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David Solit
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Journal Articles

Abstract B029: Tumor immune microenvironment determinants of response to lenvatinib and a PD-1 blockade in clear cell renal cell carcinoma

Lynda Vuong, Fengshen Kuo, Hui Jiang, Eduardo A. Mascareno, Phillip Rappold, Erich Sabio, Kate Weiss, Andrew Cornish, Stephen Reese, Mojca Adlesic, David Solit, Ian Frew, Oguz Akin, Yingbei Chen, Ming O. Li, Timothy A. Chan, Ari A. Hakimi
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): B029.
https://doi.org/10.1158/1538-7445.KIDNEY23-B029
Published: 15 August 2023
View article titled, Abstract B029: Tumor immune microenvironment determinants of response to lenvatinib and a PD-1 blockade in clear cell renal cell carcinoma
Journal Articles

Abstract 3628: Comprehensive identification of lineage associated cancer genes in 122 histologies

Chaitanya Bandlamudi, Walid K. Chatila, Shaleigh A. Smith, Subhiksha Nandakumar, Craig Bielski, Bastien Nguyen, Henry S. Walch, Christoph K. Kreitzer, Kanika S. Arora, Tran Thinh Ngoc, Miika Mehine, Irina Ostrovnaya, Ino de Bruijn, Hyung Jun Woo, Ritika Kundra, Christopher J. Fong, Satshil Rana, Gaofei Zhao, Mingxuan Zhang, Mark R. Zucker, Hongxin Zhang, Ryan Ptashkin, Rose Brannon, Eduard Reznik, JianJiong Gao, Maria E. Arcila, Ryma Benayed, Debyani Chakravarty, David Solit, Mark T. Donoghue, Marc Ladanyi, Nikolaus D. Schultz, Michael F. Berger, Ahmet Zehir
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3628.
https://doi.org/10.1158/1538-7445.AM2022-3628
Published: 15 June 2022
View article titled, Abstract 3628: Comprehensive identification of lineage associated cancer genes in 122 histologies
Journal Articles

Abstract 2182: Ancestry inference and population-specific disparities in a real-world clinical sequencing cohort

Kanika Arora, Thinh N. Tran, Yelena M. Kemel, Miika Mehine, Ying Liu, Shaleigh A. Smith, Subhiksha Nandakumar, Irina Ostrovnaya, Thomas C. Reynolds, Kenneth Offit, David Solit, Marc Ladanyi, Nikolaus Schultz, Ahmet Zehir, Carol L. Brown, Debyani Chakravarty, Zsofia K. Stadler, Chaitanya Bandlamudi, Michael F. Berger
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2182.
https://doi.org/10.1158/1538-7445.AM2022-2182
Published: 15 June 2022
View article titled, Abstract 2182: Ancestry inference and population-specific disparities in a real-world clinical sequencing cohort
Journal Articles

Abstract GS3-03: Genomic analysis of 733 HER2+ breast cancers identifies recurrent pathways alterations associated with anti-HER2 resistance and new therapeutic vulnerabilities

Emanuela Ferraro, Alison Smith, Anton Safonov, Paulino Tallon De Lara, Cristina Bernado', Enrique J. Arenas Lahuerta, Joaquín Arribas, David Solit, Jorge S. Reis-Filho, Neal Rosen, Larry Norton, Shanu Modi, Mark E. Robson, Chau T. Dang, Giuseppe Curigliano, Sarat Chandarlapaty, Pedram Razavi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS3-03.
https://doi.org/10.1158/1538-7445.SABCS21-GS3-03
Published: 15 February 2022
View article titled, Abstract GS3-03: Genomic analysis of 733 HER2+ breast cancers identifies recurrent pathways alterations associated with anti-HER2 resistance and new therapeutic vulnerabilities
Journal Articles

Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance

Anton Safonov, Chai Bandlamudi, Paulino Tallón de Lara, Emanuela Ferraro, Fatemeh Derakhshan, Marie Will, Mark Donoghue, Pier Selenica, Joshua Drago, Ezra Rosen, Carlos dos Anjos, Elaine Walsh, Elizabeth A Comen, Mehnaj Ahmed, Barbara Acevedo, Ahmet Zehir, Michael F Berger, David Solit, Larry Norton, Ronglai Shen, Zsofia Stadler, Simon Powell, Jorge S Reis-Filho, Sarat Chandarlapaty, Mark Robson, Pedram Razavi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS4-08.
https://doi.org/10.1158/1538-7445.SABCS21-GS4-08
Published: 15 February 2022
View article titled, Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance
Journal Articles

Abstract 99: Evolution of OncoKB, a precision oncology knowledgebase

Sarah P. Suehnholz, Ritika Kundra, Hongxin Zhang, Shaleigh Smith, Moriah Nissan, Yifu Yao, Lindsay LaFave, Kinisha Gala, Linde Miles, Maria E. Arcila, Marc Ladanyi, Michael F. Berger, Ahmet Zehir, Aijaz Syed, Julia Rudolph, Paul Sabbatini, Ross Levine, Ahmet Dogan, Jianjiong Gao, David Solit, Nikolaus Schultz, Debyani Chakravarty
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 99.
https://doi.org/10.1158/1538-7445.AM2021-99
Published: 01 July 2021
View article titled, Abstract 99: Evolution of OncoKB, a precision oncology knowledgebase
Journal Articles

Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis

Kelly L. Bolton, Ryan N. Ptashkin, Teng Gao, Lior Braunstein, Sean M. Devlin, Minal Patel, Antonin Berthon, Aijazuddin Syed, Mariko Yabe, Catherine Coombs, Nicole M. Caltabellotta, Mike Walsh, Ken Offit, Zsofia Stadler, Choonsik Lee, Paul Pharoah, Konrad H. Stopsack, Barbara Spitzer, Simon Mantha, James Fagin, Laura Boucai, Christopher J. Gibson, Benjamin Ebert, Andrew L. Young, Todd Druley, Koichi Takahashi, Nancy Gillis, Markus Ball, Eric Padron, David Hyman, Jose Baselga, Larry Norton, Stuart Gardos, Virginia Klimek, Howard Scher, Dean Bajorin, Eder Paraiso, Ryma Benayed, Maria Arcilla, Marc Ladanyi, David Solit, Michael Berger, Martin Tallman, Montserrat Garcia-Closas, Nilanjan Chatterjee, Luis Diaz, Ross Levine, Lindsay Morton, Ahmet Zehir, Elli Papaemmanuil
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5703.
https://doi.org/10.1158/1538-7445.AM2020-5703
Published: 15 August 2020
View article titled, Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis
Journal Articles

Abstract 1572: Inherited truncating RAD52 variant discovered using integrated germline- somatic analysis predicts clinical outcome in patients with lung cancers

Semanti Mukherjee, Preethi Srinivasan, Chaitanya Bandlamudi, Matthew D. Hellmann, Vignesh Ravichandran, Myvizhi Esai Selvan, Yelena Kemel, Diana Mandelker, Marjorie Zauderer, Michael Walsh, Ahmet Zehir, Maria I Carlo, Karen Cadoo, Steven M Lipkin, Marc Ladanyi, David Solit, Mark Robson, Liying Zhang, David Jones, Charles Rudin, Robert Klein, Zsofia Stadler, Joseph Vijai, Zeynep Gumus, Barry Taylor, Michael Berger, Kenneth Kenneth
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1572.
https://doi.org/10.1158/1538-7445.AM2019-1572
Published: 01 July 2019
View article titled, Abstract 1572: Inherited truncating <em>RAD52</em> variant discovered using integrated germline- somatic analysis predicts clinical outcome in patients with lung cancers
Journal Articles

Abstract 2482: A portable bioinformatics pipeline for the FDA authorized IMPACT DNAseq assay

Zuojian Tang, Nikhil Kumar, Allan Bolipata, Timothy Song, Cyriac Kandoth, Feng Liu, David Mcmanamon, Oliver Hampton, Nicholas Socci, David Solit
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2482.
https://doi.org/10.1158/1538-7445.AM2019-2482
Published: 01 July 2019
View article titled, Abstract 2482: A portable bioinformatics pipeline for the FDA authorized IMPACT DNAseq assay
Journal Articles

