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Journal Articles

Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells

Annamil Alvarez-Trotta, William Guerrant, Luisana Astudillo, Mohini Lahiry, Giulia Diluvio, Elena Shersher, Hugo Kaneku, David J. Robbins, Darren Orton, Anthony J. Capobianco

Cancer Res (2021) 81 (12): 3347–3357.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-3611

Published: 15 June 2021

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Includes: Supplementary data

Journal Articles

APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma

Heng Lu, Ajaz A. Bhat, Dunfa Peng, Zheng Chen, Shoumin Zhu, Jun Hong, Selma Maacha, Jin Yan, David J. Robbins, M. Kay Washington, Abbes Belkhiri, Wael El-Rifai

Cancer Res (2019) 79 (17): 4426–4438.

DOI: https://doi.org/10.1158/0008-5472.CAN-19-0237

Published: 03 September 2019

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Includes: Supplementary data

Journal Articles

Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription

Ke Jin, Wen Zhou, Xiaoqing Han, Zhiqiang Wang, Bin Li, Shawn Jeffries, Wensi Tao, David J. Robbins, Anthony J. Capobianco

Cancer Res (2017) 77 (16): 4228–4237.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-3156

Published: 14 August 2017

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Includes: Supplementary data

Journal Articles

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

Luisana Astudillo, Thiago G. Da Silva, Zhiqiang Wang, Xiaoqing Han, Ke Jin, Jeffrey VanWye, Xiaoxia Zhu, Kelly Weaver, Taiji Oashi, Pedro E.M. Lopes, Darren Orton, Leif R. Neitzel, Ethan Lee, Ralf Landgraf, David J. Robbins, Alexander D. MacKerell, Jr, Anthony J. Capobianco

Cancer Res (2016) 76 (12): 3593–3603.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-0061

Published: 14 June 2016

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Includes: Supplementary data

Journal Articles

Abstract P4-05-01: Genetic analysis of the role of Brca1 in suppression of basal-like breast cancer

Xin-Hai Pei, Feng Bai, Ho Lam Chan, Alexandria Scott, Matthew D Smith, Cheng Fan, Jason I Herschkowitz, Charles M Perou, Alan S Livingstone, David J Robbins, Anthony J Capobianco

Cancer Res (2015) 75 (9_Supplement): P4-05-01.

DOI: https://doi.org/10.1158/1538-7445.SABCS14-P4-05-01

Published: 01 May 2015

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Journal Articles

BRCA1 Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development

Feng Bai, Ho Lam Chan, Alexandria Scott, Matthew D. Smith, Cheng Fan, Jason I. Herschkowitz, Charles M. Perou, Alan S. Livingstone, David J. Robbins, Anthony J. Capobianco, Xin-Hai Pei

Cancer Res (2014) 74 (21): 6161–6172.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-1119

Published: 30 October 2014

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Includes: Supplementary data

Journal Articles

Notch Signaling Drives Stemness and Tumorigenicity of Esophageal Adenocarcinoma

Cancer Res (2014) 74 (21): 6364–6374.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-2051

Published: 30 October 2014

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Includes: Supplementary data

Journal Articles

Abstract 1951: Role of embryonic signaling pathways in lung cancer

Samer Singh, Dao M. Nguyen, Anthony J. Capobianco, David J. Robbins

Cancer Res (2014) 74 (19_Supplement): 1951.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1951

Published: 01 October 2014

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Journal Articles

NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis

Kelly L. Weaver, Marie-Clotilde Alves-Guerra, Ke Jin, Zhiqiang Wang, Xiaoqing Han, Prathibha Ranganathan, Xiaoxia Zhu, Thiago DaSilva, Wei Liu, Francesca Ratti, Renee M. Demarest, Cristos Tzimas, Meghan Rice, Rodrigo Vasquez-Del Carpio, Nadia Dahmane, David J. Robbins, Anthony J. Capobianco

Cancer Res (2014) 74 (17): 4741–4751.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-1547

Published: 01 September 2014

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Includes: Supplementary data

Journal Articles

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

Bin Li, Dennis Liang Fei, Colin A. Flaveny, Nadia Dahmane, Valérie Baubet, Zhiqiang Wang, Feng Bai, Xin-Hai Pei, Jezabel Rodriguez-Blanco, Brian Hang, Darren Orton, Lu Han, Baolin Wang, Anthony J. Capobianco, Ethan Lee, David J. Robbins

Cancer Res (2014) 74 (17): 4811–4821.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-0317

Published: 01 September 2014

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Includes: Supplementary data

Journal Articles

Abstract 3246: Pharmacologic targeting of the Hedgehog (HH) signal transduction pathway significantly suppresses growth of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) cells in vitro.

