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Journal Articles

Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron S. Fraser, Alex Pon, Evann C. Mitchell, Kelly A. Servage, Gabriele Allies, Isa V. Westedt, Feyza Cansiz, Jonathan Krystkiewicz, Andrea Kutritz, Dirk Schadendorf, Sean J. Morrison, Jessalyn M. Ubellacker, Anju Sreelatha, Alpaslan Tasdogan
Journal: Cancer Research
Cancer Res (2025) 85 (5): 942–955.
https://doi.org/10.1158/0008-5472.CAN-23-2194
Published: 03 March 2025
View article titled, Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity
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Includes: Supplementary data
Journal Articles

Abstract 5168: Analysis of biomarker and outcomes data: 7-year update from COLUMBUS

Reinhard Dummer, Keith Flaherty, Shibing Deng, Tao Xie, Phineas Hamilton, Nuzhat Pathan, Caroline Robert, Ana Arance, Jan Willem de Groot, Claus Garbe, Helen J. Gogas, Ralf Gutzmer, Ivana Krajsová, Gabriella Liszkay, Carmen Loquai, Mario Mandala, Dirk Schadendorf, Naoya Yamazaki, Paolo A. Ascierto, Alessandra di Pietro, Craig B. Davis
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5168.
https://doi.org/10.1158/1538-7445.AM2024-5168
Published: 22 March 2024
View article titled, Abstract 5168: Analysis of biomarker and outcomes data: 7-year update from COLUMBUS
Journal Articles

Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman, Alexander T. Bauer, Gergely Solecki, Anna S. Berghoff, Chanté D. Mayer, Katharina Frey, Nils Hebach, Manuel J. Feinauer, Nicole L. Schieber, Cedric Tehranian, Luc Mercier, Mahak Singhal, Varun Venkataramani, Marc C. Schubert, Daniel Hinze, Michael Hölzel, Iris Helfrich, Dirk Schadendorf, Stefan W. Schneider, Dana Westphal, Hellmut G. Augustin, Jacky G. Goetz, Yannick Schwab, Wolfgang Wick, Frank Winkler
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1299–1314.
https://doi.org/10.1158/0008-5472.CAN-22-3964
Published: 14 April 2023
View article titled, Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
Open the PDF for Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract CT069: Randomized phase 3 study (STARBOARD) evaluating encorafenib (enco) + binimetinib (bini) + pembrolizumab (pembro) for first-line treatment of unresectable locally advanced or metastatic BRAF V600-mutant melanoma

Dirk Schadendorf, Reinhard Dummer, Caroline Robert, Antoni Ribas, Ryan J. Sullivan, Timothy Panella, Meredith McKean, Edgardo S. Santos, Jill Clancy, Anna Polli, Alessandra di Pietro, Paolo A. Ascierto
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT069.
https://doi.org/10.1158/1538-7445.AM2023-CT069
Published: 14 April 2023
View article titled, Abstract CT069: Randomized phase 3 study (STARBOARD) evaluating encorafenib (enco) + binimetinib (bini) + pembrolizumab (pembro) for first-line treatment of unresectable locally advanced or metastatic BRAF V600-mutant melanoma
Journal Articles

Abstract 965: Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

Giuseppe Tarantino, Cora A. Ricker, Annette Wang, Will Ge, Amy Y. Huang, Shariq Madha, Jiajia Chen, Yingxiao Shi, Dennie T. Frederick, Samuel Freeman, Marta M. Holovatska, Michael P. Manos, Lisa Zimmer, Alexander Rösch, Anne Zaremba, Brendan Reardon, Jihye Park, Haitham Elmarakeby, Bastian Schilling, Anita Giobbie-Hurder, Natalie Vokes, Elizabeth I. Buchbinder, Keith Flaherty, Rizwan Haq, Catherine Wu, Genevieve Boland, F. Stephen Hodi, Eliezer Van Allen, Dirk Schadendorf, David Liu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 965.
https://doi.org/10.1158/1538-7445.AM2023-965
Published: 04 April 2023
View article titled, Abstract 965: Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma
Journal Articles

Abstract 3514: A genetic-metabolic circuit of liver-specific metastatic organotropism

