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David Lyden
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Journal Articles

Abstract 585: Utilizing CAR T cell-derived exosomes for radiotheranostic applications

Free
Sarah Qureshy, Leah Gajecki, Darren Veach, Sang Gyu Lee, Irina Matei, Lukas Carter, David Lyden, David Scheinberg, Simone Krebs
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 585.
https://doi.org/10.1158/1538-7445.AM2025-585
Published: 21 April 2025
View articletitled, Abstract 585: Utilizing CAR T cell-derived exosomes for radiotheranostic applications
Journal Articles

Abstract 1038: Identification of diagnostic biomarkers for colon adenocarcinoma by analyzing proteins in human-derived extracellular vesicles and particles

Free
Yura Seo, Yoon Dae Han, Linda Bojmar, Kyung-A Kim, Yurin Seo, David Lyden, Han Sang Kim
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1038.
https://doi.org/10.1158/1538-7445.AM2024-1038
Published: 22 March 2024
View articletitled, Abstract 1038: Identification of diagnostic biomarkers for colon adenocarcinoma by analyzing proteins in human-derived extracellular vesicles and particles
Journal Articles

Abstract PR012: Perioperative liver biopsy captures features of the liver pre-metastatic niche and predicts metastatic outcome after pancreatic cancer resection

Free
Linda Bojmar, Constantinos P. Zambirinis, Jonathan Hernandez, Jayasree Chakraborty, Samer Hanna, Diane Simeone, David Kelsen, Haiying Zhang, Irina R Matei, Per Sandström, Robert Schwartz, William R. Jarnagin, David Lyden
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): PR012.
https://doi.org/10.1158/1538-7445.PANCA22-PR012
Published: 15 November 2022
View articletitled, Abstract PR012: Perioperative liver biopsy captures features of the liver pre-metastatic niche and predicts metastatic outcome after pancreatic cancer resection
Journal Articles

Abstract C028: The lung pro-thrombotic niche drives cancer-associated thromboembolism and metastasis via extracellular vesicle ITGB2

Free
Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Linda Bojmar, Michele Cioffi, Pernille Lauritzen, Henrik Molina, Soeren Heissel, Henry B. Lengel, Xiaohong Jing, Haiying Zhang, Irina Matei, Eileen M. O'Reilly, William R. Jarnagin, David Jones, James B. Bussel, David Kelsen, Jacqueline F. Bromberg, Diane M. Simeone, David Lyden
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C028.
https://doi.org/10.1158/1538-7445.PANCA22-C028
Published: 15 November 2022
View articletitled, Abstract C028: The lung pro-thrombotic niche drives cancer-associated thromboembolism and metastasis via extracellular vesicle ITGB2
Journal Articles

Abstract 3138: The lung pro-thrombotic niche drives cancer-associated thromboembolism via exosomal ITGB2

Free
Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Linda Bojmar, Michele Cioffi, Pernille Lauritzen, Henrik Molina, Soren Heissel, Harry B. Lengel, Xiaohong Jing, Haiying Zhang, Irina Matei, Eileen M. O'Reilly, William R. Jarnagin, David R. Jones, James B. Bussel, David Kelsen, Jacqueline F. Bromberg, Diane M. Simeone, David Lyden
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3138.
https://doi.org/10.1158/1538-7445.AM2022-3138
Published: 15 June 2022
View articletitled, Abstract 3138: The lung pro-thrombotic niche drives cancer-associated thromboembolism via exosomal ITGB2
Journal Articles

Abstract P5-05-02: Extracellular vesicles from obese human breast adipose tissue promote breast cancer cell proliferation by increasing mitochondrial mass and stimulating mitochondrial respiration

Free
Shuchen Liu, Alberto Benito-Martin, Phoebe Piloco, Catherine Liu, Paul Paik, Jason A Spector, Fanny A Pelissier Vatter, David Lyden, David M Otterburn, Leslie Cohen, Olivier Elemento, Rohan Bareja, Leona Cohen-Gould, Samuel Calto, Kristy A Brown
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-05-02.
https://doi.org/10.1158/1538-7445.SABCS21-P5-05-02
Published: 15 February 2022
View articletitled, Abstract P5-05-02: Extracellular vesicles from obese human breast adipose tissue promote breast cancer cell proliferation by increasing mitochondrial mass and stimulating mitochondrial respiration
Journal Articles

Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles

Available to Purchase
Nil Grunberg, Meirav Pevsner-Fischer, Tal Goshen-Lago, Judith Diment, Yaniv Stein, Hagar Lavon, Shimrit Mayer, Oshrat Levi-Galibov, Gil Friedman, Yifat Ofir-Birin, Li-Jyun Syu, Cristina Migliore, Eyal Shimoni, Salomon M. Stemmer, Baruch Brenner, Andrzej A. Dlugosz, David Lyden, Neta Regev-Rudzki, Irit Ben-Aharon, Ruth Scherz-Shouval
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1639–1653.
https://doi.org/10.1158/0008-5472.CAN-20-2756
Published: 01 April 2021
View articletitled, Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles
Open the PDF for Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1–Mediated Secretion of Extracellular Vesicles in another window
Includes: Supplementary data
Journal Articles

Abstract IA024: Tumor exosome and exomere biomarkers for early cancer detection

Free
Ayuko Hoshino, Han Sang Kim, Linda Bojmar, Kofi Ennu Gyan, Haiying Zhang, Irina Matei, David Lyden
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): IA024.
https://doi.org/10.1158/1538-7445.TME21-IA024
Published: 01 March 2021
View articletitled, Abstract IA024: Tumor exosome and exomere biomarkers for early cancer detection
Journal Articles

Zena Werb, Ph.D, “Queen of the Matrix”: In Memoriam (1945–2020)

Free
Shahin Rafii, David Lyden
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3773–3774.
https://doi.org/10.1158/0008-5472.CAN-20-2602
Published: 15 September 2020
View articletitled, Zena Werb, Ph.D, “Queen of the Matrix”: In Memoriam (1945–2020)
Open the PDF for Zena Werb, Ph.D, “Queen of the Matrix”: In Memoriam (1945–2020) in another window
Journal Articles

Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles

Free
Pasquale Sansone, Marjan Berishaj, Vinagolu K. Rajasekhar, Claudio Ceccarelli, Qing Chang, Antonio Strillacci, Claudia Savini, Lauren Shapiro, Robert L. Bowman, Chiara Mastroleo, Sabrina De Carolis, Laura Daly, Alberto Benito-Martin, Fabiana Perna, Nicola Fabbri, John H. Healey, Enzo Spisni, Monica Cricca, David Lyden, Massimiliano Bonafé, Jacqueline Bromberg
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (8): 1927–1941.
https://doi.org/10.1158/0008-5472.CAN-16-2129
Published: 13 April 2017
View articletitled, Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles
Open the PDF for Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles in another window
Includes: Supplementary data
Journal Articles

Abstract LB-236: Self-renewal of CD133hi cells by IL6/Notch3 signaling regulates endocrine resistance in metastatic breast cancers

Free
Pasquale Sansone, Ceccarelli Claudio, Marjan Berishaj, Qing Chang, Rajasekhar Vinagolu, Fabiana Perna, Robert Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli, Donatella Santini, Taffurelli Mario, Natalie Shih, Michael Feldman, Jun James Mao, Christopher Colameco, Jinbo Chen, Angela DeMichele, Nicola Fabbri, John Healey, Monica Cricca, Giuseppe Gasparre, David Lyden, Massimiliano Bonafe, Jacqueline F. Bromberg
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-236.
https://doi.org/10.1158/1538-7445.AM2016-LB-236
Published: 15 July 2016
View articletitled, Abstract LB-236: Self-renewal of CD133hi cells by IL6/Notch3 signaling regulates endocrine resistance in metastatic breast cancers
Journal Articles

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche

Available to Purchase
Amber Jin Giles, Caitlin Marie Reid, Justin DeWayne Evans, Meera Murgai, Yorleny Vicioso, Steven Lorenz Highfill, Miki Kasai, Linda Vahdat, Crystal Lee Mackall, David Lyden, Leonard Wexler, Rosandra Natasha Kaplan
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1335–1347.
https://doi.org/10.1158/0008-5472.CAN-15-0204
Published: 14 March 2016
View articletitled, Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche
Open the PDF for Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche in another window
Includes: Supplementary data
Journal Articles

