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Journal Articles

Abstract 1428: DNA methylation predicts early onset of primary tumor in patients with Li-Fraumeni syndrome

Vallijah Subasri, Benjamin Brew, Lauren Erdman, Tanya Guha, Jordan R. Hansford, Elizabeth Cairney, Carol Portwine, Christine Elser, Jonathan L. Finlay, Kim E. Nichols, Wendy Kohlmann, Noa Alon, Ana Novokmet, Ledia Brunga, Anita Villani, Kelvin C. de Andrade, Payal P. Khincha, Sharon A. Savage, Joshua D. Schiffman, David Malkin, Anna Goldenberg
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1428.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1428
Published: 15 June 2022
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Journal Articles

Abstract 3364: Diagnosing Li-Fraumeni syndrome from the somatic genome

Brianne Laverty, Vallijah Subasri, Nicholas Light, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3364.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3364
Published: 15 June 2022
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Journal Articles

Abstract 844: Germline TP53 missense mutations at codon338 confer adult-onset cancer risk through weakened p53 protein oligomeric stability that impairs its tumor suppressive mechanisms

Nicholas W. Fischer, Jaime Turk, Noel Ong, Shili Duan, Lilia Kaustov, Christian Kratz, Kristian Pajtler, Raymond Kim, Cheryl Arrowsmith, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 844.
DOI: https://doi.org/10.1158/1538-7445.AM2022-844
Published: 15 June 2022
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Journal Articles

Abstract 849: Characterization and prevention of radiation-induced malignancies in Li-Fraumeni Syndrome

Pamela Psarianos, Nicholas Fischer, Camilla Giovino, Noel Ong, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 849.
DOI: https://doi.org/10.1158/1538-7445.AM2022-849
Published: 15 June 2022
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Journal Articles

Abstract 2021: Wilms tumor and pure erythroid leukemia arising from the same clone in an adolescent

Anita Villani, Winnie Lo, Yisu Li, Mohamed Abdelhaleem, Mary Shago, Federico Comitani, My Linh Thibodeau, Sarah Alexander, Uri Tabori, David Malkin, Adam Shlien, Jack Brzezinski
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2021.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2021
Published: 15 June 2022
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Journal Articles

Abstract 3047: Investigating the interaction between the microbiome and mutant p53 in Li-Fraumeni Syndrome

Noel Wei Ong, Camilla Maria Giovino, Nicholas William Fischer, Pamela Psarianos, David Malkin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3047.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3047
Published: 15 June 2022
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Journal Articles

Abstract 5224: The PRecision Oncology For Young peopLE (PROFYLE) Program: A national precision oncology program for children, adolescents and young adults with hard-to-cure cancer in Canada

Stephanie A. Grover, Lesleigh Abbott, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, Conrad V. Fernandez, Cynthia Hawkins, Jan-Willem Henning, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Philipp F. Lange, Michael F. Moran, Daniel A. Morgenstern, Antonia Palmer, Shahrad R. Rassekh, Donna L. Senger, Adam Shlien, Daniel Sinnett, Caron Strahlendorf, Patrick J. Sullivan, Michael D. Taylor, Suzanne Vercauteren, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5224.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5224
Published: 15 June 2022
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Journal Articles

Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma

Ana Stosic, Fabio Fuligni, Nathaniel D. Anderson, Scott Davidson, Richard de Borja, Meryl Acker, Vito Forte, Paolo Campisi, Evan J. Propst, Nikolaus E. Wolter, Rose Chami, Ozgur Mete, David Malkin, Adam Shlien, Jonathan D. Wasserman
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5625–5637.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0761
Published: 15 November 2021
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Includes: Supplementary data
Journal Articles

Abstract 636: PROFYLE: The pan-Canadian precision oncology program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Thierry Alcindor, Jason N. Berman, Jennifer A. Chan, Avram E. Denburg, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Abha Gupta, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael F. Moran, Daniel A. Morgenstern, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 636.
DOI: https://doi.org/10.1158/1538-7445.AM2021-636
Published: 01 July 2021
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Journal Articles

Abstract 886: Prediction of outcome in Li-Fraumeni Syndrome: Development of an integrative function-based prognostic model

Nicholas Fischer, David Malkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 886.
DOI: https://doi.org/10.1158/1538-7445.AM2021-886
Published: 01 July 2021
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Journal Articles

Abstract 2591: Characterizing the metabolic landscape of dermal fibroblasts in Li-Fraumeni Syndrome for the prediction of cancer risk and drug response

Pamela Psarianos, Camilla Giovino, Sangeetha Paramathas, Nish Patel, Rajesh Gupta, Ran Kafri, David Malkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2591.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2591
Published: 01 July 2021
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Journal Articles

