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Deborah A. Altomare
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Journal Articles

Abstract 4503: Polyamine blockade therapy: A strategy to block immunosuppression in pancreatic cancer

Joseph A. Goode, Sai Preethi Nakkina, Manav Gandhi, Otto Phanstiel, Deborah A. Altomare
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4503.
https://doi.org/10.1158/1538-7445.AM2023-4503
Published: 04 April 2023
View article titled, Abstract 4503: Polyamine blockade therapy: A strategy to block immunosuppression in pancreatic cancer
Journal Articles

Abstract 2896: Combination of cytokines and PM21-particle stimulation results in robust expansion of memory-like Natural Killer cells with enhanced survival

Jeremiah L. Oyer, Tayler J. Croom-Perez, Liza D. Robles-Carrillo, Thomas A. Dieffenthaller, Md Faqrul Hasan, Sarah B. Gitto, Joanna M. Mucha, Deborah A. Altomare, Robert Y. Igarashi, Alicja J. Copik
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2896.
https://doi.org/10.1158/1538-7445.AM2023-2896
Published: 04 April 2023
View article titled, Abstract 2896: Combination of cytokines and PM21-particle stimulation results in robust expansion of memory-like Natural Killer cells with enhanced survival
Journal Articles

Abstract 3546: DFMO based improvement in survival of pancreatic cancer-bearing mice is associated with modulation of immune suppression in the tumor microenvironment

Sai Preethi Nakkina, Sarah B. Gitto, Jordan M. Beardsley, Veethika Pandey, Michael M. Rohr, Jignesh Parikh, Otto Phanstiel, Deborah A. Altomare
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3546.
https://doi.org/10.1158/1538-7445.AM2022-3546
Published: 15 June 2022
View article titled, Abstract 3546: DFMO based improvement in survival of pancreatic cancer-bearing mice is associated with modulation of immune suppression in the tumor microenvironment
Journal Articles

Abstract 235: Differential polyamine expression in human pancreatic cancer supports the use of polyamine blockade therapy to modulate the in vivo pancreatic tumor microenvironment

Sai Preethi Nakkina, Sarah B. Gitto, Veethika Pandey, Jignesh Parikh, Dirk Geerts, Carlo Maurer, Kenneth P. Olive, Otto Phanstiel, Deborah A. Altomare
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 235.
https://doi.org/10.1158/1538-7445.AM2022-235
Published: 15 June 2022
View article titled, Abstract 235: Differential polyamine expression in human pancreatic cancer supports the use of polyamine blockade therapy to modulate the <em>in vivo</em> pancreatic tumor microenvironment
Journal Articles

Abstract PO-120: Differential expression of polyamine pathways in human pancreatic tumor progression and effects of polyamine blockade therapy on the in vivo pancreatic tumor microenvironment

Sai Preethi Nakkina, Sarah B. Gitto, Veethika Pandey, Jignesh G. Parikh, Dirk Geerts, Kenneth P. Olive, Otto Phanstiel, Deborah A. Altomare, Carlo Maurer
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-120.
https://doi.org/10.1158/1538-7445.PANCA21-PO-120
Published: 15 November 2021
View article titled, Abstract PO-120: Differential expression of polyamine pathways in human pancreatic tumor progression and effects of polyamine blockade therapy on the <em>in vivo</em> pancreatic tumor microenvironment
Journal Articles

Abstract PO-119: DFMO mediated improvement in survival of an orthotopic model of pancreatic cancer is associated with modulating immune suppression in the tumor microenvironment

Sai Preethi Nakkina, Sarah B. Gitto, Veethika Pandey, Jordan M. Beardsley, Michael W. Rohr, Jignesh G. Parikh, Otto Phanstiel, Deborah A. Altomare
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-119.
https://doi.org/10.1158/1538-7445.PANCA21-PO-119
Published: 15 November 2021
View article titled, Abstract PO-119: DFMO mediated improvement in survival of an orthotopic model of pancreatic cancer is associated with modulating immune suppression in the tumor microenvironment
Journal Articles

Abstract A30: Chronic inflammation induces severe stromal damage and early pancreatic tumors in mice with activated Akt1 and KRas

Sarah B. Gitto, Kathryn A. Cline, Amr S. Khaled, Deborah A. Altomare
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A30.
https://doi.org/10.1158/1538-7445.PANCA16-A30
Published: 14 December 2016
View article titled, Abstract A30: Chronic inflammation induces severe stromal damage and early pancreatic tumors in mice with activated Akt1 and KRas
Journal Articles

Abstract B60: Targeting the polyamine addiction of pancreatic cancers: Combination therapies and biomarkers

Otto Phanstiel, IV, Meenu Madan, Arjun Patel, Kristen Skruber, Deborah A. Altomare
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B60.
https://doi.org/10.1158/1538-7445.PANCA16-B60
Published: 14 December 2016
View article titled, Abstract B60: Targeting the polyamine addiction of pancreatic cancers: Combination therapies and biomarkers
Journal Articles

Abstract 4312: Loss of Ink4a and Arf each contributes to increased susceptibility to asbestos-induced malignant mesothelioma development

Deborah A. Altomare, Craig W. Menges, Jinfei Xu, Jianming Pei, Lili Zhang, Ara Tadevosyan, Erin Neumann-Domer, Zemin Liu, Michele Carbone, Ilse Chudoba, Andres J. Klein-Szanto, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4312.
https://doi.org/10.1158/1538-7445.AM2011-4312
Published: 15 April 2011
View article titled, Abstract 4312: Loss of Ink4a and Arf each contributes to increased susceptibility to asbestos-induced malignant mesothelioma development
Journal Articles

