1-5 of 5
David W. Rusnak
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

Alastair J. King, Denis R. Patrick, Roberta S. Batorsky, Maureen L. Ho, Hieu T. Do, Shu Yun Zhang, Rakesh Kumar, David W. Rusnak, Andrew K. Takle, David M. Wilson, Erin Hugger, Lifu Wang, Florian Karreth, Julie C. Lougheed, Jae Lee, David Chau, Thomas J. Stout, Earl W. May, Cynthia M. Rominger, Michael D. Schaber, Lusong Luo, Ami S. Lakdawala, Jerry L. Adams, Rooja G. Contractor, Keiran S.M. Smalley, Meenhard Herlyn, Michael M. Morrissey, David A. Tuveson, Pearl S. Huang
Journal: Cancer Research
Cancer Res (2006) 66 (23): 11100–11105.
https://doi.org/10.1158/0008-5472.CAN-06-2554
Published: 04 December 2006
View article titled, Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic <em>BRAF</em> by the Kinase Inhibitor SB-590885
Open the PDF for Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic <em>BRAF</em> by the Kinase Inhibitor SB-590885 in another window
Includes: Supplementary data
Journal Articles

Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells

Gottfried E. Konecny, Mark D. Pegram, Natarajan Venkatesan, Richard Finn, Guorong Yang, Martina Rahmeh, Michael Untch, David W. Rusnak, Glenn Spehar, Robert J. Mullin, Barry R. Keith, Tona M. Gilmer, Mark Berger, Karl C. Podratz, Dennis J. Slamon
Journal: Cancer Research
Cancer Res (2006) 66 (3): 1630–1639.
https://doi.org/10.1158/0008-5472.CAN-05-1182
Published: 01 February 2006
View article titled, Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells
Open the PDF for Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells in another window
Journal Articles

A novel, potent and selective small molecule inhibitor of B-Raf kinase, SB-590885, inhibits signal transduction and growth of cells bearing the B-Raf V600E mutation

Alastair J. King, Denis R. Patrick, Roberta S. Batorsky, Maureen L. Ho, Hieu T. Do, David W. Rusnak, Andrew K. Takle, David M. Wilson, Lifu Wang, Florian Karreth, Michael D. Schaber, John J. Voycik, Lusong Luo, Ami S. Lakdawala, Jerry L. Adams, Keiran S. M. Smalley, Meenhard Herlyn, David A. Tuveson, Pearl S. Huang
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1250.
Published: 01 May 2005
View article titled, A novel, potent and selective small molecule inhibitor of B-Raf kinase, SB-590885, inhibits signal transduction and growth of cells bearing the B-Raf V600E mutation
Journal Articles

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells

Edgar R. Wood, Anne T. Truesdale, Octerloney B. McDonald, Derek Yuan, Anne Hassell, Scott H. Dickerson, Byron Ellis, Christopher Pennisi, Earnest Horne, Karen Lackey, Krystal J. Alligood, David W. Rusnak, Tona M. Gilmer, Lisa Shewchuk
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6652–6659.
https://doi.org/10.1158/0008-5472.CAN-04-1168
Published: 16 September 2004
View article titled, A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): <subtitle>Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells</subtitle>
Open the PDF for A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): <subtitle>Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells</subtitle> in another window
Journal Articles

The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors: Potential Therapy for Cancer

David W. Rusnak, Karen Affleck, Stuart G. Cockerill, Colin Stubberfield, Robert Harris, Martin Page, Kathryn J. Smith, Stephen B. Guntrip, Malcolm C. Carter, Robert J. Shaw, Amanda Jowett, Jeremy Stables, Peter Topley, Edgar R. Wood, Perry S. Brignola, Sue H. Kadwell, Bryan R. Reep, Robert J. Mullin, Krystal J. Alligood, Barry R. Keith, Renae M. Crosby, Doris M. Murray, W. Blaine Knight, Tona M. Gilmer, Karen Lackey
Journal: Cancer Research
Cancer Res (2001) 61 (19): 7196–7203.
Published: 01 October 2001
View article titled, The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors: <subtitle>Potential Therapy for Cancer</subtitle>
Open the PDF for The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors: <subtitle>Potential Therapy for Cancer</subtitle> in another window