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Diane Simeone
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Journal Articles

Abstract PR012: Perioperative liver biopsy captures features of the liver pre-metastatic niche and predicts metastatic outcome after pancreatic cancer resection

Linda Bojmar, Constantinos P. Zambirinis, Jonathan Hernandez, Jayasree Chakraborty, Samer Hanna, Diane Simeone, David Kelsen, Haiying Zhang, Irina R Matei, Per Sandström, Robert Schwartz, William R. Jarnagin, David Lyden
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): PR012.
https://doi.org/10.1158/1538-7445.PANCA22-PR012
Published: 15 November 2022
View article titled, Abstract PR012: Perioperative liver biopsy captures features of the liver pre-metastatic niche and predicts metastatic outcome after pancreatic cancer resection
Journal Articles

Abstract P6-08-24: Family history of pancreatic cancer and the prevalence of pathogenic germline variants in a contemporary cohort of newly diagnosed breast cancers

Annie Wang, Jessica Everett, Jennifer Chun, Elianna Kaplowitz, Diane Simeone, Freya Schnabel
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-08-24.
https://doi.org/10.1158/1538-7445.SABCS19-P6-08-24
Published: 15 February 2020
View article titled, Abstract P6-08-24: Family history of pancreatic cancer and the prevalence of pathogenic germline variants in a contemporary cohort of newly diagnosed breast cancers
Journal Articles

Abstract B15: Therapeutic potential of targeting amino acid metabolism in pancreatic cancer

Martin Fernandez-Zapico, Dae Won Kim, Philip Philip, Alexander Vandell, Jonathan Eckard, Ron Korn, Giuseppe Del Priore, Diane Simeone
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B15.
https://doi.org/10.1158/1538-7445.PANCA19-B15
Published: 13 December 2019
View article titled, Abstract B15: Therapeutic potential of targeting amino acid metabolism in pancreatic cancer
Journal Articles

Abstract A10: Biomarker independant microfluidic Labyrinth for the high throughput enrichment and characterization of circulating tumor cells in pancreatic cancer

Lianette Rivera-Baez, Eric Lin, Meghna Waghray, Shamileh Fouladdel, Ebrahim Azizi, Max Wicha, Vaibhav Sahai, Diane Simeone, Sunitha Nagrath
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A10.
https://doi.org/10.1158/1538-7445.PANCA16-A10
Published: 14 December 2016
View article titled, Abstract A10: Biomarker independant microfluidic Labyrinth for the high throughput enrichment and characterization of circulating tumor cells in pancreatic cancer
Journal Articles

Abstract 3018: Cotargeting MEK and CDK4/6 to treat pancreatic adenocarcinoma

Joel D. Maust, Diane Simeone, Judith Sebolt-Leopold
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3018.
https://doi.org/10.1158/1538-7445.AM2016-3018
Published: 15 July 2016
View article titled, Abstract 3018: Cotargeting MEK and CDK4/6 to treat pancreatic adenocarcinoma
Journal Articles

Abstract 1572: Sensitive and robust targeted sequencing of pancreatic precancer and tumors using microfluidic single-molecule enrichment

Angelina I. Londoño-Joshi, Erica Pratt, Robert W. Cowan, Michael L. Samuels, Steve Kotsopoulos, Jeff Olson, Francis Long, Michelle A. Anderson, Diane Simeone, Andrew D. Rhim
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1572.
https://doi.org/10.1158/1538-7445.AM2015-1572
Published: 01 August 2015
View article titled, Abstract 1572: Sensitive and robust targeted sequencing of pancreatic precancer and tumors using microfluidic single-molecule enrichment
Journal Articles

Abstract 1594: Application of label-free microfluidic technologies for the enrichment, expansion and characterization of circulating tumor cells in pancreatic cancer

Lianette Rivera-Baez, Eric Lin, Hyeun Joong Yoon, Meghna Waghray, Shamileh Fouladdel, Ebrahim Azizi, Max Wicha, Diane Simeone, Sunitha Nagrath
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1594.
https://doi.org/10.1158/1538-7445.AM2015-1594
Published: 01 August 2015
View article titled, Abstract 1594: Application of label-free microfluidic technologies for the enrichment, expansion and characterization of circulating tumor cells in pancreatic cancer
Journal Articles

Abstract 1748: Usp9x as a novel therapeutic target in human pancreatic cancer

Anupama Pal, Marina Pasca Di Magliano, Diane Simeone, Luke Peterson, Harish Potu, Moshe Talpaz, Nicholas Donato
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1748.
https://doi.org/10.1158/1538-7445.AM2015-1748
Published: 01 August 2015
View article titled, Abstract 1748: Usp9x as a novel therapeutic target in human pancreatic cancer
Journal Articles

Abstract LB-061: Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism

Heather Schofield, Filip Bednar, Meredith Collins, Wei Yan, Yaqing Zhang, Nikhil Shyam, Jaime Eberle, Kenneth Olive, Nabeel Bardeesy, Daisuke Nakada, Diane Simeone, Sean Morrison, Marina Pasca di Magliano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-061.
https://doi.org/10.1158/1538-7445.AM2015-LB-061
Published: 01 August 2015
View article titled, Abstract LB-061: Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism
Journal Articles

Abstract LB-205: Myeloid cells are required to establish an immune-suppressive regulatory network in pancreatic cancer by activating the PD-1/PD-L1 checkpoint

YAQING ZHANG, ESHA MATHEW, FLOR MENDEZ, KEVIN FLANNAGAN, DIANE SIMEONE, MARINA PASCA DI MAGLIANO
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-205.
https://doi.org/10.1158/1538-7445.AM2015-LB-205
Published: 01 August 2015
View article titled, Abstract LB-205: Myeloid cells are required to establish an immune-suppressive regulatory network in pancreatic cancer by activating the PD-1/PD-L1 checkpoint
Journal Articles

