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David E. Root
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Journal Articles

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

Alissandra L. Hillis, Timothy D. Martin, Haley E. Manchester, Jenny Högström, Na Zhang, Emmalyn Lecky, Nina Kozlova, Jonah Lee, Nicole S. Persky, David E. Root, Myles Brown, Karen Cichowski, Stephen J. Elledge, Taru Muranen, David A. Fruman, Simon T. Barry, John G. Clohessy, Ralitsa R. Madsen, Alex Toker
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3250–3266.
https://doi.org/10.1158/0008-5472.CAN-24-0970
Published: 01 October 2024
View article titled, Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
Open the PDF for Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes

Yeying Huang, R. Taylor Durall, Nhi M. Luong, Hans J. Hertzler, Julianna Huang, Prafulla C. Gokhale, Brittaney A. Leeper, Nicole S. Persky, David E. Root, Praju V. Anekal, Paula D.L.M. Montero Llopis, Clement N. David, Jeffery L. Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A. Zahnow, Biniam Adane, Kimberly Stegmaier, Catherine E. Hawkins, Christopher Ponne, Quan Le, Geoffrey I. Shapiro, Madeleine E. Lemieux, Kyle P. Eagen, Christopher A. French
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3956–3973.
https://doi.org/10.1158/0008-5472.CAN-23-1475
Published: 01 December 2023
View article titled, EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
Open the PDF for EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes in another window
Includes: Supplementary data
Journal Articles

Abstract 3624: Non-canonical proteins are cancer cell vulnerabilities in diverse malignancies

John R. Prensner, Ian Yannuzzi, Karl Clauser, Karsten Krug, Oana Enache, Adam Brown, Amy Goodale, David E. Root, Pratiti Bandopadhayay, Todd Golub
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3624.
https://doi.org/10.1158/1538-7445.AM2022-3624
Published: 15 June 2022
View article titled, Abstract 3624: Non-canonical proteins are cancer cell vulnerabilities in diverse malignancies
Journal Articles

Abstract 3610: In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Arnav Mehta, Samuel S. Freeman, Peter M. Allen, Kira E. Olander, Kyle M. Ockerman, Clara H. Wolfe, Fabius Wiesmann, Nelson H. Knudsen, Hsiao-Wei Tsao, Arvin Iracheta-Vellve, Emily M. Schneider, Andrea N. Rivera-Rosario, Ian C. Kohnle, Hans W. Pope, Austin Ayer, Gargi Mishra, Margaret D. Zimmer, Sarah Y. Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T. Frederick, Genevieve M. Boland, W. Nicholas Haining, David E. Root, John G. Doench, Nir Hacohen, Kathleen B. Yates, Robert T. Manguso
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3610.
https://doi.org/10.1158/1538-7445.AM2022-3610
Published: 15 June 2022
View article titled, Abstract 3610: In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
Journal Articles

Abstract 73: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Lisa D. Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A. Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M. Dempster, John M. Krill-Burger, Federica Piccioni, Namrata D. Udeshi, Meagan E. Olive, Steven A. Carr, David E. Root, James M. McFarland, Francisca Vazquez, William C. Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 73.
https://doi.org/10.1158/1538-7445.AM2022-73
Published: 15 June 2022
View article titled, Abstract 73: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
Journal Articles

Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas

Lisa D Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M Dempster, John M Krill-Burger, Federica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-09-01.
https://doi.org/10.1158/1538-7445.SABCS21-P3-09-01
Published: 15 February 2022
View article titled, Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas
Journal Articles

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

Jasper E. Neggers, Brenton Paolella, Adhana Asfaw, Michael V. Rothberg, Tom A. Skipper, Radha Kalekar, Michael Burger, Neekesh Dharia, Guillaume Kugener, Jeremie Kalfon, Nancy Dumont, Yvonne Li, Liam Spurr, Annan Yang, Wenbo Wu, AndrewAdam Durbin, Brian M. Wolpin, David E. Root, Jesse Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG01.
https://doi.org/10.1158/1538-7445.AM2021-NG01
Published: 01 July 2021
View article titled, Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q
Journal Articles

Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival

Lisa D. Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua Dempster, John M. Krill-Burger, Namrata Udeshi, Meagan Olive, Steven A. Carr, David E. Root, Federica Piccioni, James M. McFarland, Francisca Vazquez, William C. Hahn
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1950.
https://doi.org/10.1158/1538-7445.AM2021-1950
Published: 01 July 2021
View article titled, Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival
Journal Articles

Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers

Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, Michael J. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Adam D. Durbin, Annan Yang, Nancy Dumont, Yvonne Y. Li, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-011.
https://doi.org/10.1158/1538-7445.PANCA20-PO-011
Published: 13 November 2020
View article titled, Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers
Journal Articles

Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines

Tsukasa Shibue, John M. Krill-Burger, Brenton R. Paolella, Benjamin Gaeta, Adhana Asfaw, Joshua M. Dempster, James M. McFarland, David E. Root, Jesse S. Boehm, Aviad Tsherniak, William C. Hahn, Francisca Vazquez
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-100.
https://doi.org/10.1158/1538-7445.AM2020-LB-100
Published: 15 August 2020
View article titled, Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines
Journal Articles

Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B-deficient cancers due to co-deletion with SMAD4

Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Radha L. Kalekar, John M. Krill-Burger, Andrew L. Hong, Guillaume Kugener, Jeremie Kalfon, Annan Yang, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Federica Piccioni, Brian M. Wolpin, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-053.
https://doi.org/10.1158/1538-7445.AM2020-LB-053
Published: 15 August 2020
View article titled, Abstract LB-053: <em>VPS4A</em> is a synthetic lethal target in <em>VPS4B</em>-deficient cancers due to co-deletion with <em>SMAD4</em>
Journal Articles

Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry

Adam D. Durbin, Guillaume Kugener, Mark W. Zimmerman, Chuan Yan, Neekesh V. Dharia, Elizabeth S. Frank, Xiang Chen, Ken N. Ross, Brenton Paolella, Michael Krill-Burger, David E. Root, Jesse S. Boehm, Francisca Vazquez, Andrew L. Hong, Aviad Tsherniak, David M. Langenau, William C. Hahn, Todd R. Golub, Brian J. Abraham, Richard A. Young, A. Thomas Look, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B10.
https://doi.org/10.1158/1538-7445.PEDCA19-B10
Published: 15 July 2020
View article titled, Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry
Journal Articles

Abstract 4344: Integrative functional proteogenomics for unannotated or uncharacterized proteins in cancer

John R. Prensner, Oana Enache, Zhe Ji, Karsten Krug, Karl R. Clauser, Xiaoping Yang, Federica Piccioni, David E. Root, Todd R. Golub
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4344.
https://doi.org/10.1158/1538-7445.AM2019-4344
Published: 01 July 2019
View article titled, Abstract 4344: Integrative functional proteogenomics for unannotated or uncharacterized proteins in cancer
Journal Articles

A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma

Tikvah K. Hayes, Flora Luo, Ofir Cohen, Amy B. Goodale, Yenarae Lee, Sasha Pantel, Mukta Bagul, Federica Piccioni, David E. Root, Levi A. Garraway, Matthew Meyerson, Cory M. Johannessen
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2352–2366.
https://doi.org/10.1158/0008-5472.CAN-18-2711
Published: 01 May 2019
View article titled, A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma
Open the PDF for A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma in another window
Includes: Supplementary data
Journal Articles

