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David C. Linehan
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Journal Articles

Abstract A004: A Phase 1B/2 trial of second line immunotherapy with pepinemab and avelumab for patients with metastatic pancreatic adenocarcinoma

Free
Luis I Ruffolo, Matthew Byrne, Bailey Hilty, Brian A Belt, Yatee Dave, Paul Burchard, Terrence Fisher, Elizabeth E. Evans, Crystal Mallow, Megan Boise, Darren Carpizo, Jen Jen Yeh, David C Linehan, Daniel Mulkerin
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A004.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A004
Published: 15 September 2024
View articletitled, Abstract A004: A Phase 1B/2 trial of second line immunotherapy with pepinemab and avelumab for patients with metastatic pancreatic adenocarcinoma
Journal Articles

Abstract A042: Clinical classification of cancer-associated fibroblast subtypes predicts prognosis and treatment response

Free
Xianlu L Peng, Elena V Kharitonova, Ian C McCabe, Changfei Luan, Ryan T Zhao, Priscilla S Chan, Arthi Hariharan, John R Leary, Ashley B Morrison, Joseph F Kearney, Hannah E Trembath, Gabriela Herrera, Ashley Cliff, Hong Jin Kim, Brian A Belt, Roheena Z Panni, David C Linehan, Jeffrey S Damrauer, Alina C Iuga, William Y Kim, Naim U Rashid, Jen Jen Yeh
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A042.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A042
Published: 15 September 2024
View articletitled, Abstract A042: Clinical classification of cancer-associated fibroblast subtypes predicts prognosis and treatment response
Journal Articles

Abstract 6213: Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes

Free
Xianlu Laura Peng, Elena Kharitonova, Joseph Kearney, Yi Xu, Priscilla Chan, Changfei Luan, Brian Belt, Roheena Panni, Arthi Hariharan, Ian McCabe, Ashley Morrison, Ashley Cliff, David C. Linehan, Alina Iuga, Naim U. Rashid, Jen Jen Yeh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6213.
https://doi.org/10.1158/1538-7445.AM2024-6213
Published: 22 March 2024
View articletitled, Abstract 6213: Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes
Journal Articles

Abstract A035: Stromal composition, fibroblast heterogeneity and spatial organization in pancreatic adenocarcinoma

Free
Dalia Elganainy, Andressa Dias Costa, Alexander Jordan, Suryun Kim, Sara A. Väyrynen, Hannah L. Williams, Chen Yuan, Douglas A. Rubinson, Kimberly Perez, Harshabad Singh, Richard F. Dunne, Thomas E. Clancy, David C. Linehan, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew Aguirre, Brian M. Wolpin, Jonathan A. Nowak
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A035.
https://doi.org/10.1158/1538-7445.PANCA2023-A035
Published: 16 January 2024
View articletitled, Abstract A035: Stromal composition, fibroblast heterogeneity and spatial organization in pancreatic adenocarcinoma
Journal Articles

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

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Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2023) 83 (3): 441–455.
https://doi.org/10.1158/0008-5472.CAN-22-3050
Published: 03 February 2023
View articletitled, Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Open the PDF for Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity in another window
Includes: Supplementary data
Journal Articles

Abstract 254: Dietary fish oil and aspirin to augment anti-PD-1 immunotherapy in metastatic melanoma

Free
Alexander C. Chacon, Shuyang S. Qin, Alexa D. Melucci, Katherine M. Jackson, Paul R. Burchard, Yatee A. Dave, Rachel Jewell, Brian A. Belt, William Tabayoyong, David C. Linehan, Peter A. Prieto
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 254.
https://doi.org/10.1158/1538-7445.AM2022-254
Published: 15 June 2022
View articletitled, Abstract 254: Dietary fish oil and aspirin to augment anti-PD-1 immunotherapy in metastatic melanoma
Journal Articles

Abstract 1605: "Reverse abscopal effect": Immunologically cold tumors alter systemic immunity and confer PD-1 resistance to immunologically hot tumors in synchronous melanoma