Abstract 682: Drug repurposing engine fueled by diverse drug similarity data

Jamal A. Elkhader, Coryandar M. Gilvary, Neel S. Madhukar, Olivier Elemento, David Solit
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 682.
https://doi.org/10.1158/1538-7445.AM2019-682
Published: 01 July 2019
View article titled, Abstract 682: Drug repurposing engine fueled by diverse drug similarity data
Journal Articles

Abstract 4158: Dissecting the role of zygosity and lineage in Lynch Syndrome-associated microsatellite Instability

Preethi Srinivasan, Chaitanya Bandlamudi, Jinru Shia, Alicia S. Latham, Philip Jonsson, Alexander Penson, Sumit Middha, Jackie Hechtman, Ahmet Zehir, Allison Richards, Shweta Chawan, Yelena Kemel, Diana Mandelker, Liying Zhang, David Hyman, Marc Ladanyi, Mark Robson, Kenneth Offit, David Solit, Barry Taylor, Michael Berger, Zsofia Stadler
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4158.
https://doi.org/10.1158/1538-7445.AM2019-4158
Published: 01 July 2019
View article titled, Abstract 4158: Dissecting the role of zygosity and lineage in Lynch Syndrome-associated microsatellite Instability
Journal Articles

Abstract 5351: Retrospective analysis of cancer exomes with Roslin, a portable and reproducible workflow infrastructure

Christopher Harris, Jaeyoung Chun, Cyriac Kandoth, Nikhil Kumar, Shweta Chavan, Ronak Shah, Ewa Reza, Aaron Gabow, Christopher A. Bolipata, Barry Taylor, Oliver A. Hampton, Nicholas D. Socci, David Solit
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5351.
https://doi.org/10.1158/1538-7445.AM2018-5351
Published: 01 July 2018
View article titled, Abstract 5351: Retrospective analysis of cancer exomes with <em>Roslin</em>, a portable and reproducible workflow infrastructure
Journal Articles

Abstract 395: Activation mechanisms of cancer associated MEK1 mutants

Yijun Gao, Matthew T. Chang, Daniel McKay, Rona D. Yaeger, Merna Torres, Keven Muniz, Drosten Matthias, Omar I. Abdel-Wahab, Mariano Barbacid, Giordano Caponigro, Darrin Stuart, David Solit, Barry S. Taylor, Zhan Yao, Neal Rosen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 395.
https://doi.org/10.1158/1538-7445.AM2017-395
Published: 01 July 2017
View article titled, Abstract 395: Activation mechanisms of cancer associated MEK1 mutants
Journal Articles

Abstract LB-070: Next generation sequencing of prostate cancer reveals germline and somatic alterations detected at diagnosis and at metastasis that may impact clinical decision making

Wassim Abida, Michael F. Walsh, Joshua Armenia, Joseph Vijai, Anuradha Gopalan, Ryan Brennan, Kristen Curtis, Maria Arcila, Daniel Danila, Angela Arnold, Dana Rathkopf, Michael J. Morris, Mark Robson, Susin Slovin, David Hyman, Jeremy Durack, Stephen B. Solomon, Herbert A. Vargas, Barry Taylor, Victor Reuter, David Solit, Michael F. Berger, Kenneth Offit, Charles L. Sawyers, Nikolaus Schultz, Howard I. Scher
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-070.
https://doi.org/10.1158/1538-7445.AM2016-LB-070
Published: 15 July 2016
View article titled, Abstract LB-070: Next generation sequencing of prostate cancer reveals germline and somatic alterations detected at diagnosis and at metastasis that may impact clinical decision making
Journal Articles

Abstract 2640: Clonal hematopoiesis identified by matched-normal blood sequencing of solid tumor patients without hematologic malignancy is common and is associated with decreased overall survival

