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David Malkin
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Journal Articles

Abstract 3540: Reduction in cell viability of hepatoblastoma cells following inhibtion of Hsp90

Ashby Kissoondoyal, Emily DeSousa, Paula R. Quaglietta, Emilie Indersie, Stefano Cairo, David Malkin, Lisandro Luques, Reto M. Baertschiger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3540.
https://doi.org/10.1158/1538-7445.AM2023-3540
Published: 04 April 2023
View article titled, Abstract 3540: Reduction in cell viability of hepatoblastoma cells following inhibtion of Hsp90
Journal Articles

Abstract 3539: Indoleamine-2,3-dioxygenase 2 (IDO-2) is expressed in hepatoblastoma cells and associated with metastatic state

Lisandro Luques, Ashby Kissoondoyal, Emily De Sousa, Paula Quaglietta, David Malkin, Stefano Cairo, Emilie Indersie, Reto Baertschiger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3539.
https://doi.org/10.1158/1538-7445.AM2023-3539
Published: 04 April 2023
View article titled, Abstract 3539: Indoleamine-2,3-dioxygenase 2 (IDO-2) is expressed in hepatoblastoma cells and associated with metastatic state
Journal Articles

Abstract 6545: Investigating secondary findings in a pediatric cancer cohort: preliminary findings

Safa Majeed, Stephenie Prokopec, Brianne Laverty, Vallijah Subasri, Michael Taylor, Yvonne Bombard, Trevor Pugh, Adam Shlien, Anita Villani, David Malkin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6545.
https://doi.org/10.1158/1538-7445.AM2023-6545
Published: 04 April 2023
View article titled, Abstract 6545: Investigating secondary findings in a pediatric cancer cohort: preliminary findings
Journal Articles

Abstract 5309: Isolation and validation of small extracellular vesicles from rhabdomyosarcoma cells

Paula R. Quaglietta, Ashby Kissoondoyal, Ethan Malkin, Salvador Mejia, Ann Gong, David Malkin, Reto M. Baertschiger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5309.
https://doi.org/10.1158/1538-7445.AM2023-5309
Published: 04 April 2023
View article titled, Abstract 5309: Isolation and validation of small extracellular vesicles from rhabdomyosarcoma cells
Journal Articles

Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Guillaume Bourque, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Paul Moorehead, Michael F. Moran, Daniel A. Morgenstern, Sapna Oberoi, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, Stephanie Villeneuve, James A. Whitlock, David Malkin, on behalf of the PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4509.
https://doi.org/10.1158/1538-7445.AM2023-4509
Published: 04 April 2023
View article titled, Abstract 4509: A pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-cure cancer: The PRecision Oncology For Young peopLE (PROFYLE) Program
Journal Articles

Abstract 53: Zebrafish tp53 mutants recapitulate Li-Fraumeni syndrome phenotypes and provide a preclinical platform for evaluating tumor preventive compounds

Kim Kobar, Erin Burnley, Lissandra Tuzi, Craig Midgen, Adam Shlien, David Malkin, Sergey V. Prykhozhij, Jason N. Berman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 53.
https://doi.org/10.1158/1538-7445.AM2023-53
Published: 04 April 2023
View article titled, Abstract 53: Zebrafish <em>tp53</em> mutants recapitulate Li-Fraumeni syndrome phenotypes and provide a preclinical platform for evaluating tumor preventive compounds
Journal Articles

Abstract 3555: Proteomic characterization of rhabdomyosarcoma-derived extracellular vesicles reveals a fusion-positive protein signature

Paula R. Quaglietta, Ashby Kissoondoyal, Ethan Malkin, David Malkin, Reto M. Baertschiger
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3555.
https://doi.org/10.1158/1538-7445.AM2023-3555
Published: 04 April 2023
View article titled, Abstract 3555: Proteomic characterization of rhabdomyosarcoma-derived extracellular vesicles reveals a fusion-positive protein signature
Journal Articles

Abstract 4670: True bench-to-bedside science: An international pilot study modeling hard-to-cure pediatric cancers to prioritize therapeutic intervention

Nadine Azzam, Nicole Melong, Lissandra Tuzi, Lisa Pinto, Jamie I. Fletcher, Alvin Kamili, Biljana Dumevska, Loretta Lau, Jennifer A. Chan, Donna L. Senger, Stephanie A. Grover, Michelle Haber, David Malkin, Jason N. Berman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4670.
https://doi.org/10.1158/1538-7445.AM2023-4670
Published: 04 April 2023
View article titled, Abstract 4670: True bench-to-bedside science: An international pilot study modeling hard-to-cure pediatric cancers to prioritize therapeutic intervention
Journal Articles

Abstract 849: Characterization and prevention of radiation-induced malignancies in Li-Fraumeni Syndrome

Pamela Psarianos, Nicholas Fischer, Camilla Giovino, Noel Ong, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 849.
https://doi.org/10.1158/1538-7445.AM2022-849
Published: 15 June 2022
View article titled, Abstract 849: Characterization and prevention of radiation-induced malignancies in Li-Fraumeni Syndrome
Journal Articles

Abstract 844: Germline TP53 missense mutations at codon338 confer adult-onset cancer risk through weakened p53 protein oligomeric stability that impairs its tumor suppressive mechanisms

