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Abstract CT085: A phase 2/3, multicenter trial of lenzilumab and azacitidine in chronic myelomonocytic leukemia: The PREACH-M trial

Devendra Hiwase, David Ross, Steven Lane, Agnes Yong, Kirsty Sharplin, David Yeung, Lisa Butler, Dale Chappell, Cameron Durrant, Timothy Hughes, Daniel Thomas

Cancer Res (2023) 83 (8_Supplement): CT085.

https://doi.org/10.1158/1538-7445.AM2023-CT085

Published: 14 April 2023

View articletitled, Abstract CT085: A phase 2/3, multicenter trial of lenzilumab and azacitidine in chronic myelomonocytic leukemia: The PREACH-M trial

Journal Articles

Abstract 1375: Activity of pemetrexed in patients with driver oncogene positive non-small cell lung cancer and squamous histology

Yunan Nie, Tejas Patil, David Ross Camidge

Cancer Res (2021) 81 (13_Supplement): 1375.

https://doi.org/10.1158/1538-7445.AM2021-1375

Published: 01 July 2021

View articletitled, Abstract 1375: Activity of pemetrexed in patients with driver oncogene positive non-small cell lung cancer and squamous histology

Journal Articles

Abstract 1881: The microtubule-disrupting drug BNC105 is a potent inducer of apoptosis in AML patient samples

Daniel J. Inglis, Debora A. Casolari, Tran Nguyen, Donna M. Beaumont, Nicole L. Wittwer, David Ross, Richard D'Andrea, Tina C. Lavranos

Cancer Res (2018) 78 (13_Supplement): 1881.

https://doi.org/10.1158/1538-7445.AM2018-1881

Published: 01 July 2018

View articletitled, Abstract 1881: The microtubule-disrupting drug BNC105 is a potent inducer of apoptosis in AML patient samples

Journal Articles

Abstract 1732: Effect of 19-substituted benzoquinone ansamycin Hsp90 inhibitors on Hsp90/Cdc37/co-chaperone complexes and casein kinase 2 (CK2) activity

Chuan-Hsin Chang, David Ross, David Siegel, Christopher J Moody, Russell Kitson

Cancer Res (2015) 75 (15_Supplement): 1732.

https://doi.org/10.1158/1538-7445.AM2015-1732

Published: 01 August 2015

View articletitled, Abstract 1732: Effect of 19-substituted benzoquinone ansamycin Hsp90 inhibitors on Hsp90/Cdc37/co-chaperone complexes and casein kinase 2 (CK2) activity

Journal Articles

Abstract 1791: 19-Substituted benzoquinone ansamycin Hsp90 inhibitors: Effects on Hsp90 co-chaperones and Hsp90-Hsf1 complexes in cellular systems

Derek A. Drechsel, Chuan-Hsin Chang, Russell Kitson, David Siegel, Christopher J. Moody, David Ross

Cancer Res (2014) 74 (19_Supplement): 1791.

https://doi.org/10.1158/1538-7445.AM2014-1791

Published: 01 October 2014

View articletitled, Abstract 1791: 19-Substituted benzoquinone ansamycin Hsp90 inhibitors: Effects on Hsp90 co-chaperones and Hsp90-Hsf1 complexes in cellular systems

Journal Articles

Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity

Chuan-Hsin Chang, Derek A. Drechsel, Russell R.A. Kitson, David Siegel, Qiang You, Donald S. Backos, Cynthia Ju, Christopher J. Moody, David Ross

Cancer Res (2014) 74 (19_Supplement): 1788.

https://doi.org/10.1158/1538-7445.AM2014-1788

Published: 01 October 2014

View articletitled, Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity

Journal Articles

Abstract 2769: The development of 19-substituted benzoquinone ansamycins as potential anticancer drugs

Chuan-Hsin Chang, Russell Kitson, David Siegel, Christopher J. Moody, David Ross

Cancer Res (2012) 72 (8_Supplement): 2769.

https://doi.org/10.1158/1538-7445.AM2012-2769

Published: 15 April 2012

View articletitled, Abstract 2769: The development of 19-substituted benzoquinone ansamycins as potential anticancer drugs

Journal Articles

Abstract 3061: Colocalization of NQO1 with the mitotic spindle in human cells

David Siegel, Jadwiga K. Kepa, David Ross

Cancer Res (2012) 72 (8_Supplement): 3061.

