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Journal Articles

Abstract PO3-14-08: Metaplastic Breast Cancer: Whole Genome Sequencing Analysis and Emerging Therapeutic Targets

Fresia Pareja, Andrea Gazzo, Higinio Dopeso, David Brown, Pier Selenica, Yingjie Zhu, Juan Blanco-Heredia, Laxmi Gusain, Xin Pei, Giacomo Montagna, Nour Abuhadra, Hanna Y Wen, Edi Brogi, Nadeem Riaz, Sarat Chandarlapaty, Maurizio Scaltriti, Larry Norton, Simon Powell, Jorge Reis-Filho, Britta Weigelt
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-14-08.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-14-08
Published: 02 May 2024
View article titled, Abstract PO3-14-08: Metaplastic Breast Cancer: Whole Genome Sequencing Analysis and Emerging Therapeutic Targets
Journal Articles

Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics

Fresia Pareja, Higinio Dopeso, Yikan Wang, Andrea Gazzo, David Brown, Pier Selenica, Jan Bernhard, Fatemeh Derakhshan, Edaise M. da Silva, Lorraine Colon-Cartagena, Thais Basili, Antonio Marra, Jillian Sue, Qiqi Ye, Arnaud Da Cruz Paula, Selma Yeni, Xin Pei, Hunter Green, Kaitlyn Gill, Yingjie Zhu, Matthew Lee, Ran Godrich, Adam Casson, Britta Weigelt, Nadeem Riaz, Hanna Y Wen, Edi Brogi, Matthew Hanna, Diana Mandelker, Jeremy Kunz, Brandon Rothrock, Sarat Chandarlapaty, Christopher Kanan, Gerard Oakley III, David Klimstra, Thomas Fuchs, Jorge Reis-Filho
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): GS03-04.
https://doi.org/10.1158/1538-7445.SABCS23-GS03-04
Published: 02 May 2024
View article titled, Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics
Journal Articles

Abstract 3936: Altered endosomal pH regulation: molecular mechanisms of oncogenesis and therapeutic dependencies

Higinio Dopeso, Yingjie Zhu, Laxmi Gusain, Thais Basili, David Brown, Fatemeh Derakhshan, Edaise M. da Silva, Richard Koche, Pierre-Jacques Hamard, Xinyu Guo, Eneda Toska, Elisa DeStanchina, Hong Zhang, Jorge Reis-Filho, Britta Weigelt, Fresia Pareja
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3936.
https://doi.org/10.1158/1538-7445.AM2024-3936
Published: 22 March 2024
View article titled, Abstract 3936: Altered endosomal pH regulation: molecular mechanisms of oncogenesis and therapeutic dependencies
Journal Articles

Abstract 1394: Comprehensive clinical and genomic analysis for patients with MYC, MYCN, and MYCL amplified solid tumors

Monica F. Chen, Allison Richards, Patrick Evans, Patrick Lee, Adam Price, Matteo Repetto, Soo Ryum Yang, Jason Chang, Rose Brannon, Ezra Rosen, David Brown, Charles Rudin, Nitya Raj, Mark G. Kris, Jorge Reis-Filho, Mark Donoghue, Alexander E. Drilon, Noura J. Choudhury
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1394.
https://doi.org/10.1158/1538-7445.AM2023-1394
Published: 04 April 2023
View article titled, Abstract 1394: Comprehensive clinical and genomic analysis for patients with <em>MYC</em>, <em>MYCN</em>, and <em>MYCL</em> amplified solid tumors
Journal Articles

Abstract PD8-02: Phylogenetic reconstruction of advanced breast cancer reveals two different routes of metastatic dissemination associated with distinct clinical outcome

David Venet, David Brown, Danai Fimereli, Bram Boeckx, Marion Maetens, Samira Majjaj, Ghizlane Rouas, Maria Capra, Giuseppina Bonizzi, Federica Contaldo, Christine Galant, Martine Piccart, Giancarlo Pruneri, Denis Larsimont, Diether Lambrechts, Françoise Rothé, Christine Desmedt, Christos Sotiriou
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD8-02.
https://doi.org/10.1158/1538-7445.SABCS19-PD8-02
Published: 15 February 2020
View article titled, Abstract PD8-02: Phylogenetic reconstruction of advanced breast cancer reveals two different routes of metastatic dissemination associated with distinct clinical outcome
Journal Articles

Abstract 805: Adaptation of mitochondrial organization to aggregation in serous ovarian cancer

Joseph P. Grieco, Stephanie Edwards, Mitchell Allen, Yao Wang, Justin Perry, Yipei Song, Nathan Swami, David Brown, Eva Schmelz
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 805.
https://doi.org/10.1158/1538-7445.AM2019-805
Published: 01 July 2019
View article titled, Abstract 805: Adaptation of mitochondrial organization to aggregation in serous ovarian cancer
Journal Articles