Abstract 2689: Investigating the molecular mechanisms linking disrupted growth homeostasis to tumourigenesis in Li-Fraumeni Syndrome

Camilla Giovino, Frank Telfer, Nish Patel, Sangeetha Paramathas, Ran Kafri, David Malkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2689.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2689
Published: 01 July 2021
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Journal Articles

Abstract 2114: Horvath clock as a predictor of cancer risk in LFS patients

Malgorzata Pienkowska, Nardin Samuel, Sanaa Choufani, Vallijah Subasri, Nish Patel, Rosanna Weksberg, Ran Kafri, David Malkin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2114.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2114
Published: 01 July 2021
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Journal Articles

Abstract 5413: Terry Fox PRecision Oncology For Young peopLE (PROFYLE): A Canadian precision medicine program for children, adolescents and young adults with hard-to-treat cancer

Stephanie A. Grover, Jason N. Berman, Jennifer A. Chan, Rebecca J. Deyell, David D. Eisenstat, Conrad V. Fernandez, Paul E. Grundy, Cynthia Hawkins, Meredith S. Irwin, Nada Jabado, Steven J. Jones, Michael Moran, Shahrad R. Rassekh, Adam Shlien, Daniel Sinnett, Poul H. Sorensen, Patrick J. Sullivan, Michael D. Taylor, Anita Villani, James A. Whitlock, David Malkin, on behalf of the Terry Fox PROFYLE Consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5413.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5413
Published: 15 August 2020
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Journal Articles

Abstract SY09-03: PROFYLEing Cancer for KiCS: The Canadian Pediatric Precision Oncology Initiative

David Malkin, Jason N. Berman, Jennifer A. Chan, Avram Denburg, Rebecca Deyell, David Eisenstadt, Conrad Fernandez, Stephanie Grover, Abha Gupta, Cynthia Hawkings, Meredith Irwin, Nada Jabado, Steven Jones, Daniel Morgenstern, Michael Moran, Rod Rasesekh, Adam Shlien, Daniel Sinnett, Poul Sorensen, Patrick Sullivan, Michael Taylor, Anita Villani, Jim Whitlock
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): SY09-03.
DOI: https://doi.org/10.1158/1538-7445.AM2020-SY09-03
Published: 15 August 2020
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Journal Articles

Abstract B07: Prospective germline next-generation sequencing in pediatric patients with neuroblastoma identifies frequent alterations in genes involved in DNA damage repair

Sarah Cohen-Gogo, Karin Langenberg-Ververgaert, Anita Villani, Winnie Lo, Ted Young, Nisha Kanwar, Scott Davidson, Nathaniel Anderson, Bailey Gallinger, Mehdi Layeghifard, Larissa Waldman, Daniel Morgenstern, Ledia Brunga, Stephen Meyn, David Malkin, Adam Shlien, Meredith Irwin
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B07.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B07
Published: 15 July 2020
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Journal Articles

Abstract IA02: Novel strategies for early cancer detection and prevention: The Li-Fraumeni syndrome story

David Malkin, Nicholas Light, Valli Subrasi, Benjamin Brew, Sangeetha Paramathas, Arash Nabbi, Sergei Prykhozhij, Trevor Pugh, Jason Berman, Anna Goldenberg, Adam Shlien
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA02.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-IA02
Published: 15 July 2020
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Journal Articles

Abstract 1639: Predictive modeling of cancer-type in Li-Fraumeni syndrome

Vallijah Subasri, Nicholas Light, Benjamin Brew, Nathaniel Anderson, Adam Shlien, Anna Goldenberg, David Malkin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1639.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1639
Published: 01 July 2019
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Journal Articles

Abstract 2506: Exploring the complex etiology of oncogenic fusions in childhood cancer

Nathaniel D. Anderson, Richard de Borja, Matthew D. Young, Fabio Fuligni, Andrej Rosic, Nicola D. Roberts, Nischalan Pillay, Jeffrey A. Toretsky, Yoshida Akihiko, Tatsuhiro Shibata, Markus Metzler, Gino Somers, Stephen W. Scherer, Adrienne M. Flanagan, Peter J. Campbell, Joshua D. Schiffman, Mary Shago, Ludmil B. Alexandrov, Jay S. Wunder, Irene L. Andrulis, David Malkin, Sam Behjati, Adam Shlien
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2506.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2506
Published: 01 July 2019
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Journal Articles

Abstract 2032: Investigating the contribution of mTORC1-dependent signaling in the microenvironment to cancer onset in Li-Fraumeni syndrome

Camilla Giovino, Nish Patel, Sangeetha Paramathas, Gaetano Zafarana, Ran Kafri, David Malkin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2032.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2032
Published: 01 July 2019
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