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David Siegel
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Journal Articles

Abstract 3678: Beyond detection: AI-based classification of breast cancer invasiveness using cell-free orphan non-coding RNAs

Mehran Karimzadeh, Taylor B. Cavazos, Nae-Chyun Chen, Noura K. Tbeileh, David Siegel, Amir Momen-Roknabadi, Jennifer Yen, Jeremy Ku, Selina Chen, Diana Corti, Alice Huang, Dang Nguyen, Rose Hanna, Ti Lam, Seda Kilinc, Philip Murzynowski, Jieyang Wang, Xuan Zhao, Andy Pohl, Babak Behsaz, Helen Li, Lisa Fish, Kim H. Chau, Marra S. Francis, Laura J. Van't Veer, Laura J. Esserman, Patrick A. Arensdorf, Hani Goodarzi, Fereydoun Hormozdiari, Babak Alipanahi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3678.
https://doi.org/10.1158/1538-7445.AM2024-3678
Published: 22 March 2024
View articletitled, Abstract 3678: Beyond detection: AI-based classification of breast cancer invasiveness using cell-free orphan non-coding RNAs
Journal Articles

Abstract 1732: Effect of 19-substituted benzoquinone ansamycin Hsp90 inhibitors on Hsp90/Cdc37/co-chaperone complexes and casein kinase 2 (CK2) activity

Chuan-Hsin Chang, David Ross, David Siegel, Christopher J Moody, Russell Kitson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1732.
https://doi.org/10.1158/1538-7445.AM2015-1732
Published: 01 August 2015
View articletitled, Abstract 1732: Effect of 19-substituted benzoquinone ansamycin Hsp90 inhibitors on Hsp90/Cdc37/co-chaperone complexes and casein kinase 2 (CK2) activity
Journal Articles

Abstract 1791: 19-Substituted benzoquinone ansamycin Hsp90 inhibitors: Effects on Hsp90 co-chaperones and Hsp90-Hsf1 complexes in cellular systems

Derek A. Drechsel, Chuan-Hsin Chang, Russell Kitson, David Siegel, Christopher J. Moody, David Ross
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1791.
https://doi.org/10.1158/1538-7445.AM2014-1791
Published: 01 October 2014
View articletitled, Abstract 1791: 19-Substituted benzoquinone ansamycin Hsp90 inhibitors: Effects on Hsp90 co-chaperones and Hsp90-Hsf1 complexes in cellular systems
Journal Articles

Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity

Chuan-Hsin Chang, Derek A. Drechsel, Russell R.A. Kitson, David Siegel, Qiang You, Donald S. Backos, Cynthia Ju, Christopher J. Moody, David Ross
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1788.
https://doi.org/10.1158/1538-7445.AM2014-1788
Published: 01 October 2014
View articletitled, Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity
Journal Articles

Abstract 3061: Colocalization of NQO1 with the mitotic spindle in human cells

David Siegel, Jadwiga K. Kepa, David Ross
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3061.
https://doi.org/10.1158/1538-7445.AM2012-3061
Published: 15 April 2012
View articletitled, Abstract 3061: Colocalization of NQO1 with the mitotic spindle in human cells
Journal Articles

Abstract 2769: The development of 19-substituted benzoquinone ansamycins as potential anticancer drugs

Chuan-Hsin Chang, Russell Kitson, David Siegel, Christopher J. Moody, David Ross
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2769.
https://doi.org/10.1158/1538-7445.AM2012-2769
Published: 15 April 2012
View articletitled, Abstract 2769: The development of 19-substituted benzoquinone ansamycins as potential anticancer drugs
Journal Articles

Abstract 2581: Indolequinone mechanism-based inhibitors of quinone reductases: Structural basis for selective inhibition of NQO2 relative to NQO1

Chao Yan, Marine Dufour, David Siegel, Philip Reigan, Joe Gomez, Biehuoy Shieh, Christopher J. Moody, David Ross
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2581.
https://doi.org/10.1158/1538-7445.AM2011-2581
Published: 15 April 2011
View articletitled, Abstract 2581: Indolequinone mechanism-based inhibitors of quinone reductases: Structural basis for selective inhibition of NQO2 relative to NQO1
Journal Articles

Abstract 570: Role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the cytotoxicity of the Hsp90 inhibitor 17AAG in human pancreatic cancer cells

Biehuoy Shieh, David Siegel, Chao Yan, Jadwiga K. Kepa, David Ross
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 570.
https://doi.org/10.1158/1538-7445.AM10-570
Published: 15 April 2010
View articletitled, Abstract 570: Role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the cytotoxicity of the Hsp90 inhibitor 17AAG in human pancreatic cancer cells
Journal Articles

Abstract 4544: Novel indolequinone inhibitors of thioredoxin reductase are active against human pancreatic cancer