Abstract 5299: Machine learning approach to personalized medicine in breast cancer patients: Development of data-driven, personalized, causal modeling through identification and understanding of optimal treatments for predicting better disease outcomes

Henry Kaplan, Anna Berry, Kristine Rinn, Erin Ellis, George Birchfield, Tanya Wahl, Xiaoyu Liu, Mariko Tameishi, J D. Beatty, Patricia Dawson, Vivek Mehta, Anna Holman, Mary Atwood, Shlece Alexander, Candy Bonham, Lauren Summers, Iya Khalil, Boris Hayete, Diane Wuest, Wei Zheng, Yuhang Liu, Xulong Wang, Thomas David Brown
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5299.
https://doi.org/10.1158/1538-7445.AM2018-5299
Published: 01 July 2018
View article titled, Abstract 5299: Machine learning approach to personalized medicine in breast cancer patients: Development of data-driven, personalized, causal modeling through identification and understanding of optimal treatments for predicting better disease outcomes
Journal Articles

Abstract 5102: TRXE-009-1 has pan-acting anticancer activity and potently inhibits colony formation of prostate cancer epithelial cell explants

Eleanor I. Ager, Dominika Butler, Alex Stevenson, Eiffe Eiffe, Andrew Heaton, Brian Gabrielli, Norman J. Maitland, David Brown
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5102.
https://doi.org/10.1158/1538-7445.AM2017-5102
Published: 01 July 2017
View article titled, Abstract 5102: TRXE-009-1 has pan-acting anticancer activity and potently inhibits colony formation of prostate cancer epithelial cell explants
Journal Articles

Abstract 1452: Interrogating the impact of pregnancy on breast cancer biology using DNA copy number profiling

Bastien Nguyen, David Venet, Françoise Rothé, Christine Desmedt, Samira Majjaj, Giancarlo Pruneri, David Brown, Fedro Peccatori, Hatem A. Azim, Christos Sotiriou
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1452.
https://doi.org/10.1158/1538-7445.AM2017-1452
Published: 01 July 2017
View article titled, Abstract 1452: Interrogating the impact of pregnancy on breast cancer biology using DNA copy number profiling
Journal Articles

Abstract 3962: Circulating tumor DNA (ctDNA) as an alternative to tumor biopsies for precision oncology: The Jules Bordet Institute experience

Philippe G. Aftimos, Marion Maetens, Françoise Rothé, David Brown, Yacine Barèche, Alexandre Irrthum, Thierry Berghmans, Joseph Kerger, Alain Hendlisz, Michail Ignatiadis, Martine Piccart, Christos Sotiriou, Ahmad Awada
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3962.
https://doi.org/10.1158/1538-7445.AM2016-3962
Published: 15 July 2016
View article titled, Abstract 3962: Circulating tumor DNA (ctDNA) as an alternative to tumor biopsies for precision oncology: The Jules Bordet Institute experience
Journal Articles

Abstract 3968: Comparison of NGS and digital PCR for the detection of point mutations in breast tumor and plasma samples

Françoise Rothé, Ghizlane Rouas, Michelle Coureau, Marion Maetens, David Brown, Christos Sotiriou, Michail Ignatiadis
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3968.
https://doi.org/10.1158/1538-7445.AM2016-3968
Published: 15 July 2016
View article titled, Abstract 3968: Comparison of NGS and digital PCR for the detection of point mutations in breast tumor and plasma samples
Journal Articles

Abstract 1519: Cantrixil targets ovarian cancer stem cells and prevents recurrence in a cisplatin-resistant animal model

Gil G. Mor, Eydis Lima, Natalia Sumi, Mary Pitruzzello, Yang Yang-Hartwich, David Brown, Andrew Heaton, Ayesha B. Alvero
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1519.
https://doi.org/10.1158/1538-7445.AM2015-1519
Published: 01 August 2015
View article titled, Abstract 1519: Cantrixil targets ovarian cancer stem cells and prevents recurrence in a cisplatin-resistant animal model
Journal Articles

Abstract 1588: Single cell analysis of AR N terminal, AR C terminal and the ARv7 splice variant in the CTCs of metastatic castration resistant prostate cancer (mCRPC) patients

James Kelvin, David Lu, Davin Packer, Richard Bambury, Dana Rathkopf, Nicole Schreiber, Zaina Arslan, Natalie Prigozhina, David Brown, Rachel Krupa, Edward Swangren, Mark Landers, Florence Lee, Dena Marrinucci, Ryan Dittamore, Howard I. Scher
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1588.
https://doi.org/10.1158/1538-7445.AM2015-1588
Published: 01 August 2015
View article titled, Abstract 1588: Single cell analysis of AR N terminal, AR C terminal and the ARv7 splice variant in the CTCs of metastatic castration resistant prostate cancer (mCRPC) patients
Journal Articles

