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Donald J. Buchsbaum
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Journal Articles

Abstract 4392: A 1st in class pan-RAS inhibitor with robust antitumor activity in PDAC models and advantages over other RAS inhibitors to escape resistance

Free
Gary A. Piazza, Dhana Sekhar Reddy Bandi, Ganji Purnachandra Nagaraju, Kristy Berry, Junwei Wang, Sindu Ramesh, Chung-Hui Huang, Upender Manne, Xi Chen, Jeremy B. Foote, Adam B. Keeton, Yulia Y. Maxuitenko, Donald J. Buchsbaum, Bassel F. El Rayes
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4392.
https://doi.org/10.1158/1538-7445.AM2025-4392
Published: 21 April 2025
View articletitled, Abstract 4392: A 1st in class pan-RAS inhibitor with robust antitumor activity in PDAC models and advantages over other RAS inhibitors to escape resistance
Journal Articles

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer

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Jeremy B. Foote, Tyler E. Mattox, Adam B. Keeton, Xi Chen, Forrest T. Smith, Kristy Berry, Thomas W. Holmes, Junwei Wang, Chung-hui Huang, Antonio Ward, Amit K. Mitra, Veronica Ramirez-Alcantara, Cherlene Hardy, Karianne G. Fleten, Kjersti Flatmark, Karina J. Yoon, Sujith Sarvesh, Ganji P. Nagaraju, Dhana Sekhar Reddy Bandi, Yulia Y. Maxuitenko, Jacob Valiyaveettil, Julienne L. Carstens, Donald J. Buchsbaum, Jennifer Yang, Gang Zhou, Elmar Nurmemmedov, Ivan Babic, Vadim Gaponeko, Hazem Abdelkarim, Michael R. Boyd, Greg Gorman, Upender Manne, Sejong Bae, Bassel F. El-Rayes, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2025) 85 (5): 956–972.
https://doi.org/10.1158/0008-5472.CAN-24-0323
Published: 03 March 2025
View articletitled, A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer
Open the PDF for A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C027: Efficacy advantages of a novel pan-RAS inhibitor, ADT-1004, over mutant- specific KRAS inhibitors for suppressing pancreatic tumor growth in murine models

Free
Dhana Sekhar Reddy Bandi, Ganji P Nagaraju, Jeremy B Foote, Adam B Keeton, Xi Chen, Kristy L Berry, Yulia Y Maxuitenko, Upender Manne, Donald J Buchsbaum, Gary A Piazza, Bassel F El-Rayes
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C027.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C027
Published: 15 September 2024
View articletitled, Abstract C027: Efficacy advantages of a novel pan-RAS inhibitor, ADT-1004, over mutant- specific KRAS inhibitors for suppressing pancreatic tumor growth in murine models
Journal Articles

Abstract C025: A novel pan-RAS/β-catenin inhibitor, ADT-030, produces tumor regression in PDX models of pancreatic cancer

Free
Dhana Sekhar Reddy Bandi, Ganji P Nagaraju, Jeremy B Foote, Adam B Keeton, Xi Chen, Kristy L Berry, Yulia Y Maxuitenko, Upender Manne, Donald J Buchsbaum, Gary A Piazza, Bassel F El-Rayes
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C025.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C025
Published: 15 September 2024
View articletitled, Abstract C025: A novel pan-RAS/β-catenin inhibitor, ADT-030, produces tumor regression in PDX models of pancreatic cancer
Journal Articles

Abstract 3323: Novel Pan-RAS inhibitor ADT-007: A unique mechanism of antitumor selectivity in pancreatic and colorectal carcinoma models

Free
Junwei Wang, Adam B. Keeton, Sindhu Ramesh, Peyton Johnson, Yulia Y. Maxuitenko, Jeremy B. Foote, Chung-Hui Huang, Kristy L. Berry, Khalda Fadlalla, Bandi D. Reddy, Ganji P. Nagaraju, Elmar Nurmemmedov, Ivan Babic, Vadim Gaponenko, Xi Chen, Bassel F. El-Rayes, Donald J. Buchsbaum, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3323.
https://doi.org/10.1158/1538-7445.AM2024-3323
Published: 22 March 2024
View articletitled, Abstract 3323: Novel Pan-RAS inhibitor ADT-007: A unique mechanism of antitumor selectivity in pancreatic and colorectal carcinoma models
Journal Articles

Abstract LB322: Antitumor activity of 1st-in-class pan-RAS inhibitor ADT-1004 in mouse models of pancreatic ductal adenocarcinoma

