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David Hughes
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Journal Articles

Abstract 182: Bridging gaps in translational biology: Exploring pharmacokinetic/pharmacodynamic/efficacy relationships and combination treatments in 3D tumor models using a microphysiological system

Tudor Petreus, Tomasz Kostrzewski, Dharaminder Singh, David Hughes
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 182.
https://doi.org/10.1158/1538-7445.AM2022-182
Published: 15 June 2022
View article titled, Abstract 182: Bridging gaps in translational biology: Exploring pharmacokinetic/pharmacodynamic/efficacy relationships and combination treatments in 3D tumor models using a microphysiological system
Journal Articles

Abstract 1931: Investigating the PK/PD/efficacy relationship of PI3K inhibitors in vitro, enabled by a microfluidic addition and removal device

Tomasz M. Kostrzewski, Dharaminder Singh, Paul Golby, Alysha Bray, David Hughes
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1931.
https://doi.org/10.1158/1538-7445.AM2019-1931
Published: 01 July 2019
View article titled, Abstract 1931: Investigating the PK/PD/efficacy relationship of PI3K inhibitors <em>in vitro</em>, enabled by a microfluidic addition and removal device
Journal Articles

Abstract 1581: Gut barrier function-related genes and colorectal cancer risk in Western European populations

Hannah Mandle, Mazda Jenab, David Hughes, Marc Gunter, Elio Riboli, Veronika Fedirko
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1581.
https://doi.org/10.1158/1538-7445.AM2019-1581
Published: 01 July 2019
View article titled, Abstract 1581: Gut barrier function-related genes and colorectal cancer risk in Western European populations
Journal Articles

Abstract LB-044: In vitro assessment of combination dosing regimens with in vivo like pharmacokinetic concentration profiles enabled by a microfluidic addition and removal device

Paul Golby, Edoardo Buffa, Tomasz Kostrzewski, David Hughes
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-044.
https://doi.org/10.1158/1538-7445.AM2018-LB-044
Published: 01 July 2018
View article titled, Abstract LB-044: In vitro assessment of combination dosing regimens with in vivo like pharmacokinetic concentration profiles enabled by a microfluidic addition and removal device
Journal Articles

Analysis of breast cancer risk modifying candidate genes in BRCA1 and BRCA2 mutation carriers

David Hughes, Isabelle Coupier, Laure Barjhoux, Sophie Ginolhac, David Goldgar, Dominique Stoppa-Lyonnet, Olga M. Sinilnikova
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 301.
Published: 01 April 2004
View article titled, Analysis of breast cancer risk modifying candidate genes in BRCA1 and BRCA2 mutation carriers
Journal Articles

CD20-induced Lymphoma Cell Death Is Independent of Both Caspases and Its Redistribution into Triton X-100 Insoluble Membrane Rafts

H. T. Claude Chan, David Hughes, Ruth R. French, Alison L. Tutt, Claire A. Walshe, Jessica L. Teeling, Martin J. Glennie, Mark S. Cragg
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5480–5489.
Published: 18 September 2003
View article titled, CD20-induced Lymphoma Cell Death Is Independent of Both Caspases and Its Redistribution into Triton X-100 Insoluble Membrane Rafts
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Journal Articles

Activated ras Oncogenes in Human Thyroid Cancers

Nick R. Lemoine, Edward S. Mayall, Fiona S. Wyllie, Christine J. Farr, David Hughes, Rose Anne Padua, Valerie Thurston, E. Dilwyn Williams, David Wynford-Thomas
Journal: Cancer Research
Cancer Res (1988) 48 (16): 4459–4463.
Published: 01 August 1988
View article titled, Activated <em>ras</em> Oncogenes in Human Thyroid Cancers
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Journal Articles

Oxygen Dependence of Binding of Misonidazole to Rodent and Human Tumors in Vitro

Allan J. Franko, Cameron J. Koch, Bonnie M. Garrecht, Janet Sharplin, David Hughes
Journal: Cancer Research
Cancer Res (1987) 47 (20): 5367–5376.
Published: 01 October 1987
View article titled, Oxygen Dependence of Binding of Misonidazole to Rodent and Human Tumors <em>in Vitro</em>
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