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Diether Lambrechts
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Journal Articles

Abstract 4122: TIL-containing patient-derived explant cultures reveal role of metformin on antigen presenting cell activation

Rita J. Turpin, Ruixian Liu, Pauliina Munne, Aino Peura, Jenna Rannikko, Gino Philips, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova, Minna Mutka, Tuomo Meretoja, Johanna Mattson, Satu Mustjoki, Päivi Saavalainen, Diether Lambrechts, Jeroen Pouwels, Maija Hollmén, Juha Klefström
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4122.
https://doi.org/10.1158/1538-7445.AM2023-4122
Published: 04 April 2023
View article titled, Abstract 4122: TIL-containing patient-derived explant cultures reveal role of metformin on antigen presenting cell activation
Journal Articles

Abstract 5785: A pan-cancer single-cell tumor micro-environment atlas predictive of immunotherapy response

Francesca Lodi, Sam Vanmassenhove, Elena Donders, Pierre Van Mol, Amelie Franken, Sarah Cappuyns, Ayse Bassez, Siel Olbrecht, Liselore Loverix, Michel Bila, Hanne Vos, Joanna Pozniak, Kevin Punie, Diether Lambrechts
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5785.
https://doi.org/10.1158/1538-7445.AM2023-5785
Published: 04 April 2023
View article titled, Abstract 5785: A pan-cancer single-cell tumor micro-environment atlas predictive of immunotherapy response
Journal Articles

Abstract 5584: Analysis of cell free DNA to predict outcome to Bevacizumab combination therapy in metastatic colorectal cancer patients

Ian S. Miller, Valentina Thomas, Tom Venken, Ingrid Arijs, Ana Barat, Johannes Betge, Tianzuo Zhan, Timo Gaiser, Matthias P. Ebert, Jochen Prehn, Rut Klinger, Darran P. O’Connor, Brian Brian Moulton, Verena Murphy, Ray McDermott, Brian Bird, Gregory Leonard, Liam Grogan, Anne Horgan, Nadine Schulte, Markus Moehler, Nicole Prannikar, Judith Franz-Werner, Hans-Peter Feustel, Diether Lambrechts, Annette T. Byrne
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5584.
https://doi.org/10.1158/1538-7445.AM2023-5584
Published: 04 April 2023
View article titled, Abstract 5584: Analysis of cell free DNA to predict outcome to Bevacizumab combination therapy in metastatic colorectal cancer patients
Journal Articles

Abstract OT2-19-01: Single cell characterization of longitudinal biopsies from breast cancer patients treated neoadjuvantly with the aromatase inhibitor letrozole and the CDK4/6 inhibitor ribociclib in concert

Marie Fongård, Chloé Steen, Salim Ghannoum, Marius Bjørnstad, Barbro Holm, Tatjana Bosnjak, Laurens Reitsma, Stephanie Geisler, Kamilla Fjermeros, Johannes Bruteig, Manouchehr Seyedzadeh, Unn-Cathrin Buvarp, Marie Loeng, Aino Vuoriluoto, Torben Lüders, Diether Lambrechts, Marianne Lyngra, Vessela Kristensen, Jürgen Geisler, Xavier Tekpli
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): OT2-19-01.
https://doi.org/10.1158/1538-7445.SABCS22-OT2-19-01
Published: 01 March 2023
View article titled, Abstract OT2-19-01: Single cell characterization of longitudinal biopsies from breast cancer patients treated neoadjuvantly with the aromatase inhibitor letrozole and the CDK4/6 inhibitor ribociclib in concert
Journal Articles

Abstract PD10-10: PD10-10 Single cell characterization of longitudinal biopsies from breast cancer patients treated with the aromatase inhibitors letrozole and exemestane in sequence

Salim Ghannoum, Chloé Steen, Marie Fongård, Marius Bjørnstad, Laurens Reitsma, Stephanie Geisler, Manouchehr Seyedzadeh, Unn-Cathrin Buvarp, Marie Loeng, Torben Lüders, Diether Lambrechts, Marianne Lyngra, Vessela Kristensen, Jürgen Geisler, Xavier Tekpli
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD10-10.
https://doi.org/10.1158/1538-7445.SABCS22-PD10-10
Published: 01 March 2023
View article titled, Abstract PD10-10: PD10-10 Single cell characterization of longitudinal biopsies from breast cancer patients treated with the aromatase inhibitors letrozole and exemestane in sequence
Journal Articles