Nicholas W. Fischer, Jaime Turk, Noel Ong, Shili Duan, Lilia Kaustov, Christian Kratz, Kristian Pajtler, Raymond Kim, Cheryl Arrowsmith, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 844.
https://doi.org/10.1158/1538-7445.AM2022-844
Published: 15 June 2022
View article titled, Abstract 844: Germline <em>TP53</em> missense mutations at codon338 confer adult-onset cancer risk through weakened p53 protein oligomeric stability that impairs its tumor suppressive mechanisms
Journal Articles

Abstract 1428: DNA methylation predicts early onset of primary tumor in patients with Li-Fraumeni syndrome

Vallijah Subasri, Benjamin Brew, Lauren Erdman, Tanya Guha, Jordan R. Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L. Finlay, Kim E. Nichols, Wendy Kohlmann, Noa Alon, Ana Novokmet, Ledia Brunga, Anita Villani, Kelvin C. de Andrade, Payal P. Khincha, Sharon A. Savage, Joshua D. Schiffman, David Malkin, Anna Goldenberg
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1428.
https://doi.org/10.1158/1538-7445.AM2022-1428
Published: 15 June 2022
View article titled, Abstract 1428: DNA methylation predicts early onset of primary tumor in patients with Li-Fraumeni syndrome
Journal Articles

Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Michael F. Moran, Daniel A. Morgenstern, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5224.
https://doi.org/10.1158/1538-7445.AM2022-5224
Published: 15 June 2022
View article titled, Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada
Journal Articles

Abstract 2021: Wilms tumor and pure erythroid leukemia arising from the same clone in an adolescent

Anita Villani, Winnie Lo, Yisu Li, Mohamed Abdelhaleem, Mary Shago, Federico Comitani, My Linh Thibodeau, Sarah Alexander, Uri Tabori, David Malkin, Adam Shlien, Jack Brzezinski
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2021.
https://doi.org/10.1158/1538-7445.AM2022-2021
Published: 15 June 2022
View article titled, Abstract 2021: Wilms tumor and pure erythroid leukemia arising from the same clone in an adolescent
Journal Articles

Abstract 3047: Investigating the interaction between the microbiome and mutant p53 in Li-Fraumeni Syndrome

Noel Wei Ong, Camilla Maria Giovino, Nicholas William Fischer, Pamela Psarianos, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3047.
https://doi.org/10.1158/1538-7445.AM2022-3047
Published: 15 June 2022
View article titled, Abstract 3047: Investigating the interaction between the microbiome and mutant p53 in Li-Fraumeni Syndrome
Journal Articles

Abstract 3364: Diagnosing Li-Fraumeni syndrome from the somatic genome

Brianne Laverty, Vallijah Subasri, Nicholas Light, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3364.
https://doi.org/10.1158/1538-7445.AM2022-3364
Published: 15 June 2022
View article titled, Abstract 3364: Diagnosing Li-Fraumeni syndrome from the somatic genome
Journal Articles

Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma

Ana Stosic, Fabio Fuligni, Nathaniel D. Anderson, Scott Davidson, Richard de Borja, Meryl Acker, Vito Forte, Paolo Campisi, Evan J. Propst, Nikolaus E. Wolter, Rose Chami, Ozgur Mete, David Malkin, Adam Shlien, Jonathan D. Wasserman
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5625–5637.
https://doi.org/10.1158/0008-5472.CAN-21-0761
Published: 15 November 2021
View article titled, Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Open the PDF for Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2591: Characterizing the metabolic landscape of dermal fibroblasts in Li-Fraumeni Syndrome for the prediction of cancer risk and drug response

Pamela Psarianos, Camilla Giovino, Sangeetha Paramathas, Nish Patel, Rajesh Gupta, Ran Kafri, David Malkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2591.
https://doi.org/10.1158/1538-7445.AM2021-2591
Published: 01 July 2021
View article titled, Abstract 2591: Characterizing the metabolic landscape of dermal fibroblasts in Li-Fraumeni Syndrome for the prediction of cancer risk and drug response
Journal Articles

Abstract 2689: Investigating the molecular mechanisms linking disrupted growth homeostasis to tumourigenesis in Li-Fraumeni Syndrome

Camilla Giovino, Frank Telfer, Nish Patel, Sangeetha Paramathas, Ran Kafri, David Malkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2689.
https://doi.org/10.1158/1538-7445.AM2021-2689
Published: 01 July 2021
View article titled, Abstract 2689: Investigating the molecular mechanisms linking disrupted growth homeostasis to tumourigenesis in Li-Fraumeni Syndrome
Journal Articles

Abstract 886: Prediction of outcome in Li-Fraumeni Syndrome: Development of an integrative function-based prognostic model

Nicholas Fischer, David Malkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 886.
https://doi.org/10.1158/1538-7445.AM2021-886
Published: 01 July 2021
View article titled, Abstract 886: Prediction of outcome in Li-Fraumeni Syndrome: Development of an integrative function-based prognostic model
Journal Articles

Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Thierry Alcindor, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Abha Gupta, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael F. Moran, Daniel A. Morgenstern, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 636.
https://doi.org/10.1158/1538-7445.AM2021-636
Published: 01 July 2021
View article titled, Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer