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David R. Newell
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Journal Articles

Abstract LB-300: In vivo evaluation of the intravenous MDM2-p53 antagonist RO6839921 alone and in combination with temozolomide in TP53 wild-type orthotopic models of neuroblastoma

Lindi Chen, Fabio Pastorino, Philip Berry, Jennifer Bonner, Katrina Wood, Gareth Veal, Mirco Ponzoni, John Lunec, David R. Newell, Deborah A. Tweddle
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-300.
DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-300
Published: 01 July 2017
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Journal Articles

Abstract 5451: Profiling inhibitors of MDM2:p53 and MDMX:p53 in relation to MDMX protein levels

Sue Tudhope, Yan Zhao, Anita Wittner, Elaine Wilmore, Annalisa Bertoli, Santosh Adhikari, Suzannah J. Harnor, Fabio Del Bello, Alessandro Piergentili, John Lunec, Ian R. Hardcastle, Roger J. Griffin, Bernard R. Golding, Celine Cano, David R. Newell, Stephen R. Wedge
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5451.
DOI: https://doi.org/10.1158/1538-7445.AM2014-5451
Published: 01 October 2014
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Journal Articles

Abstract 2744: The novel and contrasting roles of ATM and DNA-PK in the response of cells to microtubule-targeting anticancer agents

Emily V.A. Mould, Stephanie E.A. Burnell, Philip L. Berry, David R. Newell, Elaine Willmore
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2744.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2744
Published: 01 October 2014
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Journal Articles

Abstract 2399: DNA-PK is activated by microtubule-targeting agents; mechanistic studies using isogenic wild-type and DNA-PK knockout cells

Emily V.A. Mould, David R. Newell, Elaine Willmore
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2399.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2399
Published: 01 October 2014
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Journal Articles

Abstract 4748: Discovery of JNJ-42756493, a potent fibroblast growth factor receptor (FGFR) inhibitor using a fragment based approach

Patrick R. Angibaud, Laurence Mevellec, Gordon Saxty, Christophe Adelinet, Rhalid Akkari, Valerio Berdini, Pascal Bonnet, Marine Bourgeois, Xavier Bourdrez, Anne Cleasby, Helene Colombel, Imre Csoka, Werner Embrechts, Eddy Freyne, Ronaldus Gilissen, Eleonora Jovcheva, Peter King, Jean Lacrampe, Delphine Lardeau, Yannick Ligny, Steve Mcclue, Lieven Meerpoel, David R. Newell, Martin Page, Alexandra Papanikos, Elisabeth Pasquier, Isabelle Pilatte, Virginie Poncelet, Olivier Querolle, David C. Rees, Sharna Rich, Bruno Roux, Elodie Sement, Yvan Simonnet, Matthew Squires, Virginie Tronel, Tinne Verhulst, Jorge Vialard, Marc Willems, Steven J. Woodhead, Berthold Wroblowski, Christopher W. Murray, Timothy Perera
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4748.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4748
Published: 01 October 2014
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Journal Articles

Abstract 565: An investigation into the potential therapeutic benefit of targeting Skp2 in neuroblastoma.

Laura Evans, Elaine Willmore, Deborah A. Tweddle, David R. Newell
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 565.
DOI: https://doi.org/10.1158/1538-7445.AM2013-565
Published: 15 April 2013
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Journal Articles

Abstract 919: Design and preclinical pharmacological evaluation of a cleavable succinate ester solubilizing group for isoindolinone MDM2-p53 protein-protein interaction inhibitors

Yan Zhao, Huw Thomas, Junfeng Liu, Timothy J. Blackburn, Sarah Cully, Anna F. Watson, Ian R. Hardcastle, Bernard T. Golding, Roger J. Griffin, John Lunec, David R. Newell
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 919.
DOI: https://doi.org/10.1158/1538-7445.AM2012-919
Published: 15 April 2012
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Journal Articles

Abstract 2979: Combined cdk1 and PARP inhibition results in tumor regression in a KrasG12D p53L/L murine lung adenocarcinoma model

Neil Johnson, Yu-Chen Li, Zandra Walton, Danan Li, Lisa Moreau, Scott J. Rodig, Alan D. D'Andrea, Huw Thomas, David R. Newell, Nicola J. Curtin, Kwok K. Wong, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2979.
DOI: https://doi.org/10.1158/1538-7445.AM2011-2979
Published: 15 April 2011
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Journal Articles

Abstract 2548: Chemosensitization of cancer cells by KU-0060648: A dual inhibitor of DNA-PK and PI-3K

Michael A. Batey, Joanne M. Munck, Yan Zhao, Celine Cano, Michele Tavecchio, Julia Bardos, Roger J. Griffin, Helen Jenkins, Keith Menear, Graeme Smith, Pia Thommes, David R. Newell, Niall Martin, Nicola J. Curtin
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2548.
DOI: https://doi.org/10.1158/1538-7445.AM2011-2548
Published: 15 April 2011
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Journal Articles

Abstract 3882: Compromised Cdk1 activity sensitizes BRCA-proficient cancer cells to inhibition of Poly(ADP-ribose) polymerase

Neil Johnson, Yu-Chen Li, Lisa A. Moreau, Huw D. Thomas, David R. Newell, Alan D. D'andrea, Nicola J. Curtin, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3882.
DOI: https://doi.org/10.1158/1538-7445.AM10-3882
Published: 15 April 2010
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Journal Articles

Abstract 5399: Growth inhibition, cytotoxicity and signaling studies of PI3K & MEK inhibitor combinations in colorectal carcinoma cell lines

Emma J. Cox, Suzanne Kyle, Gary S. Beale, Ross J. Maxwell, David R. Newell
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5399.
DOI: https://doi.org/10.1158/1538-7445.AM10-5399
Published: 15 April 2010
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Journal Articles

Abstract 4529: Cellular pharmacokinetic and activity studies with the MDM2-p53 inhibitor Nutlin-3

Yan Zhao, Huw Thomas, John Lunec, David R. Newell
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4529.
DOI: https://doi.org/10.1158/1538-7445.AM10-4529
Published: 15 April 2010
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Journal Articles

Abstract 3626: Development of inhibitors of the fibroblast growth factor receptor (FGFR) kinase using a fragment based approach

Matthew S. Squires, Timothy Perera, Gordon Saxty, Chris Murray, Peter King, George Ward, Ruth Feltell, Sharna Rich, Patrik Angibaud, Edward J. Lewis, Ron Gilissen, Isobel Harada, Lynsey Fazal, Julie A. Irving, Mike A. Batey, Yan Zhao, David R. Newell, Neil T. Thompson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3626.
DOI: https://doi.org/10.1158/1538-7445.AM10-3626
Published: 15 April 2010
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Journal Articles

Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

Yan Zhao, Huw D. Thomas, Michael A. Batey, Ian G. Cowell, Caroline J. Richardson, Roger J. Griffin, A. Hilary Calvert, David R. Newell, Graeme C.M. Smith, Nicola J. Curtin
Journal: Cancer Research
Cancer Res (2006) 66 (10): 5354–5362.
DOI: https://doi.org/10.1158/0008-5472.CAN-05-4275
Published: 16 May 2006
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Journal Articles

Chemo-sensitization by the novel ATM inhibitor (KU-55933) is p53 independent

Yan Zhao, Yuan Lu, David R. Newell, Mark O‘connor*, Alan Lau*, Nicola Harris, Graeme C M Smith, Nicola J. Curtin
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 486.
Published: 15 April 2006
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Journal Articles

Inhibition of fibroblast growth factor receptor 3 by kinase inhibitors induces apoptosis in t(4;14) multiple myeloma

Jose Luis R. Brito, Helen Maitland, Hing Leung, Matthew Squires, Adrian Gill, Nick N. Cross, Graham Jackson, David R. Newell, Julie Irving
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 950–951.
Published: 15 April 2006
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Journal Articles

Comparative activity of the potent selective CDK2 inhibitor NU6102 in CDK2 wild-type and knock-out mouse embryo fibroblasts

Yuzhu Cheng, Lan-Zhan Wang, Nicola J. Curtin, David R. Newell
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1043–1044.
Published: 01 May 2005
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Journal Articles

Radio and chemosensitization by a novel DNA-PK inhibitor (NU7441) in colon cancer

Yan Zhao, Michael Batey, Huw Thomas, Graeme C. Smith, David R. Newell, Nicola J. Curtin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1180–1181.
Published: 01 May 2005
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Journal Articles

Activation of the p53 pathway by small molecular weight inhibitors of the MDM2-p53 interaction

Shafiq U. Ahmed, Helen Atkins, Jane Endicott, Gillian Farnie, Bernard T. Golding, Roger J. Griffin, Jan Gruber, Sabrina Guyenne, Ian R. Hardcastle, Claire Hutton, Per Kallblad, Stuart J. Kemp, David R. Newell, Martin Noble, S. Norbedo, Julian S. Northen, Rebecca J. Reid, K. Saravanan, Jean-Francois Trempe, Henriette M. G. Willems, John Lunec
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1450.
Published: 01 May 2005
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Journal Articles

In Vitro and in Vivo Antitumor Activity of ZENECA ZD0490, a Recombinant Ricin A-Chain Immunotoxin for the Treatment of Colorectal Cancer

Joanne A. Calvete, David R. Newell, Andrew F. Wright, Michael S. Rose
Journal: Cancer Research
Cancer Res (1994) 54 (17): 4684–4690.
Published: 01 September 1994
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