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Journal Articles

Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma

Jung Hyun Um, Yueyuan Zheng, Qiong Mao, Chehyun Nam, Hua Zhao, Yoon Woo Koh, Su-Jin Shin, Young Min Park, De-Chen Lin
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2850
Published: 22 April 2025
View articletitled, Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 4845: The MLL3/GRHL2 complex modulates early malignant development and anti-tumor immunity in upper aerodigestive squamous cell carcinoma

Chehyun Nam, Guowei Huang, Yueyuan Zheng, Hua Zhao, Ethan Pan, Boyan Hu, Talia Wenger, Hieu Van, Liyan Xu, En-min Li, H.Phillip Koeffler, Kai Ge, Yali Dou, Uttam K. Sinha, Young Min Park, De-Chen Lin
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4845.
https://doi.org/10.1158/1538-7445.AM2025-4845
Published: 21 April 2025
View articletitled, Abstract 4845: The MLL3/GRHL2 complex modulates early malignant development and anti-tumor immunity in upper aerodigestive squamous cell carcinoma
Journal Articles

Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy

Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W. Said, Lao Zhentang, Vikas Madan, Pushkar Dakle, Jin-Fen Xiao, Xinyi Loh, Ying Li, Liang Xu, Xiao-Qiang Xiang, Ling-Zhi Wang, Boon Cher Goh, De-Chen Lin, Wee Joo Chng, Soo-Yong Tan, Sudhakar Jha, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2023) 83 (6): 922–938.
https://doi.org/10.1158/0008-5472.CAN-21-3052
Published: 15 March 2023
View articletitled, Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
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Includes: Supplementary data
Journal Articles

A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Sai Ma, Bo Zhou, Qian Yang, Yunzhi Pan, Wei Yang, Stephen J. Freedland, Ling-Wen Ding, Michael R. Freeman, Joshua J. Breunig, Neil A. Bhowmick, Jian Pan, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (5): 1216–1229.
https://doi.org/10.1158/0008-5472.CAN-20-0652
Published: 01 March 2021
View articletitled, A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma
Open the PDF for A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4686: Core transcriptional regulatory circuitry FOXA1-MAX-SP1 promotes malignancy of hepatocellular carcinoma

Li Peng, Xiaoqing Yuan, Zhen Chen, Chaoyang Zhang, Duanqing Tian, Dong Yin, De-Chen Lin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4686.
https://doi.org/10.1158/1538-7445.AM2020-4686
Published: 15 August 2020
View articletitled, Abstract 4686: Core transcriptional regulatory circuitry FOXA1-MAX-SP1 promotes malignancy of hepatocellular carcinoma
Journal Articles

Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

Jian Pan, Tiago C. Silva, Nicole Gull, Qian Yang, Jasmine T. Plummer, Stephanie Chen, Kenji Daigo, Takao Hamakubo, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Shaoyan Hu, Li-Yan Xu, En-Min Li, Yanbing Ding, Samuel J. Klempner, Simon A. Gayther, Benjamin P. Berman, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (13): 2722–2736.
https://doi.org/10.1158/0008-5472.CAN-20-0390
Published: 02 July 2020
View articletitled, Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas
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Includes: Supplementary data
Journal Articles

RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling

Xin-Yi Loh, Qiao-Yang Sun, Ling-Wen Ding, Anand Mayakonda, Nachiyappan Venkatachalam, Mei-Shi Yeo, Tiago C. Silva, Jin-Fen Xiao, Ngan B. Doan, Jonathan W. Said, Xue-Bin Ran, Si-Qin Zhou, Pushkar Dakle, Pavithra Shyamsunder, Angele Pei-Fern Koh, Ruby Yun-Ju Huang, Benjamin P. Berman, Soo-Yong Tan, Henry Yang, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2020) 80 (2): 219–233.
https://doi.org/10.1158/0008-5472.CAN-18-2796
Published: 15 January 2020
View articletitled, RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling
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Includes: Supplementary data
Journal Articles

Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma

Rui You, You-Ping Liu, De-Chen Lin, Qing Li, Tao Yu, Xiong Zou, Mei Lin, Xiao-Long Zhang, Gui-Ping He, Qi Yang, Yi-Nuan Zhang, Yu-Long Xie, Rou Jiang, Chen-Yan Wu, Chao Zhang, Cheng Cui, Jing-Qi Wang, Yue Wang, Ai-Hua Zhuang, Gui-Fang Guo, Yi-Jun Hua, Rui Sun, Jing-Ping Yun, Zhi-Xiang Zuo, Ze-Xian Liu, Xiao-Feng Zhu, Tie-Bang Kang, Chao-Nan Qian, Hai-Qiang Mai, Ying Sun, Mu-Sheng Zeng, Lin Feng, Yi-Xin Zeng, Ming-Yuan Chen
Journal: Cancer Research
Cancer Res (2019) 79 (23): 5930–5943.
https://doi.org/10.1158/0008-5472.CAN-18-3845
Published: 02 December 2019
View articletitled, Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma
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Includes: Supplementary data
Journal Articles