Abstract PD4-06: PD4-06 Obesity-associated changes in transcriptomic profile and immune landscape of primary breast cancer revealed by bulk and single-cell gene expression data

Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Karen Van Baelen, Maxim De Schepper, Coralie Poncet, Mauro Delorenzi, Marjanka K. Schmid, Emiel Rutgers, Laura Van ’t Veer, Martine Piccart, Fatima Cardoso, Giuseppe Viale, Ayse Bassez, Hanne Vos, Patrick Neven, Ines Nevelsteen, Kevin Punie, Hans Wildiers, Giuseppe Floris, Diether Lambrechts, Ann Smeets, Elia Biganzoli, François Richard, Christine Desmedt
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD4-06.
https://doi.org/10.1158/1538-7445.SABCS22-PD4-06
Published: 01 March 2023
View article titled, Abstract PD4-06: PD4-06 Obesity-associated changes in transcriptomic profile and immune landscape of primary breast cancer revealed by bulk and single-cell gene expression data
Journal Articles

Abstract P5-05-06: ctDNA detection in seven different types of body liquids in patients with metastatic breast cancer

François Richard, Tatjana Geukens, Maxim De Schepper, Amena Mahdami, Karen Van Baelen, Marion Maetens, Ha-Linh Nguyen, Anirudh Pabba, Sophia Leduc, Edoardo Isnaldi, Maysam Hajipirloo, Emily Vanden Berghe, Imane Bachir, Sigrid Hatse, Peter Vermeulen, Evy Vanderheyden, Bram Boeckx, Diether Lambrechts, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, Wouter Van Den Bogaert, Elia Biganzoli, Giuseppe Floris, Christine Desmedt
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P5-05-06.
https://doi.org/10.1158/1538-7445.SABCS22-P5-05-06
Published: 01 March 2023
View article titled, Abstract P5-05-06: ctDNA detection in seven different types of body liquids in patients with metastatic breast cancer
Journal Articles

Abstract P6-14-12: Evaluation of changes in sequencing quality and transcriptomic profiles with increasing post-mortem interval: results from an optimization experiment within the UPTIDER tissue donation program

François Richard, Tatjana Geukens, Giuseppe Marano, Wouter Van Den Bogaert, Maxim De Schepper, Marion Maetens, Amena Mahdami, Karen Van Baelen, Ha-Linh Nguyen, Anirudh Pabba, Sophia Leduc, Edoardo Isnaldi, Maysam Hajipirloo, Imane Bachir, Evy Vanderheyden, Bram Boeckx, Diether Lambrechts, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, Elia Biganzoli, Giuseppe Floris, Christine Desmedt
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-14-12.
https://doi.org/10.1158/1538-7445.SABCS22-P6-14-12
Published: 01 March 2023
View article titled, Abstract P6-14-12: Evaluation of changes in sequencing quality and transcriptomic profiles with increasing post-mortem interval: results from an optimization experiment within the UPTIDER tissue donation program
Journal Articles

Abstract PD14-05: Portraying tumor evolution of lobular breast cancer through phylogenetic analysis

Danai Fimereli, David Venet, Mattia Rediti, David N Brown, Bram Boeckx, Marion Maetens, Samira Majjaj, Ghizlane Rouas, Maria Capra, Giuseppina Bonizzi, Federica Contaldo, Christine Galant, Martine Piccart, Giancarlo Pruneri, Denis Larsimont, Diether Lambrechts, Christine Desmedt, Françoise Rothé, Christos Sotiriou
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD14-05.
https://doi.org/10.1158/1538-7445.SABCS21-PD14-05
Published: 15 February 2022
View article titled, Abstract PD14-05: Portraying tumor evolution of lobular breast cancer through phylogenetic analysis
Journal Articles

Abstract P2-08-23: Early intratumoral changes after a single dose of anti-PD-1 treatment in patients with early breast cancer (BC)

Hanne Vos, Kathleen Lambein, François Richard, Ines Nevelsteen, Ayse Bassez, Diether Lambrechts, Kevin Punie, Hans Wildiers, Giuseppe Floris, Christine Desmedt, Ann Smeets
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-08-23.
https://doi.org/10.1158/1538-7445.SABCS21-P2-08-23
Published: 15 February 2022
View article titled, Abstract P2-08-23: Early intratumoral changes after a single dose of anti-PD-1 treatment in patients with early breast cancer (BC)
Journal Articles

