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David J. Kwiatkowski
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Journal Articles

Abstract LB288: Biomarker analysis from AMPECT correlating response to nab-sirolimus with TSC1 and TSC2 inactivating alterations

Lee D. Cranmer, Andrew J. Wagner, Vinod Ravi, Richard F. Riedel, Kristen N. Ganjoo, Brian A. Van Tine, Rashmi Chugh, Erlinda M. Gordon, David J. Kwiatkowski, Jason L. Hornick, Heng Du, Li Ding, Anita N. Schmid, Willis H. Navarro, Loretta M. Itri, Mark A. Dickson
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB288.
https://doi.org/10.1158/1538-7445.AM2023-LB288
Published: 14 April 2023
View article titled, Abstract LB288: Biomarker analysis from AMPECT correlating response to <em>nab</em>-sirolimus with <em>TSC1</em> and <em>TSC2</em> inactivating alterations
Journal Articles

Abstract CT006: First-in-class, first-in-human phase 1 trial of VT3989, an inhibitor of yes-associated protein (YAP)/transcriptional enhancer activator domain (TEAD), in patients (pts) with advanced solid tumors enriched for malignant mesothelioma and other tumors with neurofibromatosis 2 (NF2) mutations

Timothy A. Yap, David J. Kwiatkowski, Jayesh Desai, Ibiayi Dagogo-Jack, Michael Millward, Hedy L. Kindler, Anthony W. Tolcher, Sophia Frentzas, Archie W. Thurston, Len Post, F Andrew Dorr
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT006.
https://doi.org/10.1158/1538-7445.AM2023-CT006
Published: 14 April 2023
View article titled, Abstract CT006: First-in-class, first-in-human phase 1 trial of VT3989, an inhibitor of yes-associated protein (YAP)/transcriptional enhancer activator domain (TEAD), in patients (pts) with advanced solid tumors enriched for malignant mesothelioma and other tumors with neurofibromatosis 2 (NF2) mutations
Journal Articles

Abstract CT057: Phase 2, multicenter open-label basket trial of nab-sirolimus for patients with inactivating alterations in TSC1 or TSC2 (PRECISION I)

Jordi Rodon Ahnert, Brian Schulte, Michael J. Demeure, Dustin Deming, Noah Federman, Meredith A. McKean, Elizabeth Lee, Alexander Spira, David J. Kwiatkowski, Maen Hussein, Erlinda Gordon, David Crockett, Kristen Ganjoo, Lee D. Cranmer, Anita N. Schmid, Willis H. Navarro, Loretta M. Itri, Gopa Iyer
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT057.
https://doi.org/10.1158/1538-7445.AM2023-CT057
Published: 14 April 2023
View article titled, Abstract CT057: Phase 2, multicenter open-label basket trial of <em>nab</em>-sirolimus for patients with inactivating alterations in <em>TSC1</em> or <em>TSC2</em> (PRECISION I)
Journal Articles

Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex

Andrii Kovalenko, Andres Sanin, Kosmas Kosmas, Long Zhang, Ji Wang, Elie W. Akl, Krinio Giannikou, Clemens K. Probst, Thomas R. Hougard, Ryan W. Rue, Vera P. Krymskaya, John M. Asara, Hilaire C. Lam, David J. Kwiatkowski, Elizabeth P. Henske, Harilaos Filippakis
Journal: Cancer Research
Cancer Res (2021) 81 (8): 2086–2100.
https://doi.org/10.1158/0008-5472.CAN-20-2218
Published: 15 April 2021
View article titled, Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex
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Includes: Supplementary data
Journal Articles

Abstract PO-010: Kidney angiomyolipomas are defined by a unique transcriptomic profile and H3K27ac chromatin state

