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David J. Chaplin
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Journal Articles

Abstract 3203: Targeting tumor hypoxia with prodrug conjugates of potent small-molecule inhibitors of tubulin polymerization

Free
Kevin G. Pinney, Mary Lynn Trawick, Ralph P. Mason, Li Liu, David J. Chaplin, Blake A. Winn, Laxman Devkota, Tracy E. Strecker, Jeni Gerberich, Alex Winters, Yifan Wang, Matthew T. MacDonough
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3203.
https://doi.org/10.1158/1538-7445.AM2017-3203
Published: 01 July 2017
View articletitled, Abstract 3203: Targeting tumor hypoxia with prodrug conjugates of potent small-molecule inhibitors of tubulin polymerization
Journal Articles

Abstract 1816: Assessment of anti-tumor activity of the cathepsin L inhibitor, KGP94

Free
Thomas R. Wittenborn, Michael Stratford, Mary Lynn Trawick, Kevin G. Pinney, David J. Chaplin, Dietmar W. Siemann, Michael R. Horsman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1816.
https://doi.org/10.1158/1538-7445.AM2014-1816
Published: 01 October 2014
View articletitled, Abstract 1816: Assessment of anti-tumor activity of the cathepsin L inhibitor, KGP94
Journal Articles

Abstract 5071: KGP94, a small-molecule cathepsin L inhibitor with antitumor activity.

Free
Thomas Wittenborn, Mary Lynn Trawick, Kevin G. Pinney, David J. Chaplin, Dietmar W. Siemann, Michael R. Horsman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5071.
https://doi.org/10.1158/1538-7445.AM2013-5071
Published: 15 April 2013
View articletitled, Abstract 5071: KGP94, a small-molecule cathepsin L inhibitor with antitumor activity.
Journal Articles

Abstract 1416: Development and initial evaluation of the antitumor activity of a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L

Free
Mary Lynn Trawick, Kevin G. Pinney, David J. Chaplin, Michael R. Horsman, Gustavo E. Chavarria, Wara M. Arispe, G. D. Kishore Kumar
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1416.
https://doi.org/10.1158/1538-7445.AM2011-1416
Published: 15 April 2011
View articletitled, Abstract 1416: Development and initial evaluation of the antitumor activity of a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
Journal Articles

Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents

Free
Yuval Shaked, Terence Tang, Jill Woloszynek, Laura G. Daenen, Shan Man, Ping Xu, Shi-Rong Cai, Jeffrey M. Arbeit, Emile E. Voest, David J. Chaplin, Jon Smythe, Adrian Harris, Paul Nathan, Ian Judson, Gordon Rustin, Francesco Bertolini, Daniel C. Link, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2009) 69 (19): 7524–7528.
https://doi.org/10.1158/0008-5472.CAN-09-0381
Published: 01 October 2009
View articletitled, Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents
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Includes: Supplementary data
Journal Articles

Combretastatin-A-4-P induced hypertension can be controlled with conventional antihypertensive therapy in a rat model without compromising the reduction in tumor blood flow

Free
Davina J. Honess, Finuala Hylands, David J. Chaplin, Gillian M. Tozer
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 704.
Published: 01 May 2005
View articletitled, Combretastatin-A-4-P induced hypertension can be controlled with conventional antihypertensive therapy in a rat model without compromising the reduction in tumor blood flow
Journal Articles

Oxi 4503 potentiates the antitumor activity of carboplatin and paclitaxel.

Free
Klaus Edvardsen, Sofia Järnum, Kevin G. Pinney, David J. Chaplin, Jianyi Hua
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 463.
Published: 01 April 2004
View articletitled, Oxi 4503 potentiates the antitumor activity of carboplatin and paclitaxel.
Journal Articles

The First International Conference on Vascular Targeting: Meeting Overview

Free
Philip E. Thorpe, David J. Chaplin, David C. Blakey
Journal: Cancer Research
Cancer Res (2003) 63 (5): 1144–1147.
Published: 01 March 2003
View articletitled, The First International Conference on Vascular Targeting: Meeting Overview
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Journal Articles

ZD6126: A Novel Vascular-targeting Agent That Causes Selective Destruction of Tumor Vasculature

Free
Peter D. Davis, Graeme J. Dougherty, David C. Blakey, Susan M. Galbraith, Gillian M. Tozer, Angela L. Holder, Matthew A. Naylor, John Nolan, Michael R. L. Stratford, David J. Chaplin, Sally A. Hill
Journal: Cancer Research
Cancer Res (2002) 62 (24): 7247–7253.
Published: 15 December 2002
View articletitled, ZD6126: A Novel Vascular-targeting Agent That Causes Selective Destruction of Tumor Vasculature
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Journal Articles