Abstract CT135: Uncovering the genomic heterogeneity of multifocal breast cancer

Christine Desmedt, Debora Fumagalli, Elisabetta Pietri, Gabriele Zoppoli, Serena Nik-Zainal, Gunes Gundem, David Brown, Francois Rothe, Samira Majjaj, Anna Garuti, Enrico Carminati, Sherene Loi, Thomas Van Brussel, Marion Maetens, Laura Mudie, Delphine Vincent, Naima Kheddoumi, Luigi Serra, Ilaria Massa, Alberto Ballestrero, Dino Amadori, Roberto Salgado, Alexandre de Wind, Diether Lambrechts, Martine Piccart, Denis Larsimont, Peter J. Campbell, Christos Sotiriou
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT135.
https://doi.org/10.1158/1538-7445.AM2015-CT135
Published: 01 August 2015
View article titled, Abstract CT135: Uncovering the genomic heterogeneity of multifocal breast cancer
Journal Articles

Abstract S2-05: Characterization and clinical relevance of the genomic alterations defining lobular breast cancer

Christine Desmedt, Gunes Gundem, Gabriele Zoppoli, Giancarlo Pruneri, Elia Biganzoli, Marco Fornili, Debora Fumagalli, Françoise Rothé, David Brown, Peter Van Loo, Sylvain Brohée, Delphine Vincent, Naima Keddoumi, Samira Majjaj, Ghizlane Rouas, Thomas Van Brussel, Diether Lambrechts, Otto Metzger, Christine Galant, François Bertucci, Martine Piccart, Denis Larsimont, Giuseppe Viale, Peter J Campbell, Christos Sotiriou
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): S2-05.
https://doi.org/10.1158/1538-7445.SABCS14-S2-05
Published: 01 May 2015
View article titled, Abstract S2-05: Characterization and clinical relevance of the genomic alterations defining lobular breast cancer
Journal Articles

Abstract 986: Unraveling breast cancer progression through geographical and temporal sequencing

Christine Desmedt, David Brown, Borbala Szekely, Dominiek Smeets, Marcell A. Szasz, Pierre-Yves Adnet, Françoise Rothé, Zsofia I. Nagy, Zsofia Farago, Anna-Maria Tokes, Dimitrios Zardavas, Gabriele Zoppoli, Michail Ignatiadis, Lajos Pusztai, Martine Piccart, Denis Larsimont, Diether Lambrechts, Janina Kulka, Christos Sotiriou
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 986.
https://doi.org/10.1158/1538-7445.AM2014-986
Published: 01 October 2014
View article titled, Abstract 986: Unraveling breast cancer progression through geographical and temporal sequencing
Journal Articles

Abstract 1453: MicroRNA replacement and RNAi-mediated silencing of ALK as combined targeted therapies for neuroblastoma

Patrizia Perri, Daniela D. Paolo, Leslie Priddy, Annarita D. Fiore, Chiara Brignole, Fabio Pastorino, David Brown, Mirco Ponzoni
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1453.
https://doi.org/10.1158/1538-7445.AM2014-1453
Published: 01 October 2014
View article titled, Abstract 1453: MicroRNA replacement and RNAi-mediated silencing of ALK as combined targeted therapies for neuroblastoma
Journal Articles

Abstract 5137: Parallel approaches to the discovery of novel BRD4 inhibitors

David H. Jones, Marcel J. de Groot, Robert Heald, Ebenezer Arhin, Ria Goodwin, Brenda Burton, Jan Kulagowski, David Brown, Steven Irving, Richard Bazin, Deborah Bruce, Rene Devos, Steven Price, Nick Ray, Peter Lockey, John Montana, Mark R. Albertella, Simon R. Green
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5137.
https://doi.org/10.1158/1538-7445.AM2014-5137
Published: 01 October 2014
View article titled, Abstract 5137: Parallel approaches to the discovery of novel BRD4 inhibitors
Journal Articles

Abstract LB-250: Development of a miR34-based cancer therapy.

Chris Daige, Jason Wiggins, Leslie Priddy, Kevin Kelnar, Jane Zhao, Andreas Bader, David Brown
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-250.
https://doi.org/10.1158/1538-7445.AM2013-LB-250
Published: 15 April 2013
View article titled, Abstract LB-250: Development of a miR34-based cancer therapy.
Journal Articles

Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7

Can Liu, Kevin Kelnar, Alexander V. Vlassov, David Brown, Junchen Wang, Dean G. Tang
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3393–3404.
https://doi.org/10.1158/0008-5472.CAN-11-3864
Published: 01 July 2012
View article titled, Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7
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Includes: Supplementary data