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David E. Blask
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Journal Articles

Abstract 222: Exposure to dim light at night disrupts the nocturnal melatonin signal in male nude rats bearing tissue-isolated castration-sensitive VCaP human prostate cancer: Impact on tumor circadian dynamics of the Warburg effect, lipid signaling and proliferation

Erin M. Dauchy, Robert T. Dauchy, Steven M. Hill, Yan Dong, Victoria P. Belancio, Shulin Xiang, George C. Brainard, John P. Hanifin, David E. Blask
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 222.
https://doi.org/10.1158/1538-7445.AM2022-222
Published: 15 June 2022
View article titled, Abstract 222: Exposure to dim light at night disrupts the nocturnal melatonin signal in male nude rats bearing tissue-isolated castration-sensitive VCaP human prostate cancer: Impact on tumor circadian dynamics of the Warburg effect, lipid signaling and proliferation
Journal Articles

Abstract 3191: Daytime blue-enriched LED light-induced circadian amplification of the nighttime melatonin signal increases sorafenib sensitivity in human hepatocellular carcinoma via enhanced suppression of the Warburg effect

Robert T. Dauchy, David T. Pointer, Aaron E. Hoffman, Melissa A. Wren-Dail, Shulin Xiang, Lin Yuan, David E. Blask, Victoria P. Belancio, Steven M. Hill
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3191.
https://doi.org/10.1158/1538-7445.AM2017-3191
Published: 01 July 2017
View article titled, Abstract 3191: Daytime blue-enriched LED light-induced circadian amplification of the nighttime melatonin signal increases sorafenib sensitivity in human hepatocellular carcinoma via enhanced suppression of the Warburg effect
Journal Articles

Abstract 4897: Circadian/melatonin disruption by dim light at night drives human epithelial breast cancer to a metastatic phenotype

Steven M. Hill, Shulin Xiang, Robert T. Dauchy, Melissa Wren-Dail, Murali Anbalagan, Brian Rowan, Tripp Frasch, David E. Blask
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4897.
https://doi.org/10.1158/1538-7445.AM2017-4897
Published: 01 July 2017
View article titled, Abstract 4897: Circadian/melatonin disruption by dim light at night drives human epithelial breast cancer to a metastatic phenotype
Journal Articles

Abstract 874: Circadian/melatonin disruption by dim light at night drives paclitaxel resistance in breast cancer via activation of stat3

Steven M. Hill, Shulin Xiang, Robert T. Dauchy, Lulu mao, Lin Yuan, Adam Hauch, Victoria P. Belancio, Melissa A. Wren-Dail, David Pointer, Peter W. Lundberg, Whitney M. Summers, David E. Blask
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 874.
https://doi.org/10.1158/1538-7445.AM2016-874
Published: 15 July 2016
View article titled, Abstract 874: Circadian/melatonin disruption by dim light at night drives paclitaxel resistance in breast cancer via activation of stat3
Journal Articles

Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

Robert T. Dauchy, Shulin Xiang, Lulu Mao, Samantha Brimer, Melissa A. Wren, Lin Yuan, Muralidharan Anbalagan, Adam Hauch, Tripp Frasch, Brian G. Rowan, David E. Blask, Steven M. Hill
Journal: Cancer Research
Cancer Res (2014) 74 (15): 4099–4110.
https://doi.org/10.1158/0008-5472.CAN-13-3156
Published: 31 July 2014
View article titled, Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer
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Journal Articles

Abstract 4001: The circadian neurohormone melatonin inhibits aerobic glycolysis (Warburg effect) and fatty acid metabolic signaling in human colorectal and cervical cancer.

Robert T. Dauchy, Erin M. Dauchy, Lulu Mao, Melissa A. Wren, Victoria P. Belancio, Steven M. Hill, David E. Blask
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4001.
https://doi.org/10.1158/1538-7445.AM2013-4001
Published: 15 April 2013
View article titled, Abstract 4001: The circadian neurohormone melatonin inhibits aerobic glycolysis (Warburg effect) and fatty acid metabolic signaling in human colorectal and cervical cancer.
Journal Articles

Abstract 5423: Melatonin inhibits aerobic glycolysis (Warburg effect) and fatty acid metabolic signaling in human leiomyosarcoma.

Lulu Mao, Robert T. Dauchy, Erin M. Dauchy, Melissa A. Wren, Samantha D. Zeringue, Victoria P. Belancio, David E. Blask, Steven M. Hill
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5423.
https://doi.org/10.1158/1538-7445.AM2013-5423
Published: 15 April 2013
View article titled, Abstract 5423: Melatonin inhibits aerobic glycolysis (Warburg effect) and fatty acid metabolic signaling in human leiomyosarcoma.
Journal Articles

Abstract 165: The anticarcinogenic effects of melatonin on inhibition of fatty acid transport and 13-HODE production in HT29 human colorectal cancer occurs via receptor-mediated signal transduction

Robert T. Dauchy, Erin M. Dauchy, Lulu Mao, Victoria P. Belancio, Steven M. Hill, Leonard A. Sauer, David E. Blask
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 165.
https://doi.org/10.1158/1538-7445.AM2012-165
Published: 15 April 2012
View article titled, Abstract 165: The anticarcinogenic effects of melatonin on inhibition of fatty acid transport and 13-HODE production in HT29 human colorectal cancer occurs via receptor-mediated signal transduction
Journal Articles

Abstract 5167: Melatonin inhibition of linoleic acid transport and 13-HODE production in HeLa human cervical adenocarcinoma occurs via receptor-mediated signal transduction

Robert T. Dauchy, Erin M. Dauchy, Victoria P. Belancio, Lulu Mao, Steven M. Hill, Leonard A. Sauer, David E. Blask
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5167.
https://doi.org/10.1158/1538-7445.AM2012-5167
Published: 15 April 2012
View article titled, Abstract 5167: Melatonin inhibition of linoleic acid transport and 13-HODE production in HeLa human cervical adenocarcinoma occurs via receptor-mediated signal transduction
Journal Articles

Abstract 1324: Melatonin-depleted blood from healthy adult men exposed to environmental light at night stimulates growth, signal transduction and metabolic activity of tissue-isolated human prostate cancer xenografts in nude rats

Robert T. Dauchy, Kate S. Cecil, Erin M. Dauchy, John P. Hanifin, Lulu Mao, Lauren M. Slakey, Victoria P. Belancio, Steven M. Hill, George C. Brainard, David E. Blask
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1324.
https://doi.org/10.1158/1538-7445.AM2011-1324
Published: 15 April 2011
View article titled, Abstract 1324: Melatonin-depleted blood from healthy adult men exposed to environmental light at night stimulates growth, signal transduction and metabolic activity of tissue-isolated human prostate cancer xenografts in nude rats
Journal Articles

Light at Night Activates IGF-1R/PDK1 Signaling and Accelerates Tumor Growth in Human Breast Cancer Xenografts

Jinghai Wu, Robert T. Dauchy, Paul C. Tirrell, Steven S. Wu, Darin T. Lynch, Potjana Jitawatanarat, Christine M. Burrington, Erin M. Dauchy, David E. Blask, Michael W. Greene
Journal: Cancer Research
Cancer Res (2011) 71 (7): 2622–2631.
https://doi.org/10.1158/0008-5472.CAN-10-3837
Published: 31 March 2011
View article titled, Light at Night Activates IGF-1R/PDK1 Signaling and Accelerates Tumor Growth in Human Breast Cancer Xenografts
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Includes: Supplementary data
Journal Articles

Abstract 1047: Circadian disruption induced by light at night upregulates PCNA expression in tissue-isolated human breast cancer xenografts in nude rats

Jinghai Wu, Robert T. Dauchy, Paul C. Tirrell, Steven S. Wu, Erin M. Dauchy, David E. Blask, Michael W. Greene
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1047.
https://doi.org/10.1158/1538-7445.AM10-1047
Published: 15 April 2010
View article titled, Abstract 1047: Circadian disruption induced by light at night upregulates PCNA expression in tissue-isolated human breast cancer xenografts in nude rats
Journal Articles

Nocturnal oral melatonin supplementation prevents dim light during darkness-induced stimulation of signal transduction, LA uptake/metabolism and growth of tissue-isolated human breast cancer xenografts in female nude rats

David E. Blask, Robert T. Dauchy, Jean A. Krause, Leslie K. Davidson, Darin T. Lynch, Leonard A. Sauer, George C. Brainard
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 856–857.
Published: 15 April 2006
View article titled, Nocturnal oral melatonin supplementation prevents dim light during darkness-induced stimulation of signal transduction, LA uptake/metabolism and growth of tissue-isolated human breast cancer xenografts in female nude rats
Journal Articles

Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats

David E. Blask, George C. Brainard, Robert T. Dauchy, John P. Hanifin, Leslie K. Davidson, Jean A. Krause, Leonard A. Sauer, Moises A. Rivera-Bermudez, Margarita L. Dubocovich, Samar A. Jasser, Darin T. Lynch, Mark D. Rollag, Frederick Zalatan
Journal: Cancer Research
Cancer Res (2005) 65 (23): 11174–11184.
https://doi.org/10.1158/0008-5472.CAN-05-1945
Published: 01 December 2005
View article titled, Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats
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Journal Articles

Low-intensity light at night (LAN) exposure and alterations in hepatoma and human breast tumor lipid metabolism in rats: A dose-response study

Robert T. Dauchy, David E. Blask, George C. Brainard, Leonard A. Sauer, Leslie K. Davidson, Jean A. Krause, Darin T. Lynch, Erin M. Dauchy
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1124.
Published: 01 May 2005
View article titled, Low-intensity light at night (LAN) exposure and alterations in hepatoma and human breast tumor lipid metabolism in rats: A dose-response study
Journal Articles

Oral melatonin supplementation in rats and a human subject suppresses the growth activity of steroid receptor negative human breast cancer xenografts in female nude rats via an MT1 receptor-mediated suppression of signal tranduction and linoleic acid uptake and metabolism

David E. Blask, Robert T. Dauchy, Leonard A. Sauer, Leslie K. Davidson, Jean A. Krause, Darin T. Lynch, Erin M. Dauchy
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1358.
Published: 01 May 2005
View article titled, Oral melatonin supplementation in rats and a human subject suppresses the growth activity of steroid receptor negative human breast cancer xenografts in female nude rats via an MT<sub>1</sub> receptor-mediated suppression of signal tranduction and linoleic acid uptake and metabolism
Journal Articles

Eicosatetraynoic acid and thiazolidinedione drugs inhibit fatty acid transport in hepatoma 7288CTC via a pertussis toxin (PTX)-sensitive, cAMP-dependent signal transduction pathway

Leonard A. Sauer, Robert T. Dauchy, David E. Blask, Leslie K. Davidson, Jean A. Krause, Erin M. Dauchy
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1013–1014.
Published: 01 April 2004
View article titled, Eicosatetraynoic acid and thiazolidinedione drugs inhibit fatty acid transport in hepatoma 7288CTC via a pertussis toxin (PTX)-sensitive, cAMP-dependent signal transduction pathway
Journal Articles

Mechanism for the Antitumor and Anticachectic Effects of n-3 Fatty Acids

Leonard A. Sauer, Robert T. Dauchy, David E. Blask
Journal: Cancer Research
Cancer Res (2000) 60 (18): 5289–5295.
Published: 01 September 2000
View article titled, Mechanism for the Antitumor and Anticachectic Effects of n-3 Fatty Acids
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Journal Articles

13-Hydroxyoctadecadienoic Acid Is the Mitogenic Signal for Linoleic Acid-dependent Growth in Rat Hepatoma 7288CTC in Vivo

Leonard A. Sauer, Robert T. Dauchy, David E. Blask, Brenda J. Armstrong, Simone Scalici
Journal: Cancer Research
Cancer Res (1999) 59 (18): 4688–4692.
Published: 15 September 1999
View article titled, 13-Hydroxyoctadecadienoic Acid Is the Mitogenic Signal for Linoleic Acid-dependent Growth in Rat Hepatoma 7288CTC <em>in Vivo</em>
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Journal Articles

Melatonin Inhibition of Cancer Growth in Vivo Involves Suppression of Tumor Fatty Acid Metabolism via Melatonin Receptor-mediated Signal Transduction Events

David E. Blask, Leonard A. Sauer, Robert T. Dauchy, Eugene W. Holowachuk, Mary S. Ruhoff, Heather S. Kopff
Journal: Cancer Research
Cancer Res (1999) 59 (18): 4693–4701.
Published: 15 September 1999
View article titled, Melatonin Inhibition of Cancer Growth <em>in Vivo</em> Involves Suppression of Tumor Fatty Acid Metabolism via Melatonin Receptor-mediated Signal Transduction Events
Open the PDF for Melatonin Inhibition of Cancer Growth <em>in Vivo</em> Involves Suppression of Tumor Fatty Acid Metabolism via Melatonin Receptor-mediated Signal Transduction Events in another window