Mechanisms Associated with Tumor Vascular Shut-Down Induced by Combretastatin A-4 Phosphate: Intravital Microscopy and Measurement of Vascular Permeability

Free
Gillian M. Tozer, Vivien E. Prise, John Wilson, Maja Cemazar, Siqing Shan, Mark W. Dewhirst, Paul R. Barber, Borivoj Vojnovic, David J. Chaplin
Journal: Cancer Research
Cancer Res (2001) 61 (17): 6413–6422.
Published: 01 September 2001
View articletitled, Mechanisms Associated with Tumor Vascular Shut-Down Induced by Combretastatin A-4 Phosphate: Intravital Microscopy and Measurement of Vascular Permeability
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Journal Articles

Eradication of Colorectal Xenografts by Combined Radioimmunotherapy and Combretastatin A-4 3- O -Phosphate

Free
R. Barbara Pedley, Sally A. Hill, Geoffrey M. Boxer, Aiden A. Flynn, Robert Boden, Rebecca Watson, Jason Dearling, David J. Chaplin, Richard H. J. Begent
Journal: Cancer Research
Cancer Res (2001) 61 (12): 4716–4722.
Published: 01 June 2001
View articletitled, Eradication of Colorectal Xenografts by Combined Radioimmunotherapy and Combretastatin A-4 3- O -Phosphate
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Journal Articles

Combretastatin A-4 Phosphate as a Tumor Vascular-Targeting Agent: Early Effects in Tumors and Normal Tissues

Free
Gillian M. Tozer, Vivien E. Prise, John Wilson, Rosalind J. Locke, Borivoj Vojnovic, Michael R. L. Stratford, Madeleine F. Dennis, David J. Chaplin
Journal: Cancer Research
Cancer Res (1999) 59 (7): 1626–1634.
Published: 01 April 1999
View articletitled, Combretastatin A-4 Phosphate as a Tumor Vascular-Targeting Agent: Early Effects in Tumors and Normal Tissues
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Journal Articles

Human Tumor Blood Flow Is Enhanced by Nicotinamide and Carbogen Breathing

Free
Melanie E. B. Powell, Sally A. Hill, Michele I. Saunders, Peter J. Hoskin, David J. Chaplin
Journal: Cancer Research
Cancer Res (1997) 57 (23): 5261–5264.
Published: 01 December 1997
View articletitled, Human Tumor Blood Flow Is Enhanced by Nicotinamide and Carbogen Breathing
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Journal Articles

Inhibition of Nitric Oxide Synthase Induces a Selective Reduction in Tumor Blood Flow That Is Reversible with L-Arginine

Free
Gillian M. Tozer, Vivien E. Prise, David J. Chaplin
Journal: Cancer Research
Cancer Res (1997) 57 (5): 948–955.
Published: 01 March 1997
View articletitled, Inhibition of Nitric Oxide Synthase Induces a Selective Reduction in Tumor Blood Flow That Is Reversible with L-Arginine
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Journal Articles

Ischemia Reperfusion Injury in Tumors: The Role of Oxygen Radicals and Nitric Oxide

Free
Charles S. Parkins, Madeleine F. Dennis, Michael R. L. Stratford, Sally A. Hill, David J. Chaplin
Journal: Cancer Research
Cancer Res (1995) 55 (24): 6026–6029.
Published: 01 December 1995
View articletitled, Ischemia Reperfusion Injury in Tumors: The Role of Oxygen Radicals and Nitric Oxide
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Journal Articles

Combination of Nicotinamide and Hyperthermia to Eliminate Radioresistant Chronically and Acutely Hypoxic Tumor Cells

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Michael R. Horsman, David J. Chaplin, Jens Overgaard
Journal: Cancer Research
Cancer Res (1990) 50 (23): 7430–7436.
Published: 01 December 1990
View articletitled, Combination of Nicotinamide and Hyperthermia to Eliminate Radioresistant Chronically and Acutely Hypoxic Tumor Cells
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Journal Articles

Intermittent Blood Flow in a Murine Tumor: Radiobiological Effects

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David J. Chaplin, Peggy L. Olive, Ralph E. Durand
Journal: Cancer Research
Cancer Res (1987) 47 (2): 597–601.
Published: 01 January 1987
View articletitled, Intermittent Blood Flow in a Murine Tumor: Radiobiological Effects
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