https://doi.org/10.1158/1538-7445.AM2012-3061

Published: 15 April 2012

View articletitled, Abstract 3061: Colocalization of NQO1 with the mitotic spindle in human cells

Journal Articles

Abstract 2581: Indolequinone mechanism-based inhibitors of quinone reductases: Structural basis for selective inhibition of NQO2 relative to NQO1

Chao Yan, Marine Dufour, David Siegel, Philip Reigan, Joe Gomez, Biehuoy Shieh, Christopher J. Moody, David Ross

Cancer Res (2011) 71 (8_Supplement): 2581.

https://doi.org/10.1158/1538-7445.AM2011-2581

Published: 15 April 2011

View articletitled, Abstract 2581: Indolequinone mechanism-based inhibitors of quinone reductases: Structural basis for selective inhibition of NQO2 relative to NQO1

Journal Articles

Abstract 5471: Mechanism-based inhibition of NRH: quinone oxidoreductase 2 (NQO2) by a series of aminoalkylamino substituted indolequinones

David Siegel, Chao Yan, Marine Dufour, Biehuoy Shieh, Philip Reigan, Chris Moody, David Ross

Cancer Res (2010) 70 (8_Supplement): 5471.

https://doi.org/10.1158/1538-7445.AM10-5471

Published: 15 April 2010

View articletitled, Abstract 5471: Mechanism-based inhibition of NRH: quinone oxidoreductase 2 (NQO2) by a series of aminoalkylamino substituted indolequinones

Journal Articles

Abstract 570: Role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the cytotoxicity of the Hsp90 inhibitor 17AAG in human pancreatic cancer cells

Biehuoy Shieh, David Siegel, Chao Yan, Jadwiga K. Kepa, David Ross

Cancer Res (2010) 70 (8_Supplement): 570.

https://doi.org/10.1158/1538-7445.AM10-570

Published: 15 April 2010

View articletitled, Abstract 570: Role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the cytotoxicity of the Hsp90 inhibitor 17AAG in human pancreatic cancer cells

Journal Articles

Abstract 4544: Novel indolequinone inhibitors of thioredoxin reductase are active against human pancreatic cancer

Chao Yan, Biehuoy Shieh, Phillip Regan, Zhiyong Zhang, Marie Colucci, Aurélie Chilloux, Jeffery Newsome, David Siegel, Dan Chan, Christopher J. Moody, David Ross

Cancer Res (2010) 70 (8_Supplement): 4544.

https://doi.org/10.1158/1538-7445.AM10-4544

Published: 15 April 2010

View articletitled, Abstract 4544: Novel indolequinone inhibitors of thioredoxin reductase are active against human pancreatic cancer

Journal Articles

Abstract #4696: Indolequinone antitumor agents: In vitro and in vivo cytotoxicity against human pancreatic cancer

Chao Yan, Biehuoy Shieh, Phillip Reigan, Zhiyong Zhang, Marie Colucci, Aurelie Chilloux, Jeffery Newsome, David Siegel, Dan Chan, Christopher Moody, David Ross

Cancer Res (2009) 69 (9_Supplement): 4696.

Published: 01 May 2009

View articletitled, Abstract #4696: Indolequinone antitumor agents: In vitro and in vivo cytotoxicity against human pancreatic cancer

Journal Articles

Abstract #5352: Coumarin based NQO1 inhibitors. Computational modelling, biochemical effects and modulation of protein-protein interactions

Karen Nolan, Thomas Jowitt, Aldo Gutierez, Katherine Scott, Hoda Abdel-Aal Bettley, David Siegel, David Ross, Roger Whitehead, Richard Bryce, Ian Stratford

Cancer Res (2009) 69 (9_Supplement): 5352.

Published: 01 May 2009

View articletitled, Abstract #5352: Coumarin based NQO1 inhibitors. Computational modelling, biochemical effects and modulation of protein-protein interactions

Journal Articles

A single-institution prospective study evaluating the functional diffusion map (fDM) as an early imaging biomarker for overall survival in high-grade glioma

Brian Ross, Daniel Hamstra, Craig Galban, Charles Meyer, Timothy Johnson, Pia Sundgren, Christina Tsien, Larry Junck, David Ross, Alnawaz Rehemtulla, Thomas Chenevert, Theodore Lawrence

Cancer Res (2008) 68 (9_Supplement): LB-248.