Abstract 4725: Hematopoietic stem cell niche activation and progenitor mobilization mediate cancer-associated immunosuppression and metastasis

Free
Amber J. Giles, Meera Murgai, Yorleny Vicioso, Steven Highfill, Miki Kasai, Linda Vahdat, Leonard Wexler, Crystal Mackall, David Lyden, Rosandra Kaplan
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4725.
https://doi.org/10.1158/1538-7445.AM2015-4725
Published: 01 August 2015
View articletitled, Abstract 4725: Hematopoietic stem cell niche activation and progenitor mobilization mediate cancer-associated immunosuppression and metastasis
Journal Articles

Abstract 3058: Bone marrow hematopoietic stem cell niche activation and mobilization fosters the metastatic niche

Free
Amber J. Giles, Meera Murgai, Yorleny Vicioso, Steven Highfil, Crystal Mackall, Leonard Wexler, David Lyden, Rosandra Natasha Kaplan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3058.
https://doi.org/10.1158/1538-7445.AM2014-3058
Published: 01 October 2014
View articletitled, Abstract 3058: Bone marrow hematopoietic stem cell niche activation and mobilization fosters the metastatic niche
Journal Articles

Abstract B2: Oligodendritic precursor mediates vascular remodeling within glioma microenvironment in PDGF-C dependent manner

Free
Yujie Huang, David Lyden, Jeffrey Greenfield
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): B2.
https://doi.org/10.1158/1538-7445.TIM2013-B2
Published: 01 May 2014
View articletitled, Abstract B2: Oligodendritic precursor mediates vascular remodeling within glioma microenvironment in PDGF-C dependent manner
Journal Articles

Abstract 4585: Breaking metastatic dormancy during surgical resection of a primary tumor and implications for treatment strategies.

Free
Selena R. Granitto, Amber Giles, Simon Lavotshkin, Daniel Rutigliano, David Lyden, Rosandra N. Kaplan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4585.
https://doi.org/10.1158/1538-7445.AM2013-4585
Published: 15 April 2013
View articletitled, Abstract 4585: Breaking metastatic dormancy during surgical resection of a primary tumor and implications for treatment strategies.
Journal Articles

Abstract 546: Effects of high-dose radiotherapy on the bone marrow microenvironment in the 4T1 model of breast cancer

Free
Lauren Q. Shapiro, Pasquale Sansone, Selena Granitto, David Lyden, Jacqueline Bromberg
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 546.
https://doi.org/10.1158/1538-7445.AM2011-546
Published: 15 April 2011
View articletitled, Abstract 546: Effects of high-dose radiotherapy on the bone marrow microenvironment in the 4T1 model of breast cancer
Journal Articles

Abstract 5766: The Hsp90 inhibitor PU-H71 is a potent suppressor of metastasis in triple-negative breast cancer models

Free
Eloisi Caldas Lopes, Paula Bos, Hector Peinado, Leandro Cerchietti, Simon Lavotshkin, Ari Melnick, David Lyden, Gabriela Chiosis
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5766.
https://doi.org/10.1158/1538-7445.AM10-5766
Published: 15 April 2010
View articletitled, Abstract 5766: The Hsp90 inhibitor PU-H71 is a potent suppressor of metastasis in triple-negative breast cancer models
Journal Articles

Elevated levels of circulating bone marrow-derived hematopoietic progenitor cells in newly diagnosed breast cancer patients

Free
Rosandra Kaplan, Daniel Rutigliano, Elan Bomsztyk, Daniel Rafii, Emma Sidebotham, Elisa Port, Linda Vahdat, David Lyden
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4193.
Published: 01 May 2008
View articletitled, Elevated levels of circulating bone marrow-derived hematopoietic progenitor cells in newly diagnosed breast cancer patients
Journal Articles

Bone marrow-derived cells contribute to developing lymph vessels at the tumor invasive front

Free
Selena Granitto, Hannah Lederman, Rosandra Kaplan, David Lyden
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5844.
Published: 01 May 2008
View articletitled, Bone marrow-derived cells contribute to developing lymph vessels at the tumor invasive front