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Abstract 6334: In vivo efficacy and toxicity of a reduced potency DNA guanine mono-alkylating ADC payload suitable for the treatment of solid tumors

Paul J. Jackson, Paolo Andriollo, Nicolas Veillard, George Procopiou, David E. Thurston

Cancer Res (2022) 82 (12_Supplement): 6334.

DOI: https://doi.org/10.1158/1538-7445.AM2022-6334

Published: 15 June 2022

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Journal Articles

Abstract 1749: A new class of DNA sequence-selective G-A cross-linking antibody-drug conjugate (ADC) payloads

George Procopiou, Paul J. Jackson, Daniella M. di Mascio, Jennifer L. Auer, Paolo Andriollo, Ilona Pysz, Khondaker M. Rahman, Keith R. Fox, David E. Thurston

Cancer Res (2022) 82 (12_Supplement): 1749.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1749

Published: 15 June 2022

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Journal Articles

Abstract 1750: Design and development of a novel highly sequence-selective guanine mono-alkylating DNA-interactive ADC payload suitable for solid tumor treatments

Paolo Andriollo, George Procopiou, Daniella M. di Mascio, Paul J. Jackson, Khondaker M. Rahman, Keith R. Fox, David E. Thurston

Cancer Res (2022) 82 (12_Supplement): 1750.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1750

Published: 15 June 2022

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Journal Articles

Abstract 9: Effect of C8-side chain on the cytotoxicity and NF-kB inhibitory capacity of pyrrolobenzodiazepines

David B. Corcoran, Thomas Lewis, Kazi S. Nahar, Christopher Fegan, Chris Pepper, David E. Thurston, Khondaker Miraz Rahman

Cancer Res (2019) 79 (13_Supplement): 9.

DOI: https://doi.org/10.1158/1538-7445.AM2019-9

Published: 01 July 2019

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Journal Articles

Abstract 211: A new class of sequence-selective DNA cross-linking ADC payloads with increased in vivotolerability

George Procopiou, Jennifer Auer, Daniella di Mascio, Keith R. Fox, Paolo Andriollo, Ilona Pysz, Francesco Cascio, Nicolas Veillard, K. Miraz Rahman, Paul J. Jackson, David E. Thurston

Cancer Res (2019) 79 (13_Supplement): 211.

DOI: https://doi.org/10.1158/1538-7445.AM2019-211

Published: 01 July 2019

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Abstract 217: Development of a rapid and efficient methodology to quantitate thiol detection in antibody-drug conjugates (ADCs)

Ilona Pysz, Paolo Andriollo, Paul J. Jackson, K M. Rahman, David E. Thurston

Cancer Res (2019) 79 (13_Supplement): 217.

DOI: https://doi.org/10.1158/1538-7445.AM2019-217

Published: 01 July 2019

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Journal Articles

Abstract LB-001: Development and evaluation of T-Zap: a novel antibody-drug conjugate for the treatment of Her2 positive breast cancer

Ricarda M. Hoffmann, Silvia Crescioli, David E. Thurston, Sophia N. Karagiannis

Cancer Res (2018) 78 (13_Supplement): LB-001.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-001

Published: 01 July 2018

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Journal Articles

Abstract 738: Development of an HPLC method for the assessment of hydrophobicity of ADC payloads

Ilona Pysz, Paul J. Jackson, Khondaker M. Rahman, David E. Thurston

Cancer Res (2018) 78 (13_Supplement): 738.

DOI: https://doi.org/10.1158/1538-7445.AM2018-738

Published: 01 July 2018

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Journal Articles

Abstract 736: Pyridinobenzodiazepines (PDDs): A new class of sequence-selective DNA mono-alkylating ADC payloads with low hydrophobicity

Nicolas Veillard, Paolo Andriollo, Julia Mantaj, Keith R. Fox, K Miraz Rahman, George Procopiou, Francesco Cascio, David B. Corcoran, Ilona Pysz, Patricia A. Cooper, Steven D. Shnyder, Yawen Ju, Edwin Tan, William M. Schopperle, Paul J. Jackson, David E. Thurston

Cancer Res (2018) 78 (13_Supplement): 736.

DOI: https://doi.org/10.1158/1538-7445.AM2018-736

Published: 01 July 2018

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Journal Articles

Abstract 5242: Further evidence that the DNA-interactive Pyrrolobenzodiazepine (PBD) Dimer SJG-136 works through a transcription factor inhibition mechanism

Julia Mantaj, Paul J. Jackson, David E. Thurston, Khondaker Miraz Rahman

Cancer Res (2017) 77 (13_Supplement): 5242.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5242

Published: 01 July 2017

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Journal Articles

Abstract 2914: Biphenylene and bipyridine connected benzofuran compounds as novel regulators of kRAS transcription

Harshul Batra, Mohammad K. Islam, David E. Thurston, Khondaker M. Rahman, Tracy A. Brooks

Cancer Res (2016) 76 (14_Supplement): 2914.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2914

Published: 15 July 2016

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Journal Articles

Abstract 4779: In silico design, synthesis and evaluation of a new family of C1-substituted pyrrolobenzodiazepines (PBDs)

Paul J. M. Jackson, George Procopiou, Nicolas Veillard, Julia Mantaj, K Miraz Rahman, David E. Thurston

Cancer Res (2016) 76 (14_Supplement): 4779.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4779

Published: 15 July 2016

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Journal Articles

Abstract 4778: Covalent bonding of a C8-conjugated pyrrolobenzodiazepine (PBD) monomer and dimer to a terminal guanine residue of DNA duplex and hairpin fragments

Julia Mantaj, Paul J. M. Jackson, Khondaker Miraz Jackson, David E. Thurston

Cancer Res (2016) 76 (14_Supplement): 4778.