A Novel Recurrent Chromosomal Inversion Implicates the Homeobox Gene Dlx5 in T-Cell Lymphomas from Lck-Akt2 Transgenic Mice

Yinfei Tan, Roman A. Timakhov, Mamta Rao, Deborah A. Altomare, Jinfei Xu, Zemin Liu, Qingshen Gao, Suresh C. Jhanwar, Antonio Di Cristofano, David L. Wiest, Janice E. Knepper, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2008) 68 (5): 1296–1302.
https://doi.org/10.1158/0008-5472.CAN-07-3218
Published: 03 March 2008
View article titled, A Novel Recurrent Chromosomal Inversion Implicates the Homeobox Gene <em>Dlx5</em> in T-Cell Lymphomas from Lck-Akt2 Transgenic Mice
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Includes: Supplementary data
Journal Articles

RAD001 (Everolimus) Delays Tumor Onset and Progression in a Transgenic Mouse Model of Ovarian Cancer

Seiji Mabuchi, Deborah A. Altomare, Denise C. Connolly, Andres Klein-Szanto, Samuel Litwin, Matthew K. Hoelzle, Harvey H. Hensley, Thomas C. Hamilton, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2408–2413.
https://doi.org/10.1158/0008-5472.CAN-06-4490
Published: 15 March 2007
View article titled, RAD001 (Everolimus) Delays Tumor Onset and Progression in a Transgenic Mouse Model of Ovarian Cancer
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Includes: Supplementary data
Journal Articles

A Mouse Model Recapitulating Molecular Features of Human Mesothelioma

Deborah A. Altomare, Charles A. Vaslet, Kristine L. Skele, Assunta De Rienzo, Karthik Devarajan, Suresh C. Jhanwar, Andrea I. McClatchey, Agnes B. Kane, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2005) 65 (18): 8090–8095.
https://doi.org/10.1158/0008-5472.CAN-05-2312
Published: 15 September 2005
View article titled, A Mouse Model Recapitulating Molecular Features of Human Mesothelioma
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Journal Articles

SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure

Paola Cacciotti, Dario Barbone, Camillo Porta, Deborah A. Altomare, Joseph R. Testa, Luciano Mutti, Giovanni Gaudino
Journal: Cancer Research
Cancer Res (2005) 65 (12): 5256–5262.
https://doi.org/10.1158/0008-5472.CAN-05-0127
Published: 15 June 2005
View article titled, SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure
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Journal Articles

Antitumor efficacy of rapamycin derivertive RAD001 in human ovarian cancer

Seiji Mabuchi, Deborah A. Altomare, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1405.
Published: 01 May 2005
View article titled, Antitumor efficacy of rapamycin derivertive RAD001 in human ovarian cancer
Journal Articles

Identification of mutations in the NF2 gene in malignant melanoma

Robin H. Edwards, Deborah A. Altomare, Cynthia S. Spittle, Mackenzie L. Devos, M. Renee Ward, Stuart R. Lessin, Barbara L. Weber, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 670.
Published: 01 May 2005
View article titled, Identification of mutations in the <em>NF2</em> gene in malignant melanoma
Journal Articles

Anti-tumor effects of fatty acid synthase inhibitor C75 on orthotopically-implanted human pancreatic ductal adenocarcinoma in nude mice.

Hui Qin Wang, Bruce A. Ruggeri, Deborah A. Altomare, Susan Jones-Bolin, Hugh Zhou, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 699.
Published: 01 April 2004
View article titled, Anti-tumor effects of fatty acid synthase inhibitor C75 on orthotopically-implanted human pancreatic ductal adenocarcinoma in nude mice.
Journal Articles

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing Rac-induced cyclin D1 expression

Guang-Hui Xiao, Ryan P. Gallagher, Justin N. Shetler, Kristine L. Skele, Deborah A. Altomare, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1277.
Published: 01 April 2004
View article titled, The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing Rac-induced cyclin D1 expression
Journal Articles

Consistent chromosomal alterations in thymic lymphomas arising in transgenic mice expressing myristoylated Akt2

Janice E. Knepper, Deborah A. Altomare, Binaifer R. Balsara, Zemin Liu, Kristine L. Skele, Harvey H. Hensley, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1176.
Published: 01 April 2004
View article titled, Consistent chromosomal alterations in thymic lymphomas arising in transgenic mice expressing myristoylated Akt2
Journal Articles

AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells

Satoshi Tanno, Sachie Tanno, Yasuhiro Mitsuuchi, Deborah A. Altomare, Guang-Hui Xiao, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2001) 61 (2): 589–593.
Published: 01 January 2001
View article titled, AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells
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Journal Articles

p16 Alterations and Deletion Mapping of 9p21–p22 in Malignant Mesothelioma

Jin Quan Cheng, Suresh C. Jhanwar, Walter M. Klein, Daphne W. Bell, Wen-Ching Lee, Deborah A. Altomare, Tsutomu Nobori, Olufunmilayo I. Olopade, Alan J. Buckler, Joseph R. Testa
Journal: Cancer Research
Cancer Res (1994) 54 (21): 5547–5551.
Published: 01 November 1994
View article titled, <em>p16</em> Alterations and Deletion Mapping of 9p21–p22 in Malignant Mesothelioma
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