The Canonical Wnt Pathway Drives Macropinocytosis in Cancer

Gil Redelman-Sidi, Anna Binyamin, Isabella Gaeta, Wilhelm Palm, Craig B. Thompson, Paul B. Romesser, Scott W. Lowe, Mukta Bagul, John G. Doench, David E. Root, Michael S. Glickman
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (16): 4658–4670.
https://doi.org/10.1158/0008-5472.CAN-17-3199
Published: 14 August 2018
View article titled, The Canonical Wnt Pathway Drives Macropinocytosis in Cancer
Open the PDF for The Canonical Wnt Pathway Drives Macropinocytosis in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2352: Defining a pediatric cancer dependency map

Neekesh V. Dharia, Clare Malone, Amanda Balboni Iniguez, Lillian Guenther, Liying Chen, Gabriela Alexe, Adam D. Durbin, Mark W. Zimmerman, Andrew Hong, Pratiti Bandopadhayay, Mariella G. Filbin, Thomas Howard, Brenton Paolella, Iris Fung, Josephine Lee, Phil Montgomery, John M. Krill-Burger, Brian J. Abraham, Jennifer Roth, David E. Root, Richard A. Young, A. Thomas Look, Rameen Beroukhim, Jesse S. Boehm, William C. Hahn, Todd R. Golub, Aviad Tsherniak, Francisca Vazquez, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2352.
https://doi.org/10.1158/1538-7445.AM2018-2352
Published: 01 July 2018
View article titled, Abstract 2352: Defining a pediatric cancer dependency map
Journal Articles

Abstract 1815: Massively parallel identification of conserved drug resistant mutations in kinases

Nicole S. Persky, Desiree Hernandez, Jonathon Cordova, Amanda Walker, Lisa Brenan, Federica Piccioni, Sasha Pantel, Yenarae Lee, Amy Goodale, Xiaoping Yang, Yoichiro Mitsuishi, Mariana Do Carmo, Cong Zhu, Aleksandr Andreev, David E. Root, Cory M. Johannessen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1815.
https://doi.org/10.1158/1538-7445.AM2018-1815
Published: 01 July 2018
View article titled, Abstract 1815: Massively parallel identification of conserved drug resistant mutations in kinases
Journal Articles

Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Brian J. Abraham, Amanda Balboni-Iniguez, Nina Weichert-Leahey, Shuning He, John M. Krill-Burger, David E. Root, Francisca Vazquez, Aviad Tsherniak, William C. Hahn, Todd R. Golub, Richard A. Young, A. Thomas Look, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2062.
https://doi.org/10.1158/1538-7445.AM2018-2062
Published: 01 July 2018
View article titled, Abstract 2062: Selective gene dependencies in <em>MYCN</em>-amplified neuroblastoma include the core transcriptional regulatory circuitry
Journal Articles

Abstract 1019: In vivo CRISPR screening identifies Ptpn2 as a target for cancer immunotherapy

Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer, Flavian D. Brown, Kathleen B. Yates, Brian C. Miller, Natalie B. Collins, Kevin Bi, Martin W. Lafleur, Vikram R. Juneja, Sarah A. Weiss, David E. Fisher, David E. Root, Arlene H. Sharpe, John G. Doench, W Nicholas Haining
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1019.
https://doi.org/10.1158/1538-7445.AM2017-1019
Published: 01 July 2017
View article titled, Abstract 1019: <em>In vivo</em> CRISPR screening identifies Ptpn2 as a target for cancer immunotherapy
Journal Articles

Abstract 394: Saturation mutagenesis of KRAS reveals the functional landscape of missense variants

Eejung Kim, Seav Huong Ly, Nicole S. Persky, Belinda Wang, Xiaoping Yang, Federica Piccioni, Katherine Labella, Mihir Doshi, Robert E. Lintner, Cong Zhu, Scott Steelman, David E. Root, Cory M. Johannessen, Alex B. Burgin, Laura E. MacConaill, William C. Hahn, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 394.
https://doi.org/10.1158/1538-7445.AM2017-394
Published: 01 July 2017
View article titled, Abstract 394: Saturation mutagenesis of KRAS reveals the functional landscape of missense variants