Meri Rogava, Tyler Joseph Aprati, Wei-Yu Chen, Johannes Melms, Clemens Hug, Amit Dipak Amin, Bryan Ngo, Michae l Lee, Patricia Ho, Yiping Wang, Stephen Tang, Ethan Earlie, Sean Chen, Thomas Tüting, Martin Röcken, Thomas K. Eigentler, Samuel F. Bakhoum, Andrei Molotkov, Akiva Mintz, Dirk Schadendorf, Lewis C. Cantley, Peter K. Sorger, Ashley Laughney, David Liu, Benjamin Izar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3514.
https://doi.org/10.1158/1538-7445.AM2023-3514
Published: 04 April 2023
View article titled, Abstract 3514: A genetic-metabolic circuit of liver-specific metastatic organotropism
Journal Articles

Abstract 6403: Molecular correlates of clinical benefit from circulating tumor DNA (ctDNA): Analysis of the COLUMBUS study

Reinhard Dummer, Nuzhat Pathan, Zhou Zhu, Caroline Robert, Ana Arance, Jan Willem B. de Groot, Claus Garbe, Helen J. Gogas, Ralf Gutzmer, Ivana Krajsová, Gabriella Liszkay, Carmen Loquai, Mario Mandala, Dirk Schadendorf, Naoya Yamazaki, Michelle Edwards, Jean Cantey-Kiser, Alessandra di Pietro, Shibing Deng, Paolo A. Ascierto, Keith Flaherty
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6403.
https://doi.org/10.1158/1538-7445.AM2022-6403
Published: 15 June 2022
View article titled, Abstract 6403: Molecular correlates of clinical benefit from circulating tumor DNA (ctDNA): Analysis of the COLUMBUS study
Journal Articles

Abstract CT197: Phase Ib study of LXH254 + trametinib (TMT) in patients (pts) with NRAS-mutant melanoma

Filippo de Braud, Christophe Dooms, Rebecca S. Heist, Celeste Lebbe, Martin Wermke, David Planchard, Dirk Schadendorf, Piotr Rutkowski, Jürgen Wolf, Paolo A. Ascierto, Ignacio Gil-Bazo, Shumei Kato, Maria Wolodarski, Meredith McKean, Eva Muñoz Couselo, Martin Sebastian, Armando Santoro, Vesselina Cooke, Luca Manganelli, Kitty Wan, Anil Gaur, Tanay S. Samant, Jaeyeon Kim, Giordano Caponigro, Xuân-Mai Couillebault, Michele Moschetta, Adil Daud
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT197.
https://doi.org/10.1158/1538-7445.AM2022-CT197
Published: 15 June 2022
View article titled, Abstract CT197: Phase Ib study of LXH254 + trametinib (TMT) in patients (pts) with <em>NRAS</em>-mutant melanoma
Journal Articles

Abstract 2487: Distinct venous brain vessels provide structures for T lymphocyte recruitment to brain tumors in mouse models of intracranial melanoma

Julia M. Messmer, Manuel Piechutta, Varun Venkataramani, Chanté Mayer, Anna S. Berghoff, Daniel Hinze, Michael Hölzel, Iris Helfrich, Dirk Schadendorf, Wolfgang Wick, Matthia A. Karreman, Frank Winkler
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2487.
https://doi.org/10.1158/1538-7445.AM2022-2487
Published: 15 June 2022
View article titled, Abstract 2487: Distinct venous brain vessels provide structures for T lymphocyte recruitment to brain tumors in mouse models of intracranial melanoma
Journal Articles

Abstract CT004: Adjuvant therapy with nivolumab (NIVO) combined with ipilimumab (IPI) vs NIVO alone in patients (pts) with resected stage IIIB-D/IV melanoma (CheckMate 915)

Georgina V. Long, Dirk Schadendorf, Michele Del Vecchio, James Larkin, Victoria Atkinson, Michael Schenker, Jacopo Pigozzo, Helen J. Gogas, Stéphane Dalle, Nicolas Meyer, Paolo A. Ascierto, Shahneen Sandhu, Thomas Eigentler, Ralf Gutzmer, Jessica C. Hassel, Caroline Robert, Matteo Carlino, Anna Maria Di Giacomo, Marcus O. Butler, Eva Muñoz-Couselo, Michael P. Brown, Piotr Rutkowski, Andrew Haydon, Jean-Jacques Grob, Jacob Schachter, Paola Queirolo, Alexander Menzies, Sandra Re, Tuba O. Bas, Veerle de Pril, Daniel Tenney, Hao Tang, Jeffrey S. Weber
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT004.
https://doi.org/10.1158/1538-7445.AM2021-CT004
Published: 01 July 2021
View article titled, Abstract CT004: Adjuvant therapy with nivolumab (NIVO) combined with ipilimumab (IPI) vs NIVO alone in patients (pts) with resected stage IIIB-D/IV melanoma (CheckMate 915)
Journal Articles

Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation–Induced DNA Damage and Melanoma Susceptibility

David de Semir, Vladimir Bezrookove, Mehdi Nosrati, Altaf A. Dar, James R. Miller, III, Stanley P. Leong, Kevin B. Kim, Wilson Liao, Liliana Soroceanu, Sean McAllister, Robert J. Debs, Dirk Schadendorf, Sancy A. Leachman, James E. Cleaver, Mohammed Kashani-Sabet
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2956–2969.
https://doi.org/10.1158/0008-5472.CAN-20-3450
Published: 01 June 2021
View article titled, Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation–Induced DNA Damage and Melanoma Susceptibility
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Includes: Supplementary data
Journal Articles

Abstract PR01: A cancer cell program promotes T-cell exclusion and resistance to checkpoint blockade

Parin Shah, Michael Cuoco, Mei-Ju Su, Johannes Melms, Rachel Leeson, Abhay Kanodia, Shaolin Mei, Jia-Ren Lin, Shu Wang, Bokang Rabasha, David Liu, Alex K. Shalek, Itay Tirosh, Peter K. Sorger, Kai Wucherpfennig, Eliezer M. Van Allen, Dirk Schadendorf, Bruce E. Johnson, Asaf Rotem, Orit Rozenblatt-Rosen, Levi A. Garraway, Charles H. Yoon, Benjamin Izar, Aviv Regev, Livnat Jerby-Arnon
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): PR01.
https://doi.org/10.1158/1538-7445.MEL2019-PR01
Published: 02 October 2020
View article titled, Abstract PR01: A cancer cell program promotes T-cell exclusion and resistance to checkpoint blockade
Journal Articles

Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity

Johannes C. Melms, Sreeram Vallabhaneni, Caitlin E. Mills, Clarence Yapp, Jia-Yun Chen, Eugenio Morelli, Patricia Waszyk, Sushil Kumar, Derrick Deming, Nienke Moret, Steven Rodriguez, Kartik Subramanian, Meri Rogava, Adam N.R. Cartwright, Adrienne Luoma, Shaolin Mei, Titus J. Brinker, David M. Miller, Alexander Spektor, Dirk Schadendorf, Nicolo Riggi, Kai W. Wucherpfennig, Peter K. Sorger, Benjamin Izar
Journal: Cancer Research
Cancer Res (2020) 80 (4): 798–810.
https://doi.org/10.1158/0008-5472.CAN-19-2330
Published: 14 February 2020
View article titled, Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract CT037: Genomic analyses and immunotherapy in advanced melanoma

F. Stephen Hodi, Jedd D. Wolchok, Dirk Schadendorf, James Larkin, Max Qian, Abdel Saci, Tina C. Young, Sujaya Srinivasan, Han Chang, Megan Wind-Rotolo, Jasmine I. Rizzo, Donald G. Jackson, Paolo A. Ascierto
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT037.
https://doi.org/10.1158/1538-7445.AM2019-CT037
Published: 01 July 2019
View article titled, Abstract CT037: Genomic analyses and immunotherapy in advanced melanoma
Journal Articles

Abstract SY45-04: Development of therapeutic strategies by resolving the tumor ecosystem

Benjamin Izar, Livnat Jerby-Arnon, Itay Tirosh, Parin Shah, Michael C. Cuoco, Christopher Rodman, Mei-Ju Su, Johannes C. Melms, Rachel Leeson, Abhay Kanodia, Jia-Ren Lin, Genevieve M. Boland, Gao Zhang, F. Stephen Hodi, Peter K. Sorger, Kai W. Wucherpfennig, Eli M. Van Allen, Dirk Schadendorf, Orit Rozenblatt-Rosen, Levi A. Garraway, Asaf Rotem, Charles H. Yoon, Aviv Regev
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): SY45-04.
https://doi.org/10.1158/1538-7445.AM2019-SY45-04
Published: 01 July 2019
View article titled, Abstract SY45-04: Development of therapeutic strategies by resolving the tumor ecosystem
Journal Articles

Abstract CT120: A randomized, open-label, open-platform, Phase II study evaluating the efficacy and safety of novel spartalizumab (PDR001) combinations in previously treated unresectable or metastatic melanoma (PLATforM)

