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David Piwnica-Worms
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Journal Articles

Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad, Pham Hong Anh Cao, Thomas L. Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V. Tellman, Caroline F. Ribeiro, Riccardo Muzzioli, Brittany E. Jewell, Hubert Pakula, Jeffrey J. Ackroyd, Mollianne M. Murray, Jenny J. Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, Jingjing Liu, Xingzhi Song, Jianhua Zhang, Albert R. Klekers, Justin M. Drake, Michael M. Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C. Farach-Carson, Massimo Loda, Livia S. Eberlin, Daniel E. Frigo
Journal: Cancer Research
Cancer Res (2024) 84 (5): 703–724.
https://doi.org/10.1158/0008-5472.CAN-23-0555
Published: 04 March 2024
View articletitled, Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity
Open the PDF for Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity in another window
Includes: Supplementary data
Journal Articles

Abstract 5036: Single dose treatment with a novel Yttrium-90-labeled high affinity anti-B7-H3 antibody selective for the 4Ig-B7-H3 isoform provides long term survivors for established radioresistant colorectal carcinoma

Sarah Glazer, Margie Sutton, Ping Yang, Federica Pisaneschi, Seth Gammon, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5036.
https://doi.org/10.1158/1538-7445.AM2023-5036
Published: 04 April 2023
View articletitled, Abstract 5036: Single dose treatment with a novel Yttrium-90-labeled high affinity anti-B7-H3 antibody selective for the 4Ig-B7-H3 isoform provides long term survivors for established radioresistant colorectal carcinoma
Journal Articles

Abstract 6416: Statins inhibit onco-dimerization of 4Ig-B7-H3

Margie Nicole Sutton, Sarah E. Glazer, Riccardo Muzzioli, Ping Yang, Seth T. Gammon, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6416.
https://doi.org/10.1158/1538-7445.AM2023-6416
Published: 04 April 2023
View articletitled, Abstract 6416: Statins inhibit onco-dimerization of 4Ig-B7-H3
Journal Articles

Abstract 2488: PET imaging of innate immunity activation In Vivo with redox-tuned 4-[18F]fluoro-1-naphthol

Seth T. Gammon, Federica Pisaneschi, Vincenzo Paolillo, Sarah Qureshy, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2488.
https://doi.org/10.1158/1538-7445.AM2022-2488
Published: 15 June 2022
View articletitled, Abstract 2488: PET imaging of innate immunity activation In Vivo with redox-tuned 4-[18F]fluoro-1-naphthol
Journal Articles

Abstract 2463: 18F-Talazoparib: A novel potential PET imaging agent of PARP

Riccardo Muzzioli, Federica Pisaneschi, Yi Rao, Seth Gammon, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2463.
https://doi.org/10.1158/1538-7445.AM2022-2463
Published: 15 June 2022
View articletitled, Abstract 2463: 18F-Talazoparib: A novel potential PET imaging agent of PARP
Journal Articles

Abstract 379: Myeloperoxidase-produced HOCl is a paracrine effector linking myeloid cells to NF-κB signaling in melanoma, mediating anti-tumor responses during early melanoma progression

Tracy W. Liu, Seth T. Gammon, Ping Yang, David T. Fuentes, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 379.
https://doi.org/10.1158/1538-7445.AM2020-379
Published: 15 August 2020
View articletitled, Abstract 379: Myeloperoxidase-produced HOCl is a paracrine effector linking myeloid cells to NF-κB signaling in melanoma, mediating anti-tumor responses during early melanoma progression
Journal Articles

Abstract 921: TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy

Caleb Gonzalez, Sarah Williamson, Seth Gammon, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 921.
https://doi.org/10.1158/1538-7445.AM2020-921
Published: 15 August 2020
View articletitled, Abstract 921: TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy
Journal Articles

Abstract 1514: Myeloid cell derived myeloperoxidase links cellular innate immunity to inhibition of NF-κB signaling in melanoma tumor cells

Tracy W. Liu, Seth T. Gammon, Ping Yang, David T. Fuentes, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1514.
https://doi.org/10.1158/1538-7445.AM2019-1514
Published: 01 July 2019
View articletitled, Abstract 1514: Myeloid cell derived myeloperoxidase links cellular innate immunity to inhibition of NF-κB signaling in melanoma tumor cells
Journal Articles

Abstract 10: Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling and preliminary biological studies on crizotinib and alectinib analogues

Mian M. Alauddin, Bhasker Radaram, Yi Rao, Ping Yang, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 10.
https://doi.org/10.1158/1538-7445.AM2019-10
Published: 01 July 2019
View articletitled, Abstract 10: Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling and preliminary biological studies on crizotinib and alectinib analogues
Journal Articles

Abstract 3514: Differential metabolic targeting of PDAC cells with Zaprinast

Yi Rao, Seth Gammon, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3514.
https://doi.org/10.1158/1538-7445.AM2018-3514
Published: 01 July 2018
View articletitled, Abstract 3514: Differential metabolic targeting of PDAC cells with Zaprinast
Journal Articles

Abstract 3139: Innate immune cells expressing myeloperoxidase directly inhibit tumor NF-κB transcriptional activation during tumor initiation

Tracy W. Liu, Seth T. Gammon, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3139.
https://doi.org/10.1158/1538-7445.AM2018-3139
Published: 01 July 2018
View articletitled, Abstract 3139: Innate immune cells expressing myeloperoxidase directly inhibit tumor NF-κB transcriptional activation during tumor initiation
Journal Articles

