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David Sims
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Journal Articles

Abstract P22: C16orf72/HAPSTR1/TAPR1 Interacts with BRCA1 and Senataxin to Regulate R-loops at Stalled Replication Forks and Confer Resistance to PARP Disruption

Free
Abhishek Bharadwaj Sharma, Muhammad Khairul Ramlee, Joel Kosmin, Martin R. Higgs, Amy Wolstenholme, George E. Ronson, Dylan Jones, Daniel Ebner, Noor Shamkhi, David Sims, Paul W. G. Wijnhoven, Josep Forment, Ian Gibbs-Seymour, Nicholas D. Lakin
Journal: Cancer Research
Cancer Res (2024) 84 (8_Supplement): P22.
https://doi.org/10.1158/1538-7445.FCS2023-P22
Published: 15 April 2024
View articletitled, Abstract P22: C16orf72/HAPSTR1/TAPR1 Interacts with BRCA1 and Senataxin to Regulate R-loops at Stalled Replication Forks and Confer Resistance to PARP Disruption
Journal Articles

Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response

Available to Purchase
Ping Zhang, Isaac Kitchen-Smith, Lingyun Xiong, Giovanni Stracquadanio, Katherine Brown, Philipp H. Richter, Marsha D. Wallace, Elisabeth Bond, Natasha Sahgal, Samantha Moore, Svanhild Nornes, Sarah De Val, Mirvat Surakhy, David Sims, Xuting Wang, Douglas A. Bell, Jorge Zeron-Medina, Yanyan Jiang, Anderson J. Ryan, Joanna L. Selfe, Janet Shipley, Siddhartha Kar, Paul D. Pharoah, Chey Loveday, Rick Jansen, Lukasz F. Grochola, Claire Palles, Andrew Protheroe, Val Millar, Daniel V. Ebner, Meghana Pagadala, Sarah P. Blagden, Timothy S. Maughan, Enric Domingo, Ian Tomlinson, Clare Turnbull, Hannah Carter, Gareth L. Bond
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1667–1680.
https://doi.org/10.1158/0008-5472.CAN-20-0177
Published: 01 April 2021
View articletitled, Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response
Open the PDF for Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response in another window
Includes: Supplementary data
Journal Articles

Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity

Free
Ilirjana Bajrami, Jessica R. Frankum, Asha Konde, Rowan E. Miller, Farah L. Rehman, Rachel Brough, James Campbell, David Sims, Rumana Rafiq, Sean Hooper, Lina Chen, Iwanka Kozarewa, Ioannis Assiotis, Kerry Fenwick, Rachael Natrajan, Christopher J. Lord, Alan Ashworth
Journal: Cancer Research
Cancer Res (2014) 74 (1): 287–297.
https://doi.org/10.1158/0008-5472.CAN-13-2541
Published: 05 January 2014
View articletitled, Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
Open the PDF for Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes

Free
Nirupa Murugaesu, Marjan Iravani, Damian Johnson, Aristotelis Antonopoulos, David Sims, Kerry Fenwick, Costas Mitsopoulos, Qiong Gao, Nick Orr, Marketa Zvelebil, Stuart Haslam, Anne Dell, Christopher Lord, Alan Ashworth, Clare Isacke
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3417.
https://doi.org/10.1158/1538-7445.AM2012-3417
Published: 15 April 2012
View articletitled, Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes
Journal Articles

Abstract 4979: Whole genome in vivo RNA interference screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor

Free
Elizabeth J. Iorns, Toby M. Ward, Sonja Dean, Anna Jegg, Nirupa Murugaesu, David Sims, Christopher Lord, Alan Ashworth, James Hnatyszyn, Mark Pegram, Marc Lippman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4979.
https://doi.org/10.1158/1538-7445.AM2011-4979
Published: 15 April 2011
View articletitled, Abstract 4979: Whole genome in vivo RNA interference screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor
Journal Articles

Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair–Deficient Cancers

Free
Sarah A. Martin, Madeleine Hewish, David Sims, Christopher J. Lord, Alan Ashworth
Journal: Cancer Research
Cancer Res (2011) 71 (5): 1836–1848.
https://doi.org/10.1158/0008-5472.CAN-10-2836
Published: 01 March 2011
View articletitled, Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair–Deficient Cancers
Open the PDF for Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair–Deficient Cancers in another window
Includes: Supplementary data