Catherine Coombs, Ahmet Zehir, Sean Devlin, Sumit Middha, Donavan Cheng, Ashwin Kishtagari, David Hyman, David Solit, Mark Robson, Jose Baselga, Maria Arcila, Martin Tallman, Ross Levine, Michael Berger
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2640.
https://doi.org/10.1158/1538-7445.AM2016-2640
Published: 15 July 2016
View article titled, Abstract 2640: Clonal hematopoiesis identified by matched-normal blood sequencing of solid tumor patients without hematologic malignancy is common and is associated with decreased overall survival
Journal Articles

Abstract CT232: SU2C Phase Ib study of the PI3K-alpha inhibitor BYL719 (alpelisib) with letrozole in ER+/HER2-metastatic breast cancer

Ingrid A. Mayer, Vandana Abramson, Justin Balko, Melinda Sanders, Dejan Juric, David Solit, Yisheng Li, Lewis Cantley, Eric Winer, Carlos Arteaga
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT232.
https://doi.org/10.1158/1538-7445.AM2015-CT232
Published: 01 August 2015
View article titled, Abstract CT232: SU2C Phase Ib study of the PI3K-alpha inhibitor BYL719 (alpelisib) with letrozole in ER+/HER2-metastatic breast cancer
Journal Articles

Abstract CT324: Phase I of oral BKM120 or BYL719 and olaparib for high-grade serous ovarian cancer or triple-negative breast cancer: Final results of the BKM120 plus olaparib cohort

Ursula A. Matulonis, Gerburg Wulf, William Barry, Michael Birrer, Shannon Westin, Tatum Spagnoletti, Katherine Bell-McGuinn, Elizabeth Obermayer, Christin Whalen, Carol Aghajanian, David Solit, Gordon Mills, Lewis Cantley, Eric Winer
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT324.
https://doi.org/10.1158/1538-7445.AM2015-CT324
Published: 01 August 2015
View article titled, Abstract CT324: Phase I of oral BKM120 or BYL719 and olaparib for high-grade serous ovarian cancer or triple-negative breast cancer: Final results of the BKM120 plus olaparib cohort
Journal Articles

Abstract 3706: Oncogenic RAF mutants that signal as functional dimers are resistant to current RAF inhibitors but sensitive to a novel inhibitor of RAF dimer kinase activity

Zhan Yao, Merna Torres, Min Wei, Aphrothiti Hanrahan, Omar Abdel-Wahab, David Solit, Lusong Luo, Poulikos Poulikakos, Neal Rosen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3706.
https://doi.org/10.1158/1538-7445.AM2014-3706
Published: 01 October 2014
View article titled, Abstract 3706: Oncogenic RAF mutants that signal as functional dimers are resistant to current RAF inhibitors but sensitive to a novel inhibitor of RAF dimer kinase activity
Journal Articles

Abstract LB-327: Loss of PTEN leads to clinical resistance to the PI3Kα inhibitor BYL719 and provides evidence of convergent evolution under selective therapeutic pressure

Pau Castel, Dejan Juric, Helen Won, Benjamin Ainscough, Haley Ellis, Saya Ebbesen, Malachi Griffith, Obi Griffith, Iyer Gopakumar, Dennis Sgroi, Steven Isakoff, Elaine Mardis, David Solit, Scott Lowe, Cornelia Quadt, Malte Peters, Michael Berger, Maurizio Scaltriti, José Baselga
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-327.
https://doi.org/10.1158/1538-7445.AM2014-LB-327
Published: 01 October 2014
View article titled, Abstract LB-327: Loss of PTEN leads to clinical resistance to the PI3Kα inhibitor BYL719 and provides evidence of convergent evolution under selective therapeutic pressure
Journal Articles

Abstract 4846: Genomic analysis of high grade bladder cancer: Defining genetic subtypes and therapeutic targets

Gopa Iyer, Hikmat Al-Ahmadie, Barry S. Taylor, Manickam Janakiraman, Oscar Lin, Nicholas D. Socci, Adriana Heguy, Agnes Viale, Bernard Bochner, Dean Bajorin, Matthew Milowsky, David Solit
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4846.
https://doi.org/10.1158/1538-7445.AM2011-4846
Published: 15 April 2011
View article titled, Abstract 4846: Genomic analysis of high grade bladder cancer: Defining genetic subtypes and therapeutic targets