Krinio Giannikou, Clemens K. Probst, Mahsa Zarei, Xintao Qiu, Melissa Duarte, Nikolas Kesten, Zachary Hebert, Raga Vadhi, Alba Font-Tello, Paloma Cejas, Charles H. Yoon, Chin-Lee Wu, Myles Brown, Elizabeth P. Henske, Henry Long, David J. Kwiatkowski
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-010.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-010
Published: 02 December 2020
View article titled, Abstract PO-010: Kidney angiomyolipomas are defined by a unique transcriptomic profile and H3K27ac chromatin state
Journal Articles

Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non–Muscle-Invasive Bladder Cancer

Joaquim Bellmunt, Jaegil Kim, Brendan Reardon, Júlia Perera-Bel, Anna Orsola, Alejo Rodriguez-Vida, Stephanie A. Wankowicz, Michaela Bowden, Justine A. Barletta, Juan Morote, Inés de Torres, Nuria Juanpere, Josep Lloreta-Trull, Silvia Hernandez, Kent W. Mouw, Mary-Ellen Taplin, Paloma Cejas, Henry W. Long, Eliezer M. Van Allen, Gad Getz, David J. Kwiatkowski
Journal: Cancer Research
Cancer Res (2020) 80 (20): 4476–4486.
https://doi.org/10.1158/0008-5472.CAN-20-0977
Published: 15 October 2020
View article titled, Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non–Muscle-Invasive Bladder Cancer
Open the PDF for Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non–Muscle-Invasive Bladder Cancer in another window
Includes: Supplementary data
Journal Articles

Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer

Jonathan T. Goldstein, Ashton C. Berger, Juliann Shih, Fujiko F. Duke, Laura Furst, David J. Kwiatkowski, Andrew D. Cherniack, Matthew Meyerson, Craig A. Strathdee
Journal: Cancer Research
Cancer Res (2017) 77 (24): 6987–6998.
https://doi.org/10.1158/0008-5472.CAN-17-1701
Published: 14 December 2017
View article titled, Genomic Activation of <em>PPARG</em> Reveals a Candidate Therapeutic Axis in Bladder Cancer
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Includes: Supplementary data
Journal Articles

Human Pluripotent Stem Cell–Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis

Lisa M. Julian, Sean P. Delaney, Ying Wang, Alexander A. Goldberg, Carole Doré, Julien Yockell-Lelièvre, Roger Y. Tam, Krinio Giannikou, Fiona McMurray, Molly S. Shoichet, Mary-Ellen Harper, Elizabeth P. Henske, David J. Kwiatkowski, Thomas N. Darling, Joel Moss, Arnold S. Kristof, William L. Stanford
Journal: Cancer Research
Cancer Res (2017) 77 (20): 5491–5502.
https://doi.org/10.1158/0008-5472.CAN-17-0925
Published: 15 October 2017
View article titled, Human Pluripotent Stem Cell–Derived <em>TSC2</em>-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis
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Includes: Supplementary data
Journal Articles

Abstract 128: Comprehensive molecular characterization of 412 muscle-invasive urothelial bladder carcinomas: final analysis of The Cancer Genome Atlas (TCGA) project

John N. Weinstein, Seth P. Lerner, David J. Kwiatkowski, Gad Getz, Jaegil Kim, Hikmat A. Al-ahmadie, Andrew D. Cherniack, Guangwu Guo, Rehan Akbani, Katherine A. Hoadley, William Y. Kim, Gordon Robertson, Andrew J. Mungall, Toshinori Hinoue, Peter W. Laird, Jonathan E. Rosenberg, Joaquim Bellmunt, Dean F. Bajorin, Margaret B. Morgan, Chad J. Creighton, Dmitry Gordenin, Joshua M. Stuart, Xiaoping Su, Michael C. Ryan, Jeffrey S. Damrauer, Wei Zhang, Yuexin Liu, Yiling Lu, Nikolaus Schultz, Raju Kucherlapati, Gordon B. Mills, Donna E. Hansel, Brian D. Robinson, Bodgen A. Czerniak, Victor E. Reuter
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 128.
https://doi.org/10.1158/1538-7445.AM2016-128
Published: 15 July 2016
View article titled, Abstract 128: Comprehensive molecular characterization of 412 muscle-invasive urothelial bladder carcinomas: final analysis of The Cancer Genome Atlas (TCGA) project
Journal Articles

