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Diane M. Simeone
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Journal Articles

Abstract B043: Dual epigenetic therapy combined with anti-PD1 rescues HMA-induced suppressive myeloid phenotype and reduces tumor growth in a PDAC model

Arturo Orlacchio, Stephen Muzyka, Catherine Do, Diane M. Simeone, Tamas Gonda
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B043.
https://doi.org/10.1158/1538-7445.PANCA2023-B043
Published: 16 January 2024
View articletitled, Abstract B043: Dual epigenetic therapy combined with anti-PD1 rescues HMA-induced suppressive myeloid phenotype and reduces tumor growth in a PDAC model
Journal Articles

Abstract B021: Clonal heterogeneity in human pancreatic adenocarcinoma and its contribution to therapeutic resistance

Despoina Kalfakakou, Emily A. Kawaler, Dylan Tamayo, Lidong Wang, Rosmel Hernandez, Amanda Ackermann, Xiaohong Jing, Cristina Hajdu, Cynthia Loomis, Adrianna Heguy, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B021.
https://doi.org/10.1158/1538-7445.PANCA2023-B021
Published: 16 January 2024
View articletitled, Abstract B021: Clonal heterogeneity in human pancreatic adenocarcinoma and its contribution to therapeutic resistance
Journal Articles

Abstract B057: An organoids-on-a-chip model to recapitulate and dissect the tumor microenvironment of PDAC

Lunan Liu, Diane M. Simeone, Weiqiang Chen
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B057.
https://doi.org/10.1158/1538-7445.PANCA2023-B057
Published: 16 January 2024
View articletitled, Abstract B057: An organoids-on-a-chip model to recapitulate and dissect the tumor microenvironment of PDAC
Journal Articles

Abstract PR005: Primary results of PanCAN-SR1, a phase 1b study evaluating Gemcitabine, nab-Paclitaxel, Canakinumab, and Spartalizumab to target IL-1β and PD-1 in metastatic pancreatic cancer with correlative tissue and blood biomarker analysis

Paul E. Oberstein, Osama Rahma, Nina Beri, Amy Stoll-D'Astice, Emily A. Kawaler, Igor Dolgalev, Gregor Werba, Victoire Cardo-Ruffino, Naïma Böllenrücher, Andressa Dias Costa, Saloney Nazeer, Matthew Squires, Jonathan Nowak, Dafna Bar-Sagi, Brian Wolpin, Diane M Simeone, Stephanie K Dougan
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): PR005.
https://doi.org/10.1158/1538-7445.PANCA22-PR005
Published: 15 November 2022
View articletitled, Abstract PR005: Primary results of PanCAN-SR1, a phase 1b study evaluating Gemcitabine, nab-Paclitaxel, Canakinumab, and Spartalizumab to target IL-1β and PD-1 in metastatic pancreatic cancer with correlative tissue and blood biomarker analysis
Journal Articles

Abstract PR010: Single-cell sequencing elucidates the effects of chemotherapy on cancer cell heterogeneity and the tumor microenvironment of human pancreatic adenocarcinoma

Daniel Weissinger, Emily A. Kawaler, Gregor Werba, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul E. Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): PR010.
https://doi.org/10.1158/1538-7445.PANCA22-PR010
Published: 15 November 2022
View articletitled, Abstract PR010: Single-cell sequencing elucidates the effects of chemotherapy on cancer cell heterogeneity and the tumor microenvironment of human pancreatic adenocarcinoma
Journal Articles

Abstract B065: Polymerase theta inhibition activates the cGAS-STING signaling pathway and elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma

Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel Hernandez, Amanda Ackermann, Despoina Kalfakakou, Emily A. Kawaler, Talia Golan, Theodore H. Welling, Agnel Sfeir, Diane M. Simeone
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B065.
https://doi.org/10.1158/1538-7445.PANCA22-B065
Published: 15 November 2022
View articletitled, Abstract B065: Polymerase theta inhibition activates the cGAS-STING signaling pathway and elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma
Journal Articles

Abstract C041: Hypomethylating therapy induces a potential immuno-suppressive myeloid phenotype by altering cancer cell cytokine secretion in PDAC

Arturo Orlacchio, Daniel Weissinger, Catherine Do, Benjamin Tycko, Diane M. Simeone, Tamas Gonda
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C041.
https://doi.org/10.1158/1538-7445.PANCA22-C041
Published: 15 November 2022
View articletitled, Abstract C041: Hypomethylating therapy induces a potential immuno-suppressive myeloid phenotype by altering cancer cell cytokine secretion in PDAC
Journal Articles

