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Donald Kufe
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Journal Articles

Abstract PO3-13-07: MUC1-C INTEGRATES CHRONIC ACTIVATION OF INTERFERON PATHWAYS WITH CHROMATIN REMODELING IN TREATMENT RESISTANCE OF TRIPLE-NEGATIVE BREAST CANCER

Nami Yamashita, Yoshihiro Morimoto, Atsushi Fushimi, Rehan Ahmad, Atrayee Bhattacharya, Yuka Inoue, Henry Withers, Geoffrey Shapiro, Tomoharu Yoshizumi, Takayuki Ueno, Shinji Ohno, Mark Long, Donald Kufe
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-13-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-13-07
Published: 02 May 2024
View article titled, Abstract PO3-13-07: MUC1-C INTEGRATES CHRONIC ACTIVATION OF INTERFERON PATHWAYS WITH CHROMATIN REMODELING IN TREATMENT RESISTANCE OF TRIPLE-NEGATIVE BREAST CANCER
Journal Articles

Abstract 3279: MUC1 is necessary for the inflammatory memory response to osimertinib resistance in NSCLC cells

Naoki Haratake, Atrayee Bhattacharya, Ayako Nakashoji, Hiroki Ozawa, Mototsugu Shimokawa, Donald Kufe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3279.
https://doi.org/10.1158/1538-7445.AM2024-3279
Published: 22 March 2024
View article titled, Abstract 3279: MUC1 is necessary for the inflammatory memory response to osimertinib resistance in NSCLC cells
Journal Articles

Abstract 4076: 4-1bb selection augments DC/AML fusion vaccine-educated T cells for adoptive cell therapy

Kathrine S. Rallis*, Jessica Liegel*, Giulia Cheloni, Dina Stroopinsky, Poorva Bindal, Kenel Dufort, Daniela Torres, Isabella Saldarriaga, Samuel Herzlinger, Abigael Morin, Raphael Kesselman, Jeremy Rosenbaum, Georges Chedid, Sophia Adamia, Donald Kufe, Jacalyn Rosenblatt, David Avigan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4076.
https://doi.org/10.1158/1538-7445.AM2023-4076
Published: 04 April 2023
View article titled, Abstract 4076: 4-1bb selection augments DC/AML fusion vaccine-educated T cells for adoptive cell therapy
Journal Articles

Abstract P1-04-09: Essential role for MUC1-C in chronic activation of cytosolic nucleotide sensing and the type I interferon pathway in triple-negative breast cancer

Nami Yamashita, Atsushi Fushimi, Yoshihiro Morimoto, Atrayee Bhattacharya, Mark Long, Song Liu, Donald Kufe
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P1-04-09.
https://doi.org/10.1158/1538-7445.SABCS21-P1-04-09
Published: 15 February 2022
View article titled, Abstract P1-04-09: Essential role for MUC1-C in chronic activation of cytosolic nucleotide sensing and the type I interferon pathway in triple-negative breast cancer
Journal Articles

MUC1-C Activates the BAF (mSWI/SNF) Complex in Prostate Cancer Stem Cells

Masayuki Hagiwara, Yota Yasumizu, Nami Yamashita, Hasan Rajabi, Atsushi Fushimi, Mark D. Long, Wei Li, Atrayee Bhattacharya, Rehan Ahmad, Mototsugu Oya, Song Liu, Donald Kufe
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (4): 1111–1122.
https://doi.org/10.1158/0008-5472.CAN-20-2588
Published: 15 February 2021
View article titled, MUC1-C Activates the BAF (mSWI/SNF) Complex in Prostate Cancer Stem Cells
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Includes: Supplementary data
Journal Articles

Abstract 492: A Novel QUATRAMER sustained injectable suspension for the intracellular delivery of Salinomycin, a stem cell inhibitor (HSB-1216), for the treatment of triple negative breast cancer

Surender M. Kharbanda, Anees Mohammad, Bhawana Gupta, Sireesh Appajosyula, Sandeep Laumas, Jugnu Jain, Donald Kufe, Harpal Singh
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 492.
https://doi.org/10.1158/1538-7445.AM2020-492
Published: 15 August 2020
View article titled, Abstract 492: A Novel QUATRAMER sustained injectable suspension for the intracellular delivery of Salinomycin, a stem cell inhibitor (HSB-1216), for the treatment of triple negative breast cancer
Journal Articles

MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells

Tsuyoshi Hata, Hasan Rajabi, Hidekazu Takahashi, Yota Yasumizu, Wei Li, Caining Jin, Mark D. Long, Qiang Hu, Song Liu, Atsushi Fushimi, Nami Yamashita, Ling Kui, Deli Hong, Masaaki Yamamoto, Masaaki Miyo, Masayuki Hiraki, Takahiro Maeda, Yozo Suzuki, Mehmet K. Samur, Donald Kufe
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (22): 5711–5722.
https://doi.org/10.1158/0008-5472.CAN-19-1034
Published: 15 November 2019
View article titled, MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells
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Includes: Supplementary data
Journal Articles

MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells

Masaaki Yamamoto, Caining Jin, Tsuyoshi Hata, Yota Yasumizu, Yan Zhang, Deli Hong, Takahiro Maeda, Masaaki Miyo, Masayuki Hiraki, Yozo Suzuki, Kunihiko Hinohara, Hasan Rajabi, Donald Kufe
Journal: Cancer Research
Cancer Res (2019) 79 (8): 2031–2041.
https://doi.org/10.1158/0008-5472.CAN-18-3259
Published: 15 April 2019
View article titled, MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells
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Includes: Supplementary data
Journal Articles

MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer

Takahiro Maeda, Masayuki Hiraki, Caining Jin, Hasan Rajabi, Ashujit Tagde, Maroof Alam, Audrey Bouillez, Xiufeng Hu, Yozo Suzuki, Masaaki Miyo, Tsuyoshi Hata, Kunihiko Hinohara, Donald Kufe
Journal: Cancer Research
Cancer Res (2018) 78 (1): 205–215.
https://doi.org/10.1158/0008-5472.CAN-17-1636
Published: 02 January 2018
View article titled, MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 3824: Targeting MUC1-C oncoprotein inhibits AKT-S6K1-elF4A pathway regulated TIGAR translation in colorectal cancer

Rehan Ahmad, Maroof Alam, Omar Al-Obaid, Masanori Hasegawa, Donald Kufe
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3824.
https://doi.org/10.1158/1538-7445.AM2016-3824
Published: 15 July 2016
View article titled, Abstract 3824: Targeting MUC1-C oncoprotein inhibits AKT-S6K1-elF4A pathway regulated TIGAR translation in colorectal cancer
Journal Articles

Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas

Audrey Bouillez, Hasan Rajabi, Sean Pitroda, Caining Jin, Maroof Alam, Akriti Kharbanda, Ashujit Tagde, Kwok-Kin Wong, Donald Kufe
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1538–1548.
https://doi.org/10.1158/0008-5472.CAN-15-1804
Published: 14 March 2016
View article titled, Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
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Includes: Supplementary data
Journal Articles

Novel Polymeric Nanoparticles for Intracellular Delivery of Peptide Cargos: Antitumor Efficacy of the BCL-2 Conversion Peptide NuBCP-9

Manoj Kumar, Dikshi Gupta, Gurpal Singh, Sapna Sharma, Madhusudan Bhat, C.K. Prashant, A.K. Dinda, Surender Kharbanda, Donald Kufe, Harpal Singh
Journal: Cancer Research
Cancer Res (2014) 74 (12): 3271–3281.
https://doi.org/10.1158/0008-5472.CAN-13-2015
Published: 12 June 2014
View article titled, Novel Polymeric Nanoparticles for Intracellular Delivery of Peptide Cargos: Antitumor Efficacy of the BCL-2 Conversion Peptide NuBCP-9
Open the PDF for Novel Polymeric Nanoparticles for Intracellular Delivery of Peptide Cargos: Antitumor Efficacy of the BCL-2 Conversion Peptide NuBCP-9 in another window
Journal Articles

Abstract C66: MUC1-C oncoprotein induces aldehyde dehydrogenase expression and activity in breast cancer cells