DOI: https://doi.org/10.1158/1538-7445.AM2016-4778

Published: 15 July 2016

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Journal Articles

Abstract 1357: In silico design and biological evaluation of benzofused polyamides targeting G-quadruplex DNA structures

Khondaker M. Rahman, AKM Azadur Rahman, Paul J. M. Jackson, David E. Thurston

Cancer Res (2016) 76 (14_Supplement): 1357.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1357

Published: 15 July 2016

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Journal Articles

Abstract 4555: C8-linked pyrrolobenzodiazepine (PBD)-benzofused hybrids as transcription factor inhibitors

David B. Corcoran, Paul J. M. Jackson, Ambereen Ajaz, Thomas Lewis, Chris Pepper, David E. Thurston, Khondaker M. Rahman

Cancer Res (2015) 75 (15_Supplement): 4555.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4555

Published: 01 August 2015

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Journal Articles

Abstract 3696: Molecular dynamics simulations of C7/C7′-linked pyrrolobenzodiazepine (PBD) dimers

Paul J. M. Jackson, Khondaker Miraz Rahman, David E. Thurston

Cancer Res (2015) 75 (15_Supplement): 3696.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3696

Published: 01 August 2015

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Journal Articles

Abstract 1986: Effect of the PBD dimer SJG-136 on expression of STAT3 dependent genes

Julia Mantaj, David E. Thurston, Khondaker M. Rahman

Cancer Res (2015) 75 (15_Supplement): 1986.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1986

Published: 01 August 2015

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Journal Articles

Abstract 1630: C8-linked pyrrolobenzodiazepine (pbd)-benzofused conjugates with low-picomolar in vitro cytotoxicity

Julia Mantaj, Paul JM Jackson, Chris Pepper, David E. Thurston, Khondaker M. Rahman

Cancer Res (2014) 74 (19_Supplement): 1630.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1630

Published: 01 October 2014

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Journal Articles

Abstract 1624: A fragment-based approach to the development of small-molecule STAT3 transcription factor inhibitors

Kazi Sharmin Nahar, Christopher Chamberlain, Aanchal Grover, Paul Jackson, Khondaker M. Rahman, David E. Thurston

Cancer Res (2014) 74 (19_Supplement): 1624.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1624

Published: 01 October 2014

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Journal Articles

Abstract 5329: Molecular dynamics simulations of sibiromycin suggest a role for the c7-sugar in transcription factor inhibition

Paul J M Jackson, Khondaker M. Rahman, David E. Thurston

Cancer Res (2014) 74 (19_Supplement): 5329.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5329

Published: 01 October 2014

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NARROW

Abstract 6334: In vivo efficacy and toxicity of a reduced potency DNA guanine mono-alkylating ADC payload suitable for the treatment of solid tumors

Abstract 1749: A new class of DNA sequence-selective G-A cross-linking antibody-drug conjugate (ADC) payloads

Abstract 1750: Design and development of a novel highly sequence-selective guanine mono-alkylating DNA-interactive ADC payload suitable for solid tumor treatments

Abstract 9: Effect of C8-side chain on the cytotoxicity and NF-kB inhibitory capacity of pyrrolobenzodiazepines

Abstract 211: A new class of sequence-selective DNA cross-linking ADC payloads with increased in vivotolerability

Abstract 217: Development of a rapid and efficient methodology to quantitate thiol detection in antibody-drug conjugates (ADCs)

Abstract LB-001: Development and evaluation of T-Zap: a novel antibody-drug conjugate for the treatment of Her2 positive breast cancer

Abstract 738: Development of an HPLC method for the assessment of hydrophobicity of ADC payloads

Abstract 736: Pyridinobenzodiazepines (PDDs): A new class of sequence-selective DNA mono-alkylating ADC payloads with low hydrophobicity

Abstract 5242: Further evidence that the DNA-interactive Pyrrolobenzodiazepine (PBD) Dimer SJG-136 works through a transcription factor inhibition mechanism

Abstract 2914: Biphenylene and bipyridine connected benzofuran compounds as novel regulators of kRAS transcription

Abstract 4779: In silico design, synthesis and evaluation of a new family of C1-substituted pyrrolobenzodiazepines (PBDs)

Abstract 4778: Covalent bonding of a C8-conjugated pyrrolobenzodiazepine (PBD) monomer and dimer to a terminal guanine residue of DNA duplex and hairpin fragments

Abstract 1357: In silico design and biological evaluation of benzofused polyamides targeting G-quadruplex DNA structures

Abstract 4555: C8-linked pyrrolobenzodiazepine (PBD)-benzofused hybrids as transcription factor inhibitors

Abstract 3696: Molecular dynamics simulations of C7/C7′-linked pyrrolobenzodiazepine (PBD) dimers

Abstract 1986: Effect of the PBD dimer SJG-136 on expression of STAT3 dependent genes

Abstract 1630: C8-linked pyrrolobenzodiazepine (pbd)-benzofused conjugates with low-picomolar in vitro cytotoxicity

Abstract 1624: A fragment-based approach to the development of small-molecule STAT3 transcription factor inhibitors

Abstract 5329: Molecular dynamics simulations of sibiromycin suggest a role for the c7-sugar in transcription factor inhibition

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