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David M. Lucas
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Journal Articles

Abstract 1029: MAPK-mediated immunomodulation in disseminated murine Emu-TCL1 chronic lymphocytic leukemia

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Aparna Lakshmanan, Yo-Ting Tsai, Amy Lehman, Ellen J. Sass, Minh Tran, Fabienne Lucas, Meixiao Long, Bonnie K. Harrington, Krista La Perle, Vincenzo Coppola, Gerard Lozanski, Natarajan Muthusamy, John C. Byrd, Michael R. Grever, David M. Lucas
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1029.
https://doi.org/10.1158/1538-7445.AM2017-1029
Published: 01 July 2017
View article titled, Abstract 1029: MAPK-mediated immunomodulation in disseminated murine Emu-TCL1 chronic lymphocytic leukemia
Journal Articles

Abstract 1721: Resistance to silvestrol is mediated by MDR1/Pgp over-expression in a lymphoblastic leukemia cell line and is reversible by treatment with rapamycin

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Sneha V. Gupta, Ellen J. Sass, Melanie E. Davis, Ryan B. Edwards, Gerard Lozanski, Nyla A. Heerema, Amy Lehman, Xiaoli Zhang, David Jarjoura, John C. Byrd, Kenneth K. Chan, A. Douglas Kinghorn, Michael Grever, Mitch A. Phelps, David M. Lucas
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1721.
https://doi.org/10.1158/1538-7445.AM2011-1721
Published: 15 April 2011
View article titled, Abstract 1721: Resistance to silvestrol is mediated by MDR1/Pgp over-expression in a lymphoblastic leukemia cell line and is reversible by treatment with rapamycin
Journal Articles

Abstract 3558: The natural product silvestrol decreases oncogenic FLT3 and miR-155 levels in FLT3-ITD positive Acute Myeloid Leukemia (AML) cells

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Houda Alachkar, Shujun Liu, Sebastian Schwind, Heiko Becker, Klaus H. Metzeler, Christopher Hickey, Jiuxia Pang, Susan P. Whitman, Kenneth K. Chan, Ramiro Garzon, David M. Lucas, Danilo Perrotti, Lai-Chu Wu, Michael R. Grever, A D. Kinghorn, Guido Marcucci
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3558.
https://doi.org/10.1158/1538-7445.AM10-3558
Published: 15 April 2010
View article titled, Abstract 3558: The natural product silvestrol decreases oncogenic FLT3 and miR-155 levels in FLT3-ITD positive Acute Myeloid Leukemia (AML) cells
Journal Articles

Silvestrol 5”’, 6”’-diacetate, a semi-synthetic rocaglate derivative from the Indonesian plant Aglaia foveolata, has anti-tumor activity against Chronic Lymphocytic Leukemia cells in vitro

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David M. Lucas, Ryan B. Edwards, Bao-Ning Su, Thomas Lin, John C. Byrd, A. Douglas Kinghorn, Michael R. Grever
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 454.
Published: 15 April 2006
View article titled, Silvestrol 5”’, 6”’-diacetate, a semi-synthetic rocaglate derivative from the Indonesian plant Aglaia foveolata, has anti-tumor activity against Chronic Lymphocytic Leukemia cells in vitro
Journal Articles

Clinical rebirth of flavopiridol in chronic lymphocytic leukemia (CLL): Utilizing in vitro and in vivo pharmacodynamic measurements to improve efficacy and interrogate relevant mechanism(s) of action

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Amy J. Johnson, David M. Lucas, Lisa L. Smith, Jamie M. S. Allison, Thomas S. Lin, Michael R. Grever, John C. Byrd
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 394.
Published: 01 May 2005
View article titled, Clinical rebirth of flavopiridol in chronic lymphocytic leukemia (CLL): Utilizing in vitro and in vivo pharmacodynamic measurements to improve efficacy and interrogate relevant mechanism(s) of action
Journal Articles

Epigenetic Profiling in Chronic Lymphocytic Leukemia Reveals Novel Methylation Targets

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Laura J. Rush, Aparna Raval, Pauline Funchain, Amy J. Johnson, Lisa Smith, David M. Lucas, Melania Bembea, Te-Hui Liu, Nyla A. Heerema, Laura Rassenti, Sandya Liyanarachchi, Ramana Davuluri, John C. Byrd, Christoph Plass
Journal: Cancer Research
Cancer Res (2004) 64 (7): 2424–2433.
https://doi.org/10.1158/0008-5472.CAN-03-2870
Published: 01 April 2004
View article titled, Epigenetic Profiling in Chronic Lymphocytic Leukemia Reveals Novel Methylation Targets
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