Abstract C028: The lung pro-thrombotic niche drives cancer-associated thromboembolism and metastasis via extracellular vesicle ITGB2

Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Linda Bojmar, Michele Cioffi, Pernille Lauritzen, Henrik Molina, Soeren Heissel, Henry B. Lengel, Xiaohong Jing, Haiying Zhang, Irina Matei, Eileen M. O'Reilly, William R. Jarnagin, David Jones, James B. Bussel, David Kelsen, Jacqueline F. Bromberg, Diane M. Simeone, David Lyden
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C028.
https://doi.org/10.1158/1538-7445.PANCA22-C028
Published: 15 November 2022
View articletitled, Abstract C028: The lung pro-thrombotic niche drives cancer-associated thromboembolism and metastasis via extracellular vesicle ITGB2
Journal Articles

Abstract 3138: The lung pro-thrombotic niche drives cancer-associated thromboembolism via exosomal ITGB2

Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Linda Bojmar, Michele Cioffi, Pernille Lauritzen, Henrik Molina, Soren Heissel, Harry B. Lengel, Xiaohong Jing, Haiying Zhang, Irina Matei, Eileen M. O'Reilly, William R. Jarnagin, David R. Jones, James B. Bussel, David Kelsen, Jacqueline F. Bromberg, Diane M. Simeone, David Lyden
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3138.
https://doi.org/10.1158/1538-7445.AM2022-3138
Published: 15 June 2022
View articletitled, Abstract 3138: The lung pro-thrombotic niche drives cancer-associated thromboembolism via exosomal ITGB2
Journal Articles

Abstract 5077: Proteomics analysis of extracellular vesicles from pancreatic cancer cells and cancer associated fibroblasts

Sharon Pan, Lisa A. Lai, Diane M. Simeone, David W. Dawson, Yuanqing Yan, Tatjana Crnogorac-Jurcevic, Ru Chen, Teresa A. Brentnall
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5077.
https://doi.org/10.1158/1538-7445.AM2022-5077
Published: 15 June 2022
View articletitled, Abstract 5077: Proteomics analysis of extracellular vesicles from pancreatic cancer cells and cancer associated fibroblasts
Journal Articles

Abstract PO-050: Precision Promise (PrP): An adaptive, multi-arm registration trial in metastatic pancreatic ductal adenocarcinoma (PDAC)

Vincent J. Picozzi, Anne-Marie Duliege, Anirban Maitra, Manuel Hidalgo, Andrew Eugene Hendifar, Gregory L. Beatty, Sudheer Doss Doss, Regina Deck, Lynn M. Matrisian, Julie Fleshman, Diane M. Simeone
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-050.
https://doi.org/10.1158/1538-7445.PANCA21-PO-050
Published: 15 November 2021
View articletitled, Abstract PO-050: Precision Promise (PrP): An adaptive, multi-arm registration trial in metastatic pancreatic ductal adenocarcinoma (PDAC)
Journal Articles

Abstract I14: Polymerase theta synthetic lethal interaction in homologous recombination-deficient pancreatic ductal adenocarcinoma

Annie Wang, Andrea Zamperone, Mohammad Sohail, Lidong Wang, Fiyinfolu Balogun, Jiufeng Li, Ende Zhao, Daniel Diolaiti, Agnel Sfeir, Diane M. Simeone
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): I14.
https://doi.org/10.1158/1538-7445.PANCA19-I14
Published: 13 December 2019
View articletitled, Abstract I14: Polymerase theta synthetic lethal interaction in homologous recombination-deficient pancreatic ductal adenocarcinoma
Journal Articles

Abstract 5579: Increased number of EMT-like CTCs relative to epithelial CTCs reveals signatures of poor outcomes in pancreatic cancer

Mina Zeinali, Vasudha Murlidhar, Shamileh Fouladdel, Mathias Hafner, Shimeng Shao, Lili Zhao, Heather Cameron, Armand Iii Bankhead, Jiaqi Shi, Kyle C. Cuneo, Vaibhav Sahai, Ebrahim Azizi, Max S. Wicha, Diane M. Simeone, Sunitha Nagrath
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5579.
https://doi.org/10.1158/1538-7445.AM2018-5579
Published: 01 July 2018
View articletitled, Abstract 5579: Increased number of EMT-like CTCs relative to epithelial CTCs reveals signatures of poor outcomes in pancreatic cancer
Journal Articles

Abstract IA21: Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immune-suppressive environment in pancreatic cancer

