden, Jeffrey J. Olson, Erwin G. Van Meir, Nigel Mackman, Daniel J. Brat
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2540–2549.
https://doi.org/10.1158/0008-5472.CAN-08-1547
Published: 17 March 2009
View articletitled, Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptional Activity
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Includes: Supplementary data
Journal Articles

The Protein Phosphatase Activity of PTEN Regulates Src Family Kinases and Controls Glioma Migration

Free
Nandini Dey, Hal E. Crosswell, Pradip De, Ramon Parsons, Qiong Peng, Jing Dong Su, Donald L. Durden
Journal: Cancer Research
Cancer Res (2008) 68 (6): 1862–1871.
https://doi.org/10.1158/0008-5472.CAN-07-1182
Published: 13 March 2008
View articletitled, The Protein Phosphatase Activity of PTEN Regulates Src Family Kinases and Controls Glioma Migration
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Journal Articles

A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity

Free
Joseph R. Garlich, Pradip De, Nandini Dey, Jing Dong Su, Xiaodong Peng, Antoinette Miller, Ravoori Murali, Yiling Lu, Gordon B. Mills, Vikas Kundra, H-K. Shu, Qiong Peng, Donald L. Durden
Journal: Cancer Research
Cancer Res (2008) 68 (1): 206–215.
https://doi.org/10.1158/0008-5472.CAN-07-0669
Published: 02 January 2008
View articletitled, A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity
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Includes: Supplementary data
Journal Articles

Early Growth Response Gene-1 Regulates Hypoxia-Induced Expression of Tissue Factor in Glioblastoma Multiforme through Hypoxia-Inducible Factor-1–Independent Mechanisms

Free
Yuan Rong, Fang Hu, RuoPan Huang, Nigel Mackman, Jonathan M. Horowitz, Randy L. Jensen, Donald L. Durden, Erwin G. Van Meir, Daniel J. Brat
Journal: Cancer Research
Cancer Res (2006) 66 (14): 7067–7074.
https://doi.org/10.1158/0008-5472.CAN-06-0346
Published: 18 July 2006
View articletitled, Early Growth Response Gene-1 Regulates Hypoxia-Induced Expression of Tissue Factor in Glioblastoma Multiforme through Hypoxia-Inducible Factor-1–Independent Mechanisms
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Journal Articles

Sensitization of radiation-resistant melanoma cell lines to radiation therapy in vivo using a novel vascular-targeted PI-3 kinase inhibitor

Free
Seunghee Kang, Zhongxing Liang, Donald L. Durden, Peter Johnstone, Hyunsuk Shim
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 470–471.
Published: 01 May 2005
View articletitled, Sensitization of radiation-resistant melanoma cell lines to radiation therapy in vivo using a novel vascular-targeted PI-3 kinase inhibitor
Journal Articles

PTEN and Hypoxia Regulate Tissue Factor Expression and Plasma Coagulation by Glioblastoma

Free
Yuan Rong, Dawn E. Post, Russell O. Pieper, Donald L. Durden, Erwin G. Van Meir, Daniel J. Brat
Journal: Cancer Research
Cancer Res (2005) 65 (4): 1406–1413.
https://doi.org/10.1158/0008-5472.CAN-04-3376
Published: 25 February 2005
View articletitled, PTEN and Hypoxia Regulate Tissue Factor Expression and Plasma Coagulation by Glioblastoma
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Journal Articles

Akt as a signaling intermediate between endothelial alpha-v integrins and p53

Free
Orla T. Cox, Linda B. Tran, Melissa Millard, Jing D. Su, Donald L. Durden, Anat Erdreich-Epstein
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 18.
Published: 01 April 2004
View articletitled, Akt as a signaling intermediate between endothelial alpha-v integrins and p53
Journal Articles

PTEN and Phosphatidylinositol 3′-Kinase Inhibitors Up-Regulate p53 and Block Tumor-induced Angiogenesis: Evidence for an Effect on the Tumor and Endothelial Compartment

Free
Jing Dong Su, Lindsey D. Mayo, David B. Donner, Donald L. Durden
Journal: Cancer Research
Cancer Res (2003) 63 (13): 3585–3592.
Published: 01 July 2003
View articletitled, PTEN and Phosphatidylinositol 3′-Kinase Inhibitors Up-Regulate p53 and Block Tumor-induced Angiogenesis: Evidence for an Effect on the Tumor and Endothelial Compartment
Open the PDF for PTEN and Phosphatidylinositol 3′-Kinase Inhibitors Up-Regulate p53 and Block Tumor-induced Angiogenesis: Evidence for an Effect on the Tumor and Endothelial Compartment in another window
Journal Articles

Plasminogen Activator Inhibitor-1 Promotes Angiogenesis by Stimulating Endothelial Cell Migration toward Fibronectin

Free
Chiho Isogai, Walter E. Laug, Hiroyuki Shimada, Paul J. Declerck, Monique F. Stins, Donald L. Durden, Anat Erdreich-Epstein, Yves A. DeClerck
Journal: Cancer Research
Cancer Res (2001) 61 (14): 5587–5594.
Published: 01 July 2001
View articletitled, Plasminogen Activator Inhibitor-1 Promotes Angiogenesis by Stimulating Endothelial Cell Migration toward Fibronectin
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Journal Articles

Integrins αvβ3 and αvβ5 Are Expressed by Endothelium of High-Risk Neuroblastoma and Their Inhibition Is Associated with Increased Endogenous Ceramide

Free
Anat Erdreich-Epstein, Hiroyuki Shimada, Susan Groshen, Ming Liu, Leonid S. Metelitsa, Kwang Sik Kim, Monique F. Stins, Robert C. Seeger, Donald L. Durden
Journal: Cancer Research
Cancer Res (2000) 60 (3): 712–721.
Published: 01 February 2000
View articletitled, Integrins αvβ3 and αvβ5 Are Expressed by Endothelium of High-Risk Neuroblastoma and Their Inhibition Is Associated with Increased Endogenous Ceramide
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Journal Articles

Kinetic Analysis of Hepatotoxicity Associated with Antineoplastic Asparaginases

Free
Donald L. Durden, Ana M. Salazar, John A. Distasio
Journal: Cancer Research
Cancer Res (1983) 43 (4): 1602–1605.
Published: 01 April 1983
View articletitled, Kinetic Analysis of Hepatotoxicity Associated with Antineoplastic Asparaginases
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Journal Articles

Alteration in Spleen Lymphoid Populations Associated with Specific Amino Acid Depletion during L-Asparaginase Treatment1

Free
John A. Distasio, Donald L. Durden, Ronald D. Paul, Mehrdad Nadji
Journal: Cancer Research
Cancer Res (1982) 42 (1): 252–258.
Published: 01 January 1982
View articletitled, Alteration in Spleen Lymphoid Populations Associated with Specific Amino Acid Depletion during L-Asparaginase Treatment1
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Journal Articles

Comparison of the Immunosuppressive Effects of Asparaginases from Escherichia coli and Vibrio succinogenes

Free
Donald L. Durden, John A. Distasio
Journal: Cancer Research
Cancer Res (1980) 40 (4): 1125–1129.
Published: 01 April 1980
View articletitled, Comparison of the Immunosuppressive Effects of Asparaginases from Escherichia coli and Vibrio succinogenes
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