Min You, Javier Varona Santos, David J. Robbins, Niramol Savaraj, Dao M. Nguyen

Cancer Res (2013) 73 (8_Supplement): 3246.

DOI: https://doi.org/10.1158/1538-7445.AM2013-3246

Published: 15 April 2013

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Journal Articles

Hedgehog Signaling Regulates Bladder Cancer Growth and Tumorigenicity

Dennis Liang Fei, Avencia Sanchez-Mejias, Zhiqiang Wang, Colin Flaveny, Jun Long, Samer Singh, Jezabel Rodriguez-Blanco, Robert Tokhunts, Camilla Giambelli, Karoline J. Briegel, Wolfgang A. Schulz, A. Jay Gandolfi, Margaret Karagas, Teresa A. Zimmers, Merce Jorda, Pablo Bejarano, Anthony J. Capobianco, David J. Robbins

Cancer Res (2012) 72 (17): 4449–4458.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-4123

Published: 30 August 2012

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Includes: Supplementary data

Journal Articles

Abstract 3336: The role of Notch signaling in esophageal adenocarcinoma

Zhiqiang Wang, Prathibha Ranganathan, Vadim Koshenkov, Feng Bai, Bin Li, Dennis Liang Fei, Alan Livingstone, Dido Franceschi, Juan Martell, David J. Robbins, Anthony J. Capobianco

Cancer Res (2012) 72 (8_Supplement): 3336.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3336

Published: 15 April 2012

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Journal Articles

Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity

Samer Singh, Zhiqiang Wang, Dennis Liang Fei, Kendall E. Black, John A. Goetz, Robert Tokhunts, Camilla Giambelli, Jezabel Rodriguez-Blanco, Jun Long, Ethan Lee, Karoline J. Briegel, Pablo A. Bejarano, Ethan Dmitrovsky, Anthony J. Capobianco, David J. Robbins

Cancer Res (2011) 71 (13): 4454–4463.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-2313

Published: 30 June 2011

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Includes: Supplementary data

Journal Articles

Abstract LB-430: Hedgehog signaling is required for the survival and tumorigenicity of cancer cells.

Samer Singh, Zhiqiang Wang, Camilla Giambelli, Jun Long, Karoline J. Briegel, Pablo A. Bejarano, Anthony J. Capobianco, David J. Robbins

Cancer Res (2011) 71 (8_Supplement): LB-430.

DOI: https://doi.org/10.1158/1538-7445.AM2011-LB-430

Published: 15 April 2011

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Journal Articles

Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors

Dennis Liang Fei, Hua Li, Courtney D. Kozul, Kendall E. Black, Samer Singh, Julie A. Gosse, James DiRenzo, Kathleen A. Martin, Baolin Wang, Joshua W. Hamilton, Margaret R. Karagas, David J. Robbins

Cancer Res (2010) 70 (5): 1981–1988.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-2898

Published: 28 February 2010

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Includes: Supplementary data

NARROW

Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells

APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma

Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

Abstract P4-05-01: Genetic analysis of the role of Brca1 in suppression of basal-like breast cancer

BRCA1 Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development

Notch Signaling Drives Stemness and Tumorigenicity of Esophageal Adenocarcinoma

Abstract 1951: Role of embryonic signaling pathways in lung cancer

NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

Abstract 3246: Pharmacologic targeting of the Hedgehog (HH) signal transduction pathway significantly suppresses growth of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) cells in vitro.

Hedgehog Signaling Regulates Bladder Cancer Growth and Tumorigenicity

Abstract 3336: The role of Notch signaling in esophageal adenocarcinoma

Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity

Abstract LB-430: Hedgehog signaling is required for the survival and tumorigenicity of cancer cells.

Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors

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