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David G. Kirsch
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Journal Articles

Abstract 523: Minnelide as a potential treatment strategy for CIC::DUX4 sarcoma

MaKenna R. Browne, Peter G. Hendrickson, David G. Kirsch
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 523.
https://doi.org/10.1158/1538-7445.AM2025-523
Published: 21 April 2025
View articletitled, Abstract 523: Minnelide as a potential treatment strategy for CIC::DUX4 sarcoma
Journal Articles

Abstract 2837: Mechanisms promoting chromosomal instability following the loss of p53 and Rb

Risha Banerjee, David G. Kirsch
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2837.
https://doi.org/10.1158/1538-7445.AM2025-2837
Published: 21 April 2025
View articletitled, Abstract 2837: Mechanisms promoting chromosomal instability following the loss of p53 and Rb
Journal Articles

Abstract 5815: Both CD4 and CD8 T cells mediate antitumor immunity to prevent development of neoantigen-expressing autochthonous sarcomas

Sabelo Mndeni Lukhele, David G. Kirsch, Jonathon E. Himes
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5815.
https://doi.org/10.1158/1538-7445.AM2025-5815
Published: 21 April 2025
View articletitled, Abstract 5815: Both CD4 and CD8 T cells mediate antitumor immunity to prevent development of neoantigen-expressing autochthonous sarcomas
Journal Articles

Abstract 6707: Direct in vivo CRISPR screen identifies BAP1 and FAT1 as potent tumor suppressors in sarcomagenesis

Jianguo Huang, Xingliang Liu, Warren Floyd, William Haugh, Andrea R. Daniel, Zhaoyu Sun, Nerissa T. Williams, Melissa J. Kasiewicz, Yaping Wu, Diana M. Cardona, Brian Piening, John T. Welle, Wesley K. Rosales, Venkatesh Rajamanickam, So Young Kim, Eric Xu, Lixia Luo, Yan Ma, Kristianne M. Oristian, Omar Lopez, Nicholas E. Sibinga, Rutulkumar Patel, Ziqiang Zhang, Alexander J. Lazar, Corinne M. Linardic, Brady Bernard, William L. Redmond, Walter J. Urba, David G. Kirsch
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6707.
https://doi.org/10.1158/1538-7445.AM2025-6707
Published: 21 April 2025
View articletitled, Abstract 6707: Direct in vivo CRISPR screen identifies BAP1 and FAT1 as potent tumor suppressors in sarcomagenesis
Journal Articles

Abstract A025: Direct in vivo CRISPR screen identifies BAP1 and FAT1 as potent tumor suppressors in sarcomagenesis

Jianguo Huang, Xingliang Liu, Warren Floyd, William Haugh, Andrea R Daniel, Zhaoyu Sun, Nerissa T Williams, Melissa J Kasiewicz, Yaping Wu, Diana M Cardona, Brian Piening, John T. Welle, Wesley K Rosales, Venkatesh Rajamanickam, So Young Kim, Eric Xu, Lixia Luo, Yan Ma, Kristianne M Oristian, Omar Lopez, Nicholas E. S. Sibinga, Rutulkumar Patel, Ziqiang Zhang, Alexander J Lazar, Corinne M Linardic, Brady Bernard, William L Redmond, Walter J Urba, David G Kirsch
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): A025.
https://doi.org/10.1158/1538-7445.GENFUNC25-A025
Published: 11 March 2025
View articletitled, Abstract A025: Direct in vivo CRISPR screen identifies BAP1 and FAT1 as potent tumor suppressors in sarcomagenesis
Journal Articles

Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors

Tona M. Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A. Ashcraft, Amy E. Stewart, Yaode Wang, Jianmin Fu, Kris C. Wood, Deborah A. Smith, Jonathan T. Yang, Christopher T. Chen, Michael F. Gensheimer, Paul B. Romesser, Steven H. Lin, David G. Kirsch, Michael B. Kastan
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB181.
https://doi.org/10.1158/1538-7445.AM2024-LB181
Published: 05 April 2024
View articletitled, Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors
Journal Articles

Abstract 2817: Combining the RCAS/TVA retrovirus system and a conditional oncohistone H3.3K27M allele to investigate radiosensitization strategies in primary mouse models of diffuse midline glioma

Sophie R. Wu, María E. Guerra Garcia, Harrison Liu, Nerissa T. Williams, Lixia Luo, Yan Ma, David G. Kirsch, Zachary J. Reitman
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2817.
https://doi.org/10.1158/1538-7445.AM2023-2817
Published: 04 April 2023
View articletitled, Abstract 2817: Combining the RCAS/TVA retrovirus system and a conditional oncohistone H3.3K27M allele to investigate radiosensitization strategies in primary mouse models of diffuse midline glioma
Journal Articles

Abstract 3320: Single-cell RNA sequencing analysis and transgenic mouse models reveal differential effects of flash vs. standard proton radiotherapy on gastrointestinal tissues and tumors

Ioannis I. Verginadis, Clara Morral Martinez, Tristan Lim, Priyanka Chowdhury, Giorgos Skoufos, Michele M. Kim, Anastasia Velalopoulou, Denisa Goia, Leo Luo, Caitlin J. Foley, Zachary J. Reitman, Andrea R. Daniel, Eric Diffenderfer, Lei Dong, James Metz, David G. Kirsch, Andy Minn, Constantinos Koumenis
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3320.
https://doi.org/10.1158/1538-7445.AM2022-3320
Published: 15 June 2022
View articletitled, Abstract 3320: Single-cell RNA sequencing analysis and transgenic mouse models reveal differential effects of flash vs. standard proton radiotherapy on gastrointestinal tissues and tumors
Journal Articles

Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP

Mark Chen, Joseph P. Foster, II, Ian C. Lock, Nathan H. Leisenring, Andrea R. Daniel, Warren Floyd, Eric Xu, Ian J. Davis, David G. Kirsch
Journal: Cancer Research
Cancer Res (2021) 81 (19): 4939–4948.
https://doi.org/10.1158/0008-5472.CAN-20-1497
Published: 01 October 2021
View articletitled, Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP
Open the PDF for Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP in another window
Includes: Supplementary data
Journal Articles

Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma

Chang-Lung Lee, Kennedy D. Brock, Stephanie Hasapis, Dadong Zhang, Alexander B. Sibley, Xiaodi Qin, Jeremy S. Gresham, Isibel Caraballo, Lixia Luo, Andrea R. Daniel, Matthew J. Hilton, Kouros Owzar, David G. Kirsch
Journal: Cancer Research
Cancer Res (2021) 81 (14): 3777–3790.
https://doi.org/10.1158/0008-5472.CAN-20-2823
Published: 15 July 2021
View articletitled, Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma
Open the PDF for Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma in another window
Includes: Supplementary data
Journal Articles

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

Pierre-Benoit Ancey, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, Solange Peters, E. Dale Abel, David G. Kirsch, Jeffrey C. Rathmell, Marie-Catherine Vozenin, Etienne Meylan
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2345–2357.
https://doi.org/10.1158/0008-5472.CAN-20-2870
Published: 01 May 2021
View articletitled, GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy
Open the PDF for GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy in another window
Includes: Supplementary data
Journal Articles

Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer

Amy J. Wisdom, David G. Kirsch
Journal: Cancer Research
Cancer Res (2020) 80 (24): 5459–5461.
https://doi.org/10.1158/0008-5472.CAN-20-3241
Published: 15 December 2020
View articletitled, Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer
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Journal Articles

Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy

Katherine D. Castle, David G. Kirsch
Journal: Cancer Research
Cancer Res (2019) 79 (22): 5685–5692.
https://doi.org/10.1158/0008-5472.CAN-19-1323
Published: 15 November 2019
View articletitled, Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy
Open the PDF for Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy in another window
Journal Articles

Abstract 4512: Identifying novel mechanisms of p53-mediated tumor suppression

Nathan H. Leisenring, Robert W. Floyd, David G. Kirsch
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4512.
https://doi.org/10.1158/1538-7445.AM2019-4512
Published: 01 July 2019
View articletitled, Abstract 4512: Identifying novel mechanisms of p53-mediated tumor suppression
Journal Articles

Abstract 792: Acetate production from glucose and coupling to mitochondrial metabolism in mammals

Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Peder J. Lund, Mariana Lopes, Benjamin A. Garcia, Kathryn E. Wellen, David G. Kirsch, Jason W. Locasale
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 792.
https://doi.org/10.1158/1538-7445.AM2019-792
Published: 01 July 2019
View articletitled, Abstract 792: Acetate production from glucose and coupling to mitochondrial metabolism in mammals
Journal Articles

Abstract LB-306: Long non-coding RNA NEAT1 promotes lung metastasis of soft tissue sarcoma by regulating RNA splicing pathways

Jianguo Huang, Eric Xu, Mohit Sachdeva, Timothy Robinson, Xiaodi Qin, Dadong Zhang, Kouros Owzar, Nalan Gokgoz, Andrew Seto, Irene Andrulis, Jay Wunder, Tomoyo Okada, Simuel Singer, Alexander Lazar, Brian Rubin, David G. Kirsch
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-306.
https://doi.org/10.1158/1538-7445.AM2019-LB-306
Published: 01 July 2019
View articletitled, Abstract LB-306: Long non-coding RNA NEAT1 promotes lung metastasis of soft tissue sarcoma by regulating RNA splicing pathways
Journal Articles

Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma

Jordan A. Torok, Patrick Oh, Katherine D. Castle, Michael Reinsvold, Yan Ma, Lixia Luo, Chang-Lung Lee, David G. Kirsch
Journal: Cancer Research
Cancer Res (2019) 79 (4): 773–782.
https://doi.org/10.1158/0008-5472.CAN-17-3103
Published: 15 February 2019
View articletitled, Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma
Open the PDF for Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis

Kristianne M. Oristian, Lisa E.S. Crose, Nina Kuprasertkul, Rex C. Bentley, Yi-Tzu Lin, Nerissa Williams, David G. Kirsch, Corinne M. Linardic
Journal: Cancer Research
Cancer Res (2018) 78 (19): 5513–5520.
https://doi.org/10.1158/0008-5472.CAN-17-3912
Published: 01 October 2018
View articletitled, Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis
Open the PDF for Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis in another window
Journal Articles

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting

Phyllis F. Cheung, Florian Neff, Christian Neander, Anna Bazarna, Konstantinos Savvatakis, Sven-Thorsten Liffers, Kristina Althoff, Chang-Lung Lee, Everett J. Moding, David G Kirsch, Dieter Saur, Alexandr V. Bazhin, Marija Trajkovic-Arsic, Mathias F. Heikenwalder, Jens T. Siveke
Journal: Cancer Research
Cancer Res (2018) 78 (17): 4997–5010.
https://doi.org/10.1158/0008-5472.CAN-18-0052
Published: 04 September 2018
View articletitled, Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting
Open the PDF for Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting in another window
Includes: Supplementary data
Journal Articles

Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors

Jacqueline D. Peacock, Matthew G. Pridgeon, Elizabeth A. Tovar, Curt J. Essenburg, Megan Bowman, Zachary Madaj, Julie Koeman, Elissa A. Boguslawski, Jamie Grit, Rebecca D. Dodd, Vadim Khachaturov, Diana M. Cardona, Mark Chen, David G. Kirsch, Flavio Maina, Rosanna Dono, Mary E. Winn, Carrie R. Graveel, Matthew R. Steensma
Journal: Cancer Research
Cancer Res (2018) 78 (13): 3672–3687.
https://doi.org/10.1158/0008-5472.CAN-17-3167
Published: 01 July 2018
View articletitled, Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors
Open the PDF for Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors in another window
Includes: Supplementary data