Abstract LB-367: [18F]FAZA PET imaging reveals precise pharmacodynamics in vivo of the novel chemotherapeutic IACS-010759

Seth T. Gammon, Federica Pisaneschi, Madhavi Bandi, Melinda Smith, Yi Rao, Vashisht G. Yennu Nanda, Yuting Sun, Michael Davies, Emilia Di Francesco, Joseph Marszalek, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-367.
https://doi.org/10.1158/1538-7445.AM2018-LB-367
Published: 01 July 2018
View articletitled, Abstract LB-367: [18F]FAZA PET imaging reveals precise pharmacodynamics in vivo of the novel chemotherapeutic IACS-010759
Journal Articles

Abstract 5461: B7-H3 regulates NF-kB signaling in cancer cells by modulating the degradation and re-synthesis of IkBα

Sarah Glazer, Seth Gammon, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5461.
https://doi.org/10.1158/1538-7445.AM2018-5461
Published: 01 July 2018
View articletitled, Abstract 5461: B7-H3 regulates NF-kB signaling in cancer cells by modulating the degradation and re-synthesis of IkBα
Journal Articles

Abstract 4217: First pre-clinical validation of radiogenomics in glioblastoma

Pascal Zinn, Sanjay Singh, Markus M. Luedi, Faramak Zandi, Aikaterini Kotrotsou, Masumeh Hatami, Ginu Thomas, Ahmed Elakkad, Joy Gumin, Erik P. Sulman, Frederick Lang, David Piwnica-Worms, Rivka R. Colen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4217.
https://doi.org/10.1158/1538-7445.AM2016-4217
Published: 15 July 2016
View articletitled, Abstract 4217: First pre-clinical validation of radiogenomics in glioblastoma
Journal Articles

Abstract 4880: A high-throughput siRNA screen identifies Nucleoside Diphosphate Kinase (NME3) as a novel host regulator of NF-êB signaling in response to Salmonella-induced activation of TLR-5

Caleb Gonzalez, Kelly Flentie, Brandon Kocher, Jayne Jayne Marasa, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4880.
https://doi.org/10.1158/1538-7445.AM2016-4880
Published: 15 July 2016
View articletitled, Abstract 4880: A high-throughput siRNA screen identifies Nucleoside Diphosphate Kinase (NME3) as a novel host regulator of NF-êB signaling in response to Salmonella-induced activation of TLR-5
Journal Articles

Abstract 2316: Fasting protects mice from lethal DNA damage by promoting small intestinal stem cell survival and by inhibiting acute inflammation

Kelsey L. Tinkum, Kristina M. Stemler, Lynn S. White, Andrew J. Loza, Sabrina Jeter-Jones, Basia M. Michalski, Catherine E. Kuzmicki, Robert Pless, Thaddeus Stappenbeck, David Piwnica-Worms, Helen Piwnica-Worms
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2316.
https://doi.org/10.1158/1538-7445.AM2015-2316
Published: 01 August 2015
View articletitled, Abstract 2316: Fasting protects mice from lethal DNA damage by promoting small intestinal stem cell survival and by inhibiting acute inflammation
Journal Articles

Abstract 210: In vivo metabolic imaging to differentiate aggressive versus indolent prostate cancer

Niki Zacharias Millward, Christopher McCullough, Youngbok Lee, Jingzhe Hu, Prasanta Dutta, David Piwnica-Worms, Pratip Bhattacharya
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 210.
https://doi.org/10.1158/1538-7445.AM2015-210
Published: 01 August 2015
View articletitled, Abstract 210: In vivo metabolic imaging to differentiate aggressive versus indolent prostate cancer
Journal Articles

Abstract 1074: Tumor-associated microglia secrete paracrine factors that promote Nf1-deficient optic glial cell growth

Anne C. Solga, Winnie W. Pong, Patrick J. Cimino, Keun Y. Kim, Jason Walker, Todd Wylie, Vincent Magrini, Joshua B. Rubin, David Piwnica-Worms, Mark H. Ellisman, Elaine R. Mardis, David H. Gutmann
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1074.
https://doi.org/10.1158/1538-7445.AM2014-1074
Published: 01 October 2014
View articletitled, Abstract 1074: Tumor-associated microglia secrete paracrine factors that promote Nf1-deficient optic glial cell growth
Journal Articles

Abstract 366: Downregulation of THBS1 is a critical step in glioblastoma angiogenesis.

Michael D. Brooks, Erin Jackson, David Piwnica-Worms, Robi D. Mitra, Joshua B. Rubin
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 366.
https://doi.org/10.1158/1538-7445.AM2013-366
Published: 15 April 2013
View articletitled, Abstract 366: Downregulation of THBS1 is a critical step in glioblastoma angiogenesis.
Journal Articles

Abstract 3939: The collagen receptor discoidin domain receptor 2 facilitates breast cancer metastasis by stabilizing Snail1 protein.

Kun Zhang, Callie Corsa, Julie Prior, David Piwnica-Worms, Gregory D. Longmore
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3939.
https://doi.org/10.1158/1538-7445.AM2013-3939
Published: 15 April 2013
View articletitled, Abstract 3939: The collagen receptor discoidin domain receptor 2 facilitates breast cancer metastasis by stabilizing Snail1 protein.