Caroline Robert, Reinhard Dummer, Ana Arance, Antoni Ribas, Jeffrey Weber, Georgina V. Long, John Haanen, Paul Nathan, Paolo A. Ascierto, Eduard Gasal, Anthony D'Amelio, Severine Bettinger, Aislyn D. Boran, Dirk Schadendorf
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT120.
https://doi.org/10.1158/1538-7445.AM2019-CT120
Published: 01 July 2019
View article titled, Abstract CT120: A randomized, open-label, open-platform, Phase II study evaluating the efficacy and safety of novel spartalizumab (PDR001) combinations in previously treated unresectable or metastatic melanoma (PLATforM)
Journal Articles

HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy

Michael F. Emmons, Fernanda Faião-Flores, Ritin Sharma, Ram Thapa, Jane L. Messina, Jurgen C. Becker, Dirk Schadendorf, Edward Seto, Vernon K. Sondak, John M. Koomen, Yian A. Chen, Eric K. Lau, Lixin Wan, Jonathan D. Licht, Keiran S.M. Smalley
Journal: Cancer Research
Cancer Res (2019) 79 (11): 2947–2961.
https://doi.org/10.1158/0008-5472.CAN-19-0040
Published: 03 June 2019
View article titled, HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy
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Includes: Supplementary data
Journal Articles

Abstract CT182: The anti-PD-1 antibody spartalizumab (PDR001) in combination with dabrafenib and trametinib in previously untreated patients with advanced BRAF V600-mutant melanoma: First efficacy, safety, and biomarker findings from the part 2 biomarker cohort of COMBi-i

Reinhard Dummer, Dirk Schadendorf, Paul Nathan, Hussein Tawbi, Caroline Robert, Paolo A. Ascierto, Antoni Ribas, Celeste Lebbé, Mario Mandala, Naoya Yamazaki, Erika Richtig, Wilson H. Miller, Eduard Gasal, Mathilde Kaper, Jan C. Brase, Bijoyesh Mookerjee, Georgina V. Long
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT182.
https://doi.org/10.1158/1538-7445.AM2018-CT182
Published: 01 July 2018
View article titled, Abstract CT182: The anti-PD-1 antibody spartalizumab (PDR001) in combination with dabrafenib and trametinib in previously untreated patients with advanced <em>BRAF</em> V600-mutant melanoma: First efficacy, safety, and biomarker findings from the part 2 biomarker cohort of COMBi-i
Journal Articles

Abstract CT001: Pembrolizumab versus placebo after complete resection of high-risk stage III melanoma: Efficacy and safety results from the EORTC 1325-MG/Keynote 054 double-blinded phase III trial

Alexander M. Eggermont, Christian U. Blank, Mario Mandala, Georgina V. Long, Victoria Atkinson, Stéphane Dalle, Andrew Haydon, Mikhail Lichinitser, Adnan Khattak, Matteo S. Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Rutger Koornstra, Leonel Hernandez-Aya, Michele Maio, Alfonsus J. van den Eertwegh, Jean-Jacques Grob, Ralf Gutzmer, Rahima Jamal, Veronica Rivas, Nageatte Ibrahim, Sandrine Marreaud, Sven Janssen, Alexander van Akkooi, Stefan Suciu, Caroline Robert
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT001.
https://doi.org/10.1158/1538-7445.AM2018-CT001
Published: 01 July 2018
View article titled, Abstract CT001: Pembrolizumab versus placebo after complete resection of high-risk stage III melanoma: Efficacy and safety results from the EORTC 1325-MG/Keynote 054 double-blinded phase III trial
Journal Articles

MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy

Julia Reinhardt, Jennifer Landsberg, Jonathan L. Schmid-Burgk, Bartomeu Bibiloni Ramis, Tobias Bald, Nicole Glodde, Dorys Lopez-Ramos, Arabella Young, Shin Foong Ngiow, Daniel Nettersheim, Hubert Schorle, Thomas Quast, Waldemar Kolanus, Dirk Schadendorf, Georgina V. Long, Jason Madore, Richard A. Scolyer, Antoni Ribas, Mark J. Smyth, Paul C. Tumeh, Thomas Tüting, Michael Hölzel
Journal: Cancer Research
Cancer Res (2017) 77 (17): 4697–4709.
https://doi.org/10.1158/0008-5472.CAN-17-0395
Published: 31 August 2017
View article titled, MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Open the PDF for MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy in another window
Includes: Supplementary data