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David M. Sabatini
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Journal Articles

Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition

Bryan Ngo, Eugenie Kim, Sophia Doll, Sophia Bustraan, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino Ferraro, Diane Kang, Jing Ni, Roger Liang, Ariana Plasger, Edward R. Kastenhuber, Roozbeh Eskandari, Sarah Bacha, Roshan Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Edouard Mullarky, Matija Snuderl, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Matthew G. Vander Heiden, Matthias Mann, Lewis C. Cantley, Michael E. Pacold
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5712.
https://doi.org/10.1158/1538-7445.AM2020-5712
Published: 15 August 2020
View article titled, Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition
Journal Articles

Abstract NG02: NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis

Samantha W. Alvarez, Vladislav O. Sviderskiy, Erdem M. Terzi, Thales Papagiannakopoulos, Andre L. Moreira, Sylvia Adams, David M. Sabatini, Kıvanç Birsoy, Richard L. Possemato
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): NG02.
https://doi.org/10.1158/1538-7445.AM2018-NG02
Published: 01 July 2018
View article titled, Abstract NG02: NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis
Journal Articles

Abstract 4988: Genome-wide CRISPR screen and metabolite profiling reveal a new mechanism of methotrexate sensitivity

Naama Kanarek, Elizaveta Freinkman, Jason Cantor, Monther Abu-Remaileh, Tim Wang, David M. Sabatini
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4988.
https://doi.org/10.1158/1538-7445.AM2017-4988
Published: 01 July 2017
View article titled, Abstract 4988: Genome-wide CRISPR screen and metabolite profiling reveal a new mechanism of methotrexate sensitivity
Journal Articles

Abstract IA02: Regulation of growth by the mTOR pathway

David M. Sabatini
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): IA02.
https://doi.org/10.1158/1538-7445.Transcontrol16-IA02
Published: 14 March 2017
View article titled, Abstract IA02: Regulation of growth by the mTOR pathway
Journal Articles

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

Taru Muranen, Laura M. Selfors, Julie Hwang, Lisa L. Gallegos, Jonathan L. Coloff, Carson C. Thoreen, Seong A. Kang, David M. Sabatini, Gordon B. Mills, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2016) 76 (24): 7168–7180.
https://doi.org/10.1158/0008-5472.CAN-16-0155
Published: 15 December 2016
View article titled, ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Open the PDF for ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP in another window
Includes: Supplementary data
Journal Articles

Abstract IA-16: Control of growth by mTOR signaling

David M. Sabatini
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): IA-16.
https://doi.org/10.1158/0008-5472.FBCR09-IA-16
Published: 28 October 2014
View article titled, Abstract IA-16: Control of growth by mTOR signaling
Journal Articles

Abstract SY01-01: Regulation of growth by the mTOR pathway.

David M. Sabatini
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): SY01-01.
https://doi.org/10.1158/1538-7445.AM2013-SY01-01
Published: 15 April 2013
View article titled, Abstract SY01-01: Regulation of growth by the mTOR pathway.
Journal Articles

Abstract 4317: PTEN-null tumors cohabiting the same lung display differential Akt activation and sensitivity to dietary restriction.

Natasha L. Curry, Mari Mino-Kenudson, Trudy G. Oliver, Omer H. Yilmaz, Vedat O. Yilmaz, Jade Moon, Tyler Jacks, David M. Sabatini, Nada Y. Kalaany
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4317.
https://doi.org/10.1158/1538-7445.AM2013-4317
Published: 15 April 2013
View article titled, Abstract 4317: PTEN-null tumors cohabiting the same lung display differential Akt activation and sensitivity to dietary restriction.
Journal Articles

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

Qingsong Liu, Chunxiao Xu, Sivapriya Kirubakaran, Xin Zhang, Wooyoung Hur, Yan Liu, Nicholas P. Kwiatkowski, Jinhua Wang, Kenneth D. Westover, Peng Gao, Dalia Ercan, Mario Niepel, Carson C. Thoreen, Seong A. Kang, Matthew P. Patricelli, Yuchuan Wang, Tanya Tupper, Abigail Altabef, Hidemasa Kawamura, Kathryn D. Held, Danny M. Chou, Stephen J. Elledge, Pasi A. Janne, Kwok-Kin Wong, David M. Sabatini, Nathanael S. Gray
Journal: Cancer Research
Cancer Res (2013) 73 (8): 2574–2586.
https://doi.org/10.1158/0008-5472.CAN-12-1702
Published: 15 April 2013
View article titled, Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Open the PDF for Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR in another window
Includes: Supplementary data
Journal Articles

Rapamycin disruption of mTOR-mLST8-raptor complex inhibits cell motility

Lei Liu, Fengjun Li, Christopher S. Beevers, Jun Chung, David M. Sabatini, Peter J. Houghton, Shile Huang
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 324.
Published: 15 April 2006
View article titled, Rapamycin disruption of mTOR-mLST8-raptor complex inhibits cell motility