Abstract 1202: ERG344: A novel IRG1 inhibitor for the treatment of colon cancer

Adonia E. Papathanassiu, Francesca Lodi, Hong A. Vu, Diether Lambrechts
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2021-1202
Published: 01 July 2021
View article titled, Abstract 1202: ERG344: A novel IRG1 inhibitor for the treatment of colon cancer
Journal Articles

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G.P. Grünewald, Adrian Liston, Chantal Mathieu, Christophe M. Deroose, Johannes V. Swinnen, Diether Lambrechts, Diego di Bernardo, Shinya Kuroda, Katrien De Bock, Sarah-Maria Fendt
Journal: Cancer Research
Cancer Res (2021) 81 (8): 1988–2001.
https://doi.org/10.1158/0008-5472.CAN-20-1954
Published: 15 April 2021
View article titled, Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis
Open the PDF for Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts

Jessica Giordano, Xing Yi Woo, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C. O'Farrell, Elodie Modave, Diether Lambrechts, Petra ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Bingliang Fang, Jack Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Jeffrey A. Moscow, Carol J. Bult, Claudio Isella, Livio Trusolino, Annette T. Byrne, Jos Jonkers, Jeffrey H. Chuang, Enzo Medico, EurOPDX consortium & PDXNET consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1118.
https://doi.org/10.1158/1538-7445.AM2020-1118
Published: 15 August 2020
View article titled, Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts
Journal Articles

Abstract 794: Molecular analysis of archival inflammatory myofibroblastic tumor tissue samples from EORTC 90101 “CREATE” and correlation with response to crizotinib

Che-Jui Lee, Patrick Schöffski, Elodie Modave, Bram Boeckx, Diether Lambrechts, Maria Debiec-Rychter, Raf Sciot, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Agnieszka Wozniak
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 794.
https://doi.org/10.1158/1538-7445.AM2020-794
Published: 15 August 2020
View article titled, Abstract 794: Molecular analysis of archival inflammatory myofibroblastic tumor tissue samples from EORTC 90101 “CREATE” and correlation with response to crizotinib
Journal Articles

Abstract 3402: BCAT1 as a druggable target in immuno-oncology

Adonia E. Papathanassiu, Francesca Lodi, Hagar Elkafrawy, Michelangelo Certo, Hong Vu, Jeong Hun Ko, Jacques Behmoaras, Claudio Mauro, Diether Lambrechts
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3402.
https://doi.org/10.1158/1538-7445.AM2020-3402
Published: 15 August 2020
View article titled, Abstract 3402: BCAT1 as a druggable target in immuno-oncology
Journal Articles

Abstract 4280: Potential molecular biomarkers of response to eribulin in patients with leiomyosarcoma

Agnieszka Wozniak, Bram Boecks, Elodie Modave, Amy Weaver, Diether Lambrechts, Bruce A. Littlefield, Patrick Schöffski
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4280.
https://doi.org/10.1158/1538-7445.AM2020-4280
Published: 15 August 2020
View article titled, Abstract 4280: Potential molecular biomarkers of response to eribulin in patients with leiomyosarcoma
Journal Articles

Abstract PD8-02: Phylogenetic reconstruction of advanced breast cancer reveals two different routes of metastatic dissemination associated with distinct clinical outcome

David Venet, David Brown, Danai Fimereli, Bram Boeckx, Marion Maetens, Samira Majjaj, Ghizlane Rouas, Maria Capra, Giuseppina Bonizzi, Federica Contaldo, Christine Galant, Martine Piccart, Giancarlo Pruneri, Denis Larsimont, Diether Lambrechts, Françoise Rothé, Christine Desmedt, Christos Sotiriou
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD8-02.
https://doi.org/10.1158/1538-7445.SABCS19-PD8-02
Published: 15 February 2020
View article titled, Abstract PD8-02: Phylogenetic reconstruction of advanced breast cancer reveals two different routes of metastatic dissemination associated with distinct clinical outcome
Journal Articles