Abstract PR03: Mesenchymal stem cells in pancreatic cancer possess unique properties in promoting tumor growth and metastasis

Meghna Waghray, Guan Grace, Malica Yalamanchili, Lidong Wang, Michele Dziubinski, Mina Zeinali, Sunitha Nagrath, Diane Simeone
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): PR03.
https://doi.org/10.1158/1538-7445.PANCA2014-PR03
Published: 30 June 2015
View article titled, Abstract PR03: Mesenchymal stem cells in pancreatic cancer possess unique properties in promoting tumor growth and metastasis
Journal Articles

Abstract 2866: Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma

Ru Chen, Sheng Pan, Anirban Maitra, Diane Simeone, David Dawson, Teresa Brentnall
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2866.
https://doi.org/10.1158/1538-7445.AM2014-2866
Published: 01 October 2014
View article titled, Abstract 2866: Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma
Journal Articles

Abstract 4434: Role of Deubiquitinase Usp9x in pancreatic cancers: Tumor promoter or tumor suppressor

Anupama Pal, Marina Pasca di Magliano, Moshe Talpaz, Michelle Dziubinski, Diane Simeone, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4434.
https://doi.org/10.1158/1538-7445.AM2014-4434
Published: 01 October 2014
View article titled, Abstract 4434: Role of Deubiquitinase Usp9x in pancreatic cancers: Tumor promoter or tumor suppressor
Journal Articles

Abstract 3477: Continuous isolation, labeling and collection of viable CTCs using an integrated microfluidic device

Rhonda M. Jack, Meggie MG Grafton, Robert A. Cieslak, Denise C. Jue, Cathy Griffith, Danika Rodrigues, Sunitha Nagrath, Diane Simeone
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3477.
https://doi.org/10.1158/1538-7445.AM2014-3477
Published: 01 October 2014
View article titled, Abstract 3477: Continuous isolation, labeling and collection of viable CTCs using an integrated microfluidic device
Journal Articles

Abstract A93: Radiation-induced phosphorylation of ATDC via ATM/MAPKAP kinase 2 signaling mediates radioresistance of pancreatic cancer cells.

Lidong Wang, Theodore Lawrence, Liang Xu, Chris Canman, Mats Ljungman, Diane Simeone, Huibin Yang, Phillip Palmbos, Gina Ney, Taylor Ann Detzler, Dawn Coleman, Mary Davis, Kevin Hicks, Corey M. Helchowski
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A93.
https://doi.org/10.1158/1538-7445.PANCA2012-A93
Published: 03 April 2014
View article titled, Abstract A93: Radiation-induced phosphorylation of ATDC via ATM/MAPKAP kinase 2 signaling mediates radioresistance of pancreatic cancer cells.
Journal Articles

Abstract A40: Cancer stem cells (CSC) and inhibition of hedgehog (Hh) pathway signaling in advanced pancreatic cancer: GDC-0449 in combination with gemcitabine (Gem).

Edward J. Kim, Gazala N. Khan, Kent Griffith, Joel Greenson, Naoko Takebe, Mark Zalupski, Diane Simeone
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A40.
https://doi.org/10.1158/1538-7445.PANCA2012-A40
Published: 03 April 2014
View article titled, Abstract A40: Cancer stem cells (CSC) and inhibition of hedgehog (Hh) pathway signaling in advanced pancreatic cancer: GDC-0449 in combination with gemcitabine (Gem).
Journal Articles

Abstract A17: Inhibiting polo-like kinases for the treatment of pancreatic cancer: Targeting kinase outliers for personalized therapy.

Iris Wei, Vishal Kothari, Sunita Shankar, Shanker Kalyana-Sundaram, Catherine Grasso, Dan Robinson, Xuhong Cao, Diane Simeone, Arul Chinnaiyan, Chandan Kumar-Sinha
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A17.
https://doi.org/10.1158/1538-7445.PANCA2012-A17
Published: 03 April 2014
View article titled, Abstract A17: Inhibiting polo-like kinases for the treatment of pancreatic cancer: Targeting kinase outliers for personalized therapy.
Journal Articles

Abstract 313: ATDC drives bladder cancer formation by promoting methylation of the PTEN promoter and inhibition of p53 function.

Phillip Palmbos, Lidong Wang, Huibin Yang, Taylor Detzler, Gina Ney, Justin Hart, Stephanie Daignault-Newton, L. Priya Kunju, Chandan Kumar-Sinha, Monica Liebert, Mats Ljungman, Diane Simeone
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 313.
https://doi.org/10.1158/1538-7445.AM2013-313
Published: 15 April 2013
View article titled, Abstract 313: ATDC drives bladder cancer formation by promoting methylation of the PTEN promoter and inhibition of p53 function.
Journal Articles

Abstract 4555: Protein and glycan biomarkers of malignant potential in pancreatic cyst fluid

Kevin Maupin, Bryan Curnutte, Zheng Cao, Katie Partyka, Mitch McDonald, Richard Kwon, Peter Allen, Randall Brand, Diane Simeone, Brian B. Haab
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4555.
https://doi.org/10.1158/1538-7445.AM2012-4555
Published: 15 April 2012
View article titled, Abstract 4555: Protein and glycan biomarkers of malignant potential in pancreatic cyst fluid
Journal Articles

Abstract 2216: Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers

Tingting Yue, Kevin Maupin, Katie Partyka, Lin Li, Michelle A. Anderson, Dean Brenner, Diane Simeone, Ziding Feng, Randall E. Brand, Brian B. Haab
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2216.
https://doi.org/10.1158/1538-7445.AM2011-2216
Published: 15 April 2011
View article titled, Abstract 2216: Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers