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David Gius
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Journal Articles

Abstract 4836: Fasting induces greater expression of mitochondrial proteins associated with fatty acid metabolism and non-shivering thermogenesis in brown adipose tissue of knock-in ACSS1K635Q mice

Aishani Sivasai Gargapati, Mahboubeh Varmazyad, David Gius
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4836.
https://doi.org/10.1158/1538-7445.AM2023-4836
Published: 04 April 2023
View article titled, Abstract 4836: Fasting induces greater expression of mitochondrial proteins associated with fatty acid metabolism and non-shivering thermogenesis in brown adipose tissue of knock-in ACSS1K635Q mice
Journal Articles

Homeostatic Roles of STING in Cell Proliferation and Chromosomal Instability

David Gius, Yueming Zhu
Journal: Cancer Research
Cancer Res (2019) 79 (7): 1295–1296.
https://doi.org/10.1158/0008-5472.CAN-19-0212
Published: 01 April 2019
View article titled, Homeostatic Roles of STING in Cell Proliferation and Chromosomal Instability
Open the PDF for Homeostatic Roles of STING in Cell Proliferation and Chromosomal Instability in another window
Journal Articles

SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth

Xianghui Zou, Yueming Zhu, Seong-Hoon Park, Guoxiang Liu, Joseph O'Brien, Haiyan Jiang, David Gius
Journal: Cancer Research
Cancer Res (2017) 77 (15): 3990–3999.
https://doi.org/10.1158/0008-5472.CAN-16-2393
Published: 01 August 2017
View article titled, SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth
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Includes: Supplementary data
Journal Articles

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

Seong-Hoon Park, Ozkan Ozden, Guoxiang Liu, Ha Yong Song, Yueming Zhu, Yufan Yan, Xianghui Zou, Hong-Jun Kang, Haiyan Jiang, Daniel R. Principe, Yong-Il Cha, Meejeon Roh, Athanassios Vassilopoulos, David Gius
Journal: Cancer Research
Cancer Res (2016) 76 (13): 3802–3812.
https://doi.org/10.1158/0008-5472.CAN-15-2498
Published: 30 June 2016
View article titled, SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth
Open the PDF for SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth in another window
Includes: Supplementary data
Journal Articles

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

Marcia C. Haigis, Chu-Xia Deng, Lydia W.S. Finley, Hyun-Seok Kim, David Gius
Journal: Cancer Research
Cancer Res (2012) 72 (10): 2468–2472.
https://doi.org/10.1158/0008-5472.CAN-11-3633
Published: 14 May 2012
View article titled, SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis
Open the PDF for SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis in another window
Journal Articles

Abstract 5005: Combined targeting of IKKα and β effectively suppresses NF-κB activation, cell survival and migration in head and neck squamous cell cancers

Carol Yan, Liesl Nottingham, Clint Allen, Tsu-Fan Cheng, Arun Pattatheyil, Xinping Yang, David Gius, Lenny Dang, Zhong Chen, Carter Van Waes
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5005.
https://doi.org/10.1158/1538-7445.AM2011-5005
Published: 15 April 2011
View article titled, Abstract 5005: Combined targeting of IKKα and β effectively suppresses NF-κB activation, cell survival and migration in head and neck squamous cell cancers
Journal Articles

Abstract SY11-01: Knockout mouse models for sirtuins: Genome integrity, metabolism, and cancer

Chuxia Deng, Hyun-Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, Tyler Lahusen, Zhen Xiao, Xiaoling Xu, Cuiling Li, Timothy D. Veenstra, Junfang Ji, Xin-Wei Wang, Seong-Hoon Park, David Gius
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): SY11-01.
https://doi.org/10.1158/1538-7445.AM2011-SY11-01
Published: 15 April 2011
View article titled, Abstract SY11-01: Knockout mouse models for sirtuins: Genome integrity, metabolism, and cancer
Journal Articles

Abstract 1328: p53 represses microRNAs let-7a and let-7b in response to ionizing radiation

Anthony D. Saleh, Jason E. Savage, David Ly, Phuongmai Nguyen, Lui Cao, Benjamin P. Soule, Tu D. Dan, William DeGraff, Toren Finkel, Curtis C. Harris, James B. Mitchel, David Gius, Nicole L. Simone
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1328.
https://doi.org/10.1158/1538-7445.AM10-1328
Published: 15 April 2010
View article titled, Abstract 1328: p53 represses microRNAs let-7a and let-7b in response to ionizing radiation
Journal Articles

Abstract #3976: The response of the microRNA let-7b to ionizing radiation may involve p53

Anthony Saleh, David Ly, Benjamin Soule, William DeGraff, Jason Savage, James Mitchell, David Gius, Nicole Simone
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3976.
Published: 01 May 2009
View article titled, Abstract #3976: The response of the microRNA let-7b to ionizing radiation may involve p53
Journal Articles

CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal H19 Differentially Methylated Region

Phuongmai Nguyen, Hengmi Cui, Kheem S. Bisht, Lunching Sun, Krish Patel, Richard S. Lee, Hiroyuki Kugoh, Mitsuo Oshimura, Andrew P. Feinberg, David Gius
Journal: Cancer Research
Cancer Res (2008) 68 (14): 5546–5551.
https://doi.org/10.1158/0008-5472.CAN-08-1005
Published: 15 July 2008
View article titled, CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <em>H19</em> Differentially Methylated Region
Open the PDF for CTCFL/BORIS Is a Methylation-Independent DNA-Binding Protein That Preferentially Binds to the Paternal <em>H19</em> Differentially Methylated Region in another window
Includes: Supplementary data
Journal Articles

A unified approach and sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening

Rebecca Brooks, James Malone, Julia Gross, Petra Gilmore, Loan Nguyen, Feng Sheng, Jason Wright, Nicholas Taylor, Israel Zighelboim, Margo Funk, Phyllis Huettner, David Gius, Dan Crimmins, Jack Ladenson, R. Townsend, Janet Rader
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 960.
Published: 01 May 2008
View article titled, A unified approach and sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening
Journal Articles

microRNA expression is altered by ionizing radiation: A novel potential therapeutic target

Nicole Simone, Benjamin Soule, Jaime Leclerc, Kristi Jacobs, James Mitchell, David Gius
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4210.
Published: 01 May 2008
View article titled, microRNA expression is altered by ionizing radiation: A novel potential therapeutic target
Journal Articles

An antisense RNA induces epigenetic silencing of a tumor suppressor gene

Wenqiang Yu, Andrew Feinberg, David Gius, Hengmi Cui
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2526.
Published: 01 May 2008
View article titled, An antisense RNA induces epigenetic silencing of a tumor suppressor gene
Journal Articles

DNA Methyltransferase 1 and 3B Activate BAG-1 Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation

Lunching Sun, Lei Huang, Phuongmai Nguyen, Kheem S. Bisht, Gil Bar-Sela, Allen S. Ho, C. Matthew Bradbury, Wenqiang Yu, Hengmi Cui, Sunmin Lee, Jane B. Trepel, Andrew P. Feinberg, David Gius
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2726–2735.
https://doi.org/10.1158/0008-5472.CAN-07-6654
Published: 15 April 2008
View article titled, DNA Methyltransferase 1 and 3B Activate <em>BAG-1</em> Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation
Open the PDF for DNA Methyltransferase 1 and 3B Activate <em>BAG-1</em> Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation in another window
Includes: Supplementary data
Journal Articles

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates

David Gius, Margo C. Funk, Eric Y. Chuang, Sheng Feng, Phyllis C. Huettner, Loan Nguyen, C. Matthew Bradbury, Mark Mishra, Shuping Gao, Barbara M. Buttin, David E. Cohn, Matthew A. Powell, Neil S. Horowitz, Bradford P. Whitcomb, Janet S. Rader
Journal: Cancer Research
Cancer Res (2007) 67 (15): 7113–7123.
https://doi.org/10.1158/0008-5472.CAN-07-0260
Published: 01 August 2007
View article titled, Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates
Open the PDF for Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates in another window
Includes: Supplementary data
Journal Articles

A genomic expression signature model for cervical carcinogenesis by molecular profiling of microdissected epithelial and stromal cells

J Daniel Pennington, David Gius, Margot Funk, Janet Rader
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2977.
Published: 01 May 2007
View article titled, A genomic expression signature model for cervical carcinogenesis by molecular profiling of microdissected epithelial and stromal cells
Journal Articles

BAG-3 modulates cell phenotype by inhibiting adhesion and altering gene expression

Jareer N. Kassis, Elizabeth A. Guancial, David Gius, Elise C. Kohn
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 632.
Published: 15 April 2006
View article titled, BAG-3 modulates cell phenotype by inhibiting adhesion and altering gene expression
Journal Articles

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome

Hengmi Cui, David Gius, Matthew C. Bradbury, Andrew P. Feinberg
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 427.
Published: 01 May 2005
View article titled, Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome
Journal Articles

A novel mechanism of epigenetic regulation in the BAG gene family

Allen S. Ho, Lunching Sun, C. Matthew Bradbury, Lei Huang, Kheem S. Bisht, David Mattson, Deedee K. Smart, C. Norman Coleman, David Gius
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 644.
Published: 01 May 2005
View article titled, A novel mechanism of epigenetic regulation in the BAG gene family
Journal Articles

Differential effects of full length and truncated forms of CAIR-1/BAG-3 on cell migration and invasion and migration-associated gene expression.

Elizabeth A. Guancial, David Gius, Elise C. Kohn, Jareer N. Kassis
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 57.
Published: 01 May 2005
View article titled, Differential effects of full length and truncated forms of CAIR-1/BAG-3 on cell migration and invasion and migration-associated gene expression.