Abstract 2969: Progress in The Cancer Genome Atlas bladder cancer project

John N. Weinstein, Jaegil Kim, Chad J. Creighton, Rehan Akbani, Katherine A. Hoadley, William Y. Kim, Margaret B. Morgan, Toshinori Hinoue, Andrew Cherniack, Xiaoping Su, Andrew J. Mungall, Michael C. Ryan, Dean F. Bajorin, Jonathan E. Rosenberg, Bogdan Czerniak, Donna Hansel, Victor E. Reuter, Brian D. Robinson, Hikmat A. Al-Ahmadie, Jeffrey S. Damrauer, Wei Zhang, Yuexin Liu, Dmitry R. Gordenin, Joshua M. Stuart, Nikolaus Schultz, Gordon Robertson, Steven JM Jones, Raju R. Kucherlapati, David J. McConkey, Peter W. Laird, Gordon B. Mills, David J. Kwiatkowski, Seth P. Lerner, TCGA Bladder Cancer Working Group, TCGA Research Network
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2969.
https://doi.org/10.1158/1538-7445.AM2015-2969
Published: 01 August 2015
View article titled, Abstract 2969: Progress in The Cancer Genome Atlas bladder cancer project
Journal Articles

Abstract 1724: Genomic mechanisms of exquisite sensitivity and acquired resistance to everolimus in a patient with anaplastic thyroid carcinoma

Nikhil Wagle, Brian C. Grabiner, Eliezer M. Van Allen, Ali Amin-Mansour, Scott C. Carter, Nathanael Gray, Justine A. Barletta, Scott J. Swanson, Daniel Ruan, David J. Kwiatkowski, Glenn J. Hanna, Robert I. Haddad, David Sabatini, Pasi A. Janne, Levi A. Garraway, Jochen H. Lorch
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1724.
https://doi.org/10.1158/1538-7445.AM2014-1724
Published: 01 October 2014
View article titled, Abstract 1724: Genomic mechanisms of exquisite sensitivity and acquired resistance to everolimus in a patient with anaplastic thyroid carcinoma
Journal Articles

Abstract 3433: ARHGAP30 and DEDD as potential genomic drivers of invasive urothelial carcinomas

Andrew L. Hong, Markus Riester, Anna C. Schinzel, Amy Schlauch, Rosalyn M. Adam, David J. Kwiatkowski, Jonathan E. Rosenberg, William C. Hahn
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3433.
https://doi.org/10.1158/1538-7445.AM2014-3433
Published: 01 October 2014
View article titled, Abstract 3433: ARHGAP30 and DEDD as potential genomic drivers of invasive urothelial carcinomas
Journal Articles

Abstract 987: Comprehensive characterization of urothelial bladder cancer: a TCGA Project update

John N. Weinstein, Jaegil Kim, Chad J. Creighton, Rehan Akbani, Katherine A. Hoadley, William Y. Kim, Margaret B. Morgan, Toshinori Hinoue, Andrew Cherniack, Xiaoping Su, Andrew J. Mungall, Michael C. Ryan, Jonathan E. Rosenberg, Dean F. Bajorin, Bogdan Czerniak, Donna Hansel, Victor E. Reuter, Brian D. Robinson, Hikmat A. Al-Ahmadie, Jeffrey S. Damrauer, Wei Zhang, Yuexin Liu, Dmitry Gordenin, Joshua M. Stuart, Nikolaus Schultz, Gordon Robertson, Raju Kucherlapati, Peter W. Laird, Gordon B. Mills, David J. Kwiatkowski, Seth P. Lerner, representing TCGA's Bladder Cancer Working Group
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 987.
https://doi.org/10.1158/1538-7445.AM2014-987
Published: 01 October 2014
View article titled, Abstract 987: Comprehensive characterization of urothelial bladder cancer: a TCGA Project update
Journal Articles

Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice

Raleigh D. Kladney, Robert D. Cardiff, David J. Kwiatkowski, Gary G. Chiang, Jason D. Weber, Jeffrey M. Arbeit, Zhi Hong Lu
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8937–8947.
https://doi.org/10.1158/0008-5472.CAN-10-1646
Published: 31 October 2010
View article titled, Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice
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Includes: Supplementary data
Journal Articles

Selective Inhibition of Growth of Tuberous Sclerosis Complex 2–Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity

Geraldine A. Finlay, Amy J. Malhowski, Yingling Liu, Barry L. Fanburg, David J. Kwiatkowski, Deniz Toksoz
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9878–9886.
https://doi.org/10.1158/0008-5472.CAN-07-1394
Published: 17 October 2007
View article titled, Selective Inhibition of Growth of <em>Tuberous Sclerosis Complex 2</em>–Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity
Open the PDF for Selective Inhibition of Growth of <em>Tuberous Sclerosis Complex 2</em>–Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity in another window
Includes: Supplementary data
Journal Articles

Platelet-Derived Growth Factor–Induced p42/44 Mitogen-Activated Protein Kinase Activation and Cellular Growth Is Mediated by Reactive Oxygen Species in the Absence of TSC2/Tuberin

Geraldine A. Finlay, Victor J. Thannickal, Barry L. Fanburg, David J. Kwiatkowski
Journal: Cancer Research
Cancer Res (2005) 65 (23): 10881–10890.
https://doi.org/10.1158/0008-5472.CAN-05-1394
Published: 01 December 2005
View article titled, Platelet-Derived Growth Factor–Induced p42/44 Mitogen-Activated Protein Kinase Activation and Cellular Growth Is Mediated by Reactive Oxygen Species in the Absence of <em>TSC2</em>/Tuberin
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Journal Articles

Estrogen Enhances whereas Tamoxifen Retards Development of Tsc Mouse Liver Hemangioma: A Tumor Related to Renal Angiomyolipoma and Pulmonary Lymphangioleiomyomatosis

Nisreen El-Hashemite, Victoria Walker, David J. Kwiatkowski
Journal: Cancer Research
Cancer Res (2005) 65 (6): 2474–2481.
https://doi.org/10.1158/0008-5472.CAN-04-3840
Published: 21 March 2005
View article titled, Estrogen Enhances whereas Tamoxifen Retards Development of Tsc Mouse Liver Hemangioma: A Tumor Related to Renal Angiomyolipoma and Pulmonary Lymphangioleiomyomatosis
Open the PDF for Estrogen Enhances whereas Tamoxifen Retards Development of Tsc Mouse Liver Hemangioma: A Tumor Related to Renal Angiomyolipoma and Pulmonary Lymphangioleiomyomatosis in another window
Journal Articles

Perturbed IFN-γ-Jak-Signal Transducers and Activators of Transcription Signaling in Tuberous Sclerosis Mouse Models: Synergistic Effects of Rapamycin-IFN-γ Treatment

Nisreen El-Hashemite, Hongbing Zhang, Victoria Walker, Karin M. Hoffmeister, David J. Kwiatkowski
Journal: Cancer Research
Cancer Res (2004) 64 (10): 3436–3443.
https://doi.org/10.1158/0008-5472.CAN-03-3609
Published: 17 May 2004
View article titled, Perturbed IFN-γ-Jak-Signal Transducers and Activators of Transcription Signaling in Tuberous Sclerosis Mouse Models: <subtitle>Synergistic Effects of Rapamycin-IFN-γ Treatment</subtitle>
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Journal Articles

Loss of Tsc1 or Tsc2 Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin

Nisreen El-Hashemite, Victoria Walker, Hongbing Zhang, David J. Kwiatkowski
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5173–5177.
Published: 18 September 2003
View article titled, Loss of <em>Tsc1</em> or <em>Tsc2</em> Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin
Open the PDF for Loss of <em>Tsc1</em> or <em>Tsc2</em> Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin in another window