Published: 01 May 2008

View articletitled, A single-institution prospective study evaluating the functional diffusion map (fDM) as an early imaging biomarker for overall survival in high-grade glioma

Journal Articles

Indolequinone mechanism-based inhibitors of NQO1 and NQO2

Cancer Res (2008) 68 (9_Supplement): 4085.

Published: 01 May 2008

View articletitled, Indolequinone mechanism-based inhibitors of NQO1 and NQO2

Journal Articles

Induction of apoptosis and cytotoxicity by indolequinones in pancreatic cancer cell lines

Cancer Res (2008) 68 (9_Supplement): 5671.

Published: 01 May 2008

View articletitled, Induction of apoptosis and cytotoxicity by indolequinones in pancreatic cancer cell lines

Journal Articles

Benzene metabolite hydroquinone up-regulates chondromodulin I and inhibits tube formation in human bone marrow endothelial cells

Hongfei Zhou, Jadwiga Kepa, David Siegel, Yuji Hiraki, David Ross

Cancer Res (2008) 68 (9_Supplement): 608.

Published: 01 May 2008

View articletitled, Benzene metabolite hydroquinone up-regulates chondromodulin I and inhibits tube formation in human bone marrow endothelial cells

Journal Articles

Using RNAi to identify modulators of the HIF pathway/hypoxia for cancer

Cancer Res (2008) 68 (9_Supplement): 2380.

Published: 01 May 2008

View articletitled, Using RNAi to identify modulators of the HIF pathway/hypoxia for cancer

Journal Articles

Downregulation of the cellular adhesion molecule VCAM-1 in human bone marrow endothelial cells after inhibition of NQO1 activity

Hongfei Zhou, Donna Dehn, Jadwiga Kepa, David Siegel, David Ross

Cancer Res (2007) 67 (9_Supplement): 5371.

Published: 01 May 2007

View articletitled, Downregulation of the cellular adhesion molecule VCAM-1 in human bone marrow endothelial cells after inhibition of NQO1 activity

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Abstract CT085: A phase 2/3, multicenter trial of lenzilumab and azacitidine in chronic myelomonocytic leukemia: The PREACH-M trial

Abstract 1375: Activity of pemetrexed in patients with driver oncogene positive non-small cell lung cancer and squamous histology

Abstract 1881: The microtubule-disrupting drug BNC105 is a potent inducer of apoptosis in AML patient samples

Abstract 1732: Effect of 19-substituted benzoquinone ansamycin Hsp90 inhibitors on Hsp90/Cdc37/co-chaperone complexes and casein kinase 2 (CK2) activity

Abstract 1791: 19-Substituted benzoquinone ansamycin Hsp90 inhibitors: Effects on Hsp90 co-chaperones and Hsp90-Hsf1 complexes in cellular systems

Abstract 1788: 19-Substituted benzoquinone ansamycins. Hsp90 inhibitors with decreased off-target toxicity

Abstract 2769: The development of 19-substituted benzoquinone ansamycins as potential anticancer drugs

Abstract 3061: Colocalization of NQO1 with the mitotic spindle in human cells

Abstract 2581: Indolequinone mechanism-based inhibitors of quinone reductases: Structural basis for selective inhibition of NQO2 relative to NQO1

Abstract 5471: Mechanism-based inhibition of NRH: quinone oxidoreductase 2 (NQO2) by a series of aminoalkylamino substituted indolequinones

Abstract 570: Role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the cytotoxicity of the Hsp90 inhibitor 17AAG in human pancreatic cancer cells

Abstract 4544: Novel indolequinone inhibitors of thioredoxin reductase are active against human pancreatic cancer

Abstract #4696: Indolequinone antitumor agents: In vitro and in vivo cytotoxicity against human pancreatic cancer

Abstract #5352: Coumarin based NQO1 inhibitors. Computational modelling, biochemical effects and modulation of protein-protein interactions

A single-institution prospective study evaluating the functional diffusion map (fDM) as an early imaging biomarker for overall survival in high-grade glioma

Indolequinone mechanism-based inhibitors of NQO1 and NQO2

Induction of apoptosis and cytotoxicity by indolequinones in pancreatic cancer cell lines

Benzene metabolite hydroquinone up-regulates chondromodulin I and inhibits tube formation in human bone marrow endothelial cells

Using RNAi to identify modulators of the HIF pathway/hypoxia for cancer

Downregulation of the cellular adhesion molecule VCAM-1 in human bone marrow endothelial cells after inhibition of NQO1 activity

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