Yaqing Zhang, Esha Mathew, Ashley Velez-Delgado, Kristen B. Long, Dongjun Li, Flor M. Mendez, Kevin Flannagan, Andrew D. Rhim, Diane M. Simeone, Gregory L. Beatty, Marina Pasca di Magliano
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): IA21.
https://doi.org/10.1158/1538-7445.PANCA16-IA21
Published: 14 December 2016
View articletitled, Abstract IA21: Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immune-suppressive environment in pancreatic cancer
Journal Articles

Abstract A62: ATDC is required for KRAS-induced pancreatic tumorigenesis

Lidong Wang, Huibin Yang, Ethan V. Abel, Phillip L. Palmbos, Christophe Halbrook, Kenneth Takeuchi, Jiaqi Shi, Yaqing Zhang, Sumithra Urs, Meghna Waghray, Marina Pasca di Magliano, Andrew D. Rhim, Howard C. Crawford, Diane M. Simeone
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A62.
https://doi.org/10.1158/1538-7445.PANCA16-A62
Published: 14 December 2016
View articletitled, Abstract A62: ATDC is required for KRAS-induced pancreatic tumorigenesis
Journal Articles

Abstract A11: Assessment of family cancer history in a pancreatic cancer clinic: A pilot study of a web-based survey

Kara Anne Schradle, Heather Gail Cameron, Riya Kumar, Erika Koeppe, Elana Leflein, Cristina Moisa, Matthew Demerath, Elena Martinez Stoffel, Diane M. Simeone
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A11.
https://doi.org/10.1158/1538-7445.PANCA16-A11
Published: 14 December 2016
View articletitled, Abstract A11: Assessment of family cancer history in a pancreatic cancer clinic: A pilot study of a web-based survey
Journal Articles

Abstract 3307: Label-free high throughput microfluidic device for the isolation and single cell multiplex gene expression analysis of circulating tumor cells from breast cancer patients

Eric Lin, Lianette Rivera, Shamileh Fouladdel, Hyeun Joong Yoon, Stephanie Guthrie, Jacob Weiner, Yadwinder S. Deol, Evan Keller, Vaibhav Sahai, Diane M. Simeone, Monika L. Burness, Ebrahim Azizi, Max S. Wicha, Sunitha Nagrath
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3307.
https://doi.org/10.1158/1538-7445.AM2016-3307
Published: 15 July 2016
View articletitled, Abstract 3307: Label-free high throughput microfluidic device for the isolation and single cell multiplex gene expression analysis of circulating tumor cells from breast cancer patients
Journal Articles

Abstract CT035: A dose escalation trial of the WEE1 inhibitor AZD1775, gemcitabine, and concurrent radiation in locally advanced pancreatic cancer

Kyle C. Cuneo, Meredith Morgan, Matthew J. Schipper, Jonathan Maybaum, Mary U. Feng, Mahmoud Al-Hawary, Diane M. Simeone, Leah D. Olson, Vaibhav Sahai, Mark Zalupski, Theodore S. Lawrence
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT035.
https://doi.org/10.1158/1538-7445.AM2016-CT035
Published: 15 July 2016
View articletitled, Abstract CT035: A dose escalation trial of the WEE1 inhibitor AZD1775, gemcitabine, and concurrent radiation in locally advanced pancreatic cancer
Journal Articles

ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms

Phillip L. Palmbos, Lidong Wang, Huibin Yang, Yin Wang, Jacob Leflein, McKenzie L. Ahmet, John E. Wilkinson, Chandan Kumar-Sinha, Gina M. Ney, Scott A. Tomlins, Stephanie Daignault, Lakshmi. P. Kunju, Xue-Ru Wu, Yair Lotan, Monica Liebert, Mats E. Ljungman, Diane M. Simeone
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (23): 5155–5166.
https://doi.org/10.1158/0008-5472.CAN-15-0603
Published: 30 November 2015
View articletitled, ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms
Open the PDF for ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms in another window
Includes: Supplementary data
Journal Articles

Abstract 1595: Analysis of circulating epithelial and EMT-like CTCs in pancreatic cancer using a sensitive microfluidic CTC capture device

Mina Zeinali, Vasudha Murlidhar, Shamileh Fouladdel, Mathius Hafner, Shimeng Shao, Ebrahim Azizi, Max S. Wicha, Kyle Cuneo, Diane M. Simeone, Sunitha Nagrath
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1595.
https://doi.org/10.1158/1538-7445.AM2015-1595
Published: 01 August 2015
View articletitled, Abstract 1595: Analysis of circulating epithelial and EMT-like CTCs in pancreatic cancer using a sensitive microfluidic CTC capture device