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David W. Hedley
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Journal Articles

Abstract 3367: Overexpression of neuropilin-1 exacerbates endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma

Pratiek N. Matkar, Krishna K. Singh, Gerald J. Prud’homme, David W. Hedley, Howard Leong-Poi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3367.
https://doi.org/10.1158/1538-7445.AM2016-3367
Published: 15 July 2016
View articletitled, Abstract 3367: Overexpression of neuropilin-1 exacerbates endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 2919: Ultrasound-mediated neuropilin-1 shRNA minicircle delivery inhibits tumour growth in an orthotopic human pancreatic adenocarcinoma model

Pratiek N. Matkar, Krishna K. Singh, Gerald J. Prud’homme, David W. Hedley, Howard Leong-Poi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2919.
https://doi.org/10.1158/1538-7445.AM2016-2919
Published: 15 July 2016
View articletitled, Abstract 2919: Ultrasound-mediated neuropilin-1 shRNA minicircle delivery inhibits tumour growth in an orthotopic human pancreatic adenocarcinoma model
Journal Articles

Abstract A106: BRCA mutation sensitizes pancreatic tumors to treatment with cisplatin

Ines Lohse, Pinjian Cao, Emin Ibrahimov, Ming-Sound Tsao, David W. Hedley
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A106.
https://doi.org/10.1158/1538-7445.PANCA2014-A106
Published: 30 June 2015
View articletitled, Abstract A106: BRCA mutation sensitizes pancreatic tumors to treatment with cisplatin
Journal Articles

Abstract A102: Combination treatment with hypoxia-activated prodrug TH-302 and radiation reduce pancreatic tumor initiating cells and tumor growth in patient-derived xenografts

Ines Lohse, Joanna Rasowski, Pinjian Cao, Melania Pintilie, Trevor Do, Emin Ibrahimov, Ming-Sound Tsao, Richard P. Hill, David W. Hedley
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A102.
https://doi.org/10.1158/1538-7445.PANCA2014-A102
Published: 30 June 2015
View articletitled, Abstract A102: Combination treatment with hypoxia-activated prodrug TH-302 and radiation reduce pancreatic tumor initiating cells and tumor growth in patient-derived xenografts
Journal Articles

Abstract 103: 64-Cu-NOTA-panitumumab F(ab')2 fragments for PET/CT imaging of pancreatic cancer

Amanda J. Boyle, David W. Hedley, Sachdev S. Sidhu, Mitchell A. Winnik, Raymond M. Reilly
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 103.
https://doi.org/10.1158/1538-7445.AM2014-103
Published: 01 October 2014
View articletitled, Abstract 103: 64-Cu-NOTA-panitumumab F(ab')2 fragments for PET/CT imaging of pancreatic cancer
Journal Articles

Abstract B74: Heterogeneity analysis of hypoxia in surgical samples of pancreatic cancer.

Neesha C. Dhani, Stefano Serra, Joerg Schwock, Jing Xu, Melania Pintilie, Steven Gallinger, Richard Hill, David W. Hedley
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B74.
https://doi.org/10.1158/1538-7445.PANCA2012-B74
Published: 03 April 2014
View articletitled, Abstract B74: Heterogeneity analysis of hypoxia in surgical samples of pancreatic cancer.
Journal Articles

Abstract A26: Targeting Wee1 in primary pancreatic cancer xenografts.

Qing Chang, Jason Moffat, David W. Hedley
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A26.
https://doi.org/10.1158/1538-7445.PANCA2012-A26
Published: 03 April 2014
View articletitled, Abstract A26: Targeting Wee1 in primary pancreatic cancer xenografts.
Journal Articles

Abstract B46: Targeting tumor initiating cells in patient-derived pancreatic xenograft models using the hypoxia-activated prodrug TH-302.

Ines Lohse, Joanna Rasowski, Emin Ibrahimov, Richard Hill, Ming S. Tsao, David W. Hedley
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B46.
https://doi.org/10.1158/1538-7445.PANCA2012-B46
Published: 03 April 2014
View articletitled, Abstract B46: Targeting tumor initiating cells in patient-derived pancreatic xenograft models using the hypoxia-activated prodrug TH-302.
Journal Articles

Abstract A43: Targeting tumor hypoxia in patient-derived pancreatic xenografts using TH302.

Ines Lohse, Joanna Rasowski, PinJiang Cao, Emin Ibrahimov, Melania Pintille, Ming S. Tsao, Richard Hill, David W. Hedley
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A43.
https://doi.org/10.1158/1538-7445.PANCA2012-A43
Published: 03 April 2014
View articletitled, Abstract A43: Targeting tumor hypoxia in patient-derived pancreatic xenografts using TH302.
Journal Articles

Abstract 2431: Inhibition of metastasis through therapeutic targeting of focal adhesion kinase (FAK) in pancreatic cancer

Neesha C. Dhani, Joerg Schwock, Ping-Jiang M. Cao, Ming-Sound Tsao, David W. Hedley
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2431.
https://doi.org/10.1158/1538-7445.AM2011-2431
Published: 15 April 2011
View articletitled, Abstract 2431: Inhibition of metastasis through therapeutic targeting of focal adhesion kinase (FAK) in pancreatic cancer
Journal Articles

