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David P. Carbone
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Journal Articles

Abstract CT249: Results from KEYMAKER-U01 substudy 3: a phase 2 umbrella study of pembrolizumab plus investigational agents in patients with non-small-cell lung cancer (NSCLC) previously treated with anti-PD-(L)1 therapy

Charu Aggarwal, James Stevenson, Dariusz M. Kowalski, Tibor Csőszi, Nir Peled, Byoung Chul Cho, Belén Rubio-Viqueira, Jiaxin Niu, David P. Carbone, Susanne M. Arnold, Mark M. Awad, Justin F. Gainor, Suman Rao, Anne S. Tsao, Heng Zhou, Omobolaji O. Akala, Elliot Chartash, Ernest Nadal
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT249.
https://doi.org/10.1158/1538-7445.AM2024-CT249
Published: 05 April 2024
View article titled, Abstract CT249: Results from KEYMAKER-U01 substudy 3: a phase 2 umbrella study of pembrolizumab plus investigational agents in patients with non-small-cell lung cancer (NSCLC) previously treated with anti-PD-(L)1 therapy
Journal Articles

Abstract 5088: Evaluating TNF-receptor associated factor 2 (TRAF2) as a targetable driver of immune resistance in LKB1 deficient non-small cell lung cancer

Bahareh Nourmohammadi, Joseph M. Amann, Rahul Shivahare, Qin Ma, Zihai Li, David P. Carbone, Jacob Kaufman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5088.
https://doi.org/10.1158/1538-7445.AM2024-5088
Published: 22 March 2024
View article titled, Abstract 5088: Evaluating TNF-receptor associated factor 2 (TRAF2) as a targetable driver of immune resistance in LKB1 deficient non-small cell lung cancer
Journal Articles

Abstract 6529: Multi-lineage de-differentiation (MLDD) towards the TTF1-low phenotype is a major determinant of immune response within STK11-deficient non-small cell lung cancer

Rahul Shivahare, No Joon Song, Bahareh Nourmohammadi, Jemal Imam, Olivia Sanabria, Joseph M. Amann, Qin Ma, Zihai Li, David P. Carbone, Jacob Kaufman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6529.
https://doi.org/10.1158/1538-7445.AM2024-6529
Published: 22 March 2024
View article titled, Abstract 6529: Multi-lineage de-differentiation (MLDD) towards the TTF1-low phenotype is a major determinant of immune response within STK11-deficient non-small cell lung cancer
Journal Articles

Abstract 4435: A causal modeling platform for testing lifestyle interventions on the microbiome and response to immunotherapy

Aaditya Pallerla, Bailey Conrad, Amna Bibi, Nyelia Williams, Caroline Wheeler, Rebecca Hoyd, Shankar Suman, Joseph Amann, Yangyang Liu, Marisa Bittoni, Shiqi Zhang, Madison Grogan, Alvin Anand, Najma Afrah, Carolyn Presley, Fred K. Tabung, Lang Li, Yael Vodovotz, Jiangjiang Zhu, David P. Carbone, Steven K. Clinton, Daniel Spakowicz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4435.
https://doi.org/10.1158/1538-7445.AM2023-4435
Published: 04 April 2023
View article titled, Abstract 4435: A causal modeling platform for testing lifestyle interventions on the microbiome and response to immunotherapy
Journal Articles

Abstract 2159: A pretreatment blood-based proteomic biomarker for enhanced decision-making in non-small cell lung cancer

Michal Harel, Petros Christopoulos, Coren Lahav, Itamar Sela, Nili Dahan, Niels Reinmuth, Ina Koch, Alona Zer, Mor Moskovitz, Adva Levy-Barda, Michal Lotem, Hovav Nechushtan, Rivka Katzenelson, Abed Agbarya, Mahmoud Abu-Amna, Maya Gottfried, Ido Wolf, Ella Tepper, Yanyan Lou, Raya Leibowitz, Adam P. Dicker, David Gandara, David P. Carbone
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2159.
https://doi.org/10.1158/1538-7445.AM2023-2159
Published: 04 April 2023
View article titled, Abstract 2159: A pretreatment blood-based proteomic biomarker for enhanced decision-making in non-small cell lung cancer
Journal Articles

Abstract A021: Older adult-specific microbes correlate with treatment response and markers of T-cell senescence in NSCLC

Daniel Spakowicz, Rebecca Hoyd, Caroline E. Wheeler, Nyelia Williams, Amna Bibi, Marium Husain, Srichandhana Rajamouli, Shankar Suman, Joseph Amann, Madison Grogan, Pooja Vibhakar, Dwight H. Owen, David P. Carbone, Ashley Rosko, Christin E. Burd, Carolyn J. Presley
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_1): A021.
https://doi.org/10.1158/1538-7445.AGCA22-A021
Published: 15 January 2023
View article titled, Abstract A021: Older adult-specific microbes correlate with treatment response and markers of T-cell senescence in NSCLC
Journal Articles

Abstract PR004: Older adult-specific microbes correlate with treatment response and markers of T-cell senescence in NSCLC