Chao Yan, Biehuoy Shieh, Phillip Regan, Zhiyong Zhang, Marie Colucci, Aurélie Chilloux, Jeffery Newsome, David Siegel, Dan Chan, Christopher J. Moody, David Ross
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4544.
https://doi.org/10.1158/1538-7445.AM10-4544
Published: 15 April 2010
View articletitled, Abstract 4544: Novel indolequinone inhibitors of thioredoxin reductase are active against human pancreatic cancer
Journal Articles

Abstract 5471: Mechanism-based inhibition of NRH: quinone oxidoreductase 2 (NQO2) by a series of aminoalkylamino substituted indolequinones

David Siegel, Chao Yan, Marine Dufour, Biehuoy Shieh, Philip Reigan, Chris Moody, David Ross
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5471.
https://doi.org/10.1158/1538-7445.AM10-5471
Published: 15 April 2010
View articletitled, Abstract 5471: Mechanism-based inhibition of NRH: quinone oxidoreductase 2 (NQO2) by a series of aminoalkylamino substituted indolequinones
Journal Articles

Abstract #5352: Coumarin based NQO1 inhibitors. Computational modelling, biochemical effects and modulation of protein-protein interactions

Karen Nolan, Thomas Jowitt, Aldo Gutierez, Katherine Scott, Hoda Abdel-Aal Bettley, David Siegel, David Ross, Roger Whitehead, Richard Bryce, Ian Stratford
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5352.
Published: 01 May 2009
View articletitled, Abstract #5352: Coumarin based NQO1 inhibitors. Computational modelling, biochemical effects and modulation of protein-protein interactions
Journal Articles

Abstract #4696: Indolequinone antitumor agents: In vitro and in vivo cytotoxicity against human pancreatic cancer

Chao Yan, Biehuoy Shieh, Phillip Reigan, Zhiyong Zhang, Marie Colucci, Aurelie Chilloux, Jeffery Newsome, David Siegel, Dan Chan, Christopher Moody, David Ross
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4696.
Published: 01 May 2009
View articletitled, Abstract #4696: Indolequinone antitumor agents: In vitro and in vivo cytotoxicity against human pancreatic cancer
Journal Articles

Indolequinone mechanism-based inhibitors of NQO1 and NQO2

David Siegel, Chao Yan, AurA©lie Chilloux, Marie Colucci, Christopher Moody, David Ross
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4085.
Published: 01 May 2008
View articletitled, Indolequinone mechanism-based inhibitors of NQO1 and NQO2
Journal Articles

Induction of apoptosis and cytotoxicity by indolequinones in pancreatic cancer cell lines

Chao Yan, David Siegel, AurA©lie Chilloux, Marie Colucci, Biehouy Shieh, Philip Reigan, Christopher Moody, David Ross
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5671.
Published: 01 May 2008
View articletitled, Induction of apoptosis and cytotoxicity by indolequinones in pancreatic cancer cell lines
Journal Articles

Benzene metabolite hydroquinone up-regulates chondromodulin I and inhibits tube formation in human bone marrow endothelial cells

Hongfei Zhou, Jadwiga Kepa, David Siegel, Yuji Hiraki, David Ross
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 608.
Published: 01 May 2008
View articletitled, Benzene metabolite hydroquinone up-regulates chondromodulin I and inhibits tube formation in human bone marrow endothelial cells
Journal Articles

Downregulation of the cellular adhesion molecule VCAM-1 in human bone marrow endothelial cells after inhibition of NQO1 activity

Hongfei Zhou, Donna Dehn, Jadwiga Kepa, David Siegel, David Ross
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5371.
Published: 01 May 2007
View articletitled, Downregulation of the cellular adhesion molecule VCAM-1 in human bone marrow endothelial cells after inhibition of NQO1 activity
Journal Articles

The metabolism of antitumor quinones by NRH:quinone oxidoreductase 2 (NQO2)

David Siegel, Philip Reigan, Wenchang Guo, David Ross
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1499.
Published: 01 May 2007
View articletitled, The metabolism of antitumor quinones by NRH:quinone oxidoreductase 2 (NQO2)
Journal Articles

Purification of NAD(P)H:quinone oxidoreductase 1 (NQO1) protein complexes using protein, immuno and tandem affinity purification techniques and identification of interacting proteins by MALDI-TOF mass spectrometry

Philip Reigan, Jadwiga Kepa, Samiha Mateen, David Siegel, David Ross
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3176.
Published: 01 May 2007
View articletitled, Purification of NAD(P)H:quinone oxidoreductase 1 (NQO1) protein complexes using protein, immuno and tandem affinity purification techniques and identification of interacting proteins by MALDI-TOF mass spectrometry
Journal Articles

Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation

Wenchang Guo, David Siegel, Philip Reigan, David Ross
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3977.
Published: 01 May 2007
View articletitled, Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation
Journal Articles

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) and the correlation of activity in human pancreatic cancer

Philip Reigan, Marie Colucci, David Siegel, Aurelie Chilloux, Christopher Moody, David Ross
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1539.
Published: 01 May 2007
View articletitled, Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) and the correlation of activity in human pancreatic cancer