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao-Ou Shu, Qiuyin Cai, Alicia Beeghly-Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck, Hoda Anton-Culver, Susana Banerjee, Javier Benitez, Line Bjørge, James D. Brenton, Ralf Butzow, Ian G. Campbell, Jenny Chang-Claude, Kexin Chen, Linda S. Cook, Daniel W. Cramer, Anna deFazio, Joe Dennis, Jennifer A. Doherty, Thilo Dörk, Diana M. Eccles, Digna Velez Edwards, Peter A. Fasching, Renée T. Fortner, Simon A. Gayther, Graham G. Giles, Rosalind M. Glasspool, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Holly R. Harris, Florian Heitz, Michelle A. Hildebrandt, Estrid Høgdall, Claus K. Høgdall, David G. Huntsman, Siddhartha P. Kar, Beth Y. Karlan, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne K. Kjaer, Anita Koushik, Diether Lambrechts, Nhu D. Le, Douglas A. Levine, Leon F. Massuger, Keitaro Matsuo, Taymaa May, Iain A. McNeish, Usha Menon, Francesmary Modugno, Alvaro N. Monteiro, Patricia G. Moorman, Kirsten B. Moysich, Roberta B. Ness, Heli Nevanlinna, Håkan Olsson, N. Charlotte Onland-Moret, Sue K. Park, James Paul, Celeste L. Pearce, Tanja Pejovic, Catherine M. Phelan, Malcolm C. Pike, Susan J. Ramus, Elio Riboli, Cristina Rodriguez-Antona, Isabelle Romieu, Dale P. Sandler, Joellen M. Schildkraut, Veronica W. Setiawan, Kang Shan, Nadeem Siddiqui, Weiva Sieh, Meir J. Stampfer, Rebecca Sutphen, Anthony J. Swerdlow, Lukasz M. Szafron, Soo Hwang Teo, Shelley S. Tworoger, Jonathan P. Tyrer, Penelope M. Webb, Nicolas Wentzensen, Emily White, Walter C. Willett, Alicja Wolk, Yin Ling Woo, Anna H. Wu, Li Yan, Drakoulis Yannoukakos, Georgia Chenevix-Trench, Thomas A. Sellers, Paul D.P. Pharoah, Wei Zheng, Jirong Long
Journal: Cancer Research
Cancer Res (2019) 79 (3): 505–517.
https://doi.org/10.1158/0008-5472.CAN-18-2726
Published: 01 February 2019
View article titled, Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk
Open the PDF for Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk in another window
Includes: Supplementary data
Journal Articles

Abstract 230: Joint genome-wide association study of endometrial cancer and ovarian cancer identifies a novel genetic risk region at 14q23.3

Tracy A. O'Mara, Dylan M. Glubb, Daniel D. Buchanan, Diether Lambrechts, Per Hall, Emma Tham, Jone Trovik, Ellen L. Goode, Peter Fasching, Thilo Dörk, Rodney J. Scott, Paul L. Auer, Roger L. Milne, Graham G. Giles, John Perry, Immaculata de Vivo, Ian Tomlinson, Douglas F. Easton, Deborah J. Thompson, Amanda B. Spurdle, E2C2, BCAC, OCAC, ECAC
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 230.
https://doi.org/10.1158/1538-7445.AM2018-230
Published: 01 July 2018
View article titled, Abstract 230: Joint genome-wide association study of endometrial cancer and ovarian cancer identifies a novel genetic risk region at 14q23.3
Journal Articles

Abstract 2579: Loss of chromosome 18q11.2-18q12.1 is predictive for progression-free survival in metastatic colorectal cancer patients treated with bevacizumab

Erik van Dijk, Hedde Biesma, Martijn Cordes, Dominiek Smeets, Maarten Neerincx, Sudipto Das, Verena Murphy, Anna Barat, Orna Bacon, Jochen H.M. Prehn, Johannes Betge, Gaiser Timo, Bozena Fender, Gerrit A. Meijer, Deborah A. McNamara, Rut Klinger, Miriam Koopman, Matthias P.A. Ebert, Elaina W. Kay, Bryan T. Hennessey, Henk M.W. Verheul, William M. Gallagher, Darran P. O'Connor, Cornelis J.A. Punt, Fotios Loupakis, Diether Lambrechts, Annette Byrne, Nicole C.T. van Grieken, Bauke Ylstra
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2579.
https://doi.org/10.1158/1538-7445.AM2018-2579
Published: 01 July 2018
View article titled, Abstract 2579: Loss of chromosome 18q11.2-18q12.1 is predictive for progression-free survival in metastatic colorectal cancer patients treated with bevacizumab