Daniel Spakowicz, Rebecca Hoyd, Caroline E. Wheeler, Nyelia Williams, Amna Bibi, Marium Husain, Srichandhana Rajamouli, Shankar Suman, Joseph Amann, Madison Grogan, Pooja Vibhakar, Dwight H. Owen, David P. Carbone, Ashley Rosko, Christin E. Burd, Carolyn J. Presley
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_1): PR004.
https://doi.org/10.1158/1538-7445.AGCA22-PR004
Published: 15 January 2023
View article titled, Abstract PR004: Older adult-specific microbes correlate with treatment response and markers of T-cell senescence in NSCLC
Journal Articles

Abstract 3523: A Black Raspberry dietary intervention to modify the gut microbiome and improve the response to immune checkpoint inhibitors

Amna Bibi, Aaditya Pallerla, Nyelia Williams, Caroline Wheeler, Rebecca Hoyd, Shankar Suman, Joseph Amann, Mounika Goruganthu, Tamio Okimoto, Yangyang Liu, Marisa Bittoni, Ni Shi, Shiqi Zhang, Alvin Anand, Kristen Heitman, Maxine Mendelson, Elizabeth M. Grainger, Madison Grogan, Carolyn J. Presley, Fred K. Tabung, Lang Li, Yael Vodovotz, Jiangjiang Zhu, David P. Carbone, Tong Chen, Steven K. Clinton, Daniel Spakowicz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3523.
https://doi.org/10.1158/1538-7445.AM2022-3523
Published: 15 June 2022
View article titled, Abstract 3523: A Black Raspberry dietary intervention to modify the gut microbiome and improve the response to immune checkpoint inhibitors
Journal Articles

Abstract CT112: AI-powered and manual assessment of PD-L1 are comparable in predicting response to neoadjuvant atezolizumab in patients (pts) with resectable non-squamous, non-small cell lung cancer (NSCLC)

John Abel, Christopher Rivard, Filip Kos, Guillaume Chhor, Yi Liu, Jennifer Giltnane, Sara Hoffman, Murray Resnick, Cyrus Hedvat, Amaro Taylor-Weiner, Farah Khalil, Alan Nicholas, Gregory A. Fishbein, Lynette M. Sholl, Natasha Rekhtman, Stephanie Hennek, Ilan Wapinski, Ann Johnson, Michael Montalto, Katja Schulze, Bruce E. Johnson, David P. Carbone, Konstantin Shilo, Andrew H. Beck, Sanja Dacic, William D. Travis, Ignacio Wistuba
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT112.
https://doi.org/10.1158/1538-7445.AM2022-CT112
Published: 15 June 2022
View article titled, Abstract CT112: AI-powered and manual assessment of PD-L1 are comparable in predicting response to neoadjuvant atezolizumab in patients (pts) with resectable non-squamous, non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 3578: Optimization of shared neoantigen vaccine design to increase vaccine potency: From bench to bedside and back

Amy R. Rappaport, Christine D. Palmer, Annie Shen, Claudia X. Dominguez, Meghan G. Hart, Lauren D. Kraemer, Sonia Koulavouth, Martina Marrali, Jason R. Jaroslavsky, Charmaine N. Nganje, Ciaran D. Scallan, Sue-Jean Hong, Leonid Gitlin, Monica Lane, Daniel V. Catenacci, Chrisann Kyi, David P. Carbone, Hossein Borghaei, Raphael Rousseau, Andrew Ferguson, Karin Jooss
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3578.
https://doi.org/10.1158/1538-7445.AM2022-3578
Published: 15 June 2022
View article titled, Abstract 3578: Optimization of shared neoantigen vaccine design to increase vaccine potency: From bench to bedside and back
Journal Articles

STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma

Michael J. Koenig, Bernice A. Agana, Jacob M. Kaufman, Michael F. Sharpnack, Walter Z. Wang, Christoph Weigel, Fabio C.P. Navarro, Joseph M. Amann, Nicole Cacciato, Rajeswara Rao Arasada, Mark B. Gerstein, Vicki H. Wysocki, Christopher Oakes, David P. Carbone
Journal: Cancer Research
Cancer Res (2021) 81 (16): 4194–4204.
https://doi.org/10.1158/0008-5472.CAN-20-3199
Published: 15 August 2021
View article titled, STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and <em>S</em>-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma
Open the PDF for STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and <em>S</em>-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1110: Targeting β-catenin enhances the therapeutic efficacy of osimertinib in EGFR- mutant non-small cell lung cancer (NSCLC)

Shankar Suman, Shu-Xiao Guan, Nastaran Navari, Rajeswara Rao Arasada, David P. Carbone, Regan M. Memmott
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1110.
https://doi.org/10.1158/1538-7445.AM2021-1110
Published: 01 July 2021
View article titled, Abstract 1110: Targeting β-catenin enhances the therapeutic efficacy of osimertinib in EGFR- mutant non-small cell lung cancer (NSCLC)
Journal Articles

Abstract PO-011: IWS1 phosphorylation promotes tumor growth and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the epigenetic regulation of U2AF2 RNA splicing

Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Salvatore Alaimo, Christos Tsatsanis, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-011.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-011
Published: 02 December 2020
View article titled, Abstract PO-011: IWS1 phosphorylation promotes tumor growth and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the epigenetic regulation of U2AF2 RNA splicing
Journal Articles

Abstract 748: Genomic characterization of recurrent small cell lung cancer through research autopsy reveals clonal diversity and candidate driver of chemoresistance

Hui-Zi Chen, Russell Bonneville, Melanie A. Krook, Michele R. Wing, Julie W. Reeser, Jharna Miya, Anoosha Paruchuri, Eric Samorodnitsky, Lianbo Yu, Amy M. Smith, Thuy Dao, Dorrelyn Martin, Qishan Guo, Hailey Magenheim, Aharon G. Freud, Sharon Cole, Gregory Otterson, Peter Shields, David P. Carbone, Patricia Allenby, Sameek Roychowdhury
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 748.
https://doi.org/10.1158/1538-7445.AM2019-748
Published: 01 July 2019
View article titled, Abstract 748: Genomic characterization of recurrent small cell lung cancer through research autopsy reveals clonal diversity and candidate driver of chemoresistance
Journal Articles

Abstract 3705: Identification of frequent HER2 activating mutations in canine primary pulmonary adenocarcinoma

Gwendolen Lorch, Karthigayini Sivaprakasam, Victoria Zissman, Nieves Perdigones, Tania Contente-Cuomo, Alexandra Nazareno, Salvatore Facista, ShukMei Wong, Winnie Liang, Joseph M. Amann, Sara L. Sinicropi-Yao, Michael J. Koenig, Krista La Perle, Timothy G. Whitsett, Muhammed Murtaza, Jeffrey Trent, David P. Carbone, William P. Hendricks
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3705.
https://doi.org/10.1158/1538-7445.AM2019-3705
Published: 01 July 2019
View article titled, Abstract 3705: Identification of frequent HER2 activating mutations in canine primary pulmonary adenocarcinoma
Journal Articles

Abstract 824: LKB1 loss in lung adenocarcinoma leads to global hypomethylation and altered FOXA binding

Michael J. Koenig, Joseph Amann, Bernice Agana, Jacob Kaufman, Vicki Wysocki, Christopher Oakes, David P. Carbone
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 824.
https://doi.org/10.1158/1538-7445.AM2019-824
Published: 01 July 2019
View article titled, Abstract 824: LKB1 loss in lung adenocarcinoma leads to global hypomethylation and altered FOXA binding
Journal Articles

Abstract 2620: Aquaporin 11 as a new predictive biomarker of overall survival and platinum-based chemotherapy response in lung adenocarcinoma patients

Michael Sharpnack, David P. Carbone, Mikhail M. Dikov, Elena E. Tchekneva
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2620.
https://doi.org/10.1158/1538-7445.AM2018-2620
Published: 01 July 2018
View article titled, Abstract 2620: Aquaporin 11 as a new predictive biomarker of overall survival and platinum-based chemotherapy response in lung adenocarcinoma patients
Journal Articles

Abstract 545: NOTCH1 co-expression analysis reveals novel insights underlying its opposing effects as an oncogenic and tumor suppressor in lung cancer

Sara L. Sinicropi-Yao, David P. Carbone, Kevin R. Coombes, Joseph M. Amann, David Lopez Lopez
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 545.
https://doi.org/10.1158/1538-7445.AM2018-545
Published: 01 July 2018
View article titled, Abstract 545: NOTCH1 co-expression analysis reveals novel insights underlying its opposing effects as an oncogenic and tumor suppressor in lung cancer
Journal Articles

Abstract 5843: The efficacy of a histone deacetylase inhibitor in combination with a MEK inhibitor in lung cancer cells harboring RAS mutations

Tadaaki Yamada, Joseph M. Amann, Azusa Tanimoto, Hirokazu Taniguchi, Takehito Shukuya, Seiji Yano, Koichi Takayama, David P. Carbone
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5843.
https://doi.org/10.1158/1538-7445.AM2018-5843
Published: 01 July 2018
View article titled, Abstract 5843: The efficacy of a histone deacetylase inhibitor in combination with a MEK inhibitor in lung cancer cells harboring RAS mutations
Journal Articles

Abstract CT082: Impact of tumor mutation burden on the efficacy of first-line nivolumab in stage iv or recurrent non-small cell lung cancer: An exploratory analysis of CheckMate 026

Solange Peters, Benjamin Creelan, Matthew D. Hellmann, Mark A. Socinski, Martin Reck, Prabhu Bhagavatheeswaran, Han Chang, William J. Geese, Luis Paz-Ares, David P. Carbone
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT082.
https://doi.org/10.1158/1538-7445.AM2017-CT082
Published: 01 July 2017
View article titled, Abstract CT082: Impact of tumor mutation burden on the efficacy of first-line nivolumab in stage iv or recurrent non-small cell lung cancer: An exploratory analysis of CheckMate 026