Free
Yulia Y. Maxuitenko, Jeremy B. Foote, Adam B. Keeton, Xi Chen, Kristy Berry, Khalda Fadlalla, Jacob Valiyaveettil, Chung-Hui Huang, Austin M. Moore, Emily C. Graff, Ganji P. Nagaraju, Julienne L. Carstens, Bassel F. El-Rayes, Donald J. Buchsbaum, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB322.
https://doi.org/10.1158/1538-7445.AM2023-LB322
Published: 14 April 2023
View articletitled, Abstract LB322: Antitumor activity of 1st-in-class pan-RAS inhibitor ADT-1004 in mouse models of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1658: ADT-007 binds RAS and inhibits RAS signaling

Free
Adam B. Keeton, Xi Chen, Jacob Valiyaveettil, Chung-Hui Huang, Tyler E. Mattox, Khalda Fadlalla, Jeremy B. Foote, Donald J. Buchsbaum, Kristy L. Berry, Elmar Nurmemmedov, Ivan Babic, Vadim Gaponenko, Gregory Gorman, Lori Coward, Yulia Y. Maxuitenko, Forrest T. Smith, Gary A. Piazza
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1658.
https://doi.org/10.1158/1538-7445.AM2023-1658
Published: 04 April 2023
View articletitled, Abstract 1658: ADT-007 binds RAS and inhibits RAS signaling
Journal Articles

Abstract 4140: Oncogenic KRAS inhibition with ADT-007 primes T cell responses in pancreatic ductal adenocarcinoma

Free
Jeremy B. Foote, Tyler E. Mattox, Adam B. Keeton, Ganji N. Purnachandra, Yulia Maxuitenko, Xi Chen, Jacob Valiyaveettil, Donald J. Buchsbaum, Gary A. Piazza, Bassel F. El-Rayes
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4140.
https://doi.org/10.1158/1538-7445.AM2023-4140
Published: 04 April 2023
View articletitled, Abstract 4140: Oncogenic KRAS inhibition with ADT-007 primes T cell responses in pancreatic ductal adenocarcinoma
Journal Articles

Abstract LB250: Development of organoid raft cultures of cervical, breast and glioblastoma tumors as quick economical ex vivo human cancer models for pre-clinical drug evaluation

Free
Nilam Sanjib Banerjee, Dianne W. Moore, Abhisek Gangrade, Donald J. Buchsbaum, Luise Burt Nabors, Thomas R. Broker, Louise T. Chow
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB250.
https://doi.org/10.1158/1538-7445.AM2021-LB250
Published: 01 July 2021
View articletitled, Abstract LB250: Development of organoid raft cultures of cervical, breast and glioblastoma tumors as quick economical ex vivo human cancer models for pre-clinical drug evaluation
Journal Articles

STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer

Free
Megan E. Conway, Joy M. McDaniel, James M. Graham, Katrin P. Guillen, Patsy G. Oliver, Stephanie L. Parker, Peibin Yue, James Turkson, Donald J. Buchsbaum, Bryan E. Welm, Richard M. Myers, Katherine E. Varley
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (20): 4355–4370.
https://doi.org/10.1158/0008-5472.CAN-20-1379
Published: 15 October 2020
View articletitled, STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer
Open the PDF for STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4700: Manipulating the breast tumor microenvironment with histone deacetylase inhibitors for more robust and durable T cell responses

Free
Tyler R. McCaw, Mingyong Liu, Mei Li, Dmytro Starenki, Sara J. Cooper, Rebecca C. Arend, Andres Forero, Donald J. Buchsbaum, Troy D. Randall
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4700.
https://doi.org/10.1158/1538-7445.AM2018-4700
Published: 01 July 2018
View articletitled, Abstract 4700: Manipulating the breast tumor microenvironment with histone deacetylase inhibitors for more robust and durable T cell responses
Journal Articles

Abstract 4710: The effect of Wnt inhibition combined with paclitaxel on tumor burden and CD8+ T cell infiltration in syngeneic murine models of ovarian cancer

Free
David W. Doo, Angelina I. Londono, Dylana J. Moore, Selene Meza-Perez, Ashwini A. Katre, Tyler R. McCaw, Haller J. Smith, Carol Y. Lin, Sara J. Cooper, J Michael Straughn, Donald J. Buchsbaum, Lyse A. Norian, Troy D. Randall, Rebecca C. Arend
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4710.
https://doi.org/10.1158/1538-7445.AM2018-4710
Published: 01 July 2018
View articletitled, Abstract 4710: The effect of Wnt inhibition combined with paclitaxel on tumor burden and CD8+ T cell infiltration in syngeneic murine models of ovarian cancer
Journal Articles

Abstract 5173: Discovery of a series of benzimidazoles as potent Wnt/β-catenin signaling inhibitors in colorectal cancer cells