Rehan Ahmad, Maroof Alam, Hasan Rajabi, Akriti Kharbanda, Donald Kufe
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): C66.
https://doi.org/10.1158/1538-7445.FBCR13-C66
Published: 15 May 2014
View article titled, Abstract C66: MUC1-C oncoprotein induces aldehyde dehydrogenase expression and activity in breast cancer cells
Journal Articles

MUC1 Is a Potential Target for the Treatment of Acute Myeloid Leukemia Stem Cells

Dina Stroopinsky, Jacalyn Rosenblatt, Keisuke Ito, Heidi Mills, Li Yin, Hasan Rajabi, Baldev Vasir, Turner Kufe, Katarina Luptakova, Jon Arnason, Caterina Nardella, James D. Levine, Robin M. Joyce, Ilene Galinsky, Yoram Reiter, Richard M. Stone, Pier Paolo Pandolfi, Donald Kufe, David Avigan
Journal: Cancer Research
Cancer Res (2013) 73 (17): 5569–5579.
https://doi.org/10.1158/0008-5472.CAN-13-0677
Published: 02 September 2013
View article titled, MUC1 Is a Potential Target for the Treatment of Acute Myeloid Leukemia Stem Cells
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Includes: Supplementary data
Journal Articles

Abstract 173: Targeting the MUC1-C oncoprotein blocks activation of FLT-3/ITD and induces death of acute myeloid leukemia cells

Suiyang Liu, Surender Kharbanda, Donald Kufe, Richard Stone
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 173.
https://doi.org/10.1158/1538-7445.AM2012-173
Published: 15 April 2012
View article titled, Abstract 173: Targeting the MUC1-C oncoprotein blocks activation of FLT-3/ITD and induces death of acute myeloid leukemia cells
Journal Articles

Abstract 2243: Targeting the MUC1-C oncoprotein synergistically enhances cytotoxicity of breast carcinoma cells in combination with PI3K inhibitors

Deepak Raina, Surender Kharbanda, Donald Kufe
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2243.
https://doi.org/10.1158/1538-7445.AM2012-2243
Published: 15 April 2012
View article titled, Abstract 2243: Targeting the MUC1-C oncoprotein synergistically enhances cytotoxicity of breast carcinoma cells in combination with PI3K inhibitors
Journal Articles

Abstract 1819: A MUC1-C oncoprotein soluble decoy receptor effectively suppresses the growth of human breast cancer cells

Govind Panchamoorthy, Deepak Raina, Hala Rehan, Surender Kharbanda, Donald Kufe
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1819.
https://doi.org/10.1158/1538-7445.AM2012-1819
Published: 15 April 2012
View article titled, Abstract 1819: A MUC1-C oncoprotein soluble decoy receptor effectively suppresses the growth of human breast cancer cells
Journal Articles

MUC1-C Oncoprotein Functions as a Direct Activator of the Nuclear Factor-κB p65 Transcription Factor

Rehan Ahmad, Deepak Raina, Maya Datt Joshi, Takeshi Kawano, Jian Ren, Surender Kharbanda, Donald Kufe
Journal: Cancer Research
Cancer Res (2009) 69 (17): 7013–7021.
https://doi.org/10.1158/0008-5472.CAN-09-0523
Published: 31 August 2009
View article titled, MUC1-C Oncoprotein Functions as a Direct Activator of the Nuclear Factor-κB p65 Transcription Factor
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Includes: Supplementary data
Journal Articles

Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells

Deepak Raina, Rehan Ahmad, Maya Datt Joshi, Li Yin, Zekui Wu, Takeshi Kawano, Baldev Vasir, David Avigan, Surender Kharbanda, Donald Kufe
Journal: Cancer Research
Cancer Res (2009) 69 (12): 5133–5141.
https://doi.org/10.1158/0008-5472.CAN-09-0854
Published: 15 June 2009
View article titled, Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells
Open the PDF for Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells in another window
Includes: Supplementary data
Journal Articles

Abstract #4251: MUC1-C oncoprotein function as a direct activator of the NF-kB p65 transcription factor

Rehan Ahmad, Deepak Raina, Maya Datt Joshi, Surender Kharbanda, Takeshi Kawano, Donald Kufe
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4251.
Published: 01 May 2009
View article titled, Abstract #4251: MUC1-C oncoprotein function as a direct activator of the NF-kB p65 transcription factor