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

Qing Chang, Igor Jurisica, Trevor Do, David W. Hedley
Journal: Cancer Research
Cancer Res (2011) 71 (8): 3110–3120.
https://doi.org/10.1158/0008-5472.CAN-10-4049
Published: 13 April 2011
View articletitled, Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Targeting Focal Adhesion Kinase with Dominant-Negative FRNK or Hsp90 Inhibitor 17-DMAG Suppresses Tumor Growth and Metastasis of SiHa Cervical Xenografts

Joerg Schwock, Neesha Dhani, Mary Ping-Jiang Cao, Jinzi Zheng, Richard Clarkson, Nikolina Radulovich, Roya Navab, Lars-Christian Horn, David W. Hedley
Journal: Cancer Research
Cancer Res (2009) 69 (11): 4750–4759.
https://doi.org/10.1158/0008-5472.CAN-09-0454
Published: 01 June 2009
View articletitled, Targeting Focal Adhesion Kinase with Dominant-Negative FRNK or Hsp90 Inhibitor 17-DMAG Suppresses Tumor Growth and Metastasis of SiHa Cervical Xenografts
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Includes: Supplementary data
Journal Articles

Suppression of the Hypoxia-Inducible Factor-1 Response in Cervical Carcinoma Xenografts by Proteasome Inhibitors

Diana C. Birle, David W. Hedley
Journal: Cancer Research
Cancer Res (2007) 67 (4): 1735–1743.
https://doi.org/10.1158/0008-5472.CAN-06-2722
Published: 16 February 2007
View articletitled, Suppression of the Hypoxia-Inducible Factor-1 Response in Cervical Carcinoma Xenografts by Proteasome Inhibitors
Open the PDF for Suppression of the Hypoxia-Inducible Factor-1 Response in Cervical Carcinoma Xenografts by Proteasome Inhibitors in another window
Includes: Supplementary data
Journal Articles

Mechanism and predictive value of PKB in gemcitabine resistance of pancreatic cancer cells and tumor xenograft models

Nhu-An Pham, Mary Cao, Ming S. Tsao, David W. Hedley
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 543.
Published: 01 May 2005
View articletitled, Mechanism and predictive value of PKB in gemcitabine resistance of pancreatic cancer cells and tumor xenograft models
Journal Articles

Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts

Cindy Y.F. Yau, Jeffery J. Wheeler, Kymberley L. Sutton, David W. Hedley
Journal: Cancer Research
Cancer Res (2005) 65 (4): 1497–1504.
https://doi.org/10.1158/0008-5472.CAN-04-2940
Published: 25 February 2005
View articletitled, Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts
Open the PDF for Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts in another window
Journal Articles

Hypoxia-inducible Factor-1α Is an Intrinsic Marker for Hypoxia in Cervical Cancer Xenografts

Vojislav Vukovic, Hans Kristian Haugland, Trudey Nicklee, Andrew J. Morrison, David W. Hedley
Journal: Cancer Research
Cancer Res (2001) 61 (20): 7394–7398.
Published: 01 October 2001
View articletitled, Hypoxia-inducible Factor-1α Is an Intrinsic Marker for Hypoxia in Cervical Cancer Xenografts
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Journal Articles

Equilibrative-Sensitive Nucleoside Transporter and Its Role in Gemcitabine Sensitivity

David R. Rauchwerger, Patricia S. Firby, David W. Hedley, Malcolm J. Moore
Journal: Cancer Research
Cancer Res (2000) 60 (21): 6075–6079.
Published: 01 November 2000
View articletitled, Equilibrative-Sensitive Nucleoside Transporter and Its Role in Gemcitabine Sensitivity
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Journal Articles

Inhibition of Phosphatidylinositide 3-Kinase Enhances Gemcitabine-induced Apoptosis in Human Pancreatic Cancer Cells

Sylvia S. W. Ng, Ming-Sound Tsao, Sue Chow, David W. Hedley
Journal: Cancer Research
Cancer Res (2000) 60 (19): 5451–5455.
Published: 01 October 2000
View articletitled, Inhibition of Phosphatidylinositide 3-Kinase Enhances Gemcitabine-induced Apoptosis in Human Pancreatic Cancer Cells
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Journal Articles

Relationships between the Mitochondrial Permeability Transition and Oxidative Stress during ara-C Toxicity

Karen L. Backway, Ernest A. McCulloch, Sue Chow, David W. Hedley
Journal: Cancer Research
Cancer Res (1997) 57 (12): 2446–2451.
Published: 01 June 1997
View articletitled, Relationships between the Mitochondrial Permeability Transition and Oxidative Stress during ara-C Toxicity
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Journal Articles

Effects of Thymidylate Synthase Inhibition on Thymidine Kinase Activity and Nucleoside Transporter Expression

Josie Pressacco, Biserka Mitrovski, Charles Erlichman, David W. Hedley
Journal: Cancer Research
Cancer Res (1995) 55 (7): 1505–1508.
Published: 01 April 1995
View articletitled, Effects of Thymidylate Synthase Inhibition on Thymidine Kinase Activity and Nucleoside Transporter Expression
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