Free
Yonghe Li, Patsy G. Oliver, Wenyan Lu, Vibha Pathak, Corinne E. Augelli-Szafran, Donald J. Buchsbaum, Mark J. Suto
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5173.
https://doi.org/10.1158/1538-7445.AM2017-5173
Published: 01 July 2017
View articletitled, Abstract 5173: Discovery of a series of benzimidazoles as potent Wnt/β-catenin signaling inhibitors in colorectal cancer cells
Journal Articles

Abstract 643: Induced MHCII expression on breast cancer cells broadens the responding T cell repertoire, delays tumor-specific T cell exhaustion, and impairs tumor growth

Free
Tyler R. McCaw, Mei Li, Selene Meza-Perez, Donald J. Buchsbaum, Dmytro Starenki, Sara Cooper, Andres Forero, Troy D. Randall
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 643.
https://doi.org/10.1158/1538-7445.AM2017-643
Published: 01 July 2017
View articletitled, Abstract 643: Induced MHCII expression on breast cancer cells broadens the responding T cell repertoire, delays tumor-specific T cell exhaustion, and impairs tumor growth
Journal Articles

Abstract 3327: The tumor associated sialyltransferase ST6Gal-I promotes a cancer stem cell phenotype and upregulates stem-related transcription factors

Free
Matthew J. Schultz, Andrew T. Holdbrooks, Asmi Chakraborty, William E. Grizzle, Charles N. Landen, Donald J. Buchsbaum, Michael G. Conner, Rebecca C. Arend, Karina J. Yoon, Chris A. Klug, Daniel C. Bullard, Robert A. Kesterson, Patsy G. Oliver, Amber K. O’Connor, Bradley K. Yoder, Susan L. Bellis
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3327.
https://doi.org/10.1158/1538-7445.AM2016-3327
Published: 15 July 2016
View articletitled, Abstract 3327: The tumor associated sialyltransferase ST6Gal-I promotes a cancer stem cell phenotype and upregulates stem-related transcription factors
Journal Articles

Abstract 4030: Epigenetic induction of MHC-II pathway expression in murine ovarian cancer cell line

Free
Taylor B. Turner, Rebecca C. Arend, Mei Li, Troy D. Randall, Andres Forero-Torres, Albert F. LoBuglio, J Michael Straughn, Donald J. Buchsbaum
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4030.
https://doi.org/10.1158/1538-7445.AM2016-4030
Published: 15 July 2016
View articletitled, Abstract 4030: Epigenetic induction of MHC-II pathway expression in murine ovarian cancer cell line
Journal Articles

Abstract 1461: MHCII-expressing breast cancer cells can induce anti-tumor immune response

Free
Mei Li, Tyler R. McCaw, Selene Meza-Perez, Troy D. Randall, Amy Weinmann, Donald J. Buchsbaum, Andres Forero, Albert F. LoBuglio
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1461.
https://doi.org/10.1158/1538-7445.AM2016-1461
Published: 15 July 2016
View articletitled, Abstract 1461: MHCII-expressing breast cancer cells can induce anti-tumor immune response
Journal Articles

The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype

Free
Matthew J. Schultz, Andrew T. Holdbrooks, Asmi Chakraborty, William E. Grizzle, Charles N. Landen, Donald J. Buchsbaum, Michael G. Conner, Rebecca C. Arend, Karina J. Yoon, Christopher A. Klug, Daniel C. Bullard, Robert A. Kesterson, Patsy G. Oliver, Amber K. O'Connor, Bradley K. Yoder, Susan L. Bellis
Journal: Cancer Research
Cancer Res (2016) 76 (13): 3978–3988.
https://doi.org/10.1158/0008-5472.CAN-15-2834
Published: 30 June 2016
View articletitled, The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype
Open the PDF for The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype in another window
Journal Articles

Abstract 2931: Calmodulin-DR5 binding in breast cancer: Independent of TRA-8 sensitivity

Free
Romone M. Fancy, Donald J. Buchsbaum, Tong Zhou, Yuhua Song
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2931.
https://doi.org/10.1158/1538-7445.AM2015-2931
Published: 01 August 2015
View articletitled, Abstract 2931: Calmodulin-DR5 binding in breast cancer: Independent of TRA-8 sensitivity
Journal Articles

Abstract A100: Role of HER3 ligand-independent activation in EGFR resistance in pancreatic cancer

Free
Donald J. Buchsbaum, Tong Zhou
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A100.
https://doi.org/10.1158/1538-7445.PANCA2014-A100
Published: 30 June 2015
View articletitled, Abstract A100: Role of HER3 ligand-independent activation in EGFR resistance in pancreatic cancer