Super-Enhancer–Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma

Li Peng, Binyuan Jiang, Xiaoqing Yuan, Yuntan Qiu, Jiangyun Peng, Yongsheng Huang, Chaoyang Zhang, Yin Zhang, Zhaoyu Lin, Jinsong Li, Weicheng Yao, Weixi Deng, Yaqin Zhang, Meng Meng, Xi Pan, Chunquan Li, Dong Yin, Xinyu Bi, Guancheng Li, De-Chen Lin
Journal: Cancer Research
Cancer Res (2019) 79 (3): 572–584.
https://doi.org/10.1158/0008-5472.CAN-18-0367
Published: 01 February 2019
View articletitled, Super-Enhancer–Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma

Jiang Yuan, Yan-Yi Jiang, Anand Mayakonda, Moli Huang, Ling-Wen Ding, Han Lin, Fenggang Yu, Yanan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha Savage, Jeffrey W. Tyner, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6614–6626.
https://doi.org/10.1158/0008-5472.CAN-17-1143
Published: 30 November 2017
View articletitled, Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma

Ye Chen, Liang Xu, Marina Dutra-Clarke, Anand Mayakonda, De-Chen Lin, Lynnette Koh, Yuk Kien Chong, Edwin Sandanaraj, Vikas Madan, Henry Yang, Ngan Doan, Jonathan W. Said, William H. Yong, Markus Müschen, Beng Ti Ang, Carol Tang, Joshua J. Breunig, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1524.
https://doi.org/10.1158/1538-7445.AM2017-1524
Published: 01 July 2017
View articletitled, Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma
Journal Articles

Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target

Liang Xu, Ye CHEN, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Steve E. Savinoff, Ngan Doan, Jonathan W. Said, William H. Yong, Henry Yang, Ling-Wen Ding, Yan-Yi Jiang, Jeffrey W. Tyner, Jianhong Ching, Jean-Paul Kovalik, Markus Müschen, Joshua J. Breunig, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2569.
https://doi.org/10.1158/1538-7445.AM2017-2569
Published: 01 July 2017
View articletitled, Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target
Journal Articles

Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma

De-Chen Lin, Anand Mayakonda, Huy Q. Dinh, Pinbo Huang, Lehang Lin, Xiaoping Liu, Ling-wen Ding, Jie Wang, Benjamin P. Berman, Er-Wei Song, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (9): 2255–2265.
https://doi.org/10.1158/0008-5472.CAN-16-2822
Published: 30 April 2017
View articletitled, Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Ling-Wen Ding, Qiao-Yang Sun, Kar-Tong Tan, Wenwen Chien, Anand Mayakonda Thippeswamy, Allen Eng Juh Yeoh, Norihiko Kawamata, Yasunobu Nagata, Jin-Fen Xiao, Xin-Yi Loh, De-Chen Lin, Manoj Garg, Yan-Yi Jiang, Liang Xu, Su-Lin Lim, Li-Zhen Liu, Vikas Madan, Masashi Sanada, Lucia Torres Fernández, Hema Preethi, Michael Lill, Hagop M. Kantarjian, Steven M. Kornblau, Satoru Miyano, Der-Cherng Liang, Seishi Ogawa, Lee-Yung Shih, Henry Yang, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (2): 390–400.
https://doi.org/10.1158/0008-5472.CAN-16-1303
Published: 16 January 2017
View articletitled, Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling

Haibo Sun, De-Chen Lin, Qi Cao, Xiao Guo, Helene Marijon, Zhiqiang Zhao, Sigal Gery, Liang Xu, Henry Yang, Brendan Pang, Victor Kwan Min Lee, Huey Jin Lim, Ngan Doan, Jonathan W. Said, Peiguo Chu, Anand Mayakonda, Tom Thomas, Charles Forscher, Erkan Baloglu, Sharon Shacham, Raja Rajalingam, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2687–2697.
https://doi.org/10.1158/0008-5472.CAN-15-1572
Published: 01 May 2016
View articletitled, CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling
Open the PDF for CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma

Liang Xu, De-Chen Lin, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shi-zhu Yu, Michael Kahn, Dong Yin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 122.
https://doi.org/10.1158/1538-7445.AM2015-122
Published: 01 August 2015
View articletitled, Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma
Journal Articles

Abstract 4944: Identification of B-cell lymphoma 6 as a novel therapeutic target in glioblastoma

Ye Chen, Liang Xu, Masaharu Hazawa, Anand M. Thippeswamy, Henry Yang, Markus Müschen, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4944.
https://doi.org/10.1158/1538-7445.AM2015-4944
Published: 01 August 2015
View articletitled, Abstract 4944: Identification of B-cell lymphoma 6 as a novel therapeutic target in glioblastoma
Journal Articles

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

De-Chen Lin, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1815–1827.
https://doi.org/10.1158/0008-5472.CAN-14-1433
Published: 30 April 2015
View articletitled, Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma
Open the PDF for Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma in another window
Includes: Supplementary data