Free
Shuyang S. Qin, Booyeon J. Han, Alexander C. Chacon, Alexa D. Melucci, Alyssa R. Williams, Rachel Jewell, Minsoo Kim, David C. Linehan, Scott A. Gerber, Peter A. Prieto
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1605.
https://doi.org/10.1158/1538-7445.AM2022-1605
Published: 15 June 2022
View articletitled, Abstract 1605: "Reverse abscopal effect": Immunologically cold tumors alter systemic immunity and confer PD-1 resistance to immunologically hot tumors in synchronous melanoma
Journal Articles

Abstract PO-013: MTAP protein expression is lost in nearly one-third of primary pancreatic cancers and is associated with sensitivity to MAT2A inhibition in patient-derived organoid models

Free
Sara A. Väyrynen, Annan Yang, Junning Wang, Jinming Zhang, Kristen Lowder, Kevin S. Kapner, Tim Bosse, Sri Raghavan, Andressa Dias Costa, Hannah Williams, Chen Yuan, Ashley Pelton, Vicente Morales-Oyarvide, Douglas A. Rubinson, Lauren Brais, Emma Reilly, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, Brian M. Wolpin, Jonathan A Nowak, Andrew J Aguirre
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-013.
https://doi.org/10.1158/1538-7445.PANCA20-PO-013
Published: 13 November 2020
View articletitled, Abstract PO-013: MTAP protein expression is lost in nearly one-third of primary pancreatic cancers and is associated with sensitivity to MAT2A inhibition in patient-derived organoid models
Journal Articles

Abstract PR-001: Neoadjuvant therapy is associated with altered composition of immune cell infiltration and an anti-tumorigenic microenvironment in resected pancreatic cancer

Free
Andressa Dias Costa, Sara Väyrynen, Akhil Chawla, Jinming Zhang, Juha P. Väyrynen, Mai Chan Lau, Hannah L. Williams, Chen Yuan, Vicente Morales-Oyarvide, Douglas A. Rubinson, Thomas E. Clancy, Lauren K. Brais, Emma Reilly, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew J. Aguirre, Brian M. Wolpin, Jonathan A. Nowak
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PR-001.
https://doi.org/10.1158/1538-7445.PANCA20-PR-001
Published: 13 November 2020
View articletitled, Abstract PR-001: Neoadjuvant therapy is associated with altered composition of immune cell infiltration and an anti-tumorigenic microenvironment in resected pancreatic cancer
Journal Articles

Abstract B48: Targeting the semaphorin 4D-plexin B axis to augment FOLFIRINOX in a murine model of pancreatic adenocarcinoma

Free
Luis I. Ruffolo, Katherine M. Jackson, Nicholas Ullman, Alexander Chacon, Alexa Melucci, Paul Burchard, Mary Georger, Rachel Jewell, Peter Prieto, Brian Belt, Crystal Mallow, Elizabeth Evans, Terrence Fisher, Maurice Zauderer, Christina Wu, Brian Olson, Gregory B. Lesinski, David C. Linehan
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B48.
https://doi.org/10.1158/1538-7445.PANCA19-B48
Published: 13 December 2019
View articletitled, Abstract B48: Targeting the semaphorin 4D-plexin B axis to augment FOLFIRINOX in a murine model of pancreatic adenocarcinoma
Journal Articles

Abstract 4150: Blockade of CXCR2 mediated granulocytic MDSC recruitment synergizes with CCR2 inhibition of inflammatory monocytes and restores anti-tumor immunity in pancreatic adenocarcinoma

Free
Timothy M. Nywening, Brian A. Belt, Roheena Z. Panni, Darren Cullinan, Dominic E. Sanford, Ryan C. Fields, William G. Hawkins, David G. DeNardo, William E. Gillanders, Peter Goedegebuure, David C. Linehan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4150.
https://doi.org/10.1158/1538-7445.AM2016-4150
Published: 15 July 2016
View articletitled, Abstract 4150: Blockade of CXCR2 mediated granulocytic MDSC recruitment synergizes with CCR2 inhibition of inflammatory monocytes and restores anti-tumor immunity in pancreatic adenocarcinoma
Journal Articles

Abstract 619: Identification of clinically actionable genomic alterations in the tumor and circulation of pancreatic cancer patients

Free
Mark Sausen, Jillian Phallen, Vilmos Adleff, Siân Jones, Rebecca J. Leary, Karli Lytle, Sonya Parpart-Li, Derek Murphy, Michael T. Barrett, David C. Linehan, Anirban Maitra, Ralph Hruban, Daniel D. Von Hoff, Julia S. Johansen, Luis A. Diaz, Jeffrey A. Drebin, Victor E. Velculescu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 619.
https://doi.org/10.1158/1538-7445.AM2015-619
Published: 01 August 2015
View articletitled, Abstract 619: Identification of clinically actionable genomic alterations in the tumor and circulation of pancreatic cancer patients
Journal Articles

Abstract B60: Role of inflammatory monocyte mobilization in metastatic pancreatic cancer

Free
Roheena Z. Panni, Dominic E. Sanford, Brian A. Belt, Timothy M. Nywening, Peter Goedegebuure, David C. Linehan
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B60.
https://doi.org/10.1158/1538-7445.PANCA2014-B60
Published: 30 June 2015
View articletitled, Abstract B60: Role of inflammatory monocyte mobilization in metastatic pancreatic cancer
Journal Articles

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

Free
Yu Zhu, Brett L. Knolhoff, Melissa A. Meyer, Timothy M. Nywening, Brian L. West, Jingqin Luo, Andrea Wang-Gillam, S. Peter Goedegebuure, David C. Linehan, David G. DeNardo
Journal: Cancer Research
Cancer Res (2014) 74 (18): 5057–5069.
https://doi.org/10.1158/0008-5472.CAN-13-3723
Published: 14 September 2014
View articletitled, CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
Open the PDF for CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models in another window
Includes: Supplementary data
Journal Articles

Abstract A64: Peripheral blood monocytes predict survival in pancreatic cancer.

Free
Dominic E. Sanford, Brian A. Belt, Roheena Z. Panni, Jonathan B. Mitchem, David G. Denardo, S. Peter Goedegebuure, David C. Linehan
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): A64.
https://doi.org/10.1158/1538-7445.TUMIMM2012-A64
Published: 02 April 2014
View articletitled, Abstract A64: Peripheral blood monocytes predict survival in pancreatic cancer.
Journal Articles

Abstract B83: Targeting tumor-infiltrating macrophages decreases pancreatic tumor-initiating cells and improves chemotherapeutic responses by relieving immune suppression.

Free
Jonathan B. Mitchem, Donal J. Brennan, Dominic E. Sanford, Brett L. Knolhoff, Yu Zhu, Belt Brian, Andrea Wang-Gillam, Peter Goedegebuure, David C. Linehan, David G. DeNardo
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): B83.
https://doi.org/10.1158/1538-7445.TUMIMM2012-B83
Published: 02 April 2014
View articletitled, Abstract B83: Targeting tumor-infiltrating macrophages decreases pancreatic tumor-initiating cells and improves chemotherapeutic responses by relieving immune suppression.
Journal Articles

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

Free
Jonathan B. Mitchem, Donal J. Brennan, Brett L. Knolhoff, Brian A. Belt, Yu Zhu, Dominic E. Sanford, Larisa Belaygorod, Danielle Carpenter, Lynne Collins, David Piwnica-Worms, Stephen Hewitt, Girish Mallya Udupi, William M. Gallagher, Craig Wegner, Brian L. West, Andrea Wang-Gillam, Peter Goedegebuure, David C. Linehan, David G. DeNardo
Journal: Cancer Research
Cancer Res (2013) 73 (3): 1128–1141.
https://doi.org/10.1158/0008-5472.CAN-12-2731
Published: 31 January 2013
View articletitled, Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
Open the PDF for Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses in another window
Includes: Supplementary data
Journal Articles

Abstract LB-148: Depletion of myeloid derived suppressor cells in pancreatric cancer results in decreased tumor growth

Free
Jonathan Mitchem, Matthew Porembka, William G. Hawkins, Simon Peter Goedegebuure, David C. Linehan
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-148.
https://doi.org/10.1158/1538-7445.AM10-LB-148
Published: 15 April 2010
View articletitled, Abstract LB-148: Depletion of myeloid derived suppressor